48
Views
28
CrossRef citations to date
0
Altmetric
Original Article

Endogenous Prostaglandins and Microflora Modulate DNA Synthesis and Neuroendocrine Peptides in the Rat Gastrointestinal Tract

, , , &
Pages 691-699 | Received 26 Aug 1996, Accepted 14 Mar 1997, Published online: 08 Jul 2009

References

  • Baumgartner A, Koelz H R, Halter F. Indomethacin and turnover of mucosal cells in the rat. Am J Physiol 1986; 250: G830–5
  • Uribe A. Indomethacin accelerates clearance of labelled cells and increases DNA synthesis in gastrointestinal mucosa of the rat. Dig Dis Sci 1992; 37: 403–8
  • Uribe A, Johansson C, Rubio C. Cell proliferation of the rat gastrointestinal mucosa after treatment with E2 prostaglandin and indomethacin. Digestion 1987; 36: 539–50
  • Kuwayama H, Nakajima N, Matsuo Y, Eastwood G L. Effects of single parenteral indomethacin injection in rats fundic and antral epithelial proliferation. J Clin Gastroenterol 1990; 12: S72–5
  • Alam M, Midtvedt T, Uribe A. Differential cell kinetics in the ileum and colon of gcrmfree rats. Scand J Gastroenterol 1994; 29: 445–51
  • Uribe A, Midtvedt T, Jaramillo E, Theodorsson E. Epithelial cell proliferation in the proximal small intestine of germfree rats. Acta Chir Scand Suppl 1991; 562–92
  • Uribe A, Alam M, Johansson O, Midtvedt T, Theodorsson E. Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat. Gastroenterology 1994; 107: 1259–69
  • Vane J R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature [New Biol] 1971; 231: 232–5
  • Alam M, Midtvedt T, Uribe A. Indomethacin and prostaglandin E2 induce trophic changes in the jejunal epithelium of gcrmfree rats by different cell kinetic mechanisms. Eur J Gastroenterol Hepatol 1992; 4: 551–7
  • Uribe A, Grimelius L, Theodorsson E, Riis-Angelo L, Johansson C. Oral E2 prostaglandins affect endocrine cell populations in the gastric antrum of the rat. Eur J Clin Invest 1989; 19: 146–53
  • Uribe A, Kapraali M, Grape T, Johansson O. Oral prostaglandin E2 influences the cnterochromaffin-like and somatostatin cell populations in the oxyntic mucosa of the rat. J Clin Gastroenterol 1992; 14: S43–51, Suppl I
  • Kuwayama H, Eastwood G L. Effect of water immersion, restraint stress and chronic indomethacin ingestion on gastric antral and fundic epithelial proliferation. Gastroenterology 1985; 86: 362–5
  • Helig L G. Radioimmunological determination of pancreatic and gut-glucagon in plasma. Diabetologia 1971; 7: 10–9
  • Theodorsson-Norheim E, Rossel S. Characterisation of human plasma neurotensin-like immunoreactivity after fat digestion. Regul Pept 1983; 6: 207–18
  • Grill C, Curiae M, Roovete A, Effendic S. A stimulatory effect of glucagon on somatostatin release is impared in non-insulin dependent mellitus. J Clin Endocrinol Metab 1984; 59: 293
  • Brodin E, Lindefors N, Theodorsson-Norheim E, Rossel S. Tachykinins multiplicity in rat central nervous system as studied using antisera raised against substance P and neurokinin A. Regul Pept 1986; 13: 253–72
  • Theodorsson-Norheim E, Norheim I, Oberg K, Lundberg J M, Tatemoto K, Lindgren PG., Neuropeptide K. a major tachykinin in plasma and tumor tissues from carcinoid patints. Biochem Biophys Res Commun 1985; 131: 77–83
  • Uribe A. Indomethacin inhibits cell proliferation in the oxyntic epithelium of the rat. Prostaglandins 1993; 45: 15–26
  • Nygard G, Anthony A, Piasecki C, Trevethick M A, Hudson M, Dhilon A P, et al. Acute indomethacin-induced jejunal injury in the rat: early morphological and biochemical changes. Gastroenterology 1994; 106: 567–75
  • Robert A. An intestinal disease produced experimentally by a prostaglandin deficiency. Gastroenterology 1975; 69: 1045–7
  • Abrams G D, Bauer H, Sprinz H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. Lab Invest 1963; 12: 355–64
  • Khoury K A, Floch M H, Hersh T. Small intestinal mucosal cell proliferation and bacterial flora in the conventionalization of the germfree mouse. J Exp Med 1969; 160: 659–70
  • Kwan K C, Breawlt G O, Umberhawer E R, Mc Mahon F G, Duggan DE. Kinetics of indomethacin absorption, elimination and enterohepatic circulation in man. J Pharm Biopharm 1976; 4: 255–80
  • Duggan D E, Hogans A F, Kwan K C, Mc Mahon FG. The metabolism of indomethacin in man. J Pharm Exp Ther 1972; 181: 563–75
  • Saxerholt H. Intestinal bilirubin metabolism. thesis, Karolinska Institute, Stockholm 1990
  • Midtvedt T, Carlstedt-Duke B, Höverstad T, Midtvedt A C, Norin K E, Saxerholt H. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. Appl Exp Environ Microbiol 1987; 53: 2866–71
  • Jakab G, de Webster H F, Salamon I, Mezey E. Neural and non-neural origin of calcitonin gene-related peptide (CGRP) in the gastric mucosa. Neuropeptides 1993; 24: 117–22

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.