Mechanisms of Mucosal Injury and Healing: the Role of Non-steroidal Anti-inflammatory Drugs

References

• McCarthy DM. Non-steroidal anti-inflammatory drugs-the clinical dilemmas. Scand J Gastroenterol 1992; 27: 9–16, Suppl 192
   PubMed Web of Science ®Google Scholar
• Vane, Jr. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol) 1971; 231: 232–5
   PubMedGoogle Scholar
• Weissman G. The actions of NSAIDs. Hospital Practice 1991; 26: 60–76
   Google Scholar
• Levi S, Goodlad R A, Lee C Y, Stamp G, Walport M J, Wright N A, et al. Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 1990; 336: 840–3
   PubMed Web of Science ®Google Scholar
• Inauen W, Wyss P A, Kayser S, Baumgartner A, Schürer-Maly C C, Koelz H R, et al. Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. Gastroenterology 1988; 95: 636–41
   PubMed Web of Science ®Google Scholar
• Sandor Z, Szabo S. Pharmacologic approaches and pathogenic basis for NSAID gastropathy. Practical Gastroenterol 1991; 15: 30–43
   Google Scholar
• Jeremy J Y, Mikhailidis D P, Barradoas M A, Kirk R M, et al. Effects of the prodrug nabumetone and its active metabolite 6-MNA, on human and rat gastric mucosal prostanoids and platelet function. Drugs 1990c; 40: 53–6, Suppl 5
   PubMedGoogle Scholar
• Friedel H A, Todd PA. Nabumetone. Drugs 1988; 35: 504–24
   PubMedGoogle Scholar
• DeWitt D L, Meade E A, Smith WL. PGH synthase isoenzyme selectivity: the potential for safer non-steroidal drugs. Am J Med 1993; 95: 40S–4S
   PubMedGoogle Scholar
• Lee M, Cryer B, Feldman M. Effects of very low doses of aspirin (ASA) on platelet thromboxane B2 (TXB2) synthesis and on gastric prostaglandin (PG) output and mucosal injury in humans. Gastroenterology 1993; 104: A131
   Google Scholar
• YaChu J K, Goddard P J, Lichtenberger LM. Morphological effects of aspirin and prostaglandin on the canine gastric mucosal surface. Gastroenterology 1990; 98: 592–606
   PubMedGoogle Scholar
• Banerjee RK. Non-steroidal anti-inflammatory drugs inhibit gastric peroxidase activity. Biochim Biophys Acta 1990; 1034: 275–80
   PubMed Web of Science ®Google Scholar
• Romano M, Razandi M, Raza A, Szabo S, Ivey KJ. Cysteamine protects gastric epithelial cell monolayers against drug-induced damage: evidence for direct cellular protection by sulphydryl compounds. Gut 1992; 33: 30–8
   PubMed Web of Science ®Google Scholar
• Soldato Del Foschi D, Benoni G, Scarpignato C. Oxygen-free radicals interact with indomethacin to cause gastrointestinal injury. Agents Actions 1985; 17: 484–8
   Google Scholar
• Wallace J L, Keenan C M, Granger DN. Gastric ulceration induced by anti-inflammatory drugs is aneutrophil-dependent process. Am J Physiol 1990; 259: G462–7, GI-Liver Physiol 22
   PubMed Web of Science ®Google Scholar
• McCarthy DM. Pathogenic mechanisms of gastroduodenal injury: non-steroidal anti-inflammatory drugs. Curr Opin Gastroenterol 1991; 7: 876–80
   Google Scholar
• Búzás G, Demel Z, Hamar J. The effect of allopurinol on acidified aspirin-induced gastric mucosal injury and lipid peroxidation in rats. Digestion 1991; 49: 15
   Google Scholar
• Sallie R W, Swanson N R, Reed WD. Non-steroidal anti-inflammatory drugs are associated with increased levels of xanthine oxidase activity and depletion of glutathione within human gastric mucosa. Aust-NZ J Med 1989; 19: 595
   Google Scholar
• Granger D N, Hernandez L A, Grisham MB. Reactive oxygen metabolites: mediators of cell injury in the digestive system. Viewpoints of Dig Dis (AGA) 1986; 18: 13–6
   Google Scholar
• Bast A, Haenen G, Doelman CJ. Oxidants and anti-oxidants: state of the art. Am J Med 1991; 91: 2S–13S, Suppl 3C
   PubMed Web of Science ®Google Scholar
• Takeuchi K, Ueshima K, Hironaka Y, Fujioka Y, et al. Oxygen free-radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Digestion 1991; 49: 175–84
   PubMed Web of Science ®Google Scholar
• Wallace JL. Gastroduodenal mucosal defense. Curr Opin Gastroenterol 1991; 7: 870–5
   Google Scholar
• Hudson N, Balsitis M, Hawkey CJ. Reduction in angiogenesis in non-steroidal anti-inflammatory drug associated gastric ulcers. Digestion 1991; 49: 19
   Google Scholar
• Levi S, Goodlad R A, Lee C Y, Stamp G, Walport M J, Wright N A, et al. Non-steroidal anti-inflammatory drugs inhibit the processes of mucosal cell proliferation associated with duodenal ulcer healing. Digestion 1992; 53: 129–33
   PubMedGoogle Scholar
• Myszor M, Hodgson H JF. Non-steroidal anti-inflammatory drugs and gastric DNA synthesis. Scand J Gastroenterol 1990; 25: 197–202
   PubMed Web of Science ®Google Scholar
• Wang J Y, Yamasaki S, Takeuchi K, Okabe S. Delayed healing of acetic acid-induced gastric ulcers by rats with indomethacin. Gastroenterology 1989; 96: 393–402
   PubMedGoogle Scholar
• Tarnawski A, Stachura J, Douglass T G, Krause W J, Gergely H, Sarfeh IJ. Indomethacin impairs quality of experimental gastric ulcer healing: a quantitative histological and ultra-structural analysis. Mechanisms of injury, protection and repair of the upper gastrointestinal tract, A Garner, P O'Brien. John Wiley and Sons, New York 1991; 521–31
   Google Scholar
• Tarnawski A, Stachura J, Gergely H, Hollander D. Gastric microvascular endothelium: a major target for aspirin-induced injury and arachidonic acid protection. An ultrastructural analysis in the rat. Eur J Clin Invest 1990; 20: 432–40
   PubMedGoogle Scholar