Normal Inflammatory Bowel Disease Mucosa Conceals Alterations in Natural Killer Cell Activity

References

• Gibson P. R., Dow E. L., Selby W. S., Strickland R. G., Jewell D. P. Natural killer cells and spontaneous cell-mediated cytotoxicity in the human intestine. Clin Exp Immunol 1984; 56: 438–44
   PubMed Web of Science ®Google Scholar
• Gibson P. R., Hermanowicz A., Jewell D. P. Factors affecting the spontaneous cell-mediated cytotoxicity of intestinal mononuclear cells. Immunology 1984; 53: 267–74
   PubMed Web of Science ®Google Scholar
• van Tol E. A F, Verspaget H. W., Pena A. S., Elzo Kraemer C. V., Lamers C. B H W. The CD56 adhesion molecule is the major determinant for detecting non-MHC-restricted cytotoxic mononuclear cells from the intestinal lamina propria. Eur J Immunol 1992; 22: 23–9
   PubMed Web of Science ®Google Scholar
• Gibson P. R., Jewell D. P. Local immune mechanisms in inflammatory bowel disease and colorectal carcinoma. Natural killer cells and their activity. Gastroenterology 1986; 90: 12–9
   PubMed Web of Science ®Google Scholar
• Fiocchi C., Youngman K. R., Yen-Lieberman B., Tubbs R. R. Modulation of intestinal immune reactivity by interleukin 2. Phenotypic and functional analysis of lymphokine-activated killer cells from human intestinal mucosa. Dig Dis Sci 1988; 33: 1305–15
   PubMed Web of Science ®Google Scholar
• Shanahan F., Brogan M., Targan S. Human mucosal cytotoxic effector cells. Gastroenterology 1987; 92: 1951–57
   PubMed Web of Science ®Google Scholar
• Lanier L. L., Le A. M., Civin C. I., Loken M. R., Phillips J. H. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 1986; 136: 4480–86
   PubMed Web of Science ®Google Scholar
• Hersey P., Bolhuis R. ‘Nonspecific’ MHC-unrestricted killer cells and their receptors. Immunol Today 1987; 8: 233–9
   PubMedGoogle Scholar
• Whiteside T. L., Herberman R. B. The role of natural killer cells in human disease. Clin Immun Immunopathol 1989; 53: 1–23
   PubMedGoogle Scholar
• Robertson M. J., Ritz J. Biology and clinical relevance of human natural killer cells. Blood 1990; 76: 2421–38
   PubMed Web of Science ®Google Scholar
• Oldham R. K. Natural killer cells: history, relevance, and clinical applications. Nat Immun Cell Growth Regul 1990; 9: 297–312
   PubMedGoogle Scholar
• MacDermott R. P., Franklin G. O., Jenkins K. M., Kodner I. J., Nash G. S., Weinrieb I. J. Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities. Gastroenterology 1980; 78: 47–56
   PubMed Web of Science ®Google Scholar
• MacDermott R. P., Bragdon M. J., Kodner I. J., Bertovich M. J. Deficient cell-mediated cytotoxicity and hyporesponsiveness to interferon and mitogenic lectin activation by inflammatory bowel disease peripheral blood and intestinal mononuclear cells. Gastroenterology 1986; 90: 6–11
   PubMed Web of Science ®Google Scholar
• Fiocchi C., Tubbs R. R., Youngman K. R. Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity. Gastroenterology 1985; 88: 625–37
   PubMed Web of Science ®Google Scholar
• Hogan P. G., Hapel A. J., Doe W. F. Lymphokine-activated and natural killer cell activity in human intestinal mucosa. J Immunol 1985; 135: 1731–8
   PubMed Web of Science ®Google Scholar
• Bull D. M., Bookman M. A. Isolation and functional characterization of human intestinal mucosal lymphoid cells. J Clin Invest 1977; 59: 966–74
   PubMed Web of Science ®Google Scholar
• Fiocchi C., Battisto J. R., Farmer R. G. Gut mucosal lymphocytes in inflammatory bowel disease. Isolation and preliminary functional characterization. Dig Dis Sci 1979; 24: 705–17
   PubMed Web of Science ®Google Scholar
• Beeken W. L., Gundel R. M., St. Andre-Ukena S., McAuliffe T. In vitro cellular cytotoxicity for a human colon cancer cell line by mucosal mononuclear cells of patients with colon cancer and other disorders. Cancer 1985; 55: 1024–29
   PubMed Web of Science ®Google Scholar
• Hirata I., Berrebi G., Austin L. L., Keren D. F., Dobbins W. O. Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease. Dig Dis Sci 1986; 31: 593–603
   PubMed Web of Science ®Google Scholar
• Lanier L. L., Phillips J. H. Evidence for three types of human cytotoxic lymphocyte. Immunol Today 1986; 7: 132–4
   PubMedGoogle Scholar
• Nagler A., Lanier L. L., Cwirla S., Phillips J. H. Comparative studies of human FcRIITpositive and negative natural killer cells. J Immunol 1989; 153: 3183–91
   Google Scholar
• Gibson P. R., Verhaar H. J J, Selby W. S., Jewell D. P. The mononuclear cells of human mesenteric blood, intestinal mucosa and mesenteric lymph nodes: compartmentalization of NK cells. Clin Exp Immunol 1984; 56: 445–52
   PubMed Web of Science ®Google Scholar
• Shorter R. G., McGill D. B., Baker R. C. Cytotoxicity of mononuclear cells for autologous colonic epithelial cells in colonic disease. Gastroenterology 1984; 86: 13–22
   PubMed Web of Science ®Google Scholar
• Gibson P. R., van de Pol E., Pullman W., Doe W. F. Lysis of colonic epithelial cells by allogenic mononuclear and lymphokine activated killer cells derived from peripheral blood and intestinal mucosa: evidence against a pathogenic role in inflammatory disease. Gut 1988; 29: 1076–84
   PubMed Web of Science ®Google Scholar
• Aparicio-Pages M. N., Verspaget H. W., Pena A. S., et al. In vitro cellular cytotoxicity in Crohn's disease and ulcerative colitis: relation with disease activity and treatment, and the effect of recombinant gamma-interferon. J Clin Lab Immunol 1989; 29: 119–24
   PubMedGoogle Scholar
• Taunk J., Roberts A. I., Ebert E. Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology 1992; 102: 69–75
   PubMed Web of Science ®Google Scholar
• Sjölund O. B., Schaffalitzky de Muckadell O. B., Fahrenkrug J., Håkanson R., Peterson B. G., Sundler F. Peptide containing nerves fibers in the gut wall in Crohn's disease. Gut 1983; 24: 724–33
   PubMed Web of Science ®Google Scholar
• Koch T. R., Carney J. A., Go V. L. Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel disease. Dig Dis Sci 1987; 32: 369–76
   PubMed Web of Science ®Google Scholar
• van Tol E. A F, Verspaget H. W., Lamers C. B H W. Neuropeptide regulation of cell-mediated cytotoxicity against human tumor cells. Neuropeptides 1990; 16: 25–32
   PubMed Web of Science ®Google Scholar
• van Tol E. A F, Verspaget H. W., Pefia A. S., Jansen J. B M J, Aparicio-Pagés M. N., Lamers C. B H W. Modulatory effects of VIP and related peptides from the gastrointestinal tract on cell mediated cytotoxicity against tumor cells in vitro. Immunol Invest 1991; 20: 257–67
   PubMed Web of Science ®Google Scholar