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Review Article

Review: Abnormal Intestinal Permeability in Crohn's Disease: A Possible Pathogenic Factor

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Pages 321-328 | Published online: 08 Jul 2009

References

  • Kirsner J B, Shorter R G. Recent developments in nonspecific inflammatory bowel disease (second of two parts). N Engl J Med 1982; 306: 837–848
  • Shorter R G, Huizenga K A, Spencer R J. A working hypothesis for the etiology and pathogenesis of nonspecific inflammatory bowel disease. Dig Dis 1972; 17: 1024–1032
  • Gebbers J O, Otto H F. Alterations of the intestinal mucosal block in ulcerative colitis and Crohn's disease-Immunological and ultrastructural findings and considerations of the pathogenesis. Klin Paediatr 1985; 197: 341–348
  • Stöcker W, Otte M, Scriba P C. Zur Immu-nopathogenese des Morbus Crohn. Dtsch Med Wochenschr 1984; 109: 1–3
  • Thyberg J, Graf W, Klingenström P. Intestinal fine structures in Crohn's disease. Virchows Arch 1981; 391: 141–152
  • Walker W A, Isselbacher K J. Uptake and transport of macromolecules by the intestine. Possible role in clinical disorders. Gastroenterology 1974; 67: 531–550
  • Ward M. The pathogenesis of Crohn's disease. Lancet 1977; 1: 903–905
  • Hollander D. Crohn's disease-a permeability disorder of the tight junction. Gut 1988; 29: 1621–1624
  • Husby S, Jensenius J C, Svehag S E. Passage of unde-graded dietary antigen into the blood of healthy adults-Quantification, estimation of size distribution, and relation of uptake to levels of specific antibodies. Scand J Immunol 1985; 22: 83–92
  • Brandtzaeg P, Halstensen T S, Kett K, Rognum T O. Local immunopathology in inflammatory bowel disease. Inflammatory bowel disease, G Jarnerot. Raven Press, New York 1987; 21–35
  • The Management of Crohn's disease, H A. Oberhelm, I T. Weterman, A S. Pena, C C. Booth. Excerpta Medica, Amsterdam 1976; 216
  • Kushner R F, Shapir J, Sitrin M D. Endoscopic, radiographic, and clinical response to prolonged bowel rest and home parenteral nutrition in Crohn's disease. JPEN 1986; 10: 568–573
  • Muller J M, Keller H W, Erasmi H, Pichlmaier H. Total parenteral nutrition as the sole therapy in Crohn's disease-a prospective study. Br J Surg 1983; 70: 40–43
  • Saverymuttu S, Hodgson H JF, Chadwick V S. Controlled trial comparing prednisolone with an elemental diet plus non-absorbable antibiotics in active Crohn's disease. Gut 1985; 26: 994–998
  • Jones V A, Dickinson R J, Workman E, Wilson A J, Freeman A H, Hunter J O. Crohn's disease: maintenance of remission by diet. Lancet 1985; 2: 177–180
  • Cooper B T. The small intestinal permeability barrier. Gut defences in clinical practice, M S. Losowsky, R V. Heatley. Churchill-Livingstone, Edinburgh 1986; 117–132
  • Bjamason I, Peters T J, Levi J. Intestinal permeability: Clinical correlates. Dig Dis 1986; 4: 83–92
  • Fordtran J S, Floyd C R, Maynard F E, Soter N, Kinney J. Permeability characteristics of the human small intestine. J Clin Invest 1965; 44: 1935–1944
  • Loehry C A, Kingham J, Baker J. Small intestinal permeability in animals and man. Gut 1973; 14: 683–688
  • Cobden I, Rothwell J, Axon A TR. Passive permeability in experimental intestinal damage in rats. Clin Sci 1981; 60: 115–118
  • Hamilton I, Rothwell J, Archer D, Axon A TR. Permeability of the rat small intestine to carbohydrate probe molecules. Clin Sci 1987; 73: 189–196
  • Maxton D G, Bjarnasson I, Reynolds A P, Catt S D, Peters T J, Menzies I S. Lactulose 51Cr-labelled ethylendiaminetetra-acetate L-rhamnose and poly-ethyleneglycol 500 as probe markers for assessment in vivo of human intestinal permeability. Clin Sci 1986; 71: 71–80
  • Wright E M. The passive permeability of the small intestine. Biomembranes, D H. Smyth. Plenum Press, London 1974; Vol. 4A: 159–198
  • Menzies I S. Transmucosal passage of inert molecules in health and disease. Intestinal absorption and secretion, E Skadhauge, K Heintze. MTP Press Ltd, Lancaster 1983; 527–543
  • Fisher R B, Parsons D S. The gradient of mucosal surface area in the small intestine of the rat. J Anat 1950; 84: 263–285
  • Chadwick V S, Phillips S F, Hofmann A F. Measurements of intestinal permeability using low molecular weight polyethyleneglycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals. Gastroenterology 1977; 73: 247–251
  • Menzies I S. Absorption of intact oligosaccharide in health and disease. Biochem Soc Trans 1974; 2: 1042–1047
  • Beach R C, Menzies I S, Graham S C, Scopes J W. Gastrointestinal permeability changes in the preterm neonate. Archives of diseases in childhood 1982; 57: 141–145
  • Cobden I, Rothwell J. Axon ATR. Intestinal permeability and screening tests for coeliac disease. Gut 1980; 21: 512–518
  • Chadwick V S, Phillips S F. Hofmann AF. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). I. Chemical analysis and biological properties of PEG 400. Gastroenterology 1977; 73: 241–246
  • Tagesson C, Andersson PÅ, Andersson T, Bolin T, Källberg M, Sjödahl R. Passage of molecules through the wall of the gastrointestinal tract. Measurement of intestinal permeability to polyethylene glycols in the 634–1338-dalton range (PEG 1000). Scand J Gastroenterol 1983; 18: 481–486
  • Bjarnason I, Peters T J, Veall N. A persistent defect of intestinal permeability in coeliac disease as demonstrated by a 51-Cr-labelled EDTA absorption test. Lancet 1983; 1: 323–325
  • Bjarnason I, O'Morain C, Levi A J, Peters T J. Absorption of 51-chromium-labeled ethylenedi-aminetetraacetate in inflammatory bowel disease. Gastroenterology 1983; 85: 318–822
  • Casellas F, Aguade S, Soriano B, Accarino A, Molero J, Guarner L. Intestinal permeability to 99m-Tc-diethylenetriaminopentaacetic acid in inflammatory bowel disease. Am J Gastroenterol 1986; 81: 767–770
  • Sundqvist T, Magnusson K E, Sjödahl R, Stjernström R, Tagesson C. Passage of molecules through the wall of gastrointestinal tract. II. Application of low-molecular weight polyethyleneglycol and a deterministic mathematical model for determining intestinal permeability in man. Gut 1980; 21: 208–214
  • Sundqvist T. Probing intestinal permeability in man [Medical Dissertations 124]. Linkopings University, Linköping 1981
  • Magnusson K E, Sundqvist T. Modelling of intestinal permeability in man to polyethylene glycols (PEG 400 and PEG1000). Acta Physiol Scand 1985; 125: 289–296
  • Olaison G, Sjödahl R, Tagesson C. Decreased permeability to different-sized polyethyleneglycols in ileocaecal Crohn's disease-A sign of jejunal abnormality. Acta Chir Scand 1987; 153: 373–377
  • Olaison G, Sjödahl R, Leandersson P, Tagesson C. Abnormal intestinal permeability pattern in colonic Crohn's disease. Absorption of low molecular weight polyethylene glycols after oral and colonic load. Scand J Gastroenterol 1989; 24: 571–576
  • Ukabam S O, Cooper B T. Small intestinal permeability to mannitol, lactulose, and polyethylene glycol 400 in celiac disease. Dig Dis Sci 1984; 29: 809–816
  • Falchuk K R, Isselbacher K J. Circulating antibodies to bovine albumin in ulcerative colitis and Crohn's disease. Gastroenterology 1976; 70: 5–8
  • Doe F W, Booth C C, Brown D L. Evidence for com-plementbinding immune complexes in adult coeliac disease, Crohn's disease and ulcerative colitis. Lancet 1973; 402–403
  • Fiasse R, Lurhuma A Z, Cambiaso C J, Mazsson P L, Dive C. Circulating immune complexes and disease activity in Crohn's disease. Gut 1978; 19: 611–617
  • Hodgson H JF, Potter B J, Jewell D P. Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol 1977; 29: 187–196
  • Ambrose N S, Johnson M, Burdon D W, Keighley M RB. Incidence of pathogenenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery. Br J Surg 1984; 71: 623–635
  • Auer I O, Röder A, Wensinck F, Van de Merve J P, Schmidt H. Selected bacterial antibodies in Crohn's disease and ulcerative colitis. Scand J Gastroenterol 1983; 18: 217–233
  • Peisson S, Danielsson D. On the occurrence of serum antibodies to bacteroides fragilis and sero-groups of e. coli in patients with Crohn's disease. Scand J Infect Dis 1979; 19: 61–67, suppl
  • Grybovski J D, Thayer W R, Gabrielsson I W, Spiro H M. Disacchariduria in gastrointestinal disease. Gastroenterology 1963; 45: 633–637
  • Hollander D, Vadheim C M, Brettholz E, Petersen G M, Delahunty T, Rotter J I. Increased intestinal permeability in patients with Crohn's disease and their relatives-A possible etiologic factor. Ann Intern Med 1986; 105: 883–885
  • Katz K D, Hollander D, McElae C. Delineation of the range of intestinal permeability abnormalities in patients with Crohn's disease and their healthy relatives. Gastroenterology 1988; 94: A218
  • Rask-Madsen J, Hammersgaard E A, Knudsen E. Rectal electrolyte transport and mucosal permeability in ulcerative colitis and Crohn's disease. J Lab Clin Med 1973; 81: 342–353
  • O'Morain C A, Abelov C A, Cheruu L R, Fleischner G M. Chromium 51-ethylenediaminetetraacetate: a useful test in the assessment of inflammatory bowel disease. J Lab Clin Med 1986; 108: 430–435
  • Olaison G, Leandersson P, Sjödahl R, Tagesson C. Intestinal permeability to polyethyleneglycols 600 in Crohn's disease. Peroperative determination in a denned segment of the small intestine. Gut 1988; 29: 196–199
  • Olaison G, Sjodahl R, Leandersson P, Tagesson C. Increase in permeability and phospholipase A2 activity of colonic mucosa in Crohn's colitis. Digestion 1989; 43: 228–233
  • Beeken W L, Busch H J, Sylwester D L. Intestinal protein loss in Crohn's disease. Gastroenterology 1972; 62: 207–215
  • Florent C, l'Hirondel C, Desmazures C, Girau-Deaux V. Evaluation de l'évoulutivitè de la maladie de Crohn et de la rectocolite hemorraggique par la mesure de la clairance fecale de l'alfa1-antitrypsine. Gastroenterol Clin Biol 1981; 5: 193–197
  • Karbach U, Ewe K, Bodenstein H. Alpha,-anti-trypsin, a reliable endogenous marker for intestinal protein loss and its application in patients with Crohn's disease. Gut 1983; 24: 718–723
  • Fischbach W, Becker W, Mössner J, Koch W, Rein-Ers C. Faecal alpha-1-antitrypsin and excretion of 111indium granulocytes in assessment of disease activity in chronic inflammatory bowel diseases. Gut 1987; 28: 386–393
  • Kingham J GC, Loehry C A. Selectivity of small intestinal exudate in celiac disease and Crohn's disease. Dig Dis 1978; 23: 33–38
  • Dourmashkin R R, Davies H, Wells C. Epithelial patchy necrosis in Crohn's disease. Human Pathol 1983; 14: 643–648
  • Marin M L, Greenstein A J, Geller S A, Gordon R E, Aufses A H. A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organization. Am J Gastroenterol 1983; 78: 537–547
  • Rickert R R, Carter H W. The ‘early’ ulcerative lesion of Crohn's disease: Correlative light- and scanning electron-microscopic studies. J Clin Gastroenterol 1980; 2: 11–19
  • Makiyama K, Bennet M K, Jewell D P. Endoscopic appearances of the rectal mucosa of patients with Crohn's disease visualised with a magnifying colono-scope. Gut 1984; 25: 337–340
  • Dunne W T, Cooke W T, Allan R N. Enzymatic and morphometric evidence for Crohn's disease as a diffuse lesion of the gastrointestinal tract. Gut 1977; 18: 290–294
  • Dvorak A M, Connel A B, Dickersin G R. Crohn's disease: a scanning electron microscopic study. Human Pathol 1979; 10: 165–177
  • Dvorak A M, Dickersin G R. Crohn's disease: transmission electron microscopic studies. Human Pathol 1980; 11: 561–571
  • Ramage J K, Hunt R H, Perdue M H. Changes in intestinal permeability and epithelial differentiation during inflammation in the rat. Gut 1988; 29: 57–61
  • Christiansen P A, Kirsner J B, Ablaza J. D-xylose and its use in the diagnosis of malabsorptive states. Am J Med 1959; 27: 443–453
  • Shiner M, Vakil B J, Wilcox P B. Urinary xylose excretion in steatorrhea. Gut 1962; 3: 240–244
  • Dotevall G, Kock N G. Absorption studies in regional enterocolitis (Mb. Crohn). Scand J Gastroenterol 1968; 3: 293–296
  • Hertzberg J N, Myren J, Semb L S. Regional enterocolitis (Crohn's disease)-absorption studies after surgical treatment. Scand J Gastroenterol 1969; 4: 569–573
  • Gerson C D, Cohen N, Janowitz H D. Small intestinal absorptive function in regional enteritis. Gastroenterology 1973; 64: 907–912
  • Sturnioli G C, Molokhia M M, Shields R, Turnberg L A. Zinc absorption in Crohn's disease. Gut 1980; 21: 387–391
  • Pearson A DJ, Eastham E J, Laker M F, Craft A W, Nelson R. Intestinal permeability in children with Crohn's disease and coeliac disease. Br Med J 1982; 285: 20–21
  • Heuman R, Sjödahl R. Tagesson C. Passage of molecules through the wall of the gastrointestinal tract-Intestinal permeability to polyethyleneglycol 1000 in patients with Crohn's disease. Acta Chir Scand 1982; 148: 281–284
  • Magnusson K-E, Sundqvist T, Sjödahl R, Tagesson C. Altered intestinal permeability to low-molecular weight polyethyleneglycols (PEG 400) in patients with Crohn's disease. Acta Chir Scand 1983; 149: 323–327
  • Peled Y, Watz C, Gilat T. Measurement of intestinal permeability using 51Cr-EDTA. Am J Gastroenterol 1985; 80: 770–773
  • Jenkins R T, Goodacre R L, Rooney P J, Bienen-Stock J, Sivakumaran T, Walker W HC. Studies of intestinal permeability in inflammatory diseases using polyethylene glycol 400. Clin Biochem 1986; 19: 298–302
  • Auer I O, Röder A, Wensinck F, Van de Merve J P, Schmidt H. Selected bacterial antibodies in Crohn's disease and ulcerative colitis. Scand J Gastroenterol 1983; 18: 217–233
  • Sanderson I R, Boulton P, Menzies I, Walker-Smith J A. Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet. Gut 1987; 28: 1073–1076
  • Andre F, Andre C, Emery Y, Forichon J, Des-Cos L, Minaire Y. Assessment of the lactulose-mannitol test in Crohn's disease. Gut 1988; 29: 511–515

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