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Original Article

Long-Term Effects of Oral Propranolol on Splanchnic and Systemic Haemodynamics in Patients with Cirrhosis and Oesophageal Varices

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Pages 933-939 | Received 29 Jan 1991, Accepted 31 Mar 1991, Published online: 08 Jul 2009

References

  • Lebrec D, Nouel O, Corbie M, Benhamou J P. Propranolol-A medical treatment for portal hypertension?. Lancet 1980; 2: 180–182
  • Lebrec D, Hillon P, Munoz C, Goldfarb G, Nouel O, Benhamou J P. The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study. Hepatology 1982; 2: 523–527
  • Cales P, Braillon A, Jiron I J, Lebrec D. Superior portosystemic collateral circulation estimated by azygos blood flow in patients with cirrhosis. Lack of correlation with oesophageal varices and gastrointestinal bleeding. Effect of propranolol. J Hepatol 1984; 1: 37–46
  • Garcia-Tsao G, Grace N, Groszmann R, et al. Short-term effects of propranolol on portal venous pressure. Hepatology 1986; 1: 101–106
  • Bosch J, Masti R, Kravetz D, et al. Effects of propranolol on azygos venous blood flow and hepatic and systemic hemodynamics in cirrhosis. Hepatology 1984; 4: 1200–1205
  • Bendtsen F, Henriksen J H, SØrensen T I A, Christensen N J. Effect of oral propranolol on circulating catecholamines in cirrhosis: relationship to severity of disease and splanchnic haemo-dynamics. J Hepatol 1990; 10: 198–204
  • Vorobioff J, Picabea E, Villavicencio R, et al. Acute and chronic hemodynamic effects of propranolol in unselected cirrhotic patients. Hepatology 1987; 4: 648–653
  • Groszmann R J, Bosch J, Grace N D, et al. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Gastroenterology 1990; 99: 1401–1407
  • Pomier-Layrargues G, Villeneuve J P, Willems B, Huet P M, Marleau D. Systemic and hepatic hemodynamics after variceal hemorrhage: effects of propranolol and placebo. Gastroenterology 1987; 93: 1218–1224
  • The PROVA Study Group. Randomized multi-center trial of sclerotherapy and/or propranolol for prophylaxis of first hemorrhage from oesophageal varices in cirrhosis. Medicine Group (UK), Abingdon 1990; 1192, In: Abstracts of World Congress of Gastroenterology (Sydney, 1990)
  • Henriksen J H. Variability of hydrostatic hepatic vein and ascites fluid pressure in patients with liver cirrhosis. Scand J Clin Invest 1980; 40: 430–435
  • Henriksen J H, Bendtsen F, SØrensen T I A, Stadeager C, Ring-Larsen H. Reduced central blood volume in cirrhosis. Gastroenterology 1989; 97: 1506–1513
  • Henriksen J H, Winkler K. Hepatic blood flow determination. A comparison of 99mTc-diethyl-IDA and indocyanine green as hepatic blood flow indicators in man. J Hepatol 1987; 4: 66–70
  • Bosch J, Groszmann R. Measurement of azygos venous blood flow by a continuous thermal dilution technique: an index of blood through gas-troesophageal collaterals in cirrhosis. Hepatology 1984; 4: 424–429
  • Gluud C, Henriksen J H, Copenhagen Study Group for Liver Diseases. Liver haemodynamics and function in alcoholic cirrhosis. Relation to testosterone treatment and ethanol consumption. J Hepatol 1987; 4: 168–173
  • Henriksen J H, Christensen N J, Ring-Larsen H. Noradrenaline and adrenaline concentrations in various vascular beds in patients with cirrhosis. Relation to haemodynamics. Clin Physiol 1981; 1: 293–304
  • Bichet D G, Van Putten V T, Schrier E W. Potential role of increased sympathetic activity in impaired sodium and water retention in cirrhosis. N Engl J Med 1982; 307: 1152–1157
  • Keller U, Gerber P P G, Buhler F R, Stauffacher W. Role of the splanchnic bed in extracting circulating adrenaline and noradrenaline in patients with cirrhosis of the liver. Clin Sci 1984; 67: 45–49
  • Willet J R, Esler M, Jennings G, Dudley F J. Sympathetic tone modulates portal venous pressure in alcoholic cirrhosis. Lancet 1986; 2: 939–943
  • Morlan R, Lee S, Hadengue A, Braillon L A, Lebrec D. Hemodynamic effects of a clonidine-induced decrease in sympathetic tone in cirrhosis. Hepatology 1987; 7: 149–154
  • Bendtsen F, Henriksen J H, SØrensen T I A. Propranolol and haemodynamic response in cirrhosis. J Hepatol 1991, (in press)
  • Bendtsen F, Henriksen J H, Becker U, SØrensen T I A. Effect of oral propranolol on splanchnic oxygen uptake and haemodynamics in cirrhosis. J Hepatol 1987; 5: 137–143
  • Vinel J P, Caucanas J P, Cales P, Suduca J M, Voigt J J, Pascal J P. Effect of propranolol on metabolic activity of the liver in patients with cirrhosis. J Hepatol 1988; 7: 186–192
  • Kroeger R, Groszmann R J. Effect of selective blockade of beta-2-adrenergic receptors on portal and systemic hemodynamics in a portal hypertensive rat model. Gastroenterology 1985; 88: 896–900
  • Lebrec D, Poynard T, Bernau J, et al. A randomized controlled study of propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a final report. Hepatology 1984; 4: 355–358
  • Pascal J P, Cales P, Multicenter Study Group. Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med 1987; 317: 856–861
  • Ideo G, Bellati G, Fesce E, Grimoldi D. Nadolol can prevent the first gastrointestinal bleeding in cirrhotics: a prospective, randomized study. Hepatology 1988; 8: 6–9

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