Peptic Ulcer Pathophysiology: Acid, Bicarbonate, and Mucosal Function

References

• Bonnevie O, Kallehauge H E, Wulff H R, Wulff M R. Prognostic value of the augmented histamine test in ulcer-disease and X-ray negative dyspepsia. Scand J Gastroenterol 1971; 6: 723–9
   PubMed Web of Science ®Google Scholar
• Kronborg O. Gastric acid secretion and risk of recurrence of duodenal ulcer within six to eight years after truncal vagotomy and drainage. Gut 1974; 15: 714–9
   PubMed Web of Science ®Google Scholar
• Andersen D, Amdrup E, Hostrup H, Sørensen F H. The Aarhus County Vagotomy Trial: trends in the problem of recurrent ulcer after parietal cell vagotomy and selective gastric vagotomy with drainage. World J Surg 1982; 6: 86–92
   PubMed Web of Science ®Google Scholar
• Rune S J, Møllman K M, Rahbek I. Frequency of relapses in duodenal ulcer patients treated with cimetidine during symptomatic periods. Scand J Gastroenterol 1980; 15(Suppl 58)85–92
   Google Scholar
• Bendtsen F, Rosenkilde-Gram B, Tage-Jensen U, Ovesen L, Rune S J. Duodenal bulb acidity in patients with duodenal ulcer. Gastroenterology 1987; 93: 1263–9
   PubMed Web of Science ®Google Scholar
• Archambault A P, Rovelstad R A, Carlson H C. In situ pH of duodenal bulb contents in normal and duodenal ulcer subjects. Gastroenterology 1967; 52: 940–7
   PubMed Web of Science ®Google Scholar
• Aynaciyan A V, Bingham J R. pH of the duodenum of patients with and without duodenal ulcers measured with a radio-telemetering capsule. Gastroenterology 1969; 56: 476–82
   PubMedGoogle Scholar
• McCloy R F, Greenberg G R, Baron J H. Duodenal pH in health and duodenal ulcer disease: effect of a meal, Coca-Cola, smoking, and Cimetidine. Gut 1984; 25: 386–92
   PubMed Web of Science ®Google Scholar
• Quigley E MM, Turnberg L A. pH of the microclimate lining human gastric and duodenal mucosa in vivo. Studies in control subjects and duodenal ulcer patients. Gastroenterology 1987; 92: 1876–84
   PubMed Web of Science ®Google Scholar
• Eriksen C A, Sadek S S, Cushieri A. 24-hour ambulatory dual gastroduodenal pH monitoring. Ann Surg 1988; 208: 702–7
   PubMed Web of Science ®Google Scholar
• Kerrigan D D, Read N W, Taylor M E, Houghton L A, Johnson A G. Duodenal bulb acidity and the natural history of duodenal ulceration. Lancet 1989; i: 61–3
   Google Scholar
• Schierbeck N P. Ueber kohlensäure im ventrikel. Scand Arch Physiol 1892; 3: 437–73
   Google Scholar
• Garner A, Flemström G, Allen A. Gastroduodenal alkaline and mucus secretion. Scand J Gastroenterol 1983; 18(Suppl 87)25–41
   Google Scholar
• Isenberg J I, Flemström G. Physiology and pathophysiology of gastroduodenal bicarbonate secretion. Viewpoints Dig Dis 1991; 23: 27–33
   Google Scholar
• Yao B, Hogan L, Bukhave K, Koss M A, Isenberg J I. Bicarbonate transport by rabbit duodenum in vitro: effect of vasoactive intestinal polypeptide, prostaglandin E2, and cyclic adenosine monophosphate. Gastroenterology 1993; 104: 732–40
   PubMed Web of Science ®Google Scholar
• Ainsworth M A, Koss M A, Hogan D L, Isenberg J I. Higher proximal duodenal bicarbonate secretion is independent of Brunner's glands. Gastroenterology 1994; 106: A38
   Google Scholar
• Ainsworth M A, Amelsberg M, Hogan D L, Isenberg J I. Acid/base transport is similar in isolated mammalian duodenal villus and crypt cells. Gastroenterology 1994; 106: A37
   Google Scholar
• Flemström G, Kivilaakso E. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 1983; 84: 787–94
   PubMed Web of Science ®Google Scholar
• Fahrenkrug J, Schaffalitzky de Muckadell O B, Rune S J. pH threshold for release of secretin in normal subjects and in patients with duodenal ulcer and patients with chronic pancreatitis. Scand J Gastroenterol 1978; 13: 177–86
   PubMed Web of Science ®Google Scholar
• Ovesen L, Bendtsen F, Tage-Jensen U, Pedersen N T, Gram B R, Rune S J. Intraluminal pH in the stomach, duodenum, and proximal jejunum in normal subjects and patients with exocrine pancreatic insufficiency. Gastroenterology 1986; 90: 958–62
   PubMed Web of Science ®Google Scholar
• Ainsworth M A, Kjeldsen J, Olsen O, Christensen P, Schaffalitzky de Muckadell O B. Duodenal disappearance rate of acid during inhibition of mucosal bicarbonate secretion. Digestion 1990; 47: 121–9
   PubMedGoogle Scholar
• Mertz-Nielsen A, Hillingsø J, Eskerod O, Bukhave K, Rask-Madsen J. Muscarinic M-receptor inhibition reduces gastroduodenal bicarbonate secretion and promotes gastric prostaglandin E2 synthesis in healthy volunteers. Gut 1994, In press.
   Google Scholar
• Forssell H. Studies on gastric bicarbonate secretion in man. Acta Chir Scand 1987; Suppl 540: 1–54
   Google Scholar
• Knutson L, Flemström G. Duodenal mucosal bicarbonate secretion in man. Stimulation by acid and inhibition by the alpha2-adrenoceptor agonist clonidine. Gut 1989; 30: 1708–15
   PubMed Web of Science ®Google Scholar
• Ainsworth M A, Kjeldsen J, Schaffalitzky de Muckadell O B. Morphine inhibits secretion of bicarbonate from the human duodenal mucosa. Scand J Gastroenterol 1990; 25: 1066–75
   PubMed Web of Science ®Google Scholar
• Sababi M, Nylander O. Interaction between prostanoids, nitric oxide and VIP in modulation of duodenal alkaline secretion and motility in the rat in vivo. Gastroenterology 1994; 106: A119
   Google Scholar
• Bukhave K, Rask-Madsen J, Hogan D L, Koss M A, Isenberg J I. Proximal duodenal prostaglandin E2 release and mucosal bicarbonate secretion are altered in patients with duodenal ulcer. Gastroenterology 1990; 99: 951–5
   PubMedGoogle Scholar
• Mertz-Nielsen A, Hillingsø J, Rask-Madsen J. Evidence for decreased gastric and duodenal mucosal bicarbonate secretion in humans during cyclooxygenase inhibition with indomethacin. In manuscript, submitted.
   Google Scholar
• Guslandi M. Effects of anti-ulcer drugs on gastrointestinal bicarbonate secretion. Eur J Gastroenterol Hepatol 1990; 2: 27–31
   Google Scholar
• Mertz-Nielsen A, Hillingsø J, Bukhave K, Rask-Madsen J. Omeprazole increases duodenal bicarbonate secretion in man. Gastroenterology 1994; 106: A138
   Google Scholar
• Isenberg J I, Selling J A, Hogan D L, Koss M A. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 1987; 316: 374–9
   PubMed Web of Science ®Google Scholar
• Mertz-Nielsen A, Hillingsø J, Bukhave K, Rask-Madsen J. Gastric bicarbonate secretion and release of prostaglandin E2 are increased in duodenal ulcer-patients, but not inHelicobacter pylori positive healthy subjects. In manuscript, submitted.
   Google Scholar
• Rapier R C, Dreilinger A D, Nyberg L M, Koss M A, Hogan D L, Isenberg J I. Helicobacter pylori diminishes proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer disease. Gastroenterology 1994; 106: A164
   Google Scholar
• Ainsworth M A, Hogan D L, Koss M A, Isenberg J I. Cigarette smoking inhibits acid-stimulated duodenal mucosal bicarbonate secretion. Ann Intern Med 1993; 119: 882–6
   PubMed Web of Science ®Google Scholar
• Seier Poulsen S, Kirkegaard P, Skov Olsen P, Kürstein Jensen K, Christiansen J. Role of delayed gastric emptying in the pathogenesis of cysteamine-induced duodenal ulcer in the rat. Scand J Gastroenterol 1982; 17: 325–30
   PubMedGoogle Scholar
• Kirkegaard P, Petersen B, Skov Olsen P, Seier Poulsen S, Christiansen J. The mechanism of gastrin release in cysteamine-induced duodenal ulcer. Scand J Gastroenterol 1982; 17: 609–12
   PubMed Web of Science ®Google Scholar
• Kirkegaard P, Seier Poulsen S, Loud F B, Halse C, Christiansen J. Cysteamine-induced duodenal ulcer and acid secretion in the rat. Scand J Gastroenterol 1980; 15: 621–4
   PubMed Web of Science ®Google Scholar
• Kirkegaard P, Seier Poulsen S, Halse C, Loud F B, Skov Olsen P, Christiansen J. The effect of cysteamine on the Brunner gland secretion in the rat. Scand J Gastroenterol 1981; 16: 93–6
   PubMed Web of Science ®Google Scholar
• Seier Poulsen S, Kirkegaard P, Skov Olsen P, Christiansen J. Brunner's glands of the rat during cysteamine ulceration. Scand J Gastroenterol 1981; 16: 459–64
   PubMedGoogle Scholar
• Elder J B, Williams G, Lacey E, Gregory H. Cellular localisation of human urogastrone/epidermal growth factor. Nature 1978; 271: 466–7
   PubMed Web of Science ®Google Scholar
• Heitz Ph U, Kasper M, Van Noorden S, Polak J M, Gregory H, Pearse A GE. Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands. Gut 1978; 19: 408–13
   PubMedGoogle Scholar
• Kirkegaard P, Skov Olsen P, Seier Poulsen S, Nexø E. Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. Gastroenterology 1983; 85: 1277–83
   PubMed Web of Science ®Google Scholar
• Podolsky D K. Peptide growth factors in the gastrointestinal tract. Physiology of the gastrointestinal tract, D H Alpers, et al. Raven Press, New York 1994; 2: 129–68
   Google Scholar
• Skov Olsen P., Seier Poulsen S, Therkelsen K, Nexø E. Oral administration of synthetic human urogastrone promotes healing of chronic duodenal ulcers in rats. Gastroenterology 1986; 90: 911–7
   PubMed Web of Science ®Google Scholar
• Skov Olsen P, Seier Poulsen S, Kirkegaard P, Nexø E. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 1984; 87: 103–8
   PubMed Web of Science ®Google Scholar
• Skov Olsen P, Poulsen S S, Therkelsen K, Nexø E. Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. Gut 1986; 27: 1443–9
   PubMedGoogle Scholar
• Nexø E, Seier Poulsen S. Does epidermal growth factor play a role in the action of sucralfate?. Scand J Gastroenterol 1987; 22(Suppl 127)45–49
   Google Scholar
• Svanes K, Gislason H, Guttu K, Herfjord J K, Fevang J, Grønbech J E. Role of blood flow in adaptive protection of the cat gastric mucosa. Gastroenterology 1991; 100: 1249–58
   PubMed Web of Science ®Google Scholar
• Guttu K, Rosok B, Svanes K, Grønbech J E. Release of bicarbonate from damaged and restituted gastric mucosa in the cat. Gastroenterology 1993; 105: 74–83
   PubMedGoogle Scholar
• Sorbye H, Guttu K, Gislason H, Grong K, Svanes K. Gastric mucosal injury and associated changes in mucosal blood flow and gastric fluid secretion caused by dimethyl sulfoxide (DMSO) in rats. Dig Dis Sci 1993; 38: 1243–50
   PubMedGoogle Scholar
• Kvernebo K, Lunde O C, Stranden E, Larsen S. Human gastric blood circulation evaluated by endoscopic laser doppler flowmetry. Scand J Gastroenterol 1986; 21: 685–92
   PubMed Web of Science ®Google Scholar
• Line P D, Mowinckel P, Lien B, Kvernebo K. Repeated measurement variation and precision of laser Doppler flowmetry measurements. Microvasc Res 1992; 43: 285–93
   PubMed Web of Science ®Google Scholar
• Holm L, Perry M A. Role of blood flow in gastric acid secretion. Am J Physiol 1988; 254: G281–93
   Google Scholar
• Holm L, Jägara A. Role of prostaglandins in regulation of gastric mucosal blood flow and acid secretion. Am J Physiol 1992; 263: G446–51
   Google Scholar
• Holm L, Jägara A. Histamine is not involved in pentagastrin-induced gastric mucosal vasodilation in the rat. Am J Physiol 1994; 266: G55–61
   Google Scholar
• Højgaard L, Andersen J R, Krag E. A new method for measurement of the electrical potential difference across the stomach wall. Scand J Gastroenterol 1987; 22: 847–58
   PubMed Web of Science ®Google Scholar
• Højgaard L, Ewald H, Holm I E, Bünger C, Krag E, Bülow J B. The effect of IV indomethacin on the gastric mucosal electrical potential difference and blood flow in anaesthetized dogs. Clin Physiol 1988; 8: 433–42
   PubMedGoogle Scholar
• Højgaard L, Bülow J B, Madsen J. Gastric mucosal electrical potential difference, pH, blood flow, and morphology during hypoxia and selective gastric ischaemia with and without allopurinol pretreatment in anaesthetized dogs. Acta Physiol Scand 1990; 139: 185–92
   PubMedGoogle Scholar
• Davies G R, Simmonds N J, Stevens T R, Sheaff M T, Banatvala N, Laurenson I F, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994; 35: 179–85
   PubMed Web of Science ®Google Scholar
• Hovendal C. Adrenergic influence on canine gastric acid secretion and gastric mucosal blood flow before and after parietal cell vagotomy. Thesis. Odense University, Odense 1985; 64
   Google Scholar
• Bech K. The role of somatostatin and serotonin in the β-adrenoceptor regulation of gastric function. Thesis. Odense University, Odense 1987; 69
   Google Scholar
• Axelsson C K. Clinical implications of serum pepsinogen and progastricsin in man. Scand J Clin Lab Invest 1992; Suppl 210: 81–96
   Google Scholar