Cellular and Molecular Mechanisms of Gastric Ulcer Healing. Is the Quality of Mucosal Scar Affected by Treatment?

References

• Richardson C T. Pathogenetic factors in peptic ulcer disease. Am J Med 1985; 79: 1–7
   PubMed Web of Science ®Google Scholar
• Isenberg J I. Peptic ulcer. Disease a month Dec, 1981; 1–58
   PubMedGoogle Scholar
• Lam S K. Pathogenesis and pathophysiology of duodenal ulcer. J Clin Gastroenterol 1991; 13: 447–72
   Web of Science ®Google Scholar
• Healing and repair in Robbins pathologic basis of disease, S L Robbins, R S Cotran, V Kumar. W. B. Saunders, Philadelphia 1989
   Google Scholar
• Tarnawski A, Erickson R A. Sucralfate—24 years later: current concepts of its protective and therapeutic actions. Eur J Gastroenterol Hepatol 1991; 3: 795–810
   Web of Science ®Google Scholar
• Tarnawski A, Halter F, Schmassmann A, Vatier J, Carner A. Experimental models for the assessment of antacid action on gastrointestinal mucosa and ulcer healing. Eur J Gastroenterol Hepatol 1992; 4: 966–76
   Web of Science ®Google Scholar
• Tarnawski A, Hollander D, Stachura J, Krause W J, Eltorai M, Dabros W, et al. Vascular and microvascular changes—key factors in the development of acetic acid-induced gastric ulcers in rats. J Clin Gastroenterol 1990; 12(Suppl 1)S148–57
   PubMed Web of Science ®Google Scholar
• Piasecki C. Evidence for an infarctive pathogenesis of acute and chronic gastroduodenal ulceration. J Physiol Pharmacol 1992; 43: 99–112
   PubMedGoogle Scholar
• Helpap B, Hattori T, Gedigk P. Repair of gastric ulcer. A cell kinetic study. Virchows Arch ‘A’ 1981; 392: 159–70
   PubMed Web of Science ®Google Scholar
• Helander H E. Morphologic studies on the margin of gastric corpus wounds in the rat. J Submicrosc Cytol 1983; 15: 627–43
   PubMedGoogle Scholar
• Tarnawski A, Stachura J, Durbin T, Sarfeh I J, Gergely H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 1992; 102: 695–8
   PubMed Web of Science ®Google Scholar
• Lee H, Hansson H-A, Norstrom E, Helander H F. Immunoreactivities for epidermal growth factor (EGF) and for EGF receptors in rats with gastric ulcer. Cell Tissue Res 1991; 265: 211–8
   PubMed Web of Science ®Google Scholar
• Tarnawski A, Hollander D, Stachura J, Gergely H, Krause W J, Sarfeh I J. Role of angiogenesis in healing of experimental gastric ulcer. Mechanisms of peptic ulcer healing, F Halter, A Garner, G NJ Tytgat. Falk Symposium 59, Kluwer, Dordrecht 1991
   Google Scholar
• Tarnawski A, Stachura J, Krause W J, Douglass T G, Gergely H. Quality of gastric ulcer healing—a new, emerging concept. J Clin Gastroenterol 1991; 13: S42–7
   Web of Science ®Google Scholar
• Wright N A, Pike C, Elia G. Induction of a novel epidermal growth factor—secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 1990; 343: 82–5
   PubMed Web of Science ®Google Scholar
• Tarnawski A, Hollander D, Stachura J, Sarfeh I J, Gergely H, Krause W J. Angiogenic response of gastric mucosa to ethanol injury is abolished by indomethacin. Gastroenterology 1989; 96: A505
   Google Scholar
• Tarnawski A, Hollander D, Stachura J, Sheffield M, Gergely H, Krause W J. Angiogenic response of damaged gastric mucosa—a prostaglandin mediated process?. Gastroenterology 1990; 98: A136
   Google Scholar
• Szabo S, Folkman J, Vattay P, Morales R E, Kato K. Duodenal ulcerogens: effect of FGF on cysteamine induced duodenal ulcers. Mechanisms of peptic ulcer healing, F Halter, A Garner, G NJ Tytgat. Kluwer, Dordrecht 1991
   Google Scholar
• Folkman J, Szabo S, Stovroff M, McNeil P, Li W, Shing Y. Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann Surg 1991; 214: 414–27
   PubMed Web of Science ®Google Scholar
• Szabo S, Folkman J, Vattay P, Morales R E, Pinkus G S, Kato K. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factors in rats. Gastroenterology 1994; 106: 1106–11
   PubMed Web of Science ®Google Scholar
• Tarnawski A, Stachura J, Douglass T G, Krause W J, Gergely H, Sarfeh I J. Indomethacin impairs quality of experimental gastric ulcer healing: a quality histologic and ultrastructural analysis. Mechanisms of injury, protection and repair of the upper gastrointestinal tract, A Garner, P O'Brian. John Wiley, Chichester 1991
   Google Scholar
• Klagsburn M. Angiogenesis factors. Endothelial cells, U S Ryan. CRP Press, Boca Raton 1988
   Google Scholar
• Tarnawski A, Douglass T G, Stachura J, Krause W J. Quality of gastric ulcer healing: histological and ultrastructural assessment. Aliment Pharmacol Ther 1991; 5(Suppl 1)80–90
   Google Scholar
• Tarnawski A, Hollander D, Krause W J, Dabros W, Stachura J, Gergely H. 'Healed' experimental gastric ulcers remain histologically and ultrastructurally abnormal. J Clin Gastroenterol 1990; 12(Suppl 1)S139–47
   Google Scholar
• Litman A, Hanscom D H. The course of recurrent ulcer. Gastroenterology 1971; 61: 585–91
   Web of Science ®Google Scholar
• Tarnawski A, Santos A M, Hanke S, Stachura J, Douglass T G, Sarfeh I J. Quality of ulcer healing. Is it influenced by antiulcer drugs?. Scand J Gastroenterol 1995; 30(Suppl 208)9–13
   Google Scholar
• Tarnawski A, Hollander D, Stachura J, Gergely H, Krause W J, Zipser R D. Trophic effect of long term sucralfate treatment on the gastric mucosa. A key to prophylactic efficacy?. Gastroenterology 1985; 88: 1610, (Abstr)
   Web of Science ®Google Scholar
• Tarnawski A, Stachura J, Durbin T, Gergely H, Douglass T G. Sucralfate treatment induces increased expression of EGF, TGFα and their common receptor in the gastric mucosa. A key to the ulcer healing and trophic action?. Gastroenterology 1992; A175: 102, (Abstr)
   Google Scholar
• Tarnawski A, Santos A M, Stachura J, Sarfeh I J. Sucralfate increases expression of EGF and its receptor in the margins of experimental gastric ulcer; a key to improved quality of ulcer healing?. Gastroenterology 1994; A194: 106
   Google Scholar
• Tarnawski A, Santos A M, Tanoue K, Stachura J, Sarfeh I J. Sucralfate treatment enhances expression of EGF, its receptor and bFGF in ulcerated gastric mucosa. A major mechanism for its superior quality of ulcer healing?. World Congress of Gastroenterology, Los Angeles, CA, October, 2–71994
   Google Scholar