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Review Article

Neurohormonal Control of Gallbladder Motility

, &
Pages 737-750 | Published online: 08 Jul 2009

References

  • Ivy A C, Bergh G S. The applied physiology of the extrahepatic biliary tract. JAMA 1934; 103: 1500–4
  • Svanvik J, Allen B, Pellegrini C, Bernhoft R, Way L. Variations in concentrating function of the gallbladder in the conscious monkey. Gastroenterology 1984; 86: 919–25
  • Rádberg G, Asztely M, Moonen M, Svanvik J. Concentration and evacuation of the gallbladder studied simultaneously by ultrasonography and 99mTc-labeled diethyl-iminodiacetic acid scintigraphy. Scand J Gastroenterol 1993; 28: 709–13
  • Schusdziarra V. Gastrointestinale Hormone und Neuropeptide. Kohlhammer, Stuttgart 1985
  • Lamers CBHW, Jansen JBMJ. Cholinergic and hormonal regulation of post-prandial gallbladder contraction in humans. Nerves and the gastrointestinal tract, MV Singer, H Goebell. Kluwer, Lancaster 1989; 213–8
  • Niebergall-Roth E, Teyssen S, Singer MV. Neurohormonal control of gallbladder motility by intraileal and intracolonic nutrients–review. Berl Muench Tieraerztl Wochenschr 1996; 109: 87–94
  • Svenberg T, Christofides N D, Fitzpatrick M L, Areola-Oritz F, Bloom S R, Williams R B. Interdigestive biliary output in man: relationship to fluctuations in plasma motilin and effect of atropine. Gut 1982; 23: 1024–8
  • Schwartz T W, Stenquist B, Olbe L. Cephalic phase of pancreatic polypeptide secretion studied by sham feeding in man. Scand J Gastroenterol 1979; 14: 313–20
  • Taylor I L, Feldman M, Richardson C T, Walsh J H. Gastric and cephalic stimulation of human pancreatic polypeptide release. Gastroenterology 1978; 75: 432–7
  • Taylor I L, Impicciatore M, Carter D C, Walsh J H. Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs. Am J Physiol 1978; 235: E443–7
  • Lonovics J, Guzman S, Devitt P, Hejtmancik K E, Suddith R L, Rayford P L, et al. Release of pancreatic polypeptide in humans by infusion of cholecystokinin. Gastroenterology 1980; 79: 817–22
  • Hildebrand P, Beglinger C, Gyr K, Jansen JBMJ, Rovati L C, Zuercher M, et al. Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary response in man. J Clin Invest 1990; 85: 640–6
  • Schaffalitzky de Muckadell O B, Fahrenkrug J, Hoist JJ. Release of vasoactive intestinal polypeptide (VIP) by electrical stimulation of the vagal nerves. Gastroenterology 1977; 72: 373–5
  • Ryan J P. Motility of the gallbladder and biliary tree. Physiology of the gastrointestinal tract. 2nd ed., LR Johnson. Raven Press, New York 1987; 695–721
  • Park C Y, Pae Y S, Hong SS. Radiologic studies on emptying of the huamn gallbladder. Am Surg 1970; 171: 294–9
  • Herzog R J, Nelson J A. The role of cholecystokinin in radiographic opacification of the gallbladder. Invest Radiol 1076; 11: 440–7
  • Levitt M D, Bond J. Use of the constant perfusion tehcnique in the nonsteady state. Gastroenterology 1977; 73: 1450–3
  • Englert E, Chiu V S. Quantitation analysis of human biliary evacuation with a radioisotopic technique. Gastroenterology 1966; 50: 506–18
  • Krishnamurthy G T, Bobba V R, Kingston E. Radionuclide ejection fraction: a technique for quantitative analysis of motor function of the human gallbladder. Gastroenterology 1981; 80: 482–90
  • Everson G T, Braverman D Z, Johnson M L, Kem F, Jr. A critical evaluation of real-time ultrasonography for the study of gallbladder volume and contraction. Gastroenterology 1980; 79: 40–6
  • Moreland A F. Collection and withdrawal of body fluids and infusion techniques. Methods of animal experimentation, WI Gay. Academic Press, New York 1965; Vol. I: 1–42
  • Debas H T, Yamagishi T. Evidence for a pyloro-cholecystic reflex for gallbladder contraction. Ann Surg 1979; 190: 170–6
  • Strah K M, Pappas T N, Melendez R L, Debas H T. Contrasting cholinergic dependence of pancreatic and gallbladder response to cholecystokinin. Am J Physiol 1986; 250: G665–9
  • Keane F B, DiMagno E P, Dozois R R, Go VLW. Relationship among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma pancreatic polypeptide and motilin. Gastroenterology 1980; 78: 310–6
  • Traynor O J, Dozois R R, DiMagno EP. Canine interdigestive and postprandial gallbladder motility and emptying. Am J Physiol 1984; 246: G426–32
  • Ura K, Sama S K, Condon RE. Antral control of gallbladder cyclic motor activity in the fasting state. Gastroenterology 1992; 102: 295–302
  • Tanaka M, Sarr M G, Miller L J, Malgelada J-R. Changes in tone of canine gallbladder measured by an electronic pneumatic barostat. Am J Physiol 1990; 259: G314–20
  • Itoh Z, Takahashi I. Periodic contractions of the canine gallbladder during the interdigestive state. Am J Physiol 1981; 240: G183–9
  • Matsumoto T, Sarna S K, Condon R E, Dodds W J, Mochinaga N. Canine gallbladder cyclic motor activity. Am J Physiol 1988; 225: G409–16
  • Takahashi I, Nakaya M, Suzuki T, Itoh Z. Postprandial changes in contractile activity and bile concentration in gallbladder of the dog. Am J Physiol 1982; 243: G365–71
  • Peeters T L, Vantrappen G, Janssens J. Bile acid output and the interdigestive migrating complex in normals and in cholecys-tectomized patients. Gastroenterology 1980; 79: 678–86
  • Boldyreff W. Einige neue Seiten der Tatigkeit des Pankreas: Der Übertritt des Pankreassaftes und anderer Darmsekrete in den Magen; die physiologische und klinische Bedeutung dieser Erscheinung. Ergeb Physiol 1911; 11: 185–217
  • Itoh Z, Takahashi I, Nakaya M, Suzuki T, Arai H, Wakbayashi K. Interdigestive gallbladder bile concentration in relation to periodic contraction of gallbladder in the dogs. Gastroenterology 1982; 83: 645–51
  • Scott R B, Eidt P B, Shaffer EA. Regulation of fasting canine duodenal bile acid delivery by sphincter of Oddi and gallbladder. Am J Physiol 1985; 249: G622–33
  • Marzio L, Matteo N, Capone F, DiFelice F, De Angelis C, Mezzetti A, et al. Gallbladder contraction and its relationship to interdigestive duodenal motor activity in normal human subjects. Dig Dis Sci 1988; 33: 540–4
  • Qvist N, øster-jørgensen E, Rasmussen L, Kraglund K, Pedersen SA. The relationship between gallbladder dynamics and the migrating motor complex in fasting healthy subjects. Scand J Gastroenterol 1988; 23: 562–6
  • DiMagno E P, Hendricks J C, Go VLW, Dozois R R. Relationships among canine fasting pancreatic and biliary secretions, pancreatic duct pressure, and duodenal phase III motor activity–Boldyreff revisited. Dig Dis Sci 1979; 24: 689–93
  • Stolk MFJ, van Erepecum K J, Smout AJPM, Akkermans LMA, Jansen JBMJ, Lamers CBHW, et al. Motor cycles with phase III in antrum are associated with high motilin levels and prolonged gallbladder emptying. Am J Physiol 1993; 264: G596–600
  • Magee D F, Naruse S, Pap A. Vagal control of gallbladder contraction. J Physiol 1984; 355: 65–70
  • Abiru H, Sarna S K, Condon RE. Contractile mechanisms of gallbladder filling and emptying in dogs. Gastroenterology 1994; 106: 1652–61
  • Code C F, Schlegel J F. The gastrointestinal interdigestive housekeeper: motor correlates of the interdigestive myoelectric complex of the dog. Proceedings of the 4th International Symposium on GI Motility., EE Daniel. Mitchell, Vancouver 1973; 631–4
  • Takahashi T, May D, Owyang C. Cholinergic dependence of gallbladder response to cholecystokinin in the guinea pig in vivo. Am J Physiol 1991; 261: G565–9
  • Johnson F E, Boyden E A. The effect of double vagotomy on the motor activity on the human gallbladder. Surgery 1952; 32: 591–601
  • Parkin GJS, Smith R B, Johnston D. Galbladder volume contractility after truncal, selective and highly selective (parietal-cell) vagotomy in man. Ann Surg 1972; 178: 581–6
  • Polak J M, Pearse AGE, Garaud J-C, Bloom S R. Cellular localization of vasoactive intestinal peptide in the mamalian and avian gastrointestinal tract. Gut 1974; 15: 720–4
  • Sundler F, Alumets J, Hakanson R, Ingemansson S, Fahrenkrug J, Schaffalitzky De Muckadell O. VIP innervation of the gallbladder. Gastroenterology 1977; 72: 1375–7
  • Jansson R, Steen G, Svanvik J. Effects of intravenous vasoactive intestinal peptide (VIP) on gallbladder function in the cat. Gastroenterology 1978; 75: 47–50
  • Vagne M, Troitskoja V. Effects of secretin, glucagon, and VIP on gallbladder contraction. Digestion 1976; 14: 62–7
  • Ryan J P, Cohen S. Effect of vasoactive intestinal polypeptide on basal and cholecystokinin induced gallbladder pressure. Gastroenterology 1977; 73: 870–2
  • Bryant M G, Bloom S R, Polak JM. Possible dual role of vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet 1976; 1: 991–3
  • Bult H, Boeckxstaens G E, Pewlckmans P A, Jordaens F H, van Maercke Y M, Herman A G. Nitric oxide as an inhibitory non-adrenergic non-cholinerigc neurotransmitter. Nature 1990; 345: 346–7
  • Mourelle M, Guarner F, Molero X, Moncada S, Malagelada J-R. Regulation of gallbladder motility by the arginine-nitric oxide pathway in guinea pigs. Gut 1993; 34: 911–5
  • Schjoldager B, Poulsen S S, Schmidt P, Coy D H, Hoist JJ. Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am J Physiol 1991; 260: G577–85
  • Helmstaedter V, Kreppein W, Domschke W, Mitznegg P, Yanaihara N, Wunsch E, et al. Immunohistochemical localization of motilin in endocrine cells of the small intestine of humans and monkey. Gastroenterology 1979; 76: 897–902
  • Itoh Z, Takeuchi S, Aizawa I, Mori K, Taminato T, Seino Y, et al. Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs. Am J Dig Dis 1978; 23: 929–35
  • Lee K Y, Chey W Y, Tai H-H, Yajima H. Radioimmunoassay of motilin: validation of studies on the relationship between plasma motilin and interdigestive myoelectric activity of the duodenum of the dog. Am J Dig Dis 1978; 23: 789–95
  • Suzuki T, Takahashi I, Itoh Z. Motilin and gallbladder: New dimensions in gastrointestinal physiology. Peptides 1981; 2: 229–33
  • Takahashi I, Suzuki T, Aizawa I, Itoh Z. Comparison of gallbladder contractions induced by motilin and cholecystokinin in dogs. Gastroenterology 1982; 82: 419–24
  • Nilsson B I, Svenberg T, Tollström T, Hellstrom P M, Samuelson K, Schnell P-O. Relationship between interdigestive gallbladder emptying, plasma motilin and migrating motor complex in man. Acta Physiol Scand 1990; 139: 55–61
  • Meyer B M, Beglinger C, Jansen JBMJ, Rovati L C, Werth B A, Hildebrand P, et al. Role of cholecystokinin in regulation of gastrointestinal motor functions. Lancet 1989; 2: 12–5
  • Niederau C, Heintges T, Rovati L, Strohmeyer G. Effects of loxiglumide on gallbladder emptying in healthy volunteers. Gastroenterology 1989; 97: 1331–6
  • Malesci A, DeFazio C, Festorazzi S, Bonato C, Valentini A, Tacconi M, et al. Effect of loxiglumide on gallbladder contractile reponse to cerulein and food in humans. Gastroenterology 1990; 98: 1307–10
  • Schmidt W E, Creutzfeld W, Schleser A, Choudhury A R, Nustede R, Hocker M, et al. Role of CCK in regulation of pancreaticobiliary functions and GI motility in humans: effect of loxiglumide. Am J Physiol 1991; 260: G197–206
  • Liddle R A, Geertz B J, Kanayama S, Beccaria L, Coker L D, Turnbull T A, et al. Effects of a novel cholecystokinin (CCK) receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. J Clin Invest 1989; 84: 1220–5
  • Chen Y F, Chey W Y, Lee K Y, Chang T M. Cyclic change in plasma concentration and exocrine pancreatic secretion in the interdigestive state of dog. Gastroenterology 1983; 84: 1122
  • Dale W E, Turkelson C M, Solomon TE. Role of cholecystokinin in intestinal phase and meal-induced pancreatic secretion. Am J Physiol 1989; 257: G782–90
  • Burgess R, Ling N, Butcher M, Guillemin R. Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone. Proc Natl Acad Sci USA 1973; 70: 684–8
  • Schusdziarra V. Somatostatin–physiological and pathophysiological aspects. Scand J Gastroenterol 1983; 18: 69–84, Suppl 82
  • Aizawa I, Itoh Z, Harris V, Unger R H. Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog. J Clin Invest 1981; 68: 206–13
  • Creutzfeld W, Lankisch P G, Fölsch UR. Hemmung der sekretin- und cholecystokinin-pankreozymin-induzierten Saft-und Enzymsekretion des Pankreas und der Gallenblasenkon-traktion beim Menschen durch Somatostatin. Dtsch Med Wochenschr 1975; 100: 1135–8
  • Fisher R S, Rock E, Levin G, Malmud L S. Effects of somatostatin on gallbladder emptying. Gastroenterology 1987; 92: 885–90
  • Lin T-M, Chance R E. Spectrum of gastrointestinal actions of bovine PP. Gut hormones, SR Bloom. Churchill Livingstone, Edinburgh 1978; 242–6
  • Gepts W, Baetens D, DeMay J. The PP cell. Gut hormones, SR Bloom. Churchill Livingstone, Edinburgh 1978; 229–33
  • Pomeranz I S, Davison J S, Shaffer EA. In vitro effects of pancreatic polypeptide and motilin on contractility of human gallbladder. Dig Dis Sci 1983; 28: 539–14
  • Chen M H, Joffe S N, Magee D F, Murphy R F, Naruse S. Cyclic changes of plasma pancreatic polypeptide and pancreatic secretion in fasting dogs. J Physiol 1983; 341: 453–41
  • Owyang C, Achem-Karam S R, Vinik Al. Pancreatic polypeptide and intestinal migrating motor complex in humans. Effect of pancreaticobiliary secretion. Gastroenterology 1983; 84: 10–7
  • Adrian T E, Mitchenere P, Sagor G, Bloom S R. Effect of pancreatic polypeptide on gallbladder pressure and hepatic bile secretion. Am J Physiol 1982; 243: G204–7
  • Greenberg G R, McCloy R F, Chadwick V S, Adrian T E, Baron J H, Bloom S R. Effect of bovine pancreatic polypeptide on basal pancreatic and biliary outputs in man. Dig Dis Sci 1979; 24: 11–14
  • Conter R L, Roslyn J J, Muller E L, Pitt H A, Porter-Fink V, Den Besten L, et al. Effect of pancreatic polypeptide on gallbladder filling. J Surg Res 1985; 38: 461–7
  • Starke K, Lembeck F, Lorenz W, Weiss U. Gallen- und Pankreas-Sekretion unter Substanz P und einem Physalamin-Derivat. Naunyn Schmiedebergs Arch Pharmakol 1968; 260: 269–74
  • Lonovics J, Varro V, Thompson JC. The effect of cholecys-tokinin and substance P antagonists on cholecystokinin- and substance P-stimulated gallbladder contraction. Gastroenterology 1985; 88: 1637A
  • Hanyu N, Dodds W J, Layman R D, Hogan W J, Colton DG. Effect of two new cholecystokinin antagonists on gallbladder emptying in opossums. Am J Physiol 1991; 260: G258–64
  • Strunz U, Domschke W, Mitznegg P, Domschke S, Schubert E, Wunsch E, et al. Analysis of the motor effects of 13-norleucin motilin on the rabbit, guinea pig, rat, and human alimentary tract in vitro. Gastroenterology 1975; 86: 1485
  • Yamasaki T, Chijiiwa K, Chijiiwa Y. Direct contractile effect of motilin on isolated smooth muscle cells from human gallbladder. J Surg Res 1994; 56: 89–93
  • Giirtler H. Die Physiologie der Verdauung und Absorption. Lehrbuch der Physiologie der Haustiere. 4th ed., E Kolb. Fischer, Jena 1980; 177–338
  • Fisher R S, Rock E, Malmud LS. Gallbladder emptying response to sham feeding in humans. Gastroenterology 1986; 90: 1854–7
  • Hopman WPM, Jansen JBMJ, Rosenbusch G, Lamers CBHW. Cephalic stimulation of gallbladder contraction in humans: Role of cholecystokinin and the cholinergic system. Digestion 1987; 38: 197–203
  • Yamamura T, Takahashi T, Kusunoki M, Kantoh M, Seino Y, Utsunomiya J. Gallbladder dynamics and plasma cholecystokinin responses after meals, oral water, or sham feeding in healthy subjects. Am J Med Sci 1988; 295: 102–7
  • Vermeulen M, Hopman WPM, de Jong AIL, Yap S H, Lamers CBHW. Vagale stimulatie van pancreas en galblaas bij patienten met achalasie. Ned Tijdschr Geneesk 1985; 129: 1657
  • Read N W, Cooper K, Fordtran JS. Effect of modified sham feeding on jejunal transport and pancreatic and biliary secretion in man. Am J Physiol 1978; 234: 417–20
  • Hansen W E, Maurer H, Haberland H. The effect of sham-feeding on gallbladder volume and circulation of bile acids. Hepatogastroenterol 1982; 29: 108–10
  • Tankhurt E, Yegen B C, Biren T, Giirmen N, Onat F, Ercil A, et al. Influence of pirenzepine on gallbladder contraction in man induced by sham feeding or an intraduodenal meal. Digestion 1992; 51: 103–9
  • Walsh J H, Grossman M I. Gastrin. N Engl J Med 1975; 297: 1324–34
  • Knutson U, Olbe L, Ganguli PC. Gastric acid and plasma gastrin response to sham feeding in duodenal ulcer patients before and after resection of antrum and duodenal bulb. Scand J Gastroenterol 1974; 9: 351–6
  • Nilsson G, Simon J, Yalow RS. Plasma gastrin and gastric acid responses to sham feeding and feeding in dogs. Gastroenterology 1972; 63: 51–9
  • Tepperman B L, Walsh J H, Preshaw RM. Effect of antral denervation on gastrin release by sham feeding and insulin hypoglycemia in dogs. Gastroenterology 1972; 63: 973–80
  • Csendes A, Walsh J H, Grossman MI. Effects of atropine and of antral acidification on gastrin release and amino acid secretion in response to insulin and feedings in dogs. Gastroenterology 1972; 63: 257–63
  • Scarpello J H, Vinik A L, Owyang C. The intestinal phase of pancreatic polypeptide release. Gastroenterology 1982; 82: 406–12
  • Johansson C, Kollberg B, Efendic S, Uvnäs-Wallensten K. Effects of graded doses of somatostatin on gallbladder emptying and pancreatic output after oral glucose in man. Digestion 1981; 22: 24–31
  • Vagne M, Grossman M I. Cholecystokinetic potency of gastrointestinal hormones and related peptides. Am J Physiol 1968; 215: 881–4
  • Amer M S. Studies with cholecystokinin. II. Cholecystokinetic potency of porcine gastrin I and II and related peptides in three systems. Endocrinology 1969; 84: 1277–81
  • Yau W M, Makhlouf G M, Edwards LE. Mode of action of cholecystokinin and related peptides on gallbladder muscle. Gastroenterology 1973; 65: 451–6
  • Valenzuela J E, Walsh J H, Isenberg JI. Effect of gastrin on pancreatic enzyme secretion and gallbladder emptying in man. Gastroenterology 1976; 71: 1, 409–l
  • Ryan J, Cohen S. Pressure-volume response to gastrointestinal hormones. Am J Physiol 1976; 230: 1461–5
  • Cameron A J, Phillips S F, Summerskill WH. Effect of cholecystokinin, gastrin, secretin, and glucagon on human gallbladder in vitro. Proc Soc Exp Biol Med 1969; 131: 149–53
  • Ryan J, Cohen S. Interaction of gastrin I, secretin, and cholecystokinin on gallbladder smooth muscle. Am J Physiol 1976; 230: 553–6
  • Schusdziarra V, Harris V, Conlon J M, Arimura A, Unger R. Pancreatic and gastric somatostatin release in response to intragastric and intraduodenal nutrients and HC1 in the dog. J Clin Invest 1978; 62: 509–18
  • Schwartz T W, Grotzinger U, Schoon I-M, Olbe L. Vago-vagal stimulation of pancreatic polypeptide secretion by graded distension of the gastric fundus and antrum in man. Digestion 1979; 19: 307–14
  • Sarson D L, Christofides N D, Albuquerque R H, Adrian T E, Ghatei M A, Modlin I M, et al. Release of gastrointestinal hormones after an oral water load and atropine in man. Gut 1978; 19: A436
  • Hallenbeck G A. Biliary and pancreatic intraductal pressures. Alimentary canal. Section 6, Vol II of Visscher MB, Hastings AB, Pappenheim JR, Rahn H, editors. Handbook of physiology., CF Code. Waverly Press, Baltimore 1967; 1007–25
  • Hong S S, Magee D F, Crewdson F. The physiologic regulation of gallbladder evacuation. Gastroenterology 1956; 30: 625–30
  • Jazrawi R P, Pazzi P, Petroni M L, Prandini N, Paul C, Adam J A, et al. Postprandial gallbladder motor function: refilling and turnover of bile in health and cholelithiasis. Gastroenterology 1995; 109: 582–91
  • Bühner S, Teyssen S, Kern I, Wienbeck J, Niebergall-Roth E, et al. Gallbladder motility following hormonal and enteral stimuli in dogs. Gastroenterology 1997, (Abstract Digestive Disease Week, Washington D.C.)
  • Sturdevant R, Stern D, Resin H. Effect of graded doses of octapeptide of cholecystokinin on gallbladder in man. Gastroenterology 1973; 64: 452–6
  • McGregor I L, Knell J R, Meyer JH. Similar sensitivities of pancreatic and biliary secretion to cholecystokinin plus secretin infusion. Am J Dig Dis 1976; 21: 641–4
  • Spellman S J, Shaffer E A, Rosenthall L. Galbladder emptying in response to cholecystokinin. A cholescintigraphic study. Gastroenterology 1979; 77: 115–20
  • Hopman WPM, Kerstens PJSM, Jansen JBMJ, Rosenbusch G, Lamers CBHW. Effect of graded physiologic doses of cholecystokinin on gallbladder contraction measured by ultrasonography. Determination of threshold, dose-response relationships and comparison with intraduodenal bilirubin output. Gastroenterology 1985; 89: 1242–7
  • Amberg J. Canine cholecystokinesis: effect of octapeptide of cholecystokinin. Radiology 1974; 100: 223–4
  • Jansson R, Svanvik J. Effects of intravenous secretin and cholecystokinin on gallbladder net water absorption and motility in the cat. Gastroenterology 1977; 72: 63–43
  • Chowdhury J R, Berkowitz J M, Praissiman M, Fora J W. Interaction between octapeptide-cholecystokinin, gastrin, and secretin on cat gallbladder in vitro. Am J Physiol 1975; 229: 1311–5
  • Amer M S. Studies with cholecystokinin in vitro. III. Mechanism of the effect on the isolated gallbladder strip. J Pharmacol ExpTher 1972; 183: 527–34
  • Hedner P. Effect of the C-terminal octapeptide of cholecystokinin on guinea pig ileum and gallbaldder in vitro. Acta Physiol Scand 1970; 78: 232–5
  • Lamers CBHW, Poitras W P, Jansen JBMJ, Walsh J H. Relative potencies of cholecystokinin-33 and cholecystokinin-8 measured by radioimmunoassay and bioassay. Scand J Gastroenterol 1983; 18: 191–2, Suppl 83
  • Solomon T E, Yamada T, Elashoff J, Wood J, Beglinger C. Bioactivity of cholecystokinin analogues: CCK-8 is not more potent than CCK-33. Am J Physiol 1984; 247: G105–11
  • Rehfeld J F. How to measure cholecystokinin in plasma?. Gastroenterology 1984; 87: 434–8
  • Liddle R A, Goldfine I D, Rosen M S, Taplitz R A, Williams JA. Cholecystokinin bioactivity in human plasma: molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 1985; 75: 1144–52
  • Rehfeld J F. The molecular nature of cholecystokinin in plasma. An in vivo immunosorption study in rabbits. Scand J Gastroenterol 1994; 29: 110–21
  • Wiener I, Inoue K, Fagan C J, Lilja P, Watson L C, Thompson J C. Release of cholecystokinin in man. Correlation of blood levels with gallbladder contraction. Ann Surg 1981; 194: 321–7
  • Lin T-M. Actions of gastointestinal hormones and related peptides on the motor function of the biliary tract. Gastroenterology 1975; 69: 1006–22
  • Thompson J C, Fried G M, Ogden W D, Fagan C J, Inoue K, Wiener I, et al. Correlation between release of cholecystokinin and contraction of the gallbladder in patients with gallstones. Ann Surg 1982; 195: 670–6
  • Hopman WPM, Jansen JBMJ, Lamers CBHW. Effect of equimolar amounts of long chain triglycerides and medium chain triglycerides on plasma cholecystokinin and gallbladder contraction. Am J Nutr 1984; 39: 356–9
  • Hopman WPM, Jansen JBMJ, Lamers CBHW. Effect of atropine on plasma cholecystokinin response to intraduodenal fat in man. Digestion 1984; 29: 19–25
  • Hopman WPM, Jansen JBMJ, Rosenbusch G, Lamers CBHW. Role of cholecystokinin and the cholinergic system in intestinal stimulation of gallbladder contraction in man. Hepatology 1990; 11: 261–5
  • Fried G M, Ogden W D, Greeley GH, Jr, Thompson J C. Correlation of release and actions of cholecystokinin in dogs before and after vagotomy. Surgery 1983; 93: 786–91
  • Fried G M, Ogden W D, Swierczek J, Greeley GH, Jr, Rayford P L, Thompson J C. Release of cholecystokinin in conscious dogs: correlation with simultaneous measurements of gallbladder pressure and pancreatic protein secretion. Gastroenterology 1983; 85: 1113–9
  • Shiratori K, Watanabe S, Chey W Y, Lee K Y, Chang T-M. Endogenous cholecystokinin drives gallbladder emptying in dogs. Am J Physiol 1986; 251: G553–8
  • Lilja P, Fagan C J, Wiener I, Inoue K, Watson L C, Rayford P L, et al. Infusion of pure cholecystokinin in humans. Correlation between plasma concentrations of cholecystokinin and gallbladder size. Gastroenterology 1982; 83: 256–61
  • Kerstens PJSM, Lamers CBHW, Jansen JBMJ, DeJong AJL, Hessels M, Hafkenscheid JCM. Physiological plasma concentrations of cholecystokinin stimulate pancreatic enzyme secretion and gallbladder contraction in man. Life Sci 1985; 36: 565–9
  • Beglinger C, Hildebrand P, Adler G, Werth B, Luo H, Delco F, Gyr K. Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man. Eur J Clin Invest 1992; 22: 827–34
  • Pendleton R G, Bendesky R J, Schaffer L, Nolan T E, Gould R J, Clineschmidt B V. Roles of endogenous cholecystokinin in biliary, pancreatic and gastric function: studies with L-364,718, a specific cholecystokinin receptor antagonist. J Pharmacol ExpTher 1987; 241: 110–6
  • Setnikar I, Bani M, Cereda R, Chiste E, Makovec F, Pacini M A, et al. Anticholecystokinin activities of loxiglumide. Drug Res 1987; 37: 1168–71
  • Behar J, Biancani P. Pharmacologic characterization of excitatory and inhibitory cholecystokinin receptors of the cat gallbladder and sphincter of Oddi. Gastroenterology 1987; 92: 764–70
  • Takahashi T, Yamamura T, Kusunoki M, Kantoh M, Ishikawa Y, Utsunomiya J. Differences between muscular receptors and neuronal receptors for cholecystokinin-octapeptide in the guinea-pig gallbladder. Eur J Pharmacol 1987; 136: 255–8
  • Hanyu N, Dodds W J, Layman R D, Hogan W J, Chey W Y, Takhashi I. Mechanism of cholecystokinin-induced contraction of the opposum gallbladder. Gastroenterology 1990; 98: 1299–306
  • Persson CGA, Ekman M. Effect of morphine, CCK, and sympathomimetics on the sphincter of Oddi and intestinal pressure in the cat duodenum. Scand J Gastroenterol 1972; 7: 345–51
  • Ondetti M A, Rubin B, Engel SL. Cholecystokinin-pan-creozymin: recent developments. Am J Dig Dis 1970; 15: 149–56
  • Grossman M I, Konturek S J. Gastric acid does drive pancreatic bicarbonate secretion. Scand J Gastroenterol 1974; 9: 299–302
  • Stening G F, Grossman M I. Potentiation of the action of cholecystokinin by secretin. Clin Res 1969; 17: 528A
  • Lin T-M, Spray G F. Effect of pentagastrin, cholecystokinin, caerulein and glucagon oh the choledochal resistance of bile flow of dogs. Gastroenterology 1969; 56: 1178
  • Taylor I L, Kauffman GL, Jr, Walsh J H, Trout H, Chew P, Harmon J W. Role of the small intestine and gastric antrum in pancreatic polypeptide release. Am J Physiol 1981; 240: G387–91
  • Greenberg G R, McCloy R F, Adrian T E, Chadwick V S, Baron J H, Bloom S R. Inhibition of pancreas and gallbladder by pancreatic polypeptide. Lancet 1978; 1978: 1280–2
  • Conter R L, Roslyn J J, DenBesten L, Taylor I L. Pancreatic polypeptide enhances postcontractile gallbladder filling in the prairie dogs. Gastroenterology 1987; 92: 771–6
  • Mitznegg P, Bloom S R, Christofides N, Bestermann H, Domschke W, Domsche S, et al. Release of motilin in man. Scand J Gastroenterol 1976; 11: 53–6, Suppl 39
  • Fisher R S, Rock E, Malmud LS. Cholinergic effects on gallbladder emptying in humans. Gastroenterology 1985; 89: 716–22
  • Gullo L, Bolondi L, Priori P, Casanova P, Labó G. Inhibitory effect of atropine on cholecystokinin-induced gallbladder contraction in man. Digestion 1984; 29: 209–13
  • Marzio L, DiGiammarco A M, Neri M, Cuccurullo F, Malfertheiner P. Atropine antagonizes cholecystokinin and cerulein-induced gallbladder evacuation in man: a real-time ultrasonographic study. Am J Gastroenterol 1985; 80: 1–4
  • Niebergall-Roth E, Teyssen S, Rippel K, Korn A, Singer MV. Latency of intraluminal gallbladder pressure in response to intraduoenal stimulants in dogs–first results. Digestion 1997, (Abstract European Pancreatic Club, London, U.K.)
  • Takahashi I, Dodds W J, Hogan W J, Baker K, Itoh Z. Effect of vagotomy on changes in gallbladder volume during fasting and after feeding on the conscious opossum. Gastroenterology 1984; 86: 1273
  • Fletcher D M, Clark D G. Changes in canine bile-flow and composition after vagotomy. Br J Surg 1969; 56: 103–6
  • Amdrup B M, Griffith C A. The effect of vagotomy upon biliary function in dogs. J Surg Res 1970; 10: 209–12
  • Pallin B, Skoglund S. Neural and humoral control of the gallbladder emptying mechanism in the cat. Acta Physiol Scand 1964; 60: 358–62
  • Bertaccini G, DeCaro G, Endean R, Erspamer V, Lmpicciatore M. The action of caerulein on the smooth muscle of the gastrointestinal tract and the gallbladder. Br J Pharmacol 1986; 34: 291–310
  • Andersson K E, Ersson R, Hedner P. Cholecystokinetic effect and concentration of cyclic AMP in gallbladder muscle in vitro. Acta Physiol Scand 1972; 85: 511–6
  • Persson CGA. Adrenergic, cholecystokinetic and morphine induced effects on extra-hepatic biliary motility. Acta Physiol Scand 1972; 87: l–32, Suppl
  • Davison J S, Al-Hassani M. The role of non-cholinergic non-adrenergic nerves in regulating the distensibility of the guinea pig gallbladder. Gastrointestinal motility, J Christensen. Raven Press, New York 1980; 89–95
  • Takahashi T, Yamamura Y, Ishikawa M, Kantoh M, Utsonomiya J. Effects of cholecystokinin-octapeptide on the human gallbladder both in vivo and in vitro. Gastroenterol Jpn 1986; 21: 49–54
  • Zabrin M A, Wamsley J K, Innis R B, Kuhar M J. Cholecysto-kinin receptors: presence and axonal flow in the rat vagus nerve. Life Sci 1981; 29: 697–705
  • Dockray G J. Vagally mediated actions of CCK. Cholecystokinin antagonists in gastroenterology, G Adler, C Beglinger. Springer, Heidelberg 1991; 56–62
  • Yegen Bçaron;, Tankhurt E, Gurmen N, Bayram M, Oktay S, Ulusoy N B. Inhibition of cholecystokinin-induced gallbladder contraction by atropine and pirenzepine in man. Digestion 1990; 45: 176–80
  • Fosel S, Sewing D F. Enhancement of electrically stimulated guinea pig gallbladder contraction by subtreshold concentration of gastrointestinal hormones in vitro. Experientia 1978; 34: 205–6
  • Layer P, Gröger G. Regulation gastrointestinaler Funktionen durch die Ileozökalregion. Z Gastroenterol 1992; 30: 873–7
  • Bond JH, Jr, Levitt D. Fate of soluble carbohydrate in the colon of rats and man. J Clin Invest 1976; 57: 1158–64
  • Stephen A M, Haddad A C, Phillips SF. Passage of carbohydrate into the colon. Direct measurements in humans. Gastroenterology 1983; 92: 383–9
  • Miihlum A, Junker S, Meyer H. Precaecal and postileal digestibility of various fats. Contributions of digestive physiology of dogs, H Meyer. Parey, Hamburg 1989; 24–30
  • Jain N K, Boivin M, Zinsmeister A R, DiMagno E P. The ileum and carbohydrate-mediated feedback regulation of postprandial pancreaticobiliary secretion in normal humans. Pancreas 1991; 6: 495–505
  • Birch C L, Boyden E A. Reaction of gallbladder to stimulation of gastrointestinal tract. II. Response to faradic excitation of stomach, small intestine and caecum. Am J Physiol 1930; 92: 301
  • Owyang C, Green L, Rader D. Colonic inhibition of pancreatic and biliary secretion. Gastroenterology 1983; 84: 470–5
  • Sarles H, Dahl C, Badetti J. Etude de Taction des corps gras sur la contraction vésiculaire–Mise en évidence ďun phénomène hormonal inhibant contraction vésiculate. Nutr Diet 1960; 2: 223–9
  • Harper A A, Hood AJC, Mushens J, Smy R. Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa. J Physiol 1979; 292: 455–67
  • Feurle G E, Biichler M, Helmstadter V. Gastric and enteral pancreatic polypeptide (PP) immunoreactivity in the dog. Acta Histochem 1985; 77: 151–8
  • Adrian T E, Bloom S R, Bryant M G, Polak J M, Heitz P, Barnes A J. Distribution and release of human pancreatic polypeptide. Gut 1976; 17: 940–4
  • Rouller D, Schusdziarra V, Conlon J M, Harris V, Unger RH. Release of somatostatin-like immunoreactivity from the lower gut. Gastroenterology 1979; 77: 700–3
  • Tatemoto K. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic excrine secretion. Proc Natl Acad Sci USA 1982; 79: 2514–8
  • Niebergall-Roth E, Teyssen S, Singer MV. Effects of peptide YY on gastrointestinal functions. Dtsch Tieraerztl Wochenschr 1997; 104: 108–13
  • Niebergall-Roth E, Teyssen S, Singer MV. Neurohormonal control of pancreatic exocrine secretion by intraileal and intracolonic nutrients. Dtsch Tieraerztl Wochenschr 1995; 102: 385–91
  • Conter R L, Roslyn J J, Taylor IL. Effects of peptide YY on gallbladder motility. Am J Physiol 1987; 252: G736–4l
  • Grace P A, Couse N F, Taylor I L, Pitt A H. Peptide YY inhibits cholecystokinin-stimulated sphincter of oddi in the prairie dog. Surgery 1988; 104: 546–52
  • Adrian T E, Savage A P, Sagor G R, Allen J M, Bacarese-Hamilton A J, et al. Effect of peptide YY on gastric, pancreatic and biliary function in humans. Gastroenterology 1985; 89: 494–9
  • Lluis F, Fujimura M, Lonovics J, Guo Y-S, Gomez G, Greeley GH, Jr, et al. Peptide YY and galbladder contraction. Gastroenterology 1988; 94: 1441–6
  • Baba H, Fujimura M, Toda N. Mechanism of inhibitory action of peptide YY on cholecystokinin-induced contractions of isolated dog ileum. Regul Pept 1990; 27: 227–35
  • Niebergall-Roth E, Teyssen S, Wetzel D, Hartel M, Beglinger C, Riepl R L, et al. Effects of telenzepine and L-364,718 on canine pancreatic secretion before and after vagotomy. Am J Physiol 1997, in press
  • Singer M V, Solomon T E, Wood J, Grossman M I. Latency of pancreatic enzyme response to intraduodenal stimulants. Am J Physiol 1980; 238: G23–9

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