Indomethacin Decreases Gastroduodenal Mucosal Bicarbonate Secretion in Humans

References

• Hawkey CJ. Non steroidal anti-inflammatory drugs and peptic ulceration. BMJ 1990; 300: 278–84
   PubMed Web of Science ®Google Scholar
• Hudson N, Balsitis M, Everitt S, Hawkey CJ. Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 1993; 34: 742–7
   PubMed Web of Science ®Google Scholar
• Rainsford KD. Mechanisms of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. Scand J Gastroenterol 1989; 24: 1639–16, Suppl
   Web of Science ®Google Scholar
• Gamer A, Flemström G, Heylings JR. Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa. Gastroenterology 1979; 77: 451–7
   PubMed Web of Science ®Google Scholar
• Kauffman G L, Reeve J J, Grossman MI. Gastric bicarbonate secretion: effect of topical and intravenous 16,16-dimethyl prostaglandin E2. Am J Physiol 1980; 239: G44–8
   PubMed Web of Science ®Google Scholar
• Kollberg B, Aly A, Johansson C. Protection of the rat gastric mucosa by prostaglandin E2: possible relation to stimulation of the alkaline secretion. Acta Physiol Scand 1981; 113: 189–92
   PubMedGoogle Scholar
• Konturek S J, Tasler J, Bilski J, Kania J. Prostaglandins and alkaline secretion from oxyntic, antral, and duodenal mucosa of the dog. Am J Physiol 1983; 245: G539–46
   Google Scholar
• Feldman M. Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2. J Clin Invest 1983; 72: 295–303
   PubMed Web of Science ®Google Scholar
• Forssell H, Olbe L. Continuous computerized determination of gastric bicarbonate secretion in man. Scand J Gastroenterol 1985; 20: 767–74
   PubMed Web of Science ®Google Scholar
• Isenberg J, Smedfors B, Johansson C. Effect of graded doses of intraluminal H+, prostaglandin E2, and inhibition of endogenous prostaglandin synthesis on proximal duodenal bicarbonate secretion in unanesthetized rats. Gastroenterology 1985; 88: 303–7
   PubMed Web of Science ®Google Scholar
• Granstam S O, Flemström G, Nylander O. Bicarbonate secretion by the rabbit duodenum in vivo: effects of prostaglandins, vagal stimulation and some drugs. Acta Physiol Scand 1987; 131: 377–85
   PubMedGoogle Scholar
• Isenberg J I, Hogan D L, Koss M A, Selling JA. Human duodenal mucosal bicarbonate secretion: evidence for basal secretion and stimulation by hydrochloric acid and a synthetic prostaglandin El analogue. Gastroenterology 1986; 91: 370–8
   PubMed Web of Science ®Google Scholar
• Selling J A, Hogan D L, Aly A, Koss M A, Isenberg JI. Indomethacin inhibits duodenal mucosal bicarbonate secretion and endogenous prostaglandin E2 output in human subjects. Ann Med 1987; 106368–71
   Web of Science ®Google Scholar
• Rees W DW, Gibbons L C, Warhurst G, Turnberg LA. Studies of bicarbonate secretion by the normal human stomach in vivo: effect of aspirin, sodium taurocholate, and prostaglandin E2. Mechanisms of mucosal protection in the upper gastrointestinal tract, A. Allen. Raven Press, New York 1984; 119–23
   Google Scholar
• Konturek S J, Bilski J, Tasler J, Laskiewicz J. Gastroduodenal alkaline response to acid and taurocholate in conscious dogs. Am J Physiol 1984; 247: G 149–54
   Google Scholar
• Feldman M, Colturi TJ. Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology 1984; 87: 1339–43
   PubMed Web of Science ®Google Scholar
• Forssell H, Stenquist B, Olbe L. Vagal stimulation of human gastric bicarbonate secretion. Gastroenterology 1985; 89: 581–6
   PubMed Web of Science ®Google Scholar
• Odes H S, Hogan D L, Steinbach J H, Ballesteros M A, Koss M A, Isenberg JI. Measurement of gastric bicarbonate secretion in the human stomach: different methods produce discordant results. Scand J Gastroenterol 1992; 27: 829–36
   PubMed Web of Science ®Google Scholar
• Mertz-Nielsen A, Hillingsø J, Eskerod O, Bukhave K, Rask-Madsen J. Muscarinic M1-receptor inhibition reduces gastroduodenal bicarbonate secretion and promotes gastric prostaglandin E2 synthesis in healthy volunteers. Gut 1995; 36: 528–33
   PubMed Web of Science ®Google Scholar
• Mertz-Nielsen A, Eskerod O, Bukhave K, Rask-Madsen J. Misoprostol inhibits gastric mucosal release of endogenous prostaglandin E2 and thromboxane B2 in healthy volunteers. Gut 1995; 36: 511–5
   PubMed Web of Science ®Google Scholar
• Bukhave K, Gréen K, Rask-Madsen J. Comparison of radio-immunological determinations with gas chromatography mass spectrometry dosage. A study of PGE2 and PGF2, in gastrointestinal fluids. Biomed Mass Spectrom 1983; 10: 265–8
   PubMedGoogle Scholar
• Kuo J, Fox E. Sigma Stat™ Manual, Microcomputer tools for the scientist. Jandel Scientific, Augsberg, Germany 1992, Revision SSD-1.0.
   Google Scholar
• DiMagno EP. Alterations and consequences of interdigestive and poststimulatory human exocrine pancreatic secretion in health and disease. Basic science in gastroenterology. Physiology of the gut, J M Polak, S R Bloom, N A Wright, A G Butler. Glaxo Group Research Ltd., Ware, Herts, UK 1984; 251–66
   Google Scholar
• Yanaka A, Carter K J, Goddard P J, Silen W. Prostaglandin stimulates CI--HCO3− exchange in amphibian oxynticopeptic cells. Am J Physiol 1992; 262: G44–9
   Google Scholar
• Heylings J R, Feldman M. Basal and PGE2-stimulated duodenal bicarbonate secretion in the rat in vivo. Am J Physiol 1988; 255: G470–5
   Google Scholar
• Befrits R, Samuelsson K, Johansson C. Gastric inhibition by antral acidification mediated by endogenous prostaglandins. Scand J Gastroenterol 1984; 19: 899–904
   PubMed Web of Science ®Google Scholar
• Flemström G. Measurement of gastric bicarbonate secretion [editorial]. Gastroenterology 1985; 88: 2000–1
   PubMed Web of Science ®Google Scholar
• Fändriks L, Stage L. Simultaneous measurements of gastric motility and acid-bicarbonate secretions in the anaesthetized cat. Acta Physiol Scand 1986; 128: 563–73
   PubMedGoogle Scholar
• Nylander O, Kvietys P, Granger N. Effects of hydrochloric acid on duodenal and jejunal mucosal permeability in the rat. Am J Physiol 1989; 257: G653–60
   Google Scholar
• Bukhave K. Prostaglandin E2 in intestinal secretion with special reference to methodological problems in vivo and in vitro, thesis. Dan Med Bull 1992; 39: 95–103
   PubMedGoogle Scholar
• Feldman M. Gastric H+ and HCO3 secretion in response to sham feeding in humans. Am J Physiol 1985; 248: G188–91
   Google Scholar
• Ballesteros M A, Wolosin J D, Hogan D L, Koss M A, Isenberg JI. Cholinergic regulation of human proximal duodenal mucosal bicarbonate secretion. Am J Physiol 1991; 261: G327–31
   PubMed Web of Science ®Google Scholar
• Coceani F, Pace-Asciak C, Volta F, Wolfe LS. Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Am J Physiol 1967; 213: 1056–64
   PubMed Web of Science ®Google Scholar
• Cheung L Y, Jubiz W, Moore JG. Gastric prostaglandin E output during basal and stimulated acid secretion in healthy controls and patients with duodenal ulcer. J Surg Res 1976; 20: 369–72
   PubMed Web of Science ®Google Scholar
• Konturek S J, Kwiecien N, Obtulowicz W, Thor P, Konturek J W, Popiela T, et al. Vagal cholinergic control of gastric alkaline secretion in normal subjects and duodenal patients. Gut 1987; 28: 739–44
   PubMed Web of Science ®Google Scholar
• Takeuchi K, Furukawa O, Okada M, Okabe S. Duodenal ulcers induced by indomethacin plus histamine in the dog. Involvement of impaired duodenal alkaline secretion in their pathogenesis. Digestion 1988; 39: 23040
   Web of Science ®Google Scholar