9
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Bile Acids Protect the Liver against the Cholestatic Effect of Large Bilirubin Loads

, , &
Pages 1186-1193 | Received 03 Jan 1995, Accepted 25 Apr 1995, Published online: 08 Jul 2009

References

  • Crawford J M, Gollan JL. Bilirubin metabolism and the pathophysiology of jaundice. Diseases of the liver, E R Schiff. JB Lippincott, Philadelphia 1993; 42–84
  • Day RL. Inhibition of brain respiration in vitro by bilirubin. Reversal of inhibition by various means. Am J Dis Child 1954; 88: 261–4
  • Zetterstrom R, Ernster L. Bilirubin, an uncoupler of oxidative phosphorylation in isolated mitochondria. Nature 1956; 178: 1335–7
  • Kamisaka K, Gatmaitan Z, Moore C, Arias IM. Ligandin reverses bilirubin inhibition of liver mitochondrial respiration in vitro. Pediat Res 1975; 9: 903–5
  • Bowen W R, Waters WJ. Bilirubin encephalopathy: studies related to the site of inhibitory action of bilirubin on brain metabolism. Am J Dis Child 1957; 93: 21A
  • Ernster L, Herlin L, Zetterstrøm R. Experimental studies on the pathogenesis of kernicterus. Pediatrics 1957; 20: 647–52
  • Menken M, Waggoner J G, Berlin NI. The influence of bilirubin on oxidative phosphorylation and related reactions in brain and liver mitochondria: effects of protein-binding. J Neurochem 1966; 13: 1241–8
  • Mustafa M G, Cowger M L, King TE. Effects of bilirubin on mitochondrial reactions. J Biol Chem 1969; 244: 6403–14
  • Kawai K, Cowger ML. Effect of bilirubin on ATPase activity of human erythrocyte membrane. Res Commun Chem Pathol Pharmacol 1981; 32123–35
  • Simons P C, Vander Jagt DL. Bilirubin binding to human liver ligandin (gluthathione S-transferase). J Biol Chem 1980; 255: 4740–4
  • Sano K, Nakamura H, Matsuo T. Mode of inhibitory action of bilirubin on protein kinase C. Pediat Res 1985; 19: 587–90
  • Veel T, Villanger O, Holthe M R, Skjørten F S, Rêder MG. Intravenous bilirubin infusion causes vacuoluation of the cytoplasm of hepatocytes and canalicular cholestasis. Acta Physiol Scand 1991; 143: 421–9
  • Henry R J, Cannon D C, Winkelman JW. Clinical chemistry.2nd ed. New York Harper & Row 1974; 10397
  • Jendrassik L, Grof P. Vereinfachte photometrische Methoden zur Bestimmung des Blutbilirubins. Biochem Z 1938; 297: 81–9
  • Scalia S. Evaluation of mobile and stationary phases in reversed-phase high-performance liquid chromotography of conjugated bile acids. J Liquid Chrom 1987; 10: 2055–80
  • Scalia S. Group separation of free and conjugated bile acids by pre-packed anion-exchange cartridges. J Pharma Biomed Analysis 1990; 8: 235–41
  • Sandstad O, Osnes T, Skar V, Urdal P, Osnes M. Common bile duct stones are mainly brown and associated with duodenal diverticula. Gut 1994; 35: 1464–7
  • Løtveit T. The composition of biliary calculi in patients with juxtapapillary duodenal diverticula. Scand J Gastroenterol 1982; 17: 653–6
  • Crawford J M, Berken C A, Gollan JL. Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport. J Lipid Res 1988; 29: 144–56
  • Crawford J M, Gollan JL. Hepatocyte cotransport of taurocholate and bilirubin glucuronides: role of microtubules. Am J Physiol (Gastrointest Liver Physiol) 1988; 255: G121–31
  • Lamri Y, Roda A, Dumont M, Erlinger S. Immunoperoxidase localization of bile salts in rat liver cells. Evidence for a role of the Golgi apparatus in bile salt transport. J Clin Invest 1988; 82: 1173–82
  • Crawford J M, Gollan JL. Transcellular transport of organic anions in hepatocytes: still a long way to go. Hepatology 1991; 14: 192–7
  • Beuers U, Nathanson M H, Isales C M, Boyer JL. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. J Clin Invest 1993; 92: 2984–93
  • Esteller A, Gonzalez J, Hidalgo F, Lopez MA. Enhancement of maximal bilirubin excretion by bile salts in the anaesthetized rabbit. Q J Exp Physiol 1984; 69: 217–25
  • Witzleben CL. Bilirubin as a cholestatic agent. Physiologic and morphologic observations. Am J Pathol 1971; 62: 181–7
  • Witzleben C L, Pitlick P, Bermeyer J, Benoit R. Acute manganese overload. A new experimental model of intrahepatic cholestasis. Am J Pathol 1968; 53: 409–14
  • Horak W, Grabner G, Paumgartner G. Inhibition of bile salt-independent bile formation by indocyanine green. Gastroenterology 1973; 64: 1005–12
  • Latham P, Kashgarian M. The ultrastructural localization of transport ATPase in the rat liver at non-bile canalicular plasma membranes. Gastroenterology 1979; 76: 988–96
  • Sztul E S, Biemesderfer D, Caplan M J, Kashgarin M, Boyer JL. Localization of Na+, K+-ATPase a-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes. J Cell Biol 1987; 104: 1239–48
  • Owen CA, Jr. Isolated rat liver needs calcium to make bile. Proc Soc Exp Biol Med 1977; 155: 314–7
  • Reichen J, Berr F, Le M, Warren GH. Characterization of calcium deprivation-induced cholestasis in the perfused rat liver. Am J Physiol (Gastrointest Liver Physiol) 1985; 249: G48–57

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.