No Net Splanchnic Release of Glutathione in Man during N-Acetylcysteine Infusion

References

• Taniguchi N, Higashi T, Sakamoto Y, Meister A. Glutathione centennial: molecular perspectives and clinical implications. Academic Press, Inc., New York 1989
   Google Scholar
• Lauterburg B H, Velez M. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988; 29: 1153–7
   PubMed Web of Science ®Google Scholar
• Burgunder J M, Lauterburg B H. Decreased production of glutathione in patients with cirrhosis. Eur J Clin Invest 1987; 17: 408–14
   PubMed Web of Science ®Google Scholar
• Lauterburg B H, Mitchell J R. Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool. J Clin Invest 1981; 67: 1415–24
   PubMed Web of Science ®Google Scholar
• Seddon C E, Boobis A R, Davies D S. Comparative activation of paracetamol in the rat, mouse and man. Arch Toxicol 1987; 11 Suppl: 305–9
   Google Scholar
• Slattery J T, Wilson J M, Kalhorn T F, Nelson S D. Dose-dependent pharmacokinetics of acetaminophen, evidence of glutathione depletion in humans. Clin Pharmacol Ther 1987; 4: 413–8
   Google Scholar
• Lauterburg B H, Corcoran G B, Mitchell J R. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxocity of acetaminophen in rats in vivo. J Clin Invest 1983; 71: 980–91
   PubMed Web of Science ®Google Scholar
• Prescott L F, Illingworth R N, Critchley J AJH, Steward M J, Adam R D, Proudfoot A T. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. Br Med J 1979; 2: 1097–100
   PubMed Web of Science ®Google Scholar
• Rauchy J L, Lasker J M, Liebber C S, Black M. Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys 1989; 271: 270–83
   PubMedGoogle Scholar
• Poulsen H E, Vilstrup H, Almdahl T P, Dalhoff K. Direct measurement of hepatic glutathione efflux in man. J Hepatol 1990; 10(Suppl 1)S19
   Google Scholar
• Anderson M E, Bridges J B, Meister A. Direct evidence for inter-organ transport of glutathione and that non-filtration renal mechanism for glutathione utilization Involves γ-glutamyl transpeptidase. Biochem Biophys Res Comm 1980; 96: 848–53
   PubMed Web of Science ®Google Scholar
• Lauterburg B H, Adams J D, Mitchell J R. Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. Hepatology 1984; 4: 586–90
   PubMed Web of Science ®Google Scholar
• Purucker E, Wernze H. Hepatic efflux and renal extraction of plasma glutathione: marked difference between healthy subjects and the rat. Klin Wochenschr 1990; 68: 1008–12
   PubMedGoogle Scholar
• Allen K GD, Arthur J R. Inhibition by 5-sulphosalicylic acid of the glutathione reductase recycling assay glutathione analysis. Clin Chem Acta 1987; 162: 237–9
   PubMed Web of Science ®Google Scholar
• Poulsen H E, Ranek L, Andreasen P B. The hepatic glutathione content in liver diseases. Scand J Clin Invest 1981; 41: 573–6
   PubMed Web of Science ®Google Scholar
• Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969; 27: 502–22
   PubMed Web of Science ®Google Scholar
• Leevy C M, Mendelhall W L, Howard M. Estimation of hepatic blood flow with indocyanine green. J Clin Invest 1962; 41: 1169–79
   PubMed Web of Science ®Google Scholar
• Nielsen N C. Spectrophotometric determination of indocyanine green in plasma with a view to an improved correction for blank density. Scand J Clin Lab Invest 1963; 15: 613–21
   PubMed Web of Science ®Google Scholar
• Keiding S, Skak C. Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man. Liver 1987; 7: 155–62
   PubMedGoogle Scholar
• Harrison P M, Wendon J A, Grimson A ES, Alexander G JM, Williams R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. New Engl J Med 1991; 324: 1852–7
   PubMed Web of Science ®Google Scholar
• Lauterburg B H, Davies S, Mitchell J R. Ethanol suppresses hepatic glutathione synthesis in rats in vivo. J Pharmacol Exp Ther 1984; 230: 7–11
   PubMedGoogle Scholar
• Goodman S J, Mace J W, Pollac S. Serum gamma-glytamyl transpeptidase deficiency. Lancet 1971; 1: 234–5
   PubMed Web of Science ®Google Scholar
• Kaplowitz N, Fernandes-Checa J, Ookhtens M. Hepatic glutathione transport. Glutathione centennial: molecular perspectives and clinical implications, N Taniguchi, T Higashi, Y Sakamoto, A Meister. Academic Press, Inc., New York 1989; 395–406
   Google Scholar
• Vilstrup H, Bucher D, Krogh B, Damgaard S E. Elimination of infused amino acids from plasma of control subjects and of patients with cirrhosis of the liver. Eur J Clin Invest 1982; 12: 197–202
   PubMedGoogle Scholar
• Wendel A, Cikryt P. The level and half-life of glutathione in human plasma. FEBS Lett 1980; 120: 209–11
   PubMed Web of Science ®Google Scholar
• Beutler E, Gelbart T. Plasma glutathine in health and in patients with malignant disease. J Lab Clin Med 1985; 105: 581–4
   PubMed Web of Science ®Google Scholar
• Chawla R K, Lewis F W, Kutner M H, Bate D M, Roy G B, Rudman D. Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroentereol 1984; 87: 770–6
   PubMedGoogle Scholar
• Hagenfeldt L, Arvidsson A, Larsson A. Glutathione and gamma-glutamylcysteine in whole blood, plasma and erythrocytes. Clin Chem Acta 1978; 85: 167–73
   PubMedGoogle Scholar
• Owens C W, Belcher R V. A calorimetric micro-method for the determination of glutathione. Biochem J 1965; 94: 705–11
   PubMed Web of Science ®Google Scholar
• Anderson M E, Meister A. Dynamic state of glutathione in blood plasma. J Biol Chem 1980; 255: 9530–3
   PubMed Web of Science ®Google Scholar