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Review Article

Cytokines in Inflammatory Bowel Disease

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Pages 897-906 | Published online: 08 Jul 2009

References

  • Jewell D P, Snook JA. Immunology of ulcerative colitis and Crohn's disease. Inflammatory bowel disease, RN Allan, MRB Keighley, J Alexander-Williams, CF Hawkins. Churchill Livingstone, London 1990; 127–46
  • Brynskov J, Freund L, Rasmussen S N. A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active Crohn's disease. N. Engl J Med 1989; 321: 845–50
  • Brynskov J, Freund L, Rasmussen S N. Final report on a placebo-controlled, double blind, randomised, multicentre trial of cyclosporin treatment in active Crohn's disease. Scand J Gastroenterol 1991; 26: 689–95
  • Markowitz J, Daum F. Immunology of inflammatory bowel disease: summary of the proceedings of the subcommittee on immunosuppressive use in IBD. J Pediatr Gastroenterol Nutr 1991; 12: 411–23
  • Bentzen K. Cellular and molecular processes underlying immunoinflammation. Clinical impact of the monitoring of allergic inflammation, P Matsson, S Ahlstedt, P Venge, J Thorell. Academic Press, London 1991; 187–200
  • Bendtzen K. Immune hormones (cytokines); pathogenic role in autoimmune rheumatic diseases and endocrine diseases. Autoimmunity 1989; 2: 177–89
  • Miura M, Hiwatshi N. Cytokine production in inflammatory bowel disease. J Clin Lab Immunol 1985; 33: 232–44
  • Satsangi J, Wolstencroft R A, Cason J, Ainley C C, Dumonde D C, Thompson R PH. Interleukin 1 in Crohn's disease. Clin Exp Immunol 1987; 67: 594–605
  • Suzuki Y, Quinn D G, Tobin A, Whelan C A, O'Morain C. Production of interleukin 1 by highly purified monocytes in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1991; 3: 45–9
  • Hodgson H JF, Mazlam MZ. Cytokines-are they different in ulcerative colitis and Crohn's disease. Inflammatory bowel disease. Progress in basic research and clinical implications, H Goebell, H Malchow, K Ewe, C Koelbel. Kluwer Academic Publishers, Dordrecht 1991; 161–8
  • Mahida Y R, Wu K, Jewell DP. Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut 1989; 30: 835–8
  • Brynskov J, Tvede N, Vilien M, Andersen C B, Bentzen K. Increased concentrations of interleukin 1β, interleukin 2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992; 33: 55–8
  • Ligumski M, Simon P L, Karmeli F, Rachmilewitz D. Role of interleukin 1 in inflammatory bowel disease: enhanced production during active disease. Gut 1990; 31: 6869
  • Rachmilewitz D, Simon P L, Schwartz L W, Griswald D E, Fondacaro J D, Wasserman MA. Inflammatory mediators of experimental colitis in rats. Gatroenterology 1989; 97: 32637
  • Radema S A, VanDeventer S JH, Cerami A. Interleukin 18 is expressed predominantly by enterocytes in experimental colitis. Gastroenterology 1991; 100: 118–8
  • Brynskov J, Hansen M B, Reimert C, Bentzen K. Inhibitor of interleukin lα and interleukin lβ-induced T-cell activation in serum of patients with active Crohn's disease. Dig Dis Sci 1991; 36: 737–42
  • Larrick JW. Native interleukin 1 inhibitors. Immunol Today 1989; 10: 61–66
  • Bendtzen K, Svenson M, JóSsson V, Hippe E. Autoantibodies to cytokines-friends or foes. Immunol Today 1990; 11: 167–9
  • Cannon J G, Dinarello CA. Increased plasma interleukin 1 activity in women after ovulation. Science 1985; 227: 1247–9
  • Dinarello C A, Rosenwasser L J, Wolf SM. Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans. J Immunol 1981; 127: 2517–19
  • Liao Z, Grimshaw R S, Rosenstreich DL. Identification of a specific interleukin 1 inhibitor in the urine of febrile patients. J Exp Med 1984; 159: 12636
  • Seckinger P, Williamson K, Balavoine J F. A urine inhibitor of interleukin 1 activity affects both interleukin lα and 1β but not tumour necrosis factor. J Immunol 1987; 139: 1541–5
  • Seckinger P, Lowenthal J W, Williamson K, Dayer J M, Mac-Donald HR. A urine inhibitor of interleukin 1 activity that blocks ligand binding. J Immunol 1987; 139: 15469
  • Arend WP. Interleukin 1 receptor antagonists. A new member of the interleukin 1 family. J Clin Invest 1991; 88: 1445–51
  • Dinarello C A, Thompson RC. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 1991; 12: 404–10
  • Eisenberg S P, Brewer M T, Verderber E, Heimdal P, Brandhuber B J, Thompson RC. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc Natl Acad Sci 1991; 88: 5232–6
  • Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen J H, Dinarello C A, Svenson M. Human PI 7 interleukin 1 is cytotoxic for pancreatic islets of Langerhans. Science 1986; 232: 1545–7
  • Onozaki K, Matsushima K, Aggarwal B B, Oppenheim JJ. Human interleukin 1 is cytocidal factor for several tumor cell lines. J Immunol 1985; 135: 3962–8
  • Pettipher E R, Henderson B, Higgs G A, Moncada S. Arthritogenic activity of interleukin 1 in leucopaenic rabbits. Congress of the International Association for Biological Standards-Cytokines. LondonEngland 1987
  • Deem R L, Shananan F, Targan SR. Triggered human mucosal T cells release tumor necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells. Clin Exp Immunol 1991; 83: 79–84
  • Cantrell D A, Smith KA. The interleukin-2 T-cell system. Science 1984; 224: 1312–6
  • Ruscetti F W, Gallo RC. Human T lymphocyte growth factor: regulation of growth and function of T lymphocytes. Blood 1981; 57: 379–94
  • Ebert E C, Wright S C, Lipshutz W H, Haupman SP. T cell abnormalities in inflammatory bowel diseases are mediated by interleukin 2. Clin Immunol Immunopathol 1984; 33: 232–44
  • Fiocchi C. Lymphokines and the intestinal immune response. Role in inflammatory bowel disease. Immunol Invest 1989; 18: 91–102
  • Kusugami K, Matsuura T, West G A, Youngman K R, Rachmilewitz D, Fiocchi C. Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease. Gastroenterology 1991; 101: 1594–1605
  • Fiocchi C, Hilfiker M L, Youngman K R, Doerder N C, Finke JH. Interleukin 2 activity of human intestinal mucosa mononuclear cells. Decreased levels in inflammatory bowel disease. Gastroenterology 1984; 86: 734–42
  • Fiocchi C, Tubbs R, Youngman KR. Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity. Gastroenterology 1985; 88: 625–37
  • Manzano L, Alvarez-Mon M, Abreu L. Functional impairment of natural killer cells in active ulcerative colitis: revision of the defective natural killer activity by interleukin 2. Gut 1992; 33: 246–51
  • James SP. Remission of Crohn's disease after human immunodeficiency virus infection. Gastroenterology 1988; 96: 1667–9
  • Miyasaka N, Nakarama T, Russell I J, Talal N. Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol 1984; 31: 109–17
  • Davidsen B. Concanavalin A induced suppressor activity exerted by peripheral blood mononuclear cells-with special reference to chronic inflammatory bowel disease. Dan Med Bull 1988; 35: 201–22
  • Selby W S, Janossy G, Bonfill M, Jewell DP. Intestinal lymphocyte subpopulation in inflammatory bowel disease: An analysis by immunohistological and cell isolation techniques. Gut 1984; 25: 32–40
  • James S P, Fiocchi C, Graeff A S, Strober W. Immunoregulatory functions of lamina propria T in Crohn's disease. Gastroenterology 1985; 88: 1143–50
  • Cornaby A, Simpson M A, Vannrice R. Dempsey RA, Madras PN, Monaco AP. Interleukin-2 production in plasma and urine, plasma interleukin-2 receptor levels, and urine cytology as a means of monitoring renal allograft recipients. Transplant Proc 1988; 20: 108–10, Suppl 1
  • Sunder-Plassmann G, Stockenhuber F, Balcke O. Serum interleukin 2 activity in renal graft recipients. Transplant Proc 1988; 20: 387–9
  • Trotter J L, Clifford D B, Anderson C B, Van der Veen R C, Hicks B C, Banks G. Elevated serum interleukin-2 levels in chronic progressive multiple sclerosis. N Engl J Med 1988; 322: 1206
  • Wolf R E, Baethge BA. lnterleukin-lα, interleukin-2, and soluble interleukin-2 receptors in polymyositis. Arthritis Rheum 1990; 33: 1007–14
  • Brynskov J, Tvede N. Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin. Gut 1990; 31: 795–9
  • James S P, Mullin GE. Lymphokine production by mucosal T cells in inflammatory bowel disease. Inflammatory bowel disease. Progress in basic research and clinical implication, H Goebell, K Ewe, H Malchow, CH Koeibel. Kluwer Academic Publishers, Dordrecht 1991; 71–81
  • Fujii M, Sogamura K, Sabno K, Nakai M, Sugita K, Hinuma Y. High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T-cells. J Exp Med 1986; 163: 550–62
  • Sharon M, Klausner R D, Cullen B R, Chizzonite R, Leonard WJ. Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 1986; 23: 859–63
  • Teshigawara K, Wang H, Kato K, Smith KA. Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med 1986; 165: 223–38
  • Tsudo M, Kozak R W, Goldman C K, Waldman TA. Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in multichain interleukin 2 receptor complex. Proc Natl Acad Sci 1986; 83: 9694–8
  • Forsythe J L, Shenton B K, Parrot N R, Taylor R M, Proud G. Plasma interleukin 2 receptor levels in renal allograft dysfunction. Transplantation 1989; 48: 155–7
  • Adam D H, Hubscher S G, Wang L, Elisa E. Soluble interleukin-2 receptors in serum and bile of liver transplant recipients. Lancet 1989; 1: 469–71
  • Marcon L, Fritz M E, Kurman C C, Jensen J C, Nelson DL. Soluble Tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL). Clin Exp Immunol 1988; 73: 29–33
  • Lobo-Yeo A, Mieli-Verganis G, Mowat A P, Verganis D. Soluble interleukin 2 receptors in autoimmune chronic active hepatitis. Gut 1990; 31: 690–3
  • Wolf R E, Brelsford WG. Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum 1988; 31: 729–35
  • Crabtree J E, Juby L D, Heatley R V, Lobo A J, Bullimore D W, Axon A TR. Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity. Gut 1990; 31: 1033–6
  • Mahida Y R, Gallagher A, Kurlac L, Hawkey CJ. Circulating and tissue interleukin 2 receptor levels in inflammatory bowel disease. Clin Exp Immunol 1990; 82: 75–80
  • Mueller C, Knoflach P, Zielinski CC. T-cell activation in Crohn's disease. Increased levels of soluble interleukin 2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. Gastroenterology 1990; 98: 639–46
  • Mahida Y R, Patel S, Wu K, Jewell DP. Interleukin-2 receptor expression by macrophages in inflammatory bowel disease. Clin Exp Immunol 1988; 74: 382–6
  • Pallone F, Fais S, Squarcia O, Biancone L, Pozzilli P, Biorivant M. Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. Gut 1990; 28: 745–53
  • Raedler A, Schreiber S. Immunology of ulcerative colitis. Hepatogastroentcrology 1989; 36: 213–8
  • Malizia G, Calabrese A, Cottone M. Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease. Gastroenterology 1991; 100: 150–9
  • Waldmann T A, Goldman C K, Robb R J. Expression of interleukin-2 receptors in activated B cells. J Exp Med 1984; 160: 1450–66
  • Schreiber S, Raedler A, Conn A R, Rombeau J L, MacDermott RP. Increased in vitro release of soluble interleukin 2 receptors by colonic lamina propria mononuclear cells in inflammatory bowel disease. Gut 1992; 33: 23644
  • Rubin L A, Jay G, Nelson DL. The released interleukin 2 receptor binds interleukin 2 efficiently. J Immunol 1986; 137: 3841–4
  • Bendtzen K. Clinical significance of cytokines. Natural and therapeutic regulation. Sem Clin Immunol 1991; 3: 5–13
  • Snick J. Interleukin-6: an overview. Ann Rev Immunol 1990; 8: 253–78
  • Andus T, Gross V, Casar I. Activation of monocytes during inflammatory bowel disease. Pathobiology 1991; 59: 166–70
  • Mitsuyama K, Sata M, Tanikawa K. Significance of interleukin-6 in patients with inflammatory bowel disease. Gastroenterol Jpn 1991; 26: 20–8
  • Suzuki Y, Saito H, Kasanuki J, Kishimoto T, Tamura Y, Yoshida S. Significant increase of interleukin 6-production in blood mononuclear leukocytes obtained from patients with active inflammatory bowel disease. Life Sci 1990; 47: 2193–7
  • Mahida Y R, Kurlac L, Gallagher A, Hawkey CJ. High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. Gut 1991; 32: 1531–4
  • Gross V, Andus T, Caesar J, Roth M, Scholmerich J. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology 1992; 102: 514–9
  • Nielsen OH. In vitro studies on the significance of arachidonate metabolism and other oxidative processes in the inflammatory response of human neutrophils and macrophages with special reference to chronic inflammatory bowel disease. Scand J Gastroenterol 1988; 23: 1–21, Suppl 150
  • Sherry B, Cerami A. Small cytokine superfamily. Cur Opin lmmunol 1991; 3: 5660
  • Matsushima K, Morishita K, Yoshimura T. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med 1988; 167: 1883–93
  • Oppenheim J J, Zachariae C OC, Mukaida N, Matsushima K. Properties of the novel proinflammatory supergene ‘intercrine’ cytokine family. Ann Rev Immunol 1991; 9: 617–48
  • Mahida Y R, Ceska M, Lindley I, Hawkey CJ. Increased mucosal interleukin 8 (NAP-1) in active ulcerative colitis [abstract]. Gastroenterology 1991; 100: A595
  • Djeu J Y, Matsushima K, Oppenheim J J, Shiotsuki K, Blanchard DK. Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/ IL-8. J Immunol 1990; 144: 2205–10
  • Matsushima K, Oppenheim JJ. Interleukin 8 and MCAF novel inflammatory cytokines inducible by IL 1 and TNF. Cytokine 1989; 1: 2–13
  • Schroeder JM. The monocyte-derived neutrophil activating peptide (NAP-l/interleukin 8) stimulates human neutrophil arachidonate-5-lipoxygenase but not the release of cellular arachidonate. J Exp Med 1989; 170: 847–63
  • Thelen M, Peveri P, Kernen P, Von Tscharner V, Wlaz A, Baggiolini M. Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist. FASEB J 1988; 2: 27026
  • Dunham I, Sargent C A, Trowsdale J, Cambell RD. Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis. Proc Natl Acad Sci 1987; 84: 7237–41
  • Ragoussis I, Bloemer K, Weiss E H, Ziegler A. Localization of the genes for tumor necrosis factor and lymphotoxih between the HLA class I and III regions by field inversion gel electrophoresis. Immunogenetics 1988; 27: 66–9
  • Bendtzen K, Morling N, Fomsgaard A. Association between HLA-D2R and production of tumor necrosis factor α and interleukin 1 by mononuclear cells activated by pipopolysaccharide. Scand J Immunol 1988; 28: 599–606
  • Fugger L, Bendtzen K, Morling N, Ryder L, Svejgaard A. Possible correlation of TNFa-production with RFLP in humans. Eur J Haematol 1989; 43: 255–6
  • Jacob C O, Lewis G D, McDevitt HO. MHC class 11-associated variation in the production of tumor necrosis factor in mice and humans: relevance to the pathogenesis of autoimmune disease. Immunol Res 1991; 10: 156–68
  • Ellis A, McKay J, Woodrow J C, McConnell RB. Tissue antigens and inflammatory bowel disease. Front Gastroent Res 1986; 11: 35–41
  • Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. N Engl J Med 1987; 316: 379–85
  • Bendtzen K. Why is too little TNF bad. Cytokine 1991; 3: 636–7
  • Hyams J S, Treem W R, Eddy E, Wyzga N, Moore RE. Tumor necrosis factor-α is not elevated in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1991; 12: 233–6
  • Murch S H, Lamkin V A, Savage M O, Walker-Smith J A, Mac-Donald TT. Serum concentrations of tumor necrosis factor α in childhood chronic inflammatory bowel disease. Gut 1991; 32: 913–7
  • Braegger C P, Nicholls S, Murch S H, Stephens S, MacDonald TT. Tumor necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992; 339: 89–91
  • Fais S, Capobianchi M R, Pallone F. Spontaneous release of interferon γ by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon γ inducers. Gut 1991; 32: 403–7
  • MacDonald T T, Hutchings P, Choy M-Y, Murch S, Cooke A. Tumor necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990; 81: 301–5
  • Lieberman B Y, Fiocchi C, Youngman K R, Sapatnekar W K, Proffitt MR. Interferon γ production by human intestinal mucosal cells: decreased levels in inflammatory bowel disease. Dig Dis Sci 1988; 33: 1297–1304
  • Fiocchi C. Lymphokines and the intestinal immune response. Role in inflammatory bowel disease. Immunol Invest 1989; 18: 91–102
  • Mahida Y R, Lamming C ED, Gallagher A, Hawthorne A B, Hawkey CJ. 5-aminosalicylic acid is a potent inhibitor of interleukin 1β production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease. Gut 1991; 32: 50–4
  • Remvig L, Anderson B. Salicylazosulfapyridine effect on endotoxin-induced production of interleukin-1-like factor from human monocytes in vitro. Scand J Rheumatol 1990; 19: 114
  • Fujiwara M, Mitsui K, Yamamoto I. Inhibition of proliferative responses and interleukin 2 productions by salazosulfapyridine and its metabolites. Jpn J Pharmacol 1990; 54: 121–31
  • Shanahan F, Niederlehner A, Carramanzana N, Anton P. Sulfasalazine inhibits the binding of TNFa to its receptor. Immunopharmacology 1990; 20: 217–24
  • Cominelli F, Zipser R D, Dinarello CA. Sulfasalazine inhibits cytokine production in human mononuclear cells: a novel antiinflammatory mechanism. Gastroenterology 1988; 96: A96
  • Beato M, Briiggemeier U, Chalepakis G. Regulation of transcription by glucucorticoids. The hormonal control of gene transcription, P Cohen, JG Foulkes. Elsevier Science Publishers B.V., Amsterdam 1991; 117–28
  • DiRosa M, Flower R J, Hirata F, Parente L, Russo-Marie F. Antiphospholipase proteins. Prostaglandins 1984; 28: 441–2
  • Werb Z, Foley R, Munck A. Interation of glucocorticoids with macrophages. Identification of glucocorticoid receptors in monocytes and macrophages. J Exp Med 1978; 147: 1684–93
  • Bendtzen K, Petersen J. Effects of cyclosporin A (CyA) and methylprednisolone (MP) on the immune response. I. T cell-activating factor (IL-1) abrogates CyA-but not MP-induced suppression of antigen-induced lymphokine production. Immunol Lett 1982; 5: 79–83
  • Lew W, Oppenheim J J, Matsushima K. Analysis of the suppression of IL-lα and IL-1β production in human peripheral blood mononuclear adherent cells by a glucocorticoid hormone. J Immunol 1988; 140: 1895–2
  • Horst H J, Flad HD. Corticosteroid-interleukin 2 interactions: inhibition of binding of interleukin 2 to interleukin 2 receptors. Clin Exp Immunol 1987; 68: 151–61
  • Goodwin J S, Atluru D, Sierakowski S, Lianos EA. Mechanism of action of glucocorticoids. Inhibition of T cell proliferation and interleukin 2 production of hydrocortisone is reversed by leukotriene B4. J Clin Invest 1986; 77: 1244–50
  • Arya S K, Wong-Staal F, Gallo RC. Dexamethasone-mediated inhibition of human T cell growth factor and gamma interferon messenger RNA. J Immunol 1984; 133: 273–6
  • Mokoena T, Gordon S. Human macrophage activation. Modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma and alpha interferons, and dexamethasone. J Clin Invest 1985; 75: 624–31
  • Culpepper J A, Lee F. Regulation of IL-3 expression by glucocorticoids in cloned murine T lymphocytes. J Immunol 1985; 135: 3191–7
  • Wallen N, Kita H, Weiler D, Gleich GJ. Glucocorticoids inhibit cytokine-mediated eosinophil survival. J Immunol 1991; 147: 3490–5
  • Andus T, Gross V, Casar I, Krumm D, Hosp J, David M, Scholmerich J. Activation of monocytes during inflammatory bowel disease. Pathobiology 1991; 59: 166–70
  • Mukaida N, Shiro M, Matsushima K. Genomic structure of the human monocyte-derived neutrophil chemotactic factor interleukin 8. J Immunol 1989; 143: 1366–71
  • Harding M W, Galat A, Uehling D E, Schreiber SL. A receptor for the immunosuppressant FK.506 is a cis-trans peptidyi-prolyl isomerase. Nature 1989; 341: 758–60
  • Siekierka J J, Hung S HY, Poe M. Lin CS Sigal NJ. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341: 755–7
  • Elliot J F, Lin Y, Mizel S B, Bleackley R C, Harnish D G, Laetkau V. Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science 1984; 226: 1439–41
  • Bunjes D, Hardt C, Rollinghoff M, Wagner H. Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2. Eur J Immunol 1981; 11: 657–61
  • Kalman V K, Klimpel GR. Cyclosporin A inhibits the production of γ interferon but does not inhibit production of virus induced IFN α/β. Cell Immunol 1983; 78: 122–9
  • Wasik M A, Beller DI. Induction of macrophage membrane interleukin 1 expression by T-cell dependent and T-cell independent pathways is inhibited by cyclosporin A. Clin Immunol Immunopathol 1989; 52: 331–40
  • Kupiec-Weglinski J W, Filho M A, Strom T B, Tihey BL. Sparing of suppressor cells: a critical action of cyclosporine. Transplantation 1984; 38: 97–101
  • Evans C M, Philips A D, Walker-Smith J A, MacDonald TT. Activation of lamina propria T cells induces crypt epithelial proliferation and goblet cell depletion in cultured human fetal colon. Gut 1992; 33: 230–5
  • Hess A D, Colombani PM. Cyclosporin A. Mechanism of action (in vitro studies). Progr Allergy 1986; 38: 198–221
  • Knudsen P J, Dinarello C A, Strom TB. Prostaglandins post-transcriptionally inhibit monocyte expression of interleukin-1 activity by increasing intracellular cyclic adenosine mono-phosphate. J Immunol 1986; 137: 3189–94
  • Monick M, Glazier J, Hunninghake GW. Human alveolar macrophages suppress interleukin-1 (IL-1) activity via the secretion of prostaglandin E2. Am Rev Respir Dis 1987; 135: 72–7
  • Sato I Y, Kobayashi K, Yamagata N. Modulation of granuloma formation in vitro by endogenous mediators. Immunopharmacol 1991; 21: 73–82
  • Haynes D R, Wright P F, Whitehouse M W, Vernon-Roberts B. The cyclo-oxygenase inhibitor, piroxicam, enhances cytokine-induced lymphocyte proliferation in vitro and in vivo. Immunol Cell Biol 1990; 68: 225–30
  • Dinarello CA. Interleukin-1 and other growth factors. Textbook of rheumatology, WN Kelly, ED Harris, S Ruddy, CB Sledge. W.B. Saunders Company, Philadelphia 1989; 285–99
  • Baker P E, Fahey J V, Munck A. Prostaglandin inhibition of T cell proliferation is mediated at two levels. Cell Immunol 1981; 61: 52–61
  • Rappaport R H, Dodge DR. Prostaglandin E inhibits the production of human interleukin 2. J Exp Med 1982; 155: 943–8
  • Browning J L, Ribolini A. Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes. J Immunol 1987; 138: 2857–63
  • Hart P H, Vitti G F, Burgess D R, Whitty G A, Piccoli D S, Hamilton JA. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin-1 a, d prostaglandin E2. Proc Natl Acad Sci 1989; 86: 3803–7
  • Henderson B, Pettipher ER. Comparison of the in vivo inflammatory activities after intra-articular injection of natural and recombinent IL-1 alpha and IL-1 beta in the rabbit. Biochem Pharmacol 1988; 37: 4171–6
  • Hellerstein M K, Meydani S N, Meydani M, Wu K, Dinarello CA. Interleukin-1-induced anorexia in the rat. Influence of prostaglandins. J Clin Invest 1989; 84: 228–35
  • Boraschi D, Villa L, Volpini G, Bossu P, Censini S, Ghiara P. Differential activity of interleukin 1 alpha and interleukin 1 beta in the stimulation of the immune response in vivo. Eur J Immunol 1990; 20: 317–21
  • Hauptmann B, VanDamme J, Dayer JM. Modulation of IL-1 inflammatory and immunornodulatory properties by IL-6. Eur Cytokine Netw 1991; 2: 39–46
  • Ferrandiz M I, Foster SJ. Tumour necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids. Agents Actions 1991; 32: 289–94
  • Kirstein D, Thomsen M K, Ahnfelt-Rbnne I. Inhibition of leukotriene biosynthesis and polymorphonuclear leukocyte functions by orally active quinolylmethoxyphenylamines. Pharmacol Toxicol 1991; 68: 125–30
  • Marshall P J, Griswold D E, Breton J, Webb E F, Hillegas L M, Sarau HM. Pharmacology of the pyrroloimidazole, SF & F 105809. I. Inhibition of inflammatory cytokine production and of 5-lipoxygenase and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol 1991; 42: 813–24
  • Rekonen R, Ustinov J. Interferon-gamma augments hydrolysis of LTA4 to LTB4 by endothelial cells. Prostaglandins 1990; 39: 205–11
  • Merrill J P, Strom S R, Ellison G W, Myers LW. In vitro study of mediators of inflammation in multiple sclerosis. J Clin Immunol 1989; 9: 84–96
  • Maloff B L, Shaw J E, Di-Meo TM. IL-1 dependent model of inflammation mediated by neutrophils. J Pharmacol Meth 1989; 22: 133–40
  • Rubin R M, Rosenbaum JT. A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. Biochem Biophys Res Commun 1988; 154: 429–36
  • Rola-Pleszczynski M, Stankova J. Cytokine gene regulation by PGE2, LTB, and PAF. Med Inflam 1992; 1: 5–8
  • Ward P A, Warren J S, Johnson KJ. Oxygen radicals, inflammation, and tissue injury. Free Radic Biol Med 1988; 5: 403–8

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