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Original Article

Mechanisms of Gastroprotection

Pages 15-28 | Published online: 08 Jul 2009

References

  • Robert A. Cytoprotection and prostaglandins. Klin Wochenschr 1986; 64: 40–43, suppl VII
  • Konturek S J, Pawlik W. Physiology and pharmacology of prostaglandins. Dig Dis Sci 1986; 31: 6S–19S, suppl
  • Robert A. Cytoprotection and prostaglandins. Gastroenterology 1979; 77: 761–767
  • Rask-Madsen J. Role of eicosanoids in the gastrointestinal tract. Scand J Gastroenterol 1987; 22: 7–19, suppl 127
  • Whittle B, JR, Kauffman G L, Moncada S. Vasoconstriction with thromboxane A2 induced ulceration of the gastric mucosa. Nature (Lond) 1981; 292: 472–474
  • Peskar B M, Lange K, Hoppe V, Peskar BA. Etha-nol stimulates formation of leukotriene C4 in rat gastric mucosa. Prostaglandins 1986; 31: 283–293
  • Moncada S, Flower R J, Vane JR. Prostaglandins, prostacyclin, thromboxane A2 and leukotrienes. The pharmacological basis of therapeutics, A Goodman Gilman, LS Goodman, TW Rail, F Murad. MacMillan Publ, Co., New York 1985; 660–673
  • Wallace J L, Whittle B, JR. Profile of gastrointestinal damage induced by platelet-activating factor. Prostaglandins 1986; 32: 137–141
  • Wallace J L, Beck P L, Morris GP. Is there a role for leukotrienes as mediators of ethanol-induced gastric mucosal damage?. Am J Physiol 1988; 254: G117–G123
  • Konturek S J, Brzozowski T, Drozdowicz D, Beck G. Role of leukotrienes in acute gastric lesions induced by ethanol, taurocholate, aspirin, platelet-activating factor and stress in rats. Dig Dis Sci 1988; 33: 806–813
  • Saeed S A, Drew M, Denning-Kendal P A, McDonald-Gibson W, Collier HO. Inhibitors and stimulants of prostaglandin cyciooxygenase in stomach extracts. Biochem Soc Trans 1981; 9: 92–93
  • Whittle B, JR. Potential endogenous inhibitor of prostaglandin synthetase in plasma failure to inhibit cyciooxygenase in platelets and the gastric mucosa. J Pharm Pharmacol 1978; 30: 467–468
  • Vane JR. The use of isolated organs for detecting active substance in the circulating blood. Br J Pharmacol Chemother 1964; 23: 360–373
  • Chen M, Sanders M, Thomas L, Amirian D, Kauffman G, Soil AH. Prostaglandin (PG) production in canine fundic mucosa: identification of major cellular sources. Gastroenterology 1986; 90: 1371
  • Robert A, Nezamis J E, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HO, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433–443
  • Stachura J, Tarnawski A, Ivey KJ, et al. Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat. Gastroenterology 1981; 81: 211–217
  • Robert A, Nezamis J E, Field S O, Lancaster C, Davis JP. 16,16-dimethyl PGE2 prevents caerulein-induced pancreatitis in rats. Gastroenterology 1983; 84: 1287
  • Lacy E R, Ito S. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with prostaglandin. Gastroenterology 1982; 83: 619–625
  • Silen W. What is cytoprotection of the gastric mucosa?. Gastroenterology 1988; 94: 232–235
  • Lacy E R, Ito S. Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest 1984; 51: 573–583
  • Ito S, Lacy E R, Rutten M J, Critchlow J, Silen W. Rapid repair of injured gastric mucosa. Scand J Gastroenterol 1984; 19: 87–96, suppl 101
  • Tarnawski A, Hollander D, Stachura J, Krause W J, Gergely H. Prostaglandin protection of the gastric mucosa against alcohol injury–a dynamic time-related process. Role of muscular proliferative zone. Gastroenterology 1985; 88: 334–354
  • Wallace J L, Whittle BJ. Role of mucos in the repair of gastric epithelial damage in the rat. Inhibition of epithelial recovery by mucolytic agents. Gastroenterology 1986; 91: 603–611
  • Wallace J C, Whittle B, JR. Acceleration of recovery of gastric epithelial integrity by 16,16-dimethyl prostaglandin E2. Br J Pharmacol 1985; 86: 838–842
  • Guth P H, Paulsen G, Nagata H. Histological and microcirculatory changes in alcohol-induced gastric lesions in rats: effect of prostaglandin cyto-protection. Gastroenterology 1984; 87: 1083–1090
  • Leung F W, Robert A, Guth PH. Gastric mucosal blood flow in rats after administration of 16,16-dimethyl prostaglandin E2 at a cytoprotective dose. Gastroenterology 1985; 88: 1948–1953
  • Leung F W, Itoh M, Hirabayashi K, Guth PH. Role of blood flow in gastric and duodenal mucosa injury in rats. Gastroenterology 1985; 88: 282–289
  • Rowe P H, Starlinger M J, Kasdon E, Marrone G, Silen W. Effect of simulated systemic administration of aspirin, salicylate and indomethacin on amphibian gastric mucosa. Gastroenterology 1986; 90: 559–569
  • Konturek S J, Brzozowski T, Piastucki I, Radecki T, Dembinska-Kiec A. Role of prostaglandin and thromboxane biosynthesis in gastric necrosis produced by taurocholate and ethanol. Dig Dis Sci 1983; 28: 154–160
  • Whittle B, JR, Boughton-Smith NK. Biosynthesis of endogenous arachidonate products involved in gastric damage and protection. Proceedings of IUPHAR 9th International Congress of Pharmacology., W Paton, J Mitchell, P Turner. McMillan, London 1984; 345–350
  • Lefer AM. Eicosanoids as mediators of ischemia and shock. Fed Proc 1985; 44: 275–280
  • Whittle B, JR, Oren-Woldan N, Guth PH. Gastric vasoconstrictor actions of Leukotriene C4, prostaglandin F2 and thromboxane mimetic (U-46619) on the rat submucosal microcirculation in vivo. Am J Physiol 1985; 248: G580–G586
  • Vargaftig B B, Chignard M, Benveniste J, Lefort J, Wal F. Background and present status of research on platelet-activating factor (PAF-acether). Ann NY Acad Sci 1981; 3710: 119–125
  • Rosam A C, Wallace J L, Whittle B, JR. Potent ulcerogenic actions of platelet-activating factor on the stomach. Nature 1986; 319: 54–56
  • Braquet P, Etienne A, Mencia-Huerta J-M, Clostre T. Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations. Eur J Pharmacol 1988; 150: 269–276
  • Terashita Z, Imura Y, Nishikawa K, Sumida S. Is platelet activating factor (PAF) a mediator of endotoxin shock?. Eur J Pharmacol 1985; 109: 257–262
  • Robert A, Nezamis J E, Lancaster C, Davis J P, Field S O, Janchar AJ. Mild irritants prevent gastric necrosis through ‘adaptive cytoprotection' mediated by prostaglandins. Am J Physiol 1983; 245: G113–121
  • Konturek S J, Brzozowski T, Piastucki I, Radecki T, Dembinski A, Dembinska-Kiec A. Role of locally generated protaglandins in adaptive gastric cytoprotection. Dig Dis Sci 1982; 27: 967–971
  • Hawkey C J, Kemp R T, Walt R P, Bhaskar N K, Davies J, Filipowicz B. Evidence that adaptive cytoprotection in rats is not mediated by prostaglandins. Gastroenterology 1988; 94: 948–954
  • Wallace JL. Increased resistance of the rat gastric mucosa to homorrhagic damage after exposure to an irritant. Role of ‘mucoid cap' and prostaglandin synthesis. Gastroenterology 1988; 94: 22–32
  • Tarnawski A, Hollander D, Stachura J, Krause W. Arachidonic acid protection of gastric mucosa against alcohol injury: sequential analysis of morphologic and functional changes. J Lab Clin Med 1983; 102: 340–351
  • Hollander D, Tarnawski A, Gergely H, Zipser RD. Sucralfate protection of gastric mucosa against alcohol-induced necrosis: a prostaglandin mediated process?. Scand J Gastroenterol 1984; 19: 97–102, suppl 101
  • Konturek S J, Radecki T, Piastucki I, Brzozowski T, Drozdowicz D. Gastroprotection by colloidal bismuth subicitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins. Gut 1987; 28: 201–205
  • Hagel J, Renner H, Hirsch M, et al. Gastric cytoprotection by antacids and papaverine in rats. Hepa-togastroenterol 1982; 29: 271–274
  • Szelenyi I, Postuis S, Engler H. Evidence for a functional cytoprotective effect produced by antacids in the rat stomach. Eur J Pharmacol 1983; 88: 403–406
  • Konturek S J, Brzozowski T, Drozdowicz D, Nauert C. Gastroprotection by an aluminium- and magnesium hydroxide-containing antacid in rats. Role of endogenous prostanoids. Scand J Gastroenterol 1989; 24: 1113–1120
  • Konturek S J, Brzozowski T, Piastucki I, Radecki T. Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins. Gut 1982; 23: 536–540
  • Robert A, Eberle D, Kaplowitz N. Role of glutathione in gastric mucosal cytoprotection. Am J Physiol 1984; 247: G296–304
  • Szabo S, Trier J S, Frankel PW. Sulhydryl compounds may mediate gastric cytoprotection. Science 1981; 214: 200–202
  • Konturek S J, Radecki T, Brzozowski T, et al. Gastric cytoprotection by epidermal growth factor. Role of endogenous prostaglandins and DNA synthesis. Gastroenterology 1981; 81: 438–443
  • Szabo S, Usadel KH. Cytoprotection or organo-protection by somatostatin: gastric and hepatic lesions. Experientia 1982; 38: 254–255
  • Konturek S J, Kitler M E, Brzozowski T, Radecki T. Gastric protection by meciadanol, a new synthetic flavonoid inhibiting histidine decarboxylase. Dig Dis Sci 1980; 31: 847–852
  • Satoh H. Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics. Gastroenterology 1983; 84: 483–498
  • Szabo S. Experimental basis for a role for sulfhy-dryls and dopamine in ulcerogenesis: a primer for cytoprotection–organoprotection. Klin Wochen-schr 1986; 64: 116–122, suppl VII
  • Konturek S J, Brzozowski T, Radecki T, Piastucki I, Dembinski A. Cytoprotective effects of gastrointestinal hormones. Gut peptides and ulcer, A Miyoshi. Biomedical Research Foundation, Tokyo 1983; 411–417
  • Diehl F, Szabo S. Dose dependent effect of linear and cyclic somatostatin on ethanol induced gastric erosions: the role of mast cells and increased vascular permeability in the rat. Regul Pept 1986; 13: 235–243
  • Konturek S J, Piastucki I, Brzozowski T, Demb-inska-Kiec A, Gryglewski R. Role of prostaglandins in the formation of aspirin-induced gastric ulcers. Gastroenterology 1981; 80: 4–9
  • Lichtenberg L M, Richards J E, Hills BA. Effect of 16,16-dimethyl prostaglandin E2 on the surface hydrophobicity of aspirin-treated canine gastric mucosa. Gastroenterology 1985; 88: 308–314
  • Ligumsky M, Grossman M I, Kaufman GL. Endogenous gastric mucosal prostaglandins: their role in mucosal integrity. Am J Physiol 1982; 242: G337–G341
  • Hawkey CJ. Review: acute human model of gastric mucosal injury. Aliment Pharmacol Ther 1987; 1: 593–606
  • Whittle B, JR. The mechanism of gastric damage by nonsteroid anti-inflammatory drugs. Biological protection with prostaglandins, MM Cohen. Boca Raton Press, Boca Raton, Fla 1986; 1–27
  • Cohen M M, Clark L, Armstrong L, d'Souza J. Reduction in aspirin-induced fecal blood loss with low-dose misoprostal tablets in man. Dig Dis Sci 1985; 30: 305–311
  • Konturek S J, Kwiecien N, Obtulowicz W, Polanski M, Kopp B, Oleksy J. Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding in man. Gut 1983; 24: 89–93
  • Johansson C, Kolberg B, Nordemar R, Samuelson K, Borgstrom S. Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases. Gastroenterology 1980; 78: 479–483
  • Lanza FL. A double-blind study of prophylactic effect of misoprostal on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects. Dig Dis Sci 1986; 31: 1315–1365
  • Hawkey C J, Simpson G, Somerville KW. Reduction by enprostil of aspirin-induced blood loss from human gastric mucosa. Am J Med 1986; 88: 50–53
  • Agrawal N M, Godiwala T, Arimura A, Dajani EZ. Cytoprotection by synthetic prostaglandin against ethanol-induced gastric mucosal damage. A double-blind endoscopic study in human subjects. Gastro-intest Endosc 1986; 32: 67–70
  • Isenberg J I, Hogan D L, Koss M A, Selling JA. Human duodenal mucosal bicarbonate secretion. Evidence of basal secretion and stimulation of hydrochloric acid and a synthetic prostaglandin El analog. Gastroenterology 1986; 91: 370–378
  • Sato N, Kawano S, Inkada M. The effect of misoprostal on gastric mucosal hemodynamics in man: a possible mechanism of cytoprotection. Gastroenterology 1986; 90: 1616
  • Konturek S J, Kwiecien N, Obtulowicz W, Kopp B, Oleksy J. Double-blind controlled study on the effect of sucralfate on gastric prostaglandin formation and microbleeding in normal and aspirin treated man. Gut 1986; 27: 1450–1456
  • Tarnawski A, Glick M E, Stachura J, Hollander D, Gergely H. Efficacy of sucralfate and cimetidine in protection of the human gastric mucosa against alcohol injury. Am J Med 1987; 83: 31–37, suppl 3B
  • Konturek S J, Kwiecien N, Obtulowicz W, Hebzda Z. Effects of colloidal bismuth subcitrate on aspirin-induced gastric microbleeding, DNA loss and prostaglandin formation in humans. Scand J Gastroenterol 1988; 23: 861–866
  • Konturek S J, Kwiecien N, Obtulowicz W, Hebzda Z, Oleksy J. Effects of protective drugs on gastric-alkaline secretion in man. Scand J Gastroenterol 1987; 22: 1059–1063
  • Brand D L, Ronfail W M, Thompson A BR, Tapper EJ. Misoprostal, a synthetic PGE1 analog in treatment of duodenal ulcers: a multicentre double-blind study. Dig Dis Sci 1985; 30: 147S–158S, suppl
  • Wengrower D, Fich A, Goldin E, Eliakim R, Ligumsky M, Rachmilewitz D. Cytoprotective doses of arbacet with minimal antisecretory properties are not effective in duodenal ulcer healing. Dig Dis Sci 1987; 32: 857–860
  • Konturek S J, Stachura J, Radecki T, Drozdowicz D, Brzozowski T. Cytoprotective and ulcer healing properties of prostaglandin E2, colloidal bismuth and sucralfate in rats. Digestion 1987; 38: 103–113
  • Inanen W, Wyss P A, Kayser S, et al. Influence of prostaglandins, omeprazole and indomethacin on healing of experimental gastric ulcers in the rat. Gastroenterology 1988; 95: 636–641
  • Konturek S J, Dembinski A, Wazecha Z, Brzozowski T, Gregory H. Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats. Gastroenterology 1988; 94: 1300–1307
  • Konturek S J, Dembinski A, Warzecha Z, Bielanski W, Brzozowski T, Drozdowicz D. Epidermal growth factor in the gastroprotective and ulcer healing effects of colloidal bismuth subcitrate (De-Nol) in rats. Gut 1988; 29: 894–902

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