Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 28, 1993 - Issue 8
Submit an article Journal homepage
11
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Drug Metabolism and Genetic Polymorphism in Subjects with Previous Halothane Hepatitis

L. Ranek Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
,
K. Dalhoff Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
,
H. Enghusen Poulsen Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
,
K. Brøsen Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
,
H. Flachs Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
,
S. Loft Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
&
P. Wantzin Dept. of Internal Medicine A, Dept. of Clinical Chemistry, and Dept. of Clinical Immunology, Rigshospitalet, and Dept. of Pharmacology, Medical Faculty, University of Copenhagen, Copenhagen, Denmark; Dept. of Clinical Pharmacology, University of Odense, Odense, Denmark
 show all
Pages 677-680 | Received 22 Oct 1992, Accepted 19 Feb 1993, Published online: 08 Jul 2009

References

  • De Groot H, Noll T. Halothane hepatotoxicity: relation between metabolic activation, hypoxia, covalent binding, lipid peroxidation and liver cell damage. Hepatology 1983; 3: 601–6
  • Kenna J G, Neuberger J, Williams R. Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis. Hepatology 1988; 8: 1635–41
  • Farrel G, Prendergast D, Murray M. Halothane hepatitis. Detection of a constitutional susceptibility factor. N Engl J Med 1985; 313: 1310–4
  • Nelson D R, Strobel H W. Evolution of P450 proteins. Mol Biol Evolution 1987; 4: 572–93
  • Gonzalez F J. The molecular biology of cytochrome P450s. Pharmacol Rev 1989; 40: 243–88
  • Eichelbaum M, Spannbrucker N, Steincke B, Dengler H J. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 1979; 16: 183–7
  • Evans D AP, Mahgoub A, Sloan T P, Idle J R, Smith R L. A family and population study of genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet 1980; 17: 102–5
  • Brøsen K, Gram L F. Clinical significance of the spartein/ debrisoquine oxidation polymorphism. Eur J Clin Pharmacol 1989; 36: 537–47
  • Kalow W. Phenytoin: pharmacogenetic polymorphism of 4-hydroxylation. Pharmacol Ther 1990; 46: 341–7
  • Loft S. Mitronidazole and antipyrine as probes for the study of foreign compound metabolism. Pharmacol Toxicol 1990; 66(Suppl 6)1–31
  • Kellerman G, Jett J R, Luyten-Kellerman M, Moses H L, Fon-Tana R S. Variation of microsomal mixed function oxidase(s) and human lung cancer. Cancer 1980; 45: 1438–42
  • Neuberger J, Mieli-Vergani G, Tredger J M, Davis M, Williams R. Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis. Gut 1981; 22: 669–72
  • Ranek L. Halothane hepatitis: a double defect?. Hepatology 1986; 6: 538–9
  • Teisberg P. High voltage agarose gel electrophoresis in the study of C3 polymorphism. Vox Sang 1970; 19: 47–56
  • Vinks A, Inaba T, Otton S V, Kalow W. Sparteine metabolism in Canadian Caucasians. Clin Pharmacol Ther 1982; 31: 23–9
  • Drøhse A, Bathum L, Brøsen K, Gram L P. Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark. Br J Clin Pharmacol 1989; 27: 620–5
  • Døssing M, Poulsen H E, Andreasen P B. A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 1982; 32: 392–6
  • Loft S, Døssing M, Poulsen H E. Influence of dose and route of administration on disposition of metronidazole and its major metabolites. Eur J Clin Pharmacol 1986; 30: 467–73
  • Loft S, Sonne J, Poulsen H E, Petersen K T, Jørgensen B G, Døssing M. Inhibition and induction of metronidazole and antipyrine metabolism. Eur J Clin Pharmacol 1987; 32: 35–41
  • Philbert A, Andersen J, Rasmussen S N, Flachs H, Dam M. Disposition of phenytoin during pregnancy: a pharmacokinetic study. Advances in epileptology: XVth Epilepsy International Symposium, R L Porter, et al. Raven Press, New York 1984; 251–7
  • Sanz E, Villen T, Aim C, Bertilsson L. S-mephenytoin hydroxy-lation phenytypes in a Swedish population determined after coadministration with debrisoquine. Clin Pharmacol Ther 1989; 45: 495–9
  • Brøsen K, Otton S V, Gram L F. Sparteine oxidation polymorphism in Denmark. Acta Pharmacol Toxicol 1985; 57: 357–60
  • Glazko A J, Peterson F E, Chang T, Dill W A, Smith T C, Buchanan R A. Phenytoin metabolism in subjects with long and short plasma half-lives. Ther Drug Monit 1982; 4: 281–92
  • Zaric D, Larsen S F, Jacobsen E, Olesen K H, Ranek L. Halothane hepatitis in a prospective study of postoperative complications. Acta Anaesthesiol Scand 1986; 30: 529–32
  • Carney F MT, Va Dyke R A. Halothane hepatitis: a critical review. Anesth Analg (Paris) 1972; 51: 135–60
  • Dalsgaard M, Andreasen P B, Ranek L. Halothane hepatitis. Ugeskr Laeger 1974; 136: 132
  • Vesell E S. Recent progress in pharmacogenetics. Adv Pharmacol 1969; 7: 1–52
  • Takagi T, Ishii H, Takahashi H. Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. Pharmacol Biochem Behav 1983; 18(Suppl 1)461–5
  • Ekström G, Von Bahr, Ingelmann-Sundberg M. Human liver microsomal cytochrome P-450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity. Biochem Pharmacol 1989; 38: 689–93
  • Farhud D D, Walter H. Association between C3 phenotypes and various diseases. Humangenetik 1972; 17: 57–60
  • Srivastava N, Srivastava L M. Association between C3 complement types and indian childhood cirrhosis. Hum Hered 1985; 35: 268–70

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.