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Original Article

Effects of Acute and Chronic Infusion of Islet Amyloid Polypeptide on Food Intake in Rats

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Pages 83-89 | Received 03 Feb 1995, Accepted 18 May 1995, Published online: 08 Jul 2009

References

  • Westermark P, Wemstedt C, Wilander E, Sletten K. A novel peptide in the calcitonin gene related family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 1986; 140: 827–31
  • Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH. Amyloid fibrils in human insulinoma islets of Langerhans of the diabetic cat are derived from the neuropeptide like protein also present in normal islet cells. Proc Natl Acad Sci USA 1987; 84: 3881–5
  • Cooper GJS, Willis AC, Clark A, Turner RC, Sim SB, Reid KBM. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 1987; 84: 8628–32
  • Westermark P, Grimelius L. The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults. Acta Path Microbiol Scand [A] 1973; 81: 291–300
  • Bell ET. Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Pathol 1959; 35: 801–5
  • Westermark P, Wilander E. The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 1978; 15: 417–21
  • Lukinius A, Wilander E, Westermark GT, Engström U, Westermark P. Co-localization of islet amyloid polypeptide and insulin and the B cell secretory granules of the human pancreatic islets. Diabetologia 1989; 32: 240–4
  • Sowa R, Sanke T, Hirayama J, Tabata H, Furuta H, Nishimura S. Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs. Diabetologia 1990; 33: 118–20
  • Leighton B, Cooper GJS. Pancreatic amylin and calcitonin generelated peptide cause resistance to insulin in skeletal muscle in vitro. Nature 1988; 335: 632–5
  • Permert J, Larsson J, Westermark GT, Herrington MK, Christmansson L, Pour PM. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. N Engl J Med 1994; 330: 313–8
  • Sanke T, Hanabusa Y, Nakano C, Okai S, Nishimura S, Kondo M. Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in Type 2 (non-insulindependent) diabetic patients. Diabetologia 1991; 34: 129–32
  • Datta HK, Zaidi M, Wimalawansa SJ, Ghatei MA, Beacham JL, Bloom SR. In vivo and in vitro effects of amylin and amylinamide on calcium metabolism the rat and rabbit. Biochem Biophys Res Comm 1989; 162: 876–81
  • Kassir AA, Upadhyaya AK, Lim TJ, Moosa AR, Olevsky JM. Lack of effect of islet amyloid polypeptide in causing insulin resistance in conscious dogs during euglycemic clamp studies. Diabetes 1991; 40: 998–1004
  • Wimalawansa SJ, Gunasekera RD, Datta HK. Hypocalcemic actions of amylin amide in humans. J Bone Mineral Res 1992; 7: 1113–6
  • MacIntyre I. Amylinamide, bone conservation, and pancreatic β-cells. Lancet 1989; 2: 1026–7
  • Pietschmann P, Farsoudi KH, Hoffman O, Klaushofer K, Hörandner H, Peterlik M. Inhibitory effect of amylin on basal and parathyroid hormone-stimulated bone resorption in cultured neonatal mouse calvaria. Bone 1993; 14: 167–72
  • Brain SD, Wimalawansa SJ, MacIntyre I, Williams TJ. The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit. Am J Pathol 1990; 136: 487–90
  • Chance WT, Balasubramaniam A, Zhang FS, Wimalawansa SJ, Fischer JE. Anorexia following the intrahypothalamic administration of amylin. Brain Res 1991; 539: 352–4
  • Balasubramaniam A, Renugopalakrishnan V, Stein M, Fischer JE, Chance WT. Syntheses structures and anorectic effects of human and rat amylin. Peptides 1991; 12: 919–24
  • Chance WT, Balasubramaniam A, Stallion A, Fischer JE. Anorexia following the systemic injection of amylin. Brain Res 1993; 607: 185–8
  • Morley JE, Morley PMK, Flood JF. Anorectic effects of amylin in rats over the life span. Pharmacol Biochem Behav 1993; 44: 577–80
  • Lutz TA, Del Prete E, Scharrer E. Reduction in food intake in rats by intraperitoneal injection of low doses of amylin. Physiol Behav 1994; 55: 891–5
  • Morley JE, Flood JF. Amylin decreases food intake in mice. Peptides 1991; 12: 865–9
  • Weeks JR. Long-term intravenous infusion. Meth Psychobiol 1972; 2: 155–68
  • Mellville LD, Smith GP, Gibbs J. Comparison of the satiating potencies of cholecystokinin-33 and cholecystokinin-8. Pharmachol Biochem Behav 1993; 45: 85–7
  • Beaumont K, Kenney MA, Young AA, Rank TJ. High affinity amylin binding sites in rat brain. Mol Pharmacol 1993; 44: 493–7
  • Ingelfinger FJ. The diagnosis of cancer of the pancreas. N Engl J Med 1946; 235: 653–61
  • Jamal H, Bretherton-Watt D, Suda K, Ghatei MA, Bloom SR. Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin. J Endocrinol 1990; 126: 425–9
  • Huang HJS, Young AA, Koda JE, Tulp OL, Johnson MJ, Cooper GJS. Hyperamylinemia, hyperinsulinemia, and insulin resistance in genetically obese LA/N-cp rats. Hypertension 1992; I–101–9, Suppl I
  • Frontoni S, Choi SB, Banduch D, Rosetti L. In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle. Diabetes 1991; 40: 568–73
  • Koopmans SJ, Van Mansfeld ADM, Jansz HS, Krans HMJ, Radder JK, Frölich M. Amylin-induced in vivo insulin resistance in conscious rats: the liver is more sensitive to amylin than peripheral tissues. Diabetologia 1991; 34: 218–24
  • Fürnsinn C, Nowotny P, Roden M, Rohac M, Pieber T, Parzer S. Insulin resistance caused by amylin in conscious rats is independent of induced hypocalcemia and fades during long-term exposure. Acta Endocrinol 1993; 129: 360–5

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