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Review Article

The Intestinal Permeability Barrier: A Hypothesis as to Its Regulation and Involvement in Crohn's Disease

Pages 721-726 | Published online: 08 Jul 2009

References

  • Powell DW. Barrier function of epithelia. Am J Physiol 1981; 241: G275–88
  • Madara JL. Loosening tight junctions-lessons from the intestine. J Clin Invest 1989; 83: 1089–94
  • Pappenheimer JR, Reiss KZ. Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J Membr Biol 1987; 100: 123–36
  • Madara JL. Tight junction dynamics: is paracellular transport regulated?. Cell 1988; 53: 497–8
  • Hollander D. Crohn's disease-a permeability disorder of the tight junction?. Gut 1988; 29: 1621–4
  • Chadwick VS, Phillips SF, Hofmann AF. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). Chemical analysis and biological properties of PEG 400. Gastroenterology 1977; 73: 241–6
  • Menzies IS. Transmucosal passage of inert molecules in health and disease. Intestinal absorption and secretion, E Skadhauge, K Heintz, MN Higham. MTP Press, LancasterEngland 1984; 527–44
  • Peters TJ, Bjarnason I. Uses and abuses of intestinal permeability measurements. Can J Gastroenterol 1988; 2: 127–32
  • Hollander D, Ricketts D, Boyd CAR. The importance of ‘probe’ molecular geometry in determining intestinal permeability. Can J Gastroenterol 1988; 2: 35a–8a
  • Hamilton I, Rothwell J, Archer D, Axon ATR. Permeability of the rat small intestine to carbohydrate probe molecules. Clin Sci 1987; 73: 189–96
  • Hollander D, Koyama S, Dadufalza V, et al. Polyethylene glycol 900 permeability of rat intestinal and colonic segments in-vivo and brush border membrane vesicles in-vitro. J Lab Clin Med 1989; 113: 505–15
  • Krugliak P, Hollander D, Ma TY, et al. Mechanisms of polyethylene glycol 400 permeability in perfused rat intestine. Gastroenterology 1989; 97: 1164–70
  • Pappenheimer JR, Reiss KZ. Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J Membr Biol 1987; 100: 123–36
  • Madara JL, Pappenheimer JR. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol 1987; 100: 149–64
  • Madara JL. Tight junction dynamics: is paracellular transport regulated?. Cell 1988; 53: 497–8
  • Madara JL. Occluding junction structure-function relationships in a cultured epithelial monolayer. J Cell Biol 1985; 101: 2124–33
  • Claude P, Goodenough DA. Fracture faces of zonulae occludens from ‘tight’ and ‘leaky’ epithelia. J Cell Biol 1973; 58: 390–400
  • Stevenson BR, Erson JM, Bullivant S. The epithelial tight junction: structure, function and preliminary biochemical characterization. Mol Cell Biochem 1988; 83: 129–45
  • Gumbiner B. Structure, biochemistry, and assembly of epithelial tight-junctions. Am J Physiol 1987; 253: C749–58
  • Marcial MA, Carlson SL, Madara JL. Partitioning of paracellular conductance along the ileal and crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships. J Membr Biol 1984; 80: 59–70
  • Harris SM, Kennedy JG, Siegesmund KA, Yorde DE. Relationship between distention and absorption in rat intenstine. I. Effect of luminal volume on morphology of the absorbing surface. Gastroenterology 1988; 94: 1164–71
  • Ukabam SO, Cooper BT. Small intestinal permeability to man-nitol, lactulose and polyethylene glycol 400 in celiac disease. Dig Dis Sci 1984; 29: 809–16
  • Cobden I, Dickinson RJ, Rothwell J, Axon ATR. Intestinal permeability assessed by excretion ratios of two molecules: results in coeliac disease. Br Med J 1978; 2: 1060
  • Trier JS. Celiac sprue disease. Gastrointestinal diseases, M Sleisinger, J Fordtran. WB Saunders, Philadelphia 1978; 1029–51
  • Pearson ADJ, Eastman EJ, Laker MF, Craft AW, Nelson R. Intestinal permeability in children with Crohn's disease and coeliac disease. Br Med J 1982; 285: 20–1
  • Heuman R, Sjodahl R, Tagesson C. Passage of molecules through the wall of the gastrointestinal tract-intestinal permeability to polyethyleneglycol 1000 in patients with Crohn's disease. Acta Chir Scand 1982; 148: 281–4
  • Magnusson K-E, Sundqvist T, Sjodahl R, Tagesson C. Altered intestinal permeability to low-molecular weight polyethylene-glycols (PEG 400) in patients with Crohn's disease. Acta Chir Scand 1983; 149: 323–7
  • Ukabam SO, Clamp JR, Cooper BT. Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon. Digestion 1983; 27: 70–4
  • Bjarnason IC, Levi AJ, Peters TJ. Absorption of 51-chromium- labelled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology 1983; 5: 318–22
  • Peled Y, Watz C, Gilat T. Measurement of intestinal permeability using 51Ci-EDTA. Am J Gastroenterol 1985; 80: 770–3
  • Casellas F, Aguade S, Soriano B, Accarino A, Molero J, Guarner L. Intestinal permeability to 99-Tc-diethylene-triaminopentaacetic acid in inflammatory bowel disease. Am J Gastroenterol 1986; 81: 761–70
  • Jenkins RT, Goodacre RL, Rooney PJ, Bienenstock J, Si-Vakumaran T, Walker WHC. Studies of intestinal permeability in inflammatory diseases using polyethylene glycol 400. Clin Biochem 1986; 19: 299–302
  • Hollander D, Vadheim CM, Brettholz E, Petersen GM, De-Lahunty TJ, Rotter JI. Increased intestinal permeability in patients with Crohn's disease and their relatives. Ann Intern Med 1986; 105: 883–5
  • Katz KD, Hollander D, Vadheim CM, et al. Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology 1989; 97: 927–31
  • Sanderson IR, Boulton P, Menzies I, Walker-Smith JA. Improvement of abnormal lactulose\rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet. Gut 1987; 28: 1073–6
  • Andre F, Andre C, Emery Y, Descos L, Minaire Y. Assessment of the lactulose-mannitol test in Crohn's disease. Gut 1988; 29: 511–5
  • Olaison G, Sjödahl R, Tagesson C. Decreased permeability to different-sized polyethyleneglycols in ileocaecal Crohn's disease-a sign of jejunal abnormality. Acta Chir Scand 1987; 153: 373–7
  • Olaison G, Leandersson P, Sjödahl R, Tagesson C. Intestinal permeability to polyethyleneglycol 600 in Crohn's disease. Per-operative determination in a defined segment of the small intestine. Gut 1988; 29: 196–9
  • Olaison G, Sjödahl R, Leandersson P, Tagesson C. Abnormal intestinal permeability pattern in colonic Crohn's disease. Absorption of low molecular weight polyethylene glycols after oral or colonic load. Scand J Gastroenterol 1989; 24: 571–6
  • Olaison G, Sjödahl R, Leandersson P, Tagesson C. Increase in permeability and phospholipase A2 activity of colonic mucosa in Crohn's colitis. Digestion 1989; 43: 228–33
  • Ainsworth M, Eriksen J, Rasmussen JW, Schaffalitzky de Muckadell OB. Intestinal permeability of 5lCr-labelled ethyl-enediaminetetraacetic acid in patients with Crohn's disease and their healthy relatives. Scand J Gastroenterol 1989; 24: 993–8
  • Resnick RH, Royal H, Marshall W, Barron R, Werth T. Intestinal permeability in gastrointestinal disorders. Use of oral [“mTc”] DTPA. Dig Dis Sci 1990; 35: 205–11
  • Pironi L, Miglioli M, Ruggeri E, et al. Intestinal permeability (IP) to 51Cr-EDTA and postoperative recurrence of Crohn's disease (CD): a follow-up study. Gastroenterology 1991; 100(5, Pt 2)A239
  • Wyatt J, Hubl W, Vogelsang H, Lochs H. Intestinal permeability predicts acute phases of Crohn's disease. Gastroenterology 1991; 100(5, Pt 2)A848
  • Valpiani D, Ornigotti L, Ricca Rosellini S, et al. Intestinal permeability: a non invasive method in predicting Crohn's disease relapse. Gastroenterology 1991; 100(5 Pt 2)A259
  • Rutgeerts P, Peeters M, Ghoos Y, Hiele M, Geboes K, Vantrappen G. Permeability for water soluble macromolecules is increased in macroscopically normal jejunal mucosa of patients with Crohn's disease. Gastroenterology 1991; 100(5 Pt 2)A246
  • Teahon K, Smethurst P, Rideout JM, Levi J, Bjarnason I. Intestinal permeability in patients with Crohn's disease and their 1st degree relatives. Gastroenterology 1991; 100(5, Pt 2)A256
  • Teahon K, Smethurst P, Pearson M, Levi JA, Bjarnason I. The effect of elemental diet on intestinal permeability and inflammation in Crohn's disease. Gastroenterology 1991; 101: 84–9
  • Olaison G, Sjodahl R, Tagesson C. Abnormal intestinal permeability in Crohn's disease. A possible pathogenic factor. Scand J Gastroenterol 1990; 25: 321–8
  • Laker MF, Bull HJ, Menzies IJ. Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man. Eur J Clin Invest 1982; 12: 485–91

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