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Original Article

Acute Cytotoxic Effect of Cyclosporin A on Pancreatic Acinar Cells in Rats: Protective Effect of the Synthetic Protease Inhibitor E3123

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Pages 103-107 | Received 18 Jun 1991, Accepted 23 Sep 1991, Published online: 05 Aug 2009

References

  • Calne R Y, White D J G, Evans D B, et al. Cyclosporine A in cadaveric organ transplantation. Br Med J 1981; 282: 934–936
  • Starzl T E, Kintmalm G B G, Porter K A, Iwatsuki S, Schröter G P J. Liver transplantation with use of cyclosporine A and prednisone. N Engl J Med 1983; 305: 266–269
  • Ried M, Gibbon S, Kwok D, VanBuren C T, Flechner S, Kahan B D. Cyclosporine levels in human tissues of patients treated from one week to one year. Transplant Proc 1983; 15: 2434–2437
  • Doi R, Tangoku A, Chowdhury P, Blevins G T, Pasley J N, Rayford L. Effects of FK506 and cyclosporine A on exocrine pancreas in rats [abstract]. Pancreas 1990; 5: 704
  • Lorber M I, VanBuren C T, Flechner S M, Williams C, Kahan B D. Hepatobiliary and pancreatic complication of cyclosporine therapy in 466 renal transplant recipient. Transplantation 1987; 43: 35–40
  • Sutherland D E R, Maudry K C, Fryd D S. Results of pancreas-transplant registry. Diabetes 1989; 38: 46–54
  • Dubernard J M, Martinenghi S, Martin X, et al. Pancreatic transplantation in Lyon; the whole series. Transplant Proc 1990; 22: 595–596
  • Watanabe O, Baccino F M, Steer M L, Meldolesi J. Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell; early morphological changes during development of experimental pancreatitis. Am J Physiol 1984; 246: G457–467
  • Saluja A, Hashimoto S, Saluja M, Power R E, Meldolesi J, Steer M L. Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis. Am J Physiol 1987; 253: G508–516
  • Koike H, Steer M L, Meldolesi J. Pancreatic effects of ethionine; blockage of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis. Am J Physiol 1982; 242: G297–307
  • Ohshio G, Saluja A K, Lehli U, Sengupta A, Steer M L. Esterase inhibitors prevent lysosomal enzyme redistribution in two noninvasive models of experimental pancreatitis. Gastroenterology 1989; 96: 853–859
  • Steer M L, Meldolesi J, Figarella C. Pancreatitis, the role of iysosomes. Dig Dis Sci 1984; 29: 934–938
  • Greenbaum L M, Hirshkowitz A. Endogenous cathepsin activation of trypsinogen in extracts of dog pancreas. Proc Soc Exp Biol Med 1961; 107: 74–76
  • Rinderknecht H. Activation of pancreatic zymogens, normal activation, premature intrapancreatic activation, protective mechanism against inappropriate activation. Dig Dis Sci 1986; 31: 314–321
  • Iwatsuki K, Horiuchi A, Yonekura H, Chiba S. Ischemia-induced acute pancreatitis in the dog and its amelioration by a new synthetic protease inhibitor, E-3123. Asia Pacific J Pharmacol 1990; 5: 113–119
  • Tartakoff A, Jamieson J E. Fractionation of guinea pig pancreas. Methods Enzymol 1974; 31: 41–59
  • DeLisle R, Schulz I, Tyrakowski T, Haase W, Hopfer U. Isolation of stable pancreatic zymogen granules. Am J Physiol 1984; 246: G411–418
  • Bernfeld P. Amylase α and β. Method Enzymol 1955; 1: 149–158
  • McDonald J K, Ellis S. On the substrate specificity of cathepsin B1 and B2 including a new fluorogenic substrate for cathepsin B1. Life Sci 1975; 17: 1269–1276
  • Labarca C, Paigen K. A simple rapid and sensitive DNA assay procedure. Anal Biochem 1980; 102: 334–352
  • Hirano T, Saluja A, Ramareo P, Lerch M M, Saluja M, Steer M L. Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction. J Clin Invest 1991; 87: 865–869

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