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Original Article

Dihydropyridine Calcium Channel Antagonists Disrupt Migrating Myoelectric Complexes and Counteract Intestinal Disorders Associated with Morphine Withdrawal Diarrhea

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Pages 137-144 | Received 04 May 1992, Accepted 17 Aug 1992, Published online: 08 Jul 2009

References

  • Fleckenstein A. Calcium antagonism in heart and vascular smooth muscle. Med Res Rev 1985; 5: 395–425
  • Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986; 38: 321–416
  • Braunwald E. Mechanism of action of calcium-channei-blocking agents. N Engl J Med 1982; 307: 1618–27
  • Schramm M, Thomas G, Towart R, Franckowiak G. Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature 1983; 303: 535–7
  • Glossmann H, Goll A, Rombusch M, Ferry DR. Molecular pharmacology of Ca2+ channels: receptor binding studies. Nimodipine: pharmacological and clinical properties, Betz, et al. Schattauer Verlag, Stuttgart 1985; 57–73
  • Janis R A, Triggle DJ. 1,4-dihydropyridine Ca2+ channel antagonists and activators: a comparison of binding characteristics with pharmacology. Drug Dev Res 1984; 4: 257–74
  • Maggi C A, Manzini S, Meli A. Regional selectivity of calcium blockers at intestinal level. Arch Int Pharmacodyn 1985; 276: 202–21
  • Coruzzi G, Poli E. Changes in duodenal contractility induced by 'calcium antagonists' with different modes of action. Gen Pharmacol 1987; 18: 69–74
  • De Ponti F, D'Angelo L, Frigo G M, Crema A. Inhibitory effects of calcium channel blockers on intestinal motility in the dog. Eur J Pharmacol 1989; 168: 133–44
  • Santander R, Mena I, Gramisu M, Valenzuela JE. Effect of nifedipine on gastric emptying and gastrointestinal motility in man. Dig Dis Sci 1988; 33: 535–9
  • Richter J E, Dalton C B, Buice R G, Castell DO. Nifedipine: a potent inhibitor of contractions in the body of the human esophagus. Studies in healthy volunteers and patients with the nutcracker esophagus. Gastroenterology 1985; 89: 549–54
  • Blume M, Schuster M, Tucker H. Effect of nifedipine on colonic motility in the irritable bowel syndrome [abstract]. Gastroenterology 1983; 84: 1109
  • Narducci F, Bassotti G, Gaburri M, Farroni F, Morelli A. Nifedipine reduces the colonic motor responses to eating in patients with the irritable colon syndrome. Am J Gastroenterol 1985; 80: 317–9
  • Al-Saffar A, Rosell S. Effects of neurotensin and neurotensin analogues on the migrating myoelectrical complexes in the small intestine of rats. Acta Physiol Scand 1981; 112: 203–8
  • Romandini S, Cervo L, Samanin R. Evidence that drugs increasing 5-hydroxytryptamine transmission block jumping but not wet dog shakes in morphine-abstinent rats: a comparison with clonidine. J Pharm Pharmacol 1984; 36: 68–70
  • Vantrappen G, Janssens J, Hellemans J, Ghoos Y. The inter-digestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 1977; 59: 1158–66
  • Miller R J, Freedman SB. Are dihydropyridine binding sites voltage sensitive calcium channels?. Life Sci 1984; 34: 1205–21
  • Bellemann P. Interaction of the calcium channel activating 3H-Bay K 8644 and inhibiting 3H-verapamil with specific receptor sites on cultured beating myocardial cells. J Recept Res 1984; 4: 571–85
  • Spedding M. Competitive interactions between Bay K 8644 and nifedipine in K+ depolarized smooth muscle: a passive role for Ca2+?. Naunyn Schmiedebergs Arch Pharmacol 1985; 328: 464–6
  • Spedding M. Activators and inactivators of Ca++ channels: new perspectives. J Pharmacol 1985; 16: 319–43
  • Coruzzi G, Poli E. The stimulatory action of the calcium channel agonist Bay K 8644 on isolated duodenal muscle. Antagonism by nifedipine and verapamil. Naunyn Schmiedebergs Arch Pharmacol 1985; 331: 290–2
  • Nayler WG. The heterogeneity of the slow channel blockers (calcium antagonists). Int J Cardiol 1983; 3: 391–400
  • Reynolds I J, Gould R J, Snyder SH. Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. J Pharmacol Exp Ther 1984; 231: 628–32
  • Donowitz M, Levin S, Powers G, Elta G, Cohen P, Cheng H. Ca2+ channel blockers stimulate ileal and colonic water absorption. Gastroenterology 1985; 89: 858–66
  • Thollander M, Hellstrom P M, Svensson TH. Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action. Acta Physiol Scand 1989; 137: 385–92
  • Ramkumar V, El-Fakahany EE. Prolonged morphine treatment increases rat brain dihydropyridine binding sites: possible involvement in development of morphine dependence. Eur J Pharmacol 1988; 146: 73–83
  • Baeyens J M, Esposito E, Ossowska G, Samanin R. Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats. Eur J Pharmacol 1987; 137: 9–13

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