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Original Article

The Effect of Polyacrylic Acid Polymers on Small-Intestinal Function and Permeability Changes Caused by Indomethacin

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Pages 685-688 | Received 02 Jul 1990, Accepted 21 Jan 1991, Published online: 08 Jul 2009

References

  • Bjarnason I, Williams P, So A, et al. Intestinal permeability and inflammation in rheumatoid arthritis; effects of non-steroidal anti-inflammatory drugs. Lancet 1984; 2: 1171–1174
  • Bjarnason I, Zanelli G, Smith T, et al. Nonsteroidal antiinflammatory drug induced intestinal inflammation in humans. Gastroenterology 1987; 93: 48CM89
  • Rooney P J, Jenkins R T, Smith K M, Coates G. 111Indium labelled polymorphonuclear leucocyte scans in rheumatoid arthritis an important clinical cause of false positive results. Br J Rheumatol 1986; 25: 167–170
  • Bjarnason I, Zanelli G, Prouse P, et al. Blood and protein loss via small intestinal inflammation induced by non-steroidal antiinflammatory drugs. Lancet 1987; 1: 711–714
  • Bjarnason I, Price A B, Zanelli G. Clinicopathologicai features of non-steroidal antiinflammatory drug-induced small intestinal strictures. Gastroenterology 1988; 94: 1070–1074
  • Lang J, Price A B, Levi A J, Burke M, Gumpel M J, Bjarnason I. Diaphragm disease; the pathology of non-steroidal anti-inflammatory drug induced intestinal strictures. J Clin Pathol 1988; 41: 516–526
  • Bjarnason I. NSAID induced small intestinal inflammation in man. Recent advances in gastroenterology, R E Pounder. Churchill Livingstone, London 1988; Vol 7: 23–46
  • Bjarnason I, Macphearson A. The changing gastrointestinal side effect profile of nonsteroidal antiinflammatory drugs. A new approach for the prevention of a new problem. Scand J Gastroenterol 1989; 24(suppl 163)56–67
  • Bjarnason I, Williams P, Smethurst P, Peters T J, Levi A J. The effects of non-steroidal antiinflammatory drugs and prostaglandins on the permeability of the human small intestine. Gut 1886; 26: 1292–1297
  • Bjarnason I, Smethurst P, Fenn C G, Lee C E, Menzies I S, Levi A J. Misoprostol reduces indomethacin-induced changes in human small intestinal permeability. Dig Dis Sci 1989; 34: 407–411
  • Brody T M. The uncoupling of oxidative phosphorylation as a mechanism of drug action. Pharmacol Rev 1956; 7: 335–365
  • Sachs G, Collier R H, Shoemaker R L, Hirschowitz B I. The energy source of gastric H+ secretion. Biochem Biophys Acta 1968; 162: 210–219
  • Spenney J G, Brown M. Effect of acetylsalicylic acid on gastric mucosa. Gastroenterology 1977; 73: 995–999
  • Bentzel C H, Hainau B, Ho S, et al. Cytoplasmic regulation of tight junction permeability: effect of plant cytokinins. Am J Physiol 1980; 239: C75–C89
  • Meza I, Saberom, Stafani E. Cereijido Occluding junctions and cytoskeletal components in a cultured transporting epithelium. J Cell Biol 1980; 87: 746–754
  • Madara H L, Stafford J, Berenberg D, Carlson S. Functional coupling of tight junction and microfilaments in T84 monolayers. Am J Physiol 1988; 254: G416–G423
  • Schoen R T, Vender R J. Mechanism of NSAID induced gastric damage. Am J Med 1989; 86: 449–458
  • Allen G, Garner A. Mucus bicarbonate secretion in the stomach and their possible role in mucosal protection. Gut 1980; 21: 249–262
  • Foster S NE, Allen A, Pearson J P. Mechanism for the mucosal protective action of polyacrylate on the gastric mucus barrier. Gut 1985; 26: A1109
  • Hutton D A, Pearson J P, Allen A, Foster S NE. Mucolysis of the colonic mucus barrier by faecal proteinases: inhibition of interacting polyacrylate. Clin Sci 1990; 78: 265–271
  • Dettman P W, Lynn A G, Leach E C, Lloyd-Jones J G. A new role for polyacrylates in gastric mucosal protection. Gut 1985; 26: A1107
  • Menzies I S. Transmocosal passage of inert molecules in health and disease. Intestinal absorption and secretion, E Skadhauge, K Heintze. MTP Press, LancasterPa., USA 1983; 527–543, Falk symposium 36
  • Bjarnason I, Fehilly B, Smethurst P, Menzies E S, Levi A J. Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability. Gut, in press
  • Bjarnason I, Smethurst P, Clarke P, Menzies I S, Levi A J, Peters J. Effect of prostaglandins on indomethacin-induced increased intestinal permeability in man. Scand J Gastroenterol 1989; 29(suppl 164)97–103

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