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Original Article

Carboxyl Ester Lipase (Bile Salt-Stimulated Lipase), Colipase, Lipase, and Phospholipase A2 Levels in Pancreatic Enzyme Supplements

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Pages 261-267 | Received 28 Jun 1996, Accepted 29 Oct 1996, Published online: 08 Jul 2009

References

  • DiMagno EP, Go VLW, Summcrskill WHJ. Relations between pancreatic enzyme outputs and malahsorption in severe pancreatic insufficiency. N Engl J Med 1973; 288: 8135
  • Ihse L, Lilja I, Lundquist I. Intestinal concentrations of pancreatic enzymes following pancreatic replacement therapy. Scand J Gastrocntcrol 1980; 15: 137–44
  • Dutta SK, Rubin J, Harvey J. Comparative evaluation of the therapeutic efficacy of a pH-sensitive enteric coated pancreatic enzyme preparation with conventional pancreatic enzyme therapy in the treatment of exocrine pancreatic insufficiency. Gastroenterology 1983; 84: 476–82
  • Thomson M, Clague A, Cleghorn GJ, Shepherd RW. Comparative in vitro and in vivo studies of enteric-coated Pancrelipase preparations for pancreatic insufficiency. J Pediatr Gastroenterol Null 1993; 17: 407–13
  • Lebenthal E, Rolston DDK, Holsclaw DS, Jr. Enzyme therapy for pancreatic insufficiency: present status and future needs. Pancreas 1994; 9: 1–12
  • Kraisinger M, Hochhaus G, Stecenko A, Bowser F, Hendeles L. Clinical pharmacology of pancreatic enzymes in patients with cystic fibrosis and in vitro performance of microcapsulated formulations. J Clin Pharmacol 1994; 34: 158–66
  • Carroccio A, Iacono G, Montalto G, Cavataio F, Lorello D, Greco L. Pancreatic enzyme therapy in childhood celiac disease. A double-blind prospective randomized study. Dig Dis Sci 1995; 40: 255–60
  • O'Hare MMT, McMaster C, Dodge JA. Stated versus actual lipase activity in pancreatic enzyme supplements: implications for clinical use. J Pediatr Gastrocntcrol Nutr 1995; 21: 59–63
  • Blackberg L, Lombardo D, Hernell O, Guy O, Olivecrona T. Bile salt-stimulated lipase in human milk and carboxyl ester hydrolase in pancreatic juice. Are they identical enzymes? FEBS Lett 1981; 136: 284–8
  • Chen Q, Sternby B, Nilsson A. Hydrolysis of triacylglycerol arachidonic and linolcic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. Biochim Biophys Acta 1989; 1004: 372–85
  • Chen Q, Sternby B, Nilsson Å. Effects of human pancreatic lipase-colipase and carboxyl ester lipase on eicosapentaenoie and arachidonic ester bonds of triacylglycerol rich in fish oil fatty acids. Biochim Biophys Acta 1990; 1044: 111–7
  • Hernell O, Blackberg L, Chen Q, Sternby B, Nilsson Å. Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids. J Ped Gastrocnt Nutr 1993; 16: 426–31
  • Chen Q, Bläckberg L, Nilsson A, Sternby B, Hernell O. Digestion of triacylglycerols containing log-chain polyenoic fatty acids in vitro by colipase-dependent pancreatic lipase and human milk bile salt-stimulated lipase. Biochim Biophys Acta 1994; 1210: 239–43
  • Lombardo D, Guy O. Studies on the substrate specificity of a carboxyl ester hydrolasc from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters. Biochim Biophys Acta 1980; 611: 147–55
  • Lombardo D, Fauvel J, Guy O. Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters and glycerides and phospholipids. Biochim Biophys Acta 1980; 611: 136–46
  • Barros H, Sternby B, Nilsson A. Hydrolysis of phosphatidyl-inositol by human pancreatic phospholipase A2. Scand J Gastroenterol 1990; 25: 134–40
  • Andersson L, Bratt C, Arnoldsson KC, Herslöf B, Olsson NU, Sternby B. Hydrolysis of galactolipids by human pancreatic lipolytic enzymes and duodenal contents. J Lipid Res 1995; 36: 1392–400
  • Lindström M, Sternby B, Borgström B. Concerted action of carboxyl ester lipase and pancreatic lipase during lipid digestion in vitro: importance of the physico-chemical state of the substrate. Biochim Biophys Acta 1988; 959: 178–84
  • Lowe ME. Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. Gastroenterology 1994; 107: 1524–36
  • Erlanson-Albertsson C, Wisen O. Enzyme substitution in pancreatic disease: is colipase activity sufficient. Scand J Gastroenterol 1992; 27: 108–10
  • Sternby B, Nilsson Å, Melin T, Borgström B. Pancreatic lipolytic enzymes in human duodenal contents. Radioimmunoassay compared to enzyme activity. Scand J Gastroenterol 1991; 26: 859–67
  • Kozumplik V, Staffa F, Hoffmann GE. Purification of pancreatic phospholipase A2 from human duodenal juice. Biochim Biophys Acta 1989; 1002: 395–7
  • Sternby B, Kelly DG, Holtmann G, DiMagno EP. Fate of pancreatic carboxylester lipase and phospholipase A2 during aboral small intestinal transit in humans. Pancreas 1994; 9: 805
  • Sternby B. Purification of lipase and other lipolytic enzymes from the human pancreas. Scand J Gastroenterol 1993; 28: 347–51
  • Erlanson C. p-Nitrophcnylacetate as a substrate for a carboxyl-ester hydrolase in pancreatic juice and intestinal content. Scand J Gastroenterol 1970; 5: 333–6
  • De Haas GH, Postema NM, Nieuwenhuizen W, Van Decnen LLM. Purification and properties of phospholipase A from porcine pancreas. Biochim Biophys Acta 1968; 159: 103–17
  • Aho HJ, Sternby B, Kallajoki H, Nevalainen T. Carboxyl ester lipase in human tissues and in acute pancreatitis. Int J Pancreatol 1989; 5: 123–34
  • Sternby B, Akerström B. Immunoreactive pancreatic colipase lipase and phospholipase A2 in human plasma and urine from healthy individuals. Biochim Biophys Acta 1984; 789: 164–9
  • Tomasi A, Ghidini O, Bottocchia A. Blind clinical trial of a digestive enzyme preparation. Med Welt 1972; 23: 1779–80
  • Allen WM, Patterson DSP, Napier DS, Farooqi JA. An investigation into the possible reason for a decline in enzyme activity and efficacy of porcine pancreatic extracts for therapeutic use. J Biol Standard 1975; 3: 267–72
  • DiMagno EP, Malagelada JR, Go VL, Moertel CG. Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. N Engl J Med 1977; 296: 1318–22
  • Graham DY. An enteric-coated pancreatic enzyme preparation that works. Dig Dis Sci 1979; 24: 906–9
  • Robb TA, Davidson GP, Cooper DM. Solubility of oral pancreatic enzyme supplement capsules in biological fluids. Lancet 1980; 2: 544
  • Isaksson G, Ihse I. Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig Dis Sci 1983; 28: 97–102
  • DiMagno EP. Controversies in the treatment of exocrine pancreatic insufficiency. Dig Dis Sci 1982; 27: 481–4
  • Pap A, Varro V. Proteolylic inactivation of lipase as a possible cause of the uneven results obtained with enzyme substitution in pancreatic insufficiency. Hepatogastroenterology 1984; 31: 47–50
  • Dutta SK, Hlasko J. Dietary fiber in pancreatic disease: effect of high fiber diet on fat malabsorption in pancreatic insufficiency and in vitro study of the interaction of dietary fiber with pancreatic enzymes. Am J Clin Nutr 1985; 41: 517–25
  • Schneider MU, Knoll-Ruzicka ML, Domschke G, Heptner G, Domschke W. Pancreatic enzyme replacement therapy: comparative effects of conventional and enteric-coated microspheric pancreatin and acid-stable fungal enzyme preparations on stcatorrhea in chronic pancreatitis. Hepatogastroenterology 1985; 32: 97–102
  • Braga M, Cristallo M, De Franchis R, Mangiagalli A, Agape D, Primignani D, Di Carlo V. Correction of malnutrition and maldigestion with enzyme supplementation in patients with surgical suppression of exocrine pancreatic function. Surg Gynec Obstet 1988; 167: 485–92
  • Meyer JH, Elashohoff J, Porter-Fink V, Dressman J, Amidon GL. Human postprandial gastric emptying of 1–3 millimeter spheres. Gastroenterology 1988; 94: S315–25
  • Marotta F, O'Keefe SJD, Marks IN, Girdwood A, Young G. Pancreatic enzyme replacement therapy. Importance of gastric acid secretion, H2-antagonists, and enteric coating. Dig Dis Sci 1989; 34: 456–61
  • Roberts IM. Enzyme therapy for malabsorption in exocrine pancreatic insufficiency. Pancreas 1989; 4: 496–503
  • Hendeles L, Dorf A, Stecenko A, Weinberger M. Treatment failure after substitution of generic pancrelipase capsules. Correlation with in vitro lipase activity. JAMA 1990; 263: 2459–61
  • Vuoristo M, Väänänen H, Miettinen TA. Cholesterol malabsorption in pancreatic insufficiency: effects of enzyme substitution. Gastroenterology 1992; 102: 647–55
  • Pancreatic enzymes in health and disease, PG Lankisch. Springer-Verlag, Berlin 1991
  • Beger HG, Büchler M, Gyr K. The role of enzyme treatment in pancreatic disease. Digestion 1993; 54: S2

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