Ursodeoxycholic Acid Therapy in Primary Biliary Cirrhosis

References

• Batta A K, Salen G, Mirchandani R, Tint G S, Shefer S, Batta M, et al. Effect of long-term treatment with ursodiol on clinical and biochemical features and biliary bile acid metabolism in patients with primary biliary cirrhosis. Am J Gastroenterol 1993; 88: 691–700
   PubMed Web of Science ®Google Scholar
• Leuschner U, Giildiituna S, Imhof M, Hiibner K, Benjaminov A, Leuschner M. Effects of ursodeoxycholic acid after 4 to 12 years therapy in early and late stages of primary biliary cirrhosis. J Hepatol
   Google Scholar
• Bode J CH, Zelder O, Neuberger H O. Effect of taurocholate. dehydrocholate and secretin on biliary output of alkaline phosphatase and GOT. Helv Med Acta 1973; 37: 143–51
   PubMedGoogle Scholar
• Hatoff D E, Hardison W GM. Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat. Gastroenterology 1981; 80: 666–72
   PubMedGoogle Scholar
• Massarrat S A, Massarrat Sch, Arendt D, Kordes B. Daily fluctuation of cholestatic enzymes in bile and its relationship to the total bile salts concentration. Clin Biochem 1979; 12: 238–42
   PubMed Web of Science ®Google Scholar
• Hatoff D E, Hardison G M. Bile acid-dependent secretion of alkaline phosphatase in rat bile. Hepatology 1982; 2: 433–9
   PubMedGoogle Scholar
• Poupon R, Poupon R E, Balkau B, Chrétien Y, Legendre C, Levy V G. Ursodeoxycholic acid for primary biliary cirrhosis. Trends in bile acid research, G Paumgartner, A Stiehl, W Gerok. Kluwer, Dordrecht 1989; 349–53
   Google Scholar
• Kaplan M M. Primary biliarv cirrhosis. Adv Intern Med 1987; 32: 359–78
   PubMedGoogle Scholar
• Poupon R E, Chrétien Y, Balkau B, Niard A M, Poupon R, the UDCA-PBC Study Group. Ursodeoxycholic therapy for primary biliary cirrhosis: a four-vear controlled study. Hepatology 1992; 16: 91A, (abstract)
   Google Scholar
• Buschcr H-P, Zietschmann Y, Gerok W. Positive responses to methotrexate and ursodeoxycholic acid in patients with primary biliarv cirrhosis responding insufficiently to ursodeoxycholic acid alone. J Hepatol 1993; 18: 9–14
   PubMedGoogle Scholar
• Poupon R E, Chrétien Y, Poupon R, Paumgartner G. Serum bile acids in primary biliary cirrhosis: effects of ursodeoxycholic acid therapy. Hepatology 1993; 17: 599–604
   PubMed Web of Science ®Google Scholar
• Stiehl A, Rudolph G, Raedsch R, Möller B, Hopf U, Lotterer E, et al. Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis. Hepatology 1990; 3: 492–7
   Google Scholar
• Güldütuna S, Leuschner M, Wunderlich N, Nickel A, Bhatti S, Hübner K, et al. Cholic acid and ursodeoxycholic acid therapy in primary biliary cirrhosis. Changes in bile acid patterns and their correlation with liver function. Eur J Clin Pharmacol 1993; 45: 221–5
   PubMedGoogle Scholar
• Eusufzai S, Ericsson S, Cederlund T, Emarsson K, Angelin B. Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test. Gut 1991; 32: 1044–8
   PubMedGoogle Scholar
• Batta A K, Arora R, Salen G, Lint G S, Eskreis D, Katz S. Characterization of serum and urinary bile acids in patients with primary biliarv cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment. J Lipid Res 1989; 30: 1953–62
   PubMed Web of Science ®Google Scholar
• Carey J BJ, Williams G. Relief in the pruritus of jaundice with a bile acid sequestering resin. JAMA 1961; 176: 432–5
   PubMedGoogle Scholar
• Kitani K, Kanai S. Tauroursodeoxychoiate prevents tauro-cholate-induced cholestasis. Life Sci 1982; 30: 515–23
   PubMedGoogle Scholar
• Heuman D M, Mills A S, McCall J B, Hylemon P B, Pandak W M, Vlahcevic Z R. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts: in vivo studies in the rat. Gastroenterology 1991; 100: 203–11
   PubMedGoogle Scholar
• Erlinger S. Hypercholeretic bile acids: a clue to the mechanism. Hepatology 1990; 11: 888–90
   PubMedGoogle Scholar
• Miyai K, Richardson A L, Mayr W, Javitt N B. Subcellular pathology of rat liver in cholestasis and choleresis induced by bile salts. Lab Invest 1977; 36: 249–58
   PubMedGoogle Scholar
• Beuers U, Nathanson M H, Boyer J L. Effects of tauro-ursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993; 104: 604–12
   PubMed Web of Science ®Google Scholar
• Farrell G C, Duddy S K, Kass G EN, Llopis J, Gahm A, Orrenius S. Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver. J Clin Invest 1990; 85: 1255–9
   PubMedGoogle Scholar
• Combettes L, Dumont M, Berthon B, Erlinger S, Claret M. Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells. J Biol Chem 1988; 2299–303
   PubMedGoogle Scholar
• Anwer S, Engelking L R, Nolan K, Sullivan D, Zimniak P, Lester R. Hepatotoxic bile acids increase cytosolic Ca2+ activity of isolated rat hepatocytes. Hepatology 1988; 8: 887–91
   PubMed Web of Science ®Google Scholar
• Combettes L, Berthon B, Doucet E, Erlinger S, Claret M. Bile acids mobilize internal Ca2+ independently of external Ca2+ in rat hepatocytes. Eur J Biochem 1990; 190: 619–23
   PubMedGoogle Scholar
• Galle P R, Theilmann L, Raedsch R, Otto G, Stiehl A. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology 1990; 12: 486–91
   PubMed Web of Science ®Google Scholar
• Heuman D M, Pandak W M, Hylemon P B, Vlahcevic Z R. Conjugates of ursodeoxycholate protect against toxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 1991; 14: 920–6
   PubMedGoogle Scholar
• Güldütuna S, Zimmer G, Imhof M, Bhatti S, You T, Leuschner U. Molecular aspects of membrane stabilization by ursodeoxycholate. Gastroenterology 1993; 104: 1736–44
   PubMed Web of Science ®Google Scholar
• Yeagle P L. Cholesterol and the cell membrane. Biochim Biophys Acta 1985; 822: 267–87
   PubMed Web of Science ®Google Scholar
• El-Sayed M Y, Guion T A, Fayer M D. Effect of cholesterol on visoelastic properties of dipalmitoylphosphatidylcholine multibilayers as measured by laser-induced ultrasonic probe. Biochemistry 1986; 25: 4825–30
   PubMedGoogle Scholar
• Güldütuna S, Wei A, Deisinger B, You T, Bhatti S, Freisleben F, Leuschner U. Ursodeoxycholate (UDC) mimicries the membrane stabilizing effect of cholesterol on large unilamellar vesicles (LUV). Gastroenterology 1994, (abstract) (in press)
   Google Scholar
• Vessey D A, Zakim D. Membrane fluidity and the regulation of membrane bound enzymes. Horizons Biochem Biophys 1975; 1: 139–74
   Google Scholar
• Kimelberg H K, Papahadjoupoulos D. Phospholipid requirements for (Na−-K−)-ATPase activity—Head groups specificity and fatty acid fluidity. Biochim Biophys Acta 1972; 282: 277–92
   PubMed Web of Science ®Google Scholar
• Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990; 11: 12–5
   PubMed Web of Science ®Google Scholar
• Leuschner U, Güldütuna S, You T, Bhatti S, Zimmer G, Dienes H P. Ursodeoxycholic acid alters hepatocyte membrane structure and function: a therapeutic approach?. Immunology and liver, K H Meyer zum Büschenfelde, J H Hoofnagle, M Manns. Kluwer, Dordrecht 1993; 459–61
   Google Scholar
• Terasaki S, Nakanuma Y, Ogino H, Unoura M, Kobayashi K. Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy. Am J Gastroenterol 1991; 86: 1194–9
   PubMed Web of Science ®Google Scholar
• Yoshikawa M, Matsumura K, Matsumura Y, Yamao J, Kuriyama S, Ishizaka S, et al. Effects of ursodeoxycholic acid on antigen presentation. Int Hepatol Comm 1993; 1: 243–9
   Google Scholar
• Sokol R J, Devereaux M, Khandwala R, O'Brien K. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocates. Hepatology 1993; 17: 869–81
   PubMed Web of Science ®Google Scholar