Effects of Somatostatin on the Exocrine Pancreas

References

• Baskin D G, Ensinck J W. Somatostatin in epithelial cells of intestinal mucosa is present primarily as somatostatin 28. Peptides 1984; 5: 615–621
   PubMed Web of Science ®Google Scholar
• Tannenbaum G S, Ling N, Brazeau P. Somatostatin 28 is longer acting and more selective than somatostatin 14 on pituitary and pancreatic hormone release. Endocrinology 1982; 111: 101–107
   PubMed Web of Science ®Google Scholar
• Vaysse N, Chayvialle A, Pradayrol L, et al. Somatostatin 28: comparison with somatostatin 14 for plasma kinetics and low-dose effects on the exocrine pancreas in dogs. Gastroenterology 1981; 81: 700–706
   PubMed Web of Science ®Google Scholar
• Shoelson S, Polonsky K, Docherty H, Jaspan J, Rubenstein A. Evidence for the presence for somatostatin 28 in plasma. Diabetes 1982; 47: 4–7
   Google Scholar
• Baldissera F G A, Munoz-Perez M A, Holst J J. Somatostatin 1–28 circulates in human plasma. Regul Pept 1983; 6: 63–69
   PubMedGoogle Scholar
• Ensinck J W, Laschansky E C, Vogel R E, Simonowitz D A, Roos B A, Francis B H. Circulatory prosomatostatin derived peptides. J Clin Invest 1989; 83: 1580–1589
   PubMed Web of Science ®Google Scholar
• Bersani M, Thim L, Baldissera F G A, Hoist J J. Prosomatostatin 1–64 is a major product of somatostatin gene expression in pancreas and gut. J Biol Chem 1989; 264: 10633–10636
   PubMed Web of Science ®Google Scholar
• Chariot J, Roze C, Vaille C, Debray C. Effects of somatostatin on the external secretion of the pancreas of the rat. Gastroenterology 1978; 75: 832–837
   PubMed Web of Science ®Google Scholar
• Fölsch U R, Lankisch P G, Creutzfeldt W. Effects of somatostatin on basal and stimulated pancreatic secretion in the rat. Digestion 1978; 17: 194–203
   PubMed Web of Science ®Google Scholar
• Singh M. Effect of somatostatin on amylase secretion from in vivo and in vitro rat pancreas. Dig Dis Sci 1986; 31: 506–512
   PubMed Web of Science ®Google Scholar
• Susini C, Esteve J P, Bommelaer G, Vaysse N, Ribet A. Inhibition of exocrine pancreatic secretion by somatostatin in dogs. Digestion 1978; 18: 384–393
   PubMed Web of Science ®Google Scholar
• Creutzfeldt W, Lankisch P G, Fölsch U R. Hemmung der Sekretin-und Cholezystokinin-Pankreozymin-induzierten Saft-und Enzymsekretion des Pankreas und der Gallenblasenkontraktion beim Menschen durch Somatostatin. Dtsch Med Wochenschr 1975; 20: 1135–1138
   Google Scholar
• Regal H, Fink M, Luger T, Ogris E, Irsigler K. Suppression der endokrinen und exokrinen Pan-kreasfunktion durch Somatostatin beim Menschen unter Stimulation durch Sekretin und Chole-zystokinin-Pankreozymin. Wien Klin Wochenschr 1977; 89: 580–586
   PubMedGoogle Scholar
• Köhler E, Beglinger C, Dettwiler S, Whitehouse I, Gyr K. Effect of a new somatostatin analogue on pancreatic function in healthy volunteers. Pancreas 1986; 1: 154–159
   PubMedGoogle Scholar
• Layer P, Boekstegers A, Müller M K, Lötte A, Goebell H. Cyclical interdigestive pancreatic secretion in response to physiologic doses of somatostatin 14 in humans. Gastroenterology 1987; 92: 1495
   Web of Science ®Google Scholar
• Creutzfeldt W, Lembcke B, Fölsch U R, et al. Effect of somatostatin analogue (SMS 201–995, sandostatin) on pancreatic secretion in humans. Am J Med 1987, suppl 5B: 49–54
   PubMed Web of Science ®Google Scholar
• Lembcke B, Creutzfeldt W, Schleser S, Ebert R, Shaw C, Koop I. Effect of the somatostatin analogue sandostatin (SMS 201–995) on gastrointestinal pancreatic and biliary function and hormone release in normal men. Digestion 1987; 36: 108–124
   PubMed Web of Science ®Google Scholar
• Ohe M, Layer P, Wollny C, Beglinger C, Goebell H. Effects of physiological doses of somatostatin-28 on cyclical interdigestive pancreatic secretion and upper gastrointestinal motility in humans. Gastroenterology 1989; 96: 374A
   Google Scholar
• Aizawa I, Itoh Z, Harris V, Unger R H. Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog. J Clin Invest 1981; 68: 206–213
   PubMed Web of Science ®Google Scholar
• DiMagno E P, Hendricks J C, Go V L W, Dozois R R. Relationships among canine fasting pancreatic and biliary secretions, pancreatic duct pressure, and duodenal phase III motor activity—Boldyreff revisited. Dig Dis Sci 1979; 24: 689–693
   PubMed Web of Science ®Google Scholar
• Vantrappen G, Peelers T L, Janssens J. The secretory component of the interdigestive migrating motor complex in man. Scand J Gastroenterol 1979; 14: 663–667
   PubMed Web of Science ®Google Scholar
• Layer P, Chan A T H, Go V L W, DiMagno E P. Human pancreatic secretion during phase II antral motility of the interdigestive cycle. Am J Physiol 1988; 254: G249–G253
   PubMedGoogle Scholar
• Peelers T L, Janssens J, Vantrappen G R. Somatostatin and the interdigestive migrating motor complex in man. Regul Pept 1983; 5: 209–217
   PubMedGoogle Scholar
• Layer P, Ohe M, Wollny C, Beglinger C, Goebell H. Human interdigestive pancreatic secretion: response to physiological doses of somatostatin-28. Digestion 1989; 43: 157
   Google Scholar
• Albinus M, Blair E L, Case R M, et al. Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas. J Physiol 1977; 269: 77–91
   PubMed Web of Science ®Google Scholar
• Miller T A, Tepperman F S, Fang W F, Jacobson E D. Effect of somatostatin on pancreatic protein secretion induced by cholecystokinin. J Surg Res 1979; 26: 488–493
   PubMed Web of Science ®Google Scholar
• Konturek S J, Tasler J, Obtulowicz W, Coy D H, Schally A V. Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion. J Clin Invest 1976; 58: 1–6
   PubMed Web of Science ®Google Scholar
• Konturek S J, Tasler J, Cieszkowski M, Jaworek J, Arimura A, Schally A V. Studies on the inhibition of pancreatic secretion by luminal somatostatin. Am J Physiol 1981; 241: G109–G115
   PubMed Web of Science ®Google Scholar
• Lin T M, Evans D C, Shaar C J, Root M A. Action of somatostatin on stomach, pancreas, gastric mucosal blood flow and hormones. Am J Physiol 1983; 244: G40–G45
   PubMed Web of Science ®Google Scholar
• Domschke S, Domschke W, Rösch W, et al. Inhibition by somatostatin of secretin-stimulated pancreatic secretion in man: a study with pure pancreatic juice. Scand J Gastroenterol 1977; 12: 59–63
   PubMed Web of Science ®Google Scholar
• Gyr K, Beglinger C, Köhler E, Trautzl U, Keller U, Bloom S R. Circulating somatostatin—a physiological regulator of pancreatic function?. J Clin Invest 1987; 79: 1595–1600
   PubMed Web of Science ®Google Scholar
• Dollinger H C, Raptis S, Pfeiffer E F. Effects of somatostatin on exocrine and endocrine pancreatic function stimulated by intestinal hormones in man. Horm Metab Res 1976; 8: 74–78
   PubMed Web of Science ®Google Scholar
• Gullo L, Priori P, Scarpignato C, Baldoni F, Mattioli G, Barbara L. Effect of Somatostatin 14 on pure human pancreatic secretion. Dig Dis Sci 1987; 32: 1065–1070
   PubMed Web of Science ®Google Scholar
• Konturek S J, Tasler J, Jaworek J, et al. Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin. Proc Natl Acad Sci USA 1981; 78: 1967–1971
   PubMed Web of Science ®Google Scholar
• Konturek S J, Cieszkowski M, Bilski J, Konturek J, Bielanski W, Schally A V. Effects of cyclic hexapeptide analogue of somatostatin on pancreatic secretion in dogs. Proc Soc Exp Biol Med 1985; 178: 68–72
   PubMed Web of Science ®Google Scholar
• Boden G, Sivitz M C, Owen O E. Somatostatin suppresses secretin and pancreatic exocrine secretion. Science 1975; 190: 163–165
   PubMed Web of Science ®Google Scholar
• Hanssen L E, Hanssen F, Myren J. Inhibition of secretin release and pancreatic bicarbonate secretion by somatostatin infusion in man. Scand J Gastroenterol 1977; 12: 391–394
   PubMed Web of Science ®Google Scholar
• Susini C, Esteve J P, Vaysse N, Pradayrol L, Ribet A. Somatostatin 28: effects on exocrine pancreatic secretion in conscious dogs. Gastroenterology 1980; 79: 720–724
   PubMed Web of Science ®Google Scholar
• O'Shaughnessy D J, Long R G, Adrian T E, et al. Somatostatin-14 modulates postprandial glucose levels and release of gastrointestinal and pancreatic hormones. Digestion 1985; 31: 234–242
   PubMed Web of Science ®Google Scholar
• Hoist J J, Schaffalitzky de Muckadell O B, Fahrenkrug J. Somatostatin inhibits neurally stimulated pancreatic secretion indirectly. Pancreas 1990, in press
   Web of Science ®Google Scholar
• Johannsson C, Kollberg B, Efendic S, Uvnäs-Wallensten K. Effects of graded doses of somatostatin on gallbladder emptying and pancreatic enzyme output after oral glucose in man. Digestion 1981; 22: 24–31
   PubMed Web of Science ®Google Scholar
• Usadel K H, Überla K K, Leuschner U. Treatment of acute pancreatitis with somatostatin—results of a multicenter double-blind trial. Dig Dis Sci 1985; 30: 992
   Web of Science ®Google Scholar
• D'Amico D, Favia G, Biasiato R, et al. The use of somatostatin in acute pancreatitis. Results of a multicenter trial. Hepatogastroenterology 1990; 37: 92–98
   PubMed Web of Science ®Google Scholar
• Choi T K, Mok F, Zhan W H, Fan S T, Lai E C, Wong J. Somatostatin in the treatment of acute pancreatitis: a prospective randomised controlled trial. Gut 1989; 30: 223–227
   PubMed Web of Science ®Google Scholar
• Tyden G, Nyberg B, Sonnenfeld T, Thulin L. Effect of somatostatin on hyperamyiasemia following endoscopicpancreatography. Acta Chir Scand 1986; 530: 43–45, suppl
   Google Scholar
• Bordas J M, Toledo V, Mondelo F, Rodes J. Prevention of pancreatic reactions by bolus somatostatin administration in patients undergoing endoscopic retrograde cholangio-pancreatography and endoscopic sphincterotomy. Horm Res 1988; 29: 106–108
   PubMedGoogle Scholar
• Jost J O, Clemens M, Ruehland D, Bünte H. Somatostatin bei Pankreasund Dünndarmfisteln. Zentralbl Chir 1984; 109: 527–531
   PubMedGoogle Scholar
• Pederzoli P, Bassi C, Falconi M, Albrigo R, Vantini I, Micciolo R. Conservative treatment of external pancreatic fistulas with parenteral nutrition alone or in combination with continuous intravenous infusion of somatostatin, glucagon or calcitonin. Surg Gynecol Obstet 1986; 163: 428–432
   PubMedGoogle Scholar
• Prinz R A, Pickleman J, Hoffman J P. Treatment of pancreatic cutaneous fistulas with a somatostatin analog. Am J Surg 1988; 155: 36–42
   PubMed Web of Science ®Google Scholar
• Ahren B, Tranberg K G, Bengmark S. Treatment of pancreatic fistula with the somatostatin analogue SMS 201–995. Br J Surg 1988; 75: 718
   PubMed Web of Science ®Google Scholar
• Saari A, Schroeder T, Kivilaakso E, Kalima T, Lempinen M. Treatment of pancreatic fistulas with somatostatin and total parenteral nutrition. Scand J Gastroenterol 1989; 24: 859–862
   PubMed Web of Science ®Google Scholar
• Landsen F T, Adams D B, Anderson M C. Treatment of external pancreatic fistulas with somatostatin. Second place winner: Conrad Jobst award. Am Surg 1989; 55: 695–698
   PubMed Web of Science ®Google Scholar
• Vinik A I, Strodel W E, Eckhauser F E, Moattari A R, Lloyd R. Somatostatinomas, PPomas, neurotensinomas. Semin Oncol 1987; 14: 263–281
   PubMed Web of Science ®Google Scholar
• Hopman W P M, van Liessum P A, Pieters G F F M, et al. Pancreatic exocrine and gallbladder function during long-term treatment with octreotide (SMS 201–995). Digestion 1990; 45(suppl 1)72–76
   PubMedGoogle Scholar
• Morisset J. Somatostatin: a potential antigrowth factor for the exocrine pancreas. Regul Pept 1984; 10: 11–22
   PubMedGoogle Scholar
• Safati P D, Genik P, Morisset J. Caerulein and secretin induced pancreatic growth: a possible control by endogenous pancreatic somatostatin. Regul Pept 1985; 11: 261–273
   PubMedGoogle Scholar
• Senegas-Balas F, Balas D, Pradayrol L, Laval J, Bertrand C, Ribet A. Long-term effect of somatostatin 14 on mouse stomach, antrum, intestine and exocrine pancreas. Acta Anat 1985; 121: 124–132
   PubMedGoogle Scholar
• Viguerie N, Tahiri-Jouti N, Ayral A M, et al. Direct inhibitory effects of a somatostatin analog, SMS 201–995, on AR4–2J cell proliferation via pertussistoxin sensitive guanosine triphosphate-binding independent mechanism. Endocrinology 1989; 124: 1017–1025
   PubMed Web of Science ®Google Scholar
• Viguerie N, Tahiri-Jouti N, Rsteve J P, et al. Functional somatostatin receptors on a rat pancreatic acinar cell line. Am J Physiol 1988; 255: G113–G120
   PubMed Web of Science ®Google Scholar
• Schlegel W, Raptis S, Harvey R F, Oliver J M, Pfeiffer E F. Inhibition of cholecystokinin-pancreozymin release by somatostatin. Lancet 1977; 2: 166–167
   PubMed Web of Science ®Google Scholar
• Teitelbaum D H, O'Dorisio T M, Perkins W E, Gaginella T S. Somatostatin modulation of peptideinduced acetylcholine release in guinea pig ileum. Am J Physiol 1984; 246: G509–G514
   Google Scholar
• Kowal V, Wiley J W, Owyang C. Differential action of somatostatin on peptide-induced release of acetylcholine. Am J Physiol 1989; 257: G221–G225
   Google Scholar
• Price B A, Jaffe M, Zinner M J. Effect of exogenous somatostatin infusion on gastrointestinal blood flow and hormones in the conscious dog. Gastroenterology 1985; 88: 80–85
   PubMed Web of Science ®Google Scholar
• Müller M K, Kessel B, Hütt T, Layer P, Goebell H. Effects of somatostatin-14 on gastric and pancreatic responses to hormonal and neural stimulation using an isolated perfused stomach and pancreas preparation. Pancreas 1988; 3: 303–310
   PubMed Web of Science ®Google Scholar
• Robberecht P, Deschodt-Lanckman M, de Neef P, Christophe J. Effects of somatostatin on exocrine pancreatic function. Interaction with secretin. Biochem Biophys Res Comm 1975; 67: 315–323
   PubMed Web of Science ®Google Scholar
• Wächter M, Hotz J, Cherian L, Goebell H. Failure of somatostatin to inhibit pancreatic enzyme secretion in vitro. Gastroenterol Biol 1979; 3: 303
   Google Scholar
• Fahrenkrug J, Schaffalitzky de Muckadell O B, Hoist J J, Lindkaer Jensen S. Vasoactive intestinal polypeptide in vagally mediated pancreatic secretion of fluid and HCO3. Am J Physiol 1979; 237: E535–E540
   Google Scholar
• Esteve J P, Susini C, Vaysse N, et al. Binding of somatostatin to pancreatic acinar cells. Am J Physiol 1984; 247: G62–G69
   Google Scholar
• Taparel D, Susini C, Esteve J P, et al. Somatostatin analogs: correlation of receptor affinity with inhibition of cyclic AMP formation in pancreatic acinar cells. Peptides 1985; 6: 109–114
   PubMed Web of Science ®Google Scholar
• Srikant B, Yogesh C P. Somatostatin receptors on rat pancreatic acinar cells. J Biol Chem 1986; 17: 7690–7696
   Google Scholar
• Sakamoto C, Goldfine I, Williams J A. The somatostatin receptor on isolated acinar cell plasma membranes. J Biol Chem 1984; 25: 9623–9627s
   Google Scholar
• Zyznar E S, Pietri A O, Harris V, Unger R H. Evidence for the hormonal status of somatostatin in man. Diabetes 1981; 30: 883–886
   PubMed Web of Science ®Google Scholar
• Schusdziarra V, Harris V, Arimura A, Unger R H. Evidence for a role of splanchnic somatostatin in the homeostasis of ingested nutrients. Endocrinology 1979; 104: 1705–1708
   PubMed Web of Science ®Google Scholar
• Schusdziarra V, Zyznar E, Rouiller D. Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis. Science 1980; 207: 530–532
   PubMed Web of Science ®Google Scholar
• Beglinger C, Ensinck J W, Hildebrand P, Gyr K. Evidence for a hormonal role of circulating somatostatin-28 in man. Digestion 1989; 43: 128
   Google Scholar
• Baldissera F G A, Nielsen O V, Hoist J J. The intestinal mucosa preferentially releases somatostatin-28 in pigs. Regul Pept 1985; 11: 251–262
   PubMedGoogle Scholar
• Penman E, Wass J A H, Medbak S, et al. Response of circulating immunreactive somatostatin to nutritional stimuli in normal subjects. Gastroenterology 1981; 81: 692–699
   PubMed Web of Science ®Google Scholar
• Polonsky K S, Shoelson S E, Docherty H M. Plasma somatostatin 28 increases in response to feeding in man. J Clin Invest 1983; 71: 1514–1518
   PubMed Web of Science ®Google Scholar
• Ensinck J W, Laschansky E C, Vogel R E, Simonowitz D A, Roos B A, Francis B H. Circulating prosomatostatin-derived peptides. Differential responses to food ingestion. J Clin Invest 1989; 83: 1580–1589
   PubMed Web of Science ®Google Scholar
• Schusdziarra V, Rouiller D, Harris V, Conlon J M, Unger R H. The response of plasma somatostatinlike immunoreactivity to nutrients in normal and alloxan diabetic dogs. Endocrinology 1978; 103: 2264–2273
   PubMed Web of Science ®Google Scholar
• Fraser P, Henderson I. The arrangement of endocrine and exocrine pancreatic microcirculation observed in the living rabbit. J Exp Physiol 1980; 65: 151–158
   PubMedGoogle Scholar
• Henderson I, Daniel W. A comparative study of the portal vessels connecting the endocrine and exocrine pancreas, with a discussion of some functional implications. Q J Exp Physiol 1979; 64: 267–275
   PubMedGoogle Scholar
• Lifson N, Kramlinger K, Mayrand R, Lauder I. Blood flow to the rabbit pancreas with special reference to the islets of Langerhans. Gastroenterology 1980; 79: 466–473
   PubMed Web of Science ®Google Scholar
• Lifson I, Lassa C V, Disit P K. Relation between blood flow and morphology in islet organ of rat pancreas. Am J Physiol 1985; 49: E43–E48
   Google Scholar
• Hoist J J. Does the endocrine secretion of the pancreas exert a local control of the exocrine secretion? Critical review. Pancreas 1987; 2: 613–619
   PubMed Web of Science ®Google Scholar
• Hilsted I, Hoist J J. On the accuracy of radioimmunological determination of somatostatin in plasma. Regul Pept 1982; 4: 13–31
   PubMedGoogle Scholar
• Sheppard M, Shapiro B, Pimstone B, Kronbeim S, Berelowitz M, Gregory M. Metabolic clearance and plasma half-disappearance time of exogenous somatostatin in man. J Clin Endo Med 1979; 48: 50–53
   PubMed Web of Science ®Google Scholar
• Polonsky K, Jaspan I, Berelowitz M, Pugh W, Moossa A, Ling N. The in vivo metabolism of somatostatin 28: possible relationship between diminished metabolism and enhanced biological action. Endocrinology 1982; 111: 1698–1702
   PubMed Web of Science ®Google Scholar
• Larsson L I, Goltermann N, de Magistris L, Rehfeld J F, Schwartz T W. Somatostatin cell processes as pathways for paracrine secretion. Science 1979; 205: 1393–1394
   PubMed Web of Science ®Google Scholar
• Garry D J, Garry M G, Williams J A, Mahoney W C, Sorenson R L. Effects of islet hormones on amylase secretion and localization of somatostatin binding sites. Am J Physiol 1989; 256: G897–G904
   Google Scholar