Mechanism of Ursodeoxycholic Acid- and Canrenoate-Induced Biliary Bicarbonate Secretion and the Effect on Glucose- and Amino Acid-Induced Cholestasis

References

• Lake J R, Renner E L, Scharschmidt B F, et al. Inhibition of Na/H exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated ursodeoxycholate, and increased ursodeoxycholate glucu-ronidation. Gastroenterology 1988; 95: 454–463
   PubMed Web of Science ®Google Scholar
• Moseley R H, Nazzareno B, Smith D J, Boyer J L. Ursodeoxycholate stimulates Na/H exchange in rat liver basolateral plasma membrane vesicles. J Clin Invest 1987; 80: 684–690
   PubMed Web of Science ®Google Scholar
• Lake J R, van Dyke R W, Scharschmidt B F. Effects of Na-replacement and amiloride on ursodeoxycholic acid-stimulated choleresis and biliary bicarbonate secretion. Am J Physiol 1987; 252: G163–G169
   Google Scholar
• Anwer Sawkat M, Hondalus M K, Atkinson J M. Ursodeoxycholate-induced changes in hepatic Na/ H exchange and biliary HCO3 excretion. Am J Physiol 1989; 257: G371–G379
   Google Scholar
• Garcia-Marin J J, Corbic M, Dumont M, de Couet G, Erlinger S. Role of H transport in ursodeoxycholate-induced biliary HC0& secretion in the rat. Am J Physiol 1985; 249: G335–G341
   PubMed Web of Science ®Google Scholar
• Buanes T, Grotmol T, Veel T, Landsverk T, Ridderstrale Y, Raeder M. Importance of carbonic anhydrase for canalicular and ductular choleresis in the pig. Acta Physiol Scand 1988; 135: 535–544
   Google Scholar
• Zsigmond G, Solymoss B. Increased canalicular bile production induced by pregnenolone-16-alpha-carbonitrile, spironolactone and Cortisol in rats (37864). Proc Soc Exp Biol Med 1974; 145: 631–635
   PubMed Web of Science ®Google Scholar
• von Bergmann K, Schwarz H P, Paumgartner G. Effect of phenobarbital, spironolactone and preg-nenolone-16-alpha-carbonitrile on bile formation in the rat. Naunyn Schmiedebergs Arch Pharmacol 1975; 287: 33–45
   PubMed Web of Science ®Google Scholar
• Klaasen C D, Watkins J B, III. Mechanism of bile formation, hepatic uptake, and biliary excretion. Pharmacol Rev 1984; 34: 1–67
   Google Scholar
• Mathisen Ø, Ræder M, Sejersted O M, Kill F. Effect of acetazolamide on glomerulotubular balance and renal metabolic rate. Scand J Clin Lab Invest 1976; 36: 617–625
   PubMed Web of Science ®Google Scholar
• Mathisen Ø, Schistad O, Strand M. Role of osmosis in biliary NaCl secretion and bile formation. Scand J Gastroenterol 1985; 20: 971–977
   PubMed Web of Science ®Google Scholar
• Mathisen Ø, Ræder M. Mechanism of hepatic bicarbonate secretion and bile acid independent bile secretion. Eur J Clin Invest 1983; 13: 193–200
   PubMed Web of Science ®Google Scholar
• Mathisen Ø, Omland E. Aminoacid- and glucose-induced cholestasis before and during secretin stimulation. Scand J Gastroenterol 1989; 24: 851–858
   PubMed Web of Science ®Google Scholar
• Fausa O, Skålhegg B A. Quantitative determination of bile acids and their conjugates using thin-layer chromatography and a purified 3-alpha-hydroxy-steroid dehydrogenase. Scand J Gastroenterol 1974; 9: 249–254
   PubMed Web of Science ®Google Scholar
• Snedecor G W, Cochran W G. Statistical methods. 6th ed. State University Press Ames, Iowa 1967; 128–171
   Google Scholar
• Yoon Y B, Hagey L R, Hofmann A F, Gurantz D, Michelotti E L, Steinbach J H. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 1986; 90: 837–852
   PubMed Web of Science ®Google Scholar
• Van Dyke R W, Scharschmidt B F. (Na,K)-ATPase-mediated cation pumping in cultured rat hepato-cytes. J Biol Chem 1983; 258: 12912–12919
   PubMedGoogle Scholar
• Chabaud-Blot M, Dumont M, Corbie M, Erlinger S. Effect of acid-base balance on biliary bicarbonate secretion in the isolated perfused guinea pig liver. Am J Physiol 1990; 258: G863–G872
   Google Scholar
• Mathisen Ø, Omland E. Dose-dependent effects of glycine, alanine, and glucose on hepatic bile secretion, oxygen consumption, and hemodynamics. Scand J Gastroenterol 1990; 25: 1265–1273
   PubMed Web of Science ®Google Scholar
• Bassler K H, Hassinger W, Ackermann R H. Zur spezifitaet des ATP-abfalls in der leber nach intravenoeser injektion von energieliefernden substraten. Infusionstherapi 1977; 4: 42–43
   Google Scholar
• Keeffee E B, Scharschmidt B, Blankenship N M, Ockner R K. Studies of relationships among bile flow, liver plasma membrane Na-K-ATPase, and membrane micro viscosity in the rat. J Clin Invest 1979; 64: 1590–1598
   PubMed Web of Science ®Google Scholar
• Scharschmidt B F, Keeffee E B, Vessey D A, Blankenship N M, Ockner R K. In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity. Hepatology 1981; 1: 137–145
   PubMed Web of Science ®Google Scholar
• Smith D J, Gordon E R. Role of liver plasma membrane fluidity in the pathogenesis of estrogen-induced cholestasis. J Lab Clin Med 1988; 112: 679–685
   PubMed Web of Science ®Google Scholar
• Kitani K, Nagy-Zsolnai I, Kanai S, Sato Y, Ohta M. Correlation between the biliary excretion of ouabain and the lateral mobility of hepatocyte plasma membrane proteins in the rat. The effect of age and spironolactone pretreatment. Hepatology 1988; 8: 125–131
   PubMed Web of Science ®Google Scholar
• Miner PB, Jr, Sneller M, Crawford S S. Spironolactone- and canrenone-induced changes in hepatic (Na,K)ATPase activity, surface membrane cholesterol and phospholipid, and fluorescence polarization in the rat. Hepatology 1983; 4: 481–488
   Google Scholar
• Sadee W, Riegelmann S, Jones S C. Disposition of tritium-labeled spironolactone in the dog. J Pharmacol Sci 1972; 61: 1132–1135
   PubMed Web of Science ®Google Scholar
• Abshagen U, von Grodzikcki U, Hirschberger U, Rennekamp H. Effect of enterohepatic circulation on the pharmacokinetics of spironolactone in man. Naunyn Schmiedebergs Arch Pharmacol 1977; 300: 281–287
   PubMed Web of Science ®Google Scholar
• Meier P J, Knickelbein R, Moseley R H, Dobbins J W, Boyer J L. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. J Clin Invest 1985; 75: 1256–1263
   PubMed Web of Science ®Google Scholar
• Mathisen Ø, Omland E, Flatmark A. Cholestasis after cyclosporine A and glucose administration: beneficial effect of canrenoate (soldactone). Transplant Proc 1988, suppl 1: 160–161
   Web of Science ®Google Scholar
• Dowling R H, Hofmann A F, Barbara L. Workshop on ursodeoxycholic acid. MTP Press, Lancaster 1978; 1–88
   Google Scholar
• Poupon R, Chretien Y, Poupon R E, Ballet F., Calmus Y, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?. Lancet 1987; 1: 834–836
   PubMed Web of Science ®Google Scholar
• Batta A K, Salen G, Arora R, et al. Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis. Hepatology 1989; 120: 414–419
   Google Scholar
• Persson H, Friman S, Schersten T, Svanvik J, Karlberg I. Ursodeoxycholic acid for prevention of acute rejection in liver transplant recipients. Lancet 1990; 336: 52–53
   PubMed Web of Science ®Google Scholar