93
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Increased Intestinal Marker Absorption Due to Regional Permeability Changes and Decreased Intestinal Transit during Sepsis in the Rat

, , , &
Pages 1001-1008 | Received 15 Sep 1993, Accepted 16 Mar 1994, Published online: 08 Jul 2009

References

  • Sori A J., Rush B F., Lysz T W., Smith S, Machiedo G W. The gut as source of sepsis after haemorrhagic shock. Am J Surg 1988; 155: 187–92
  • Epstein M D., Tchervenkov J I., Alexander J W., Johnson J R., Vester J W. Increased gut permeability following burn trauma. Arch Surg 1991; 126: 198–200
  • Carter E A., Tompkins R G., Schiffrin E, Burke J F. Cutaneous thermal injury alters macro molecular permeabilitx of rat small intestine. Surgery 1990; 107: 335–41
  • Border J R., Hassett J, LaDuca J, Seibel R, Steinberg S, Mills B, et al. The gut origin septic states in blunt multiple trauma (ISS = 40) in the ICU. Ann Surg 1987; 206: 427–48
  • Filez L, Stalmans W, Penninckx F, Kerremans R. Influences of ischaemia and reperfusion on the feline small-intestinal mucosa. J Surg Res 1990; 49: 157–63
  • Otamiri T, Tagesson C. Ginkgo biloba extract prevents mucosal damage associated with small-intestinal ischaemia. Scand J Gastroenterol 1989; 24: 666–70
  • Weils C L., Rotstein O D., Pruett T L., Simmons R L. Intestinal bacteria translocate into experimental intra-abdominal abscesses. Arch Surg 1986; 121: 102–7
  • Mitchell T J., Ketley J M., Burdon D W., Candy D CA, Stephen J. The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers. J Med Microbiol 1987; 23: 199–204
  • Moore R, Pothoulakis C, LaMont J T., Carlson S, Madara J L. C. Difficile toxin A increases intestinal permeability and induces CI secretion. Am J Physiol 1990; 259: G165–72
  • Deitch E A., Berg R, Specian R. Endotoxin promotes the trans-IOCAUOU of bacteria from the gut. Arch Surg 1987; 122: 185–90
  • Ramage J K., Hunt R H., Perdue M H. Changes in intestinal permeability and epithelial differentiation during inflammation in the rat. Gut 1988; 29: 57–61
  • von Ritter C, Sekizuka E, Grisham M B., Granger D N. The chemotactic peptide N-formyl methionyl-leucyl-phenylalanine increases mucosal permeability in the distal ileum of the rat. Gastroenterology 1988; 95: 651–6
  • O'Dwyer S T., Michie H R., Ziegler T R., Revhaug A, Smith R J., Wiimore D W. A single dose of endotoxin increases intestinal permeability in healthy humans. Arch Surg 1988; 123: 1459–64
  • Hansson L, Alwmark A, Christensen P, Jeppsson B, Hoist E, Bengmark S. Standardized intraabdominal abscess formation with generalised sepsis: pathophysiology in the rat. Eur Surg Res 1985; 17: 155–9
  • Grass G M., Sweetana S A. In vitro measurement of gastrointestinal tissue permeabilitv using a new diffusion cell. Phar-maceut Res 1988; 5: 372–6
  • Pantzar N, Westrom B R., Luts A, Lundin S. Regional small-intestinal passage in vitro to different-sized dextrans and proteins in the rat. Scand J Gastroenterol 1993; 28: 205–11
  • Browne M K., Leslie G B. Animal models of peritonitis. Surg Gynec Obstet 1976; 143: 738–40
  • Wichterman K A., Baue A E., Chaudry I H. Sepsis and septic shock. A review of laboratory models and a proposal. J Surg Res 1980; 29: 189–201
  • Martinell S, Falk A, Haglund U, Myrvold H. Peritonitis and septic shock. An evaluation of two experimental models in the rat. Eur Surg Res 1985; 17: 160–6
  • Fink M P., Antonsson J B., Wang H L., Rothschild H R. Increased intestinal permeability in endotoxic pigs: mesenteric hypoperfusion as an etiologic factor. Arch Surg 1991; 126: 211–8
  • Deitch E A., Ma J W., Ma L, Berg R, Specian R D. Endotoxin-induced bacterial translocation: a study of mechanisms. Surgery 1989; 106: 292–9
  • Deitch E A., Taylor M, Grisham M, Ma L, Bridges W, Berg R. Endotoxin induces bacterial translocation and increases xanthine oxidase activity. J Trauma 1989; 29: 1679–83
  • Fink M P., Kaups K L., Wang H, Rothschild H R. Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeabilitv in endotoxic pigs. Surgery 1991; 110: 154–61
  • Grøgaard B, Parks D A., Granger D N., McCord J M., Forsberg J O. Effects of ischaemia and oxygen radicals on mucosal albumin clearance in intestine. Am J Physiol 1982; 242: G448–54
  • Deitch E A., Winterton J, Ma L, Berg R. The gut as a portal of entry for bacteremia. Role of protein malnutrition. Ann Surg 1987; 205: 681–92
  • Fink M P. Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Crit Care Med 1991; 19: 627–41
  • Ramage J K., Stanisz A, Scicchitano R, Hunt R H., Perdue M H. Effect of immunologic reactions on rat intestinal epitheliums. Correlation of increased permeability to chromium 51-labelled ethylenediamine-tetraacitic acid and ovalbumin during acute inflammation and anaphylaxis. Gastroenterology 1988; 94: 1368–75
  • Galligan J J., Burks T F. Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. J Pharmacol ExpTher 1983; 226: 356–61
  • Weisbrodt N W., Sussman S E., Stewart J J., Burks T F. Effect of morphine sulfate on intestinal transit and myoelectric activity of the small intestine of the rat. J Pharmacol Exp Ther 1980; 2)4: 333–8
  • Menzies I S., Jenkins A P., Heduan E, Can S D., Segal M B., Creamer B. The effect of poorly absorbed solute on intestinal absorption. Scand J Gastroenterol 1990; 25: 1257–64
  • Runkel N SF, Moody F G., Smith G S., Rodriguez L F., Chen Y, Larocco M T., et al. Alterations in rat intestinal transit by morphine promote bacterial translocation. Dig Dis Sci 1993; 38: 1530–6
  • Kueppers P M., Miller T A., Chen C-Y K., Smith G S., Rodriguez L F., Moody F G. Effect of total parenteral nutrition plus morphine on bacterial translocation in rats. Ann Surg 1993; 217: 286–92
  • Robinson E P., Faggella A M., Henry D P., Russell W L. Comparison of histamine release induced by morphine and oxymorphone administration in dogs. Am J Vet Res 1988; 49: 1699–701
  • Muldoon S M., Donlon M A., Todd R, Helgeson E A., Freas W. Plasma histamine and haemodynamic responses following administration of nalbuphine and morphine. Agents Actions 1984; 15: 229–34
  • Coupar I M. Opioid action on the intestine: the importance of the intestinal mucosa. Life Sci 1987; 41: 917–25
  • Deitch E A., Bridges W M., Ma J W., Ma L, Berg R D., Specian R D. Obstructed intestine as a reservoir for systemic infection. Am J Surg 1990; 159: 394–401
  • Hansson L. Pulmonary response to intraabdominal sepsis. An experimental study. thesis, Lund University, Lund 1992
  • Chiu C J., McArdle A H., Brown R, Scott H J., Gurd F N. Intestinal mucosal lesions in low-flow stated. 1. A morphological, haemodynamic and metabolic reappraisal. Arch Surg 1970; 101: 478–83

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.