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Original Article

Comparison of Effects of Chenodeoxycholic and Ursodeoxycholic Acid and Their Combination on Biliary Lipids in Obese Patients with Gallstones

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Pages 257-262 | Received 08 Jun 1990, Accepted 11 Sep 1990, Published online: 08 Jul 2009

References

  • Iser J H, Maton P N, Murphy G M, Dowling R H. Resistance to chenodeoxycholic acid (CDCA) treatment in obese patients with gallstones. Br Med J 1978; 1: 1509–1512
  • National Cooperative Gallstone Study Group. Chenodiol (chenodeoxycholic acid) for dissolution of gallstones. Ann Intern Med 1981; 95: 257–282
  • Roda E, Mazzella G, Roda A, . Effect of chenodeoxycholic and ursodeoxycholic acid administration on biliary lipid secretion in normal-weight and gallstone patients, G Paumgartner, A Stiehl, W Gerok, et al. Bile acids and lipids. MTP, LancasterUK 1981; 189–193
  • Maton P N, Murphy G M, Dowling R H. Lack of response to chenodeoxycholic acid in obese and non-obese patients. Gut 1980; 21: 1082–1086
  • Tint G S, Salen G, Colalillo A, et al. Ursodeoxycholic acid: a safe and effective agent for dissolving cholesterol gallstones. Ann Intern Med 1982; 351–356
  • Stiehl A, Raedsch R, Czygan P, et al. Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 1980; 79: 1192–1198
  • Podda M, Zuin M, Dioguardi M L, Festorazzi S, Dioguardi N. A combination of ursodeoxycholic acid and chenodeoxycholic acid is more effective than either alone in reducing biliary cholesterol saturation. Hepatology 1982; 2: 334–339
  • Podda M, Zuin M, Battezzati P M, Ghezzi C, de Fazio C, Dioguardi M L. Efficacy and safety of a combination of chenodeoxycholic acid and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 1989; 96: 222–229
  • Iser J H, Murphy G M, Dowling R H. Speed of change in biliary lipids and bile acids with chenodeoxycholic acid—Is intermittent therapy feasible?. Gut 1977; 18: 7–15
  • Talalay P. Enzymatic analysis of steroid hormones. Anal Biochem 1960; 119–143
  • Svanborg A, Svennerholm M. Plasma total lipid cholesterol, tryglicerides, phospholipids and free fatty acids in healthy Scandinavian population. Acta Med Scand 1961; 169: 43–49
  • Roda A, Festi D, Sama C, et al. Enzymatic determination of cholesterol in bile. Clin Chim Acta 1975; 64: 337–341
  • Thomas P J, Hofmann A F. A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenterology 1973; 65: 698–700
  • Hegardt F G, Dam H. The solubility of cholesterol in aqueous solutions of bile salts and lecithin. Z Ernaehrungswiss 1971; 10: 223–233
  • Holzbach R T, Marsh M, Olszewski M, et al. Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest 1973; 52: 1467–1479
  • Carey M C, Ko G. The importance of total lipid concentration in determining cholesterol solubility in bile and the development of critical tables for calculating ‘percent cholesterol saturation’ with a correction factor for ursodeoxycholate-rich bile. Biological effects of bile acids, G Paumgartner, A Stiehl, W Gerok. MTP, LancasterUK 1979; 299–308
  • Duane W C, Adler R D, Bennion L J, et al. Determination of bile acid pool size in man: a simplified method with advantages of increased precision, shortened analysis time and decreased isotope exposure. J Lipid Res 1975; 16: 155–158
  • Klassen C D. Gas-liquid chromatographic determination of bile acids in bile. Clin Chim Acta 1971; 35: 225–229
  • Burstein M, Samaille J. Sur un dosage rapide du cholesterol lié aux α-et aux β-lipoproteines du serum. Clin Chim Acta 1960; 5: 609
  • Snedecor G W, Cochran W C. Statistical methods7th ed. Iowa State University Press, Ames, Iowa 1980
  • Mok H Y I, Bell G D, Dowling R H. Effect of different doses of chenodeoxycholic acid on bile-lipid composition. Lancet 1974; 2: 253–257
  • Bachrach W H, Hofmann A F. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dis Dig Sci 1982; 27: 737–761
  • Tint G S, Salen G, Shefer S. Effect of ursodeoxycholic acid on cholesterol and bile acid metabolism. Gastroenterology 1986; 91: 1007–1018

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