Session 6: Is Hypergastrinaemia Dangerous to Man?

References

• Hall C N, Darkin D, Brimblecombe R, Cook A J, Kirkham J S, Northfield T C. Evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions. Gut 1986; 27: 491–498
   PubMedGoogle Scholar
• Hall C N, Kirkham J S, Northfield T C. Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions. Gut 1987; 28: 216–220
   PubMedGoogle Scholar
• Horch K. Epidemiologic, clinicopathologic, and economic aspects of gastroscopic screening of patients with pernicious anemia. Scarid J Gastroenterol 1986; 21: 21–30
   PubMedGoogle Scholar
• Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology 1985; 88: 638–648
   PubMed Web of Science ®Google Scholar
• Borch K, Renvall H, Liedberg G, Andersen B N. Relations between circulating gastrin and endocrine cell proliferation in the atrophic gastric fundic mucosa. Scand J Gastroenterol 1986; 21: 357–363
   PubMed Web of Science ®Google Scholar
• Poynter D, Pick C R, Harcourt R A, et al. Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. Gut 1985; 26: 1284–1295
   PubMed Web of Science ®Google Scholar
• Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion 1986; 35(suppl 1)42–55
   PubMed Web of Science ®Google Scholar
• Elder J B. Inhibition of acid and gastric carcinoids. Gut 1985; 26: 1279–1283
   PubMed Web of Science ®Google Scholar
• Penston J, Wormsley K G. Achlorhydria: hypergastrinaemia: carcinoids—a fiawed hypothesis?. Gut 1987; 28: 488–505
   PubMed Web of Science ®Google Scholar
• Creutzfeldt W. The achlorhydria-carcinoid sequence: role of gastrin. Digestion 1988; 39: 61–79
   PubMed Web of Science ®Google Scholar
• Johnson L R. Gastrointestinal hormones and their functions. Am Rev Physiol 1977; 39: 135–158
   PubMed Web of Science ®Google Scholar
• Johnson L R. Regulation of gastrointestinal mucosal growth. J Surg 1979; 3: 477–487
   Google Scholar
• Ryberg B, Axelson J. Håkanson R, Sundler F, Mattsson H. Trophic effects of continuous infusion of [Leu15]-gastrin-17 in the rat. Gastroenterology 1990; 98: 33–38
   PubMed Web of Science ®Google Scholar
• Tielemans Y, Axelson J, Sundler F, Willems G, Håkanson R. Serum gastrin concentration affects the self replication rate of the enterochromaffin-like cells in the rat stomach. Gut 1990; 31: 274–278
   PubMed Web of Science ®Google Scholar
• Tielemans Y, Håkanson R, Sundler F, Willems G. Proliferation of enterochromaffin-like cells in omeprazole-treated hypergastrinemic rats. Gastroenterology 1989; 96: 723–729
   PubMed Web of Science ®Google Scholar
• Ryberg B, Tielemans Y, Axelson J, et al. Gastrin stimulates the self replication rate of the enterochromaffin-like cells in the rat stomach. Effects of omeprazolde, ranitidine and gastrin-17 in intact and antrectomized rats. Gastroenterology 1990; 99: 935–942
   PubMed Web of Science ®Google Scholar
• Oscarson J, Håkanson R, Liedberg G, Lundqvist G, Sundler F, Thorell J. Variated serum gastrin concentration: trophic effects on the gastrointestinal tract of the rat. Acta Physiol Scand 1979; 475: 2–27
   Google Scholar
• Håkanson R, Blom H, Carlsson E, Larsson H, Ryberg B, Sundler G. Hypergastrinaemia produces trophic effects in stomach but not in pancreas and intestines. Regul Peptides 1986; 13: 223–233
   Google Scholar
• Bordi C, D'Adda T, Baggi M T, Pilato F P. Structure and function of endocrine cells in the oxyntic (acid-secreting) mucosa of human stomach. Scand J Gastroenterol 1989; 24(suppl 166)115–121
   PubMedGoogle Scholar
• Lönroth H, Håkanson R, Lundell L, Sundler F. Histamine containing endocrine cells in the human stomach. Gut 1990; 31: 383–338
   PubMed Web of Science ®Google Scholar
• Solcia E, Bordi C, Creutzfeldt W, et al. Histopathological classification of nonantral gastric endocrine growths in man. Digestion 1988; 41: 185–200
   PubMed Web of Science ®Google Scholar
• Yalow R S, Berson S A. Radioimmunoassay of gastrin. Gastroenterology 1970; 58: 1–14
   PubMed Web of Science ®Google Scholar
• Carney J A, Go V LW, Fairbanks V F, Moore S B, Alport E C, Nora F E. The syndrome of gastric argyrophil carcinoid tumors and nonantral gastric atrophy. Ann Intern Med 1983; 99: 761–766
   PubMed Web of Science ®Google Scholar
• Solcia E, Rindi G, Havu N, Elm G. Qualitative studies of gastric endocrine cells in patients treated long-term with orneprazole. Scand J Gastroenterol 1989; 24(suppl 166)129–137
   Google Scholar
• Hirschowitz B I, Griffith J, Pellegrin D, Cummings O W. Rapid regression of ECL-cell gastric carcinoids in 3 patients with pernicious anemia after elimination of hypergastrinemia by antrectomy. Gastroenterology 1990; 98: A286
   Google Scholar
• Håkanson R, Böttcher G, Sundler F, Vallgren S. Activation and hyperplasia of gastrin and enterochromaffin-like cells in the stomach. Digestion 1986; 35: 23–41
   PubMed Web of Science ®Google Scholar
• Larsson H, Carlsson E, Mattsson H, et al. Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 1986; 90: 391–399
   PubMed Web of Science ®Google Scholar
• Ryberg B, Carlsson E, Håkanson R, Lundell L, Mattsson H, Sundler F. Effects of partial resection of acid-secreting rnucosa on plasma gastrin and enterochromaffin-like cells in the rat stomach. Digestion 1990, (in press)
   PubMedGoogle Scholar
• Creutzfeldt W, Stöckmann F, Conlon J M, Fölsch U R, Bonatz G, Wülfrath M. Effect of short- and long-term feeding of omeprazole in rat gastric endocrine cells. Digestion 1986; 35(suppl 1)84–97
   PubMed Web of Science ®Google Scholar
• Håkan L, Carlsson E, Håkanson R, et al. Time-course of development and reversal of gastric endocrine cell hyperplasia after inhibition of acid secretion. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 1988; 95: 1477–1486
   PubMedGoogle Scholar
• Mattson H, Havu N, Bräntigam J, Carlsson K, Lundell L, Carlsson E. Partial corpectomy results in hypergastrinaemia and development of gastric ECL cell carcinoids in the rat. Gastroenterology, (in press)
   Google Scholar
• Havu N, Mattsson H, Ekman L, Carlsson E. ECL-cell carcinoids in the rat gastric mucosa following long term administration of ranitidine. Digestion 1990; 45: 189195
   Google Scholar
• Brunner G, Creutzfeldt W, Harke U, Lamberts R. Efficacy and safety of long term treatment with omeprazole in patients with acid related diseases resistant to ranitidine. Can J Gastroenterol 1989; 3(suppl A)72–76
   Google Scholar
• Brunner G, Creutzfeldt W, Harke U, Lamberts R. Therapy with omeprazole in patients with peptic ulcerations resistant to extended high-dose ranitidine treatment. Digestion 1988; 39: 80–90
   PubMed Web of Science ®Google Scholar
• Lamberts R, Creutzfeldt W, Stöckmann F, Jacubaschke U, Maas S, Brunner G. Long-term omeprazole treatment in man: effects on gastric endrocine cell populations. Digestion 1988; 39: 126–135
   PubMed Web of Science ®Google Scholar
• Roucayrol A M, Cattan D. The evolution of fundic argyrophil cell hyperplasia in non antral atrophic gastritis. Gastroenterology 1990; 98: A115
   Google Scholar
• Lanzon-Miller S, Pounder R E, Hamilton M R, et al. Twenty-four-hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine or omeprazole. Aliment Pharmacol Ther 1987; 1: 239–251
   PubMedGoogle Scholar
• Godwin D J. Carcinoid tumors: an analysis of 2837 cases. Cancer 1975; 36: 560–569
   PubMed Web of Science ®Google Scholar
• Lamers C BHW, Jansen J BMJ. Role of gastrin and cholecystokinin in tumours of the gastrointestinal tract. Eur J Cancer Clin Oncol 1988; 2: 267–273
   Google Scholar
• Morris D L, Watson S A, Durrant L G, Harrison J D. Hormonal control of gastric and colorectal cancer in man. Gut 1989; 30: 425–429
   PubMed Web of Science ®Google Scholar
• Beauchamp R D, Townsend C M, Singh P, Glass E J, Thompson J C. Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice. Ann Surg 1985; 202: 303–309
   PubMed Web of Science ®Google Scholar
• Hoosein N M, Kiener P A, Curry R C, Rovati L C, McGilbra D K, Brattain M G. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res 1988; 48: 7179–7183
   PubMed Web of Science ®Google Scholar
• Hoosein N M, Kiener P A, Curry R C, Brattain M G. Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide. Exp Cell Res 1990; 186: 15–21
   PubMed Web of Science ®Google Scholar
• Elsborg L, Mosbech J. Pernicious anaemia as a risk factor in gastric cancer. Acta Med Scand 1979; 206: 315–318
   PubMedGoogle Scholar
• Siurala M, Lehtola J, Ihamäki T. Atrophic gastritis and its sequelae. Results of 19–23 years' follow-up examinations. Scand J Gastroenterol 1974; 9: 441–446
   PubMed Web of Science ®Google Scholar
• Svendsen J H, Dahl C, Svendsen L B, Christiansen P M. Gastric cancer risk in achlorhydric patients. A long-term follow-up study. Scand J Gastroenterol 1986; 21: 16–20
   PubMed Web of Science ®Google Scholar
• Schafer L W, Larson D E, Melton L J, III, Higgins J A, Zinsmeister A R. Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota. Mayo Clin Proc 1985; 60: 444–448
   PubMedGoogle Scholar
• Carter D C. Cancer after peptic ulcer surgery. Gut 1987; 28: 921–923
   PubMedGoogle Scholar
• Caygill C PJ, Hill M J, Kirkham J S, Northfield T C. Mortality from gastric cancer following gastric surgery for peptic ulcer. Lancet 1986; 1: 929–931
   PubMed Web of Science ®Google Scholar
• Talley N J, Chute C G, Larson D E, Epstein R, Lydick E G, Melton L J. Risk of colorectal adenocarcinoma in pernicious anemia. Ann Intern Med 1989; 111: 738–742
   PubMedGoogle Scholar
• Smith J P, Wood J G, Solomon T E. Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Dig Dis Sci 1989; 34: 171–174
   PubMedGoogle Scholar