25
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Localization of a Pernicious Anaemia Autoantibody Epitope on the a'-Subunit of Human H,K-Adenosine Triphosphatase

, , , , , , , , , & show all
Pages 122-127 | Received 10 Mar 1993, Accepted 29 Jul 1993, Published online: 08 Jul 2009

References

  • Strickland R G., Mackay I R. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis 1973; 18: 426–40
  • Kaye M D., Whorwell P J., Wright R. Gastric mucosal sub-populations in pernicious anaemia and normal stomach. Clin Immunol Immunopathol 1983; 28: 431–40
  • Jeffries G H., Sleisenger M H., Margolis S. Studies of parietal cell antibody in pernicious anaemia. J Clin Invest 1965; 44: 2201–8
  • Taylor K B., Roitt I M., Doniach D, Couchman K G., Shapland C. Autoimmune phenomena in pernicious anaemia: gastric antibodies. Br Med J 1962; 2: 1347–54
  • Irvine W J., Davies S H., Delamore I W., Williams A W. Immunological relationship between pernicious anaemia and thyroid disease. Br Med J 1962; 2: 454–6
  • Hoedemaeker P J., Ito S. Ultrastructural location of gastric parietal cell antigen with peroxidase-coupled antibody. Lab Invest 1970; 22: 184–8
  • Karlsson F A., Burman P, Lööf L, Mårdh S. The major parietal cell antigen in autoimmune gastritis with pernicious anaemia is the acid-producing H,K-ATPase of the stomach. J Clin Invest 1988; 81: 475–9
  • Ljungstrom M, Norberg L, Olaisson H, Wernstedt C, Vega F V., Arvidson G, et al. Characterization of proton-transporting membranes from resting pig gastric mucosa. Biochim Biophys Acta 1984; 769: 209–19
  • Hall K, Perez G, Anderson D, Gutierrez C, Munson K, Hersey S J., et al. Location of the carbohydrates present in the H,K-ATPase vesicles isolated from hog gastric mucosa. Biochemistry 1990; 29: 701–6
  • Okamoto C T., Karpilow J M., Smolka A, Forte J G. Isolation and characterization of gastric microsomal glycoproteins. Evidence for a glycosylated β-subunit of the H,K-ATPase. Biochim Biophys Acta 1990; 1037: 360–72
  • Toh B H., Gleeson P A., Simpson R J., Moritz R L., Callaghan J M., Goldkorn I, et al. The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a /S subunit of the gastric H,K-ATPase (proton pump). Proc Natl Acad Sci USA 1990; 87: 6418–22
  • Dow C A., de Aizpurua H J., Pedersen J S., Ungar B, Toh B H. 65–70 kD protein identified by immunoblotting as the presumptive gastric microsomal autoantigen in pernicious anemia. Clin Exp Immunol 1985; 62: 732–7
  • Goldkorn I, Gleeson P A., Toh B H. Gastric parietal cell antigens of 60–90, 92, and 100–120 kDa associated with autoimmune gastritis and pernicious anaemia. J Biol Chem 1989; 264: 18768–74
  • Gleeson P A., Toh B H. Molecular targets in pernicious anaemia. Immunol Today 1991; 12: 233–8
  • Jones C M., Callaghan J M., Gleeson P A., Mori Y, Masuda T, Toh B H. The parietal cell autoantibodies recognized in neonatal thymectomy-induced murine gastritis are the α and β subunits of the gastric proton pump. Gastroenterology 1991; 101: 287–94
  • Mårdh S, Ma J Y., Song Y H., Aly A, Henriksson K. Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen atrophic gastritis and rheumatoid arthritis. Scand J Gastroenterol 1991; 26: 1089–96
  • Mårdh S, Song Y H. Characterization of antigenic structures in autoimmune atrophic gastritis with pernicious anaemia, the parietal cell H,K-ATPase and the chief cell pepsinogen are the two major antigens. Acta Physiol Scand 1989; 136: 581–7
  • Burman P, Mårdh S, Norberg Karlsson F A. Parietal cell antibodies in pernicious anaemia inhibit H,K-adenosine triphosphatase, the proton pump of the stomach. Gastroenterology 1989; 96: 1434–8
  • Maeda M, Osshiman K I., Tamura S, Futai M. Human gastric (H + K)-ATPase gene. J Biol Chem 1990; 265: 9027–32
  • Ma J Y., Song Y H., Sjöstrand S E., Rask L, Mardh S. cDNA cloning of the β-subunit of the human gastric H,K-ATPase. Biochem Biophys Res Commun 1991; 180: 39–45
  • Mårdh S, Song Y H., Carlsson C, Björkman T. Mechanism of stimulation of acid production in parietal cells isolated from the pig gastric mucosa. Acta Physiol Scand 1987; 131: 589–98
  • Chomczynski P, Sacci N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156–9
  • Gubler U, Hoffman B J. A simple and very efficient method for generating cDNA libraries. Gene 1983; 25: 263–9
  • Sanger F, Nicklen S, Coulson A R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977; 74: 5463–7
  • Sambrook J, Fritsch E F., Maniatis T. Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1989
  • Smith D B., Johnson K S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 1988; 67: 31–40
  • Gearing D P., Nicola N A., Metcalf D, Foote S, Willson T A., Gough N M., Williams R L. Production of leukemia inhibitory factor in escherichia coli by a novel procedure and its use in maintaining embryonic stem cells in culture. Bio/Technology 1989; 7: 1157–61
  • Borch K, Liedberg G. Prevalence and incidence of pernicious anemia. An evaluation for gastric screening. Scand J Gastroenterol 1984; 19: 154–60
  • Mårdh S, Cabero J L., Song Y H. H,K-ATPase, the proton pump of the stomach. Biochemistry (Life Sci Adv) 1989; 8: 55–9
  • Rabon E C., Reuben M A. Trie mechanism and structure of the gastric H,K-ATPase. Ann Rev Physiol 1990; 52: 321–44

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.