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Research Article

Analysis of Shigella flexneri-mediated infections in model organism Caenorhabditis elegans

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Pages 286-295 | Received 23 Sep 2010, Accepted 13 Dec 2010, Published online: 24 Jan 2011

References

  • Gravato-Nobre MJ, Hodgkin J. Caenorhabditis elegans as a model for innate immunity to pathogens. Cell Microbiol 2005;7:741–51.
  • Sifri CD, Begun J, Ausubel FM, Calderwood SB. Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infect Immun 2003;71:2208–17.
  • Molinaro A, Silipo A, Castro C.D, Sturiale L, Nigro G, Garozzo D, . Full structural characterization of Shigella flexneri M90T serotype 5 wild-type R-LPS and its ΔgalU mutant: glycine residue location in the inner core of the lipopolysaccharide. Glycobiology 2008;18:260–9.
  • Tiruneh M. Serodiversity and antimicrobial resistance pattern of Shigella isolates at Gondar University teaching hospital, Northwest Ethiopia. Jpn J Infect Dis 2009;62: 93–7.
  • Schroeder GN, Hilbi H. Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion. Clin Microbiol Rev 2008;21:134–56.
  • McCormick BA, Siber AM, Maurelli AT. Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium. Infect Immun 1998;66:4237–43.
  • Sakaguchi T, Kohler H, Gu X, McCormick BA, Reinecker HC. Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells. Cell Microbiol 2002;4:367–81.
  • Phalipon A, Sansonetti PJ. Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival? Immunol Cell Biol 2007;85:119–29.
  • Green J, Baldwin ML. The molecular basis for the differential regulation of the hlyE-encoded haemolysin of Escherichia coli by FNR and HlyX lies in the improved activating region 1 contact of HlyX. Microbiology 1997;143:3785–93.
  • Ludwig A, Bauer S, Benz R, Bergmann B, Goebel W. Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12. Mol Microbiol 1999;31: 557–67.
  • Oscarsson J, Mizunoe Y, Li L, Lai XH, Weislander A, Uhlin BE. Molecular analysis of the cytolytic protein ClyA (SheA) from Escherichia coli. Mol Microbiol 1999;32:1226–38.
  • Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, . E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy. Cell 2000;100:265–76.
  • Hunt S, Moir AJ, Tzokov S, Bullough PA, Artymiuk PJ, Green J. The formation and structure of Escherichia coli K-12 haemolysin E pores. Microbiology 2008;154:633–42.
  • Hunt S, Green J, Artymiuk PJ. Hemolysin E (HlyE, ClyA, SheA) and related toxins. Adv Exp Med Biol 2010;677: 116–26.
  • Burton EA, Pendergast AM, Aballay A. The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis. Appl Environ Microbiol 2006;72:5043–51.
  • Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, . A simple model host for identifying Gram-positive virulence factors. Proc Natl Acad Sci USA 2001;98:10892–7.
  • Aballay A, Ausubel FM. Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing. Proc Natl Acad Sci USA 2001;98:2735–9.
  • Labrousse A, Chauvet S, Couillault C, Kurz CL, Ewbank JJ. Caenorhabditis elegans is a model host for Salmonella typhimurium. Curr Biol 2000;10:1543–5.
  • Mallo GV, Kurz CL, Couillault C, Pujol N, Granjeaud S, Kohara Y, . Inducible antibacterial defense system in C. elegans. Curr Biol 2002;12:1209–14.
  • Couillault C, Ewbank JJ. Diverse bacteria are pathogens of Caenorhabditis elegans. Infect Immun 2002;70:4705–7.
  • Darby C, Hsu JW, Ghori N, Falkow S. Caenorhabditis elegans: plague bacteria biofilm blocks food intake. Nature 2002;417:243–4.
  • O'Rourke D, Baban D, Demidova M, Mott R, Hodgkin J. Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. Genome Res 2006;16:1005–16.
  • Joshua GW, Karlyshev AV, Smith MP, Isherwood KE, Titball RW, Wren BW. A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Microbiology 2003;149:3221–9.
  • Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, . A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 2002;297:623–6.
  • Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, Aroian RV. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci U S A 2004;101:10995–1000.
  • Nicholas HR, Hodgkin J. The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr Biol 2004;14:1256–61.
  • Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, . Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 2003;300:1921.
  • Zelensky AN, Gready JE. The C-type lectin-like domain superfamily. FEBS J 2005;272:6179–217.
  • Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank JJ. Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol 2007;8:R194.
  • Leippe M. Antimicrobial and cytolytic polypeptides of amoeboid protozoa-effector molecules of primitive phagocytes. Dev Comp Immunol 1999;23:267–79.
  • Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2006;2:e183.
  • Alper S, McBride SJ, Lackford B, Freedman JH, Schwartz DA. Specificity and complexity of the Caenorhabditis elegans innate immune response. Mol Cell Biol 2007;27:5544–53.
  • Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974;77:71–94.
  • Jain C, Yun M, Politz SM, Rao RP. A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans reveals novel roles for yeast AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis. Eukaryot Cell 2009;8:1218–27.
  • Shtonda BB, Avery L. Dietary choice behavior in Caenorhabditis elegans. J Exp Biol 2006;209:89–102.
  • Zhang Y, Lu H, Bargmann CI. Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 2005;438:179–84.
  • Ogawa M, Sasakawa C. Shigella and autophagy. Autophagy 2006;2:171–4.
  • DuPont HL, Levine MM, Hornick RB, Formal SB. Inoculum size in shigellosis and implications for expected mode of transmission. J Infect Dis 1989;159:1126–8.
  • Festing MP, Baumans V, Combas DR, Halder M, Hendriksen FM, Howard BP, . Reducing the use of laboratory animals in biomedical research: problems and possible solution. Altern Lab Anim 1998;26:283–301.
  • Shashikumar S, Rajini PS. Cypermethrin-induced alterations in vital physiological parameters and oxidative balance in Caenorhabditis elegans. Pestic Biochem Physiol 2010;97: 235–42.
  • Drickamer K, Dodd RB. C-Type lectin-like domains in Caenorhabditis elegans: predictions from the complete genome sequence. Glycobiology 1999;9:1357–69.
  • Nicholas HR, Hodgkin J. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Mol Immunol 2004;41:479–93.
  • Sperandio B, Regnault B, Guo J, Zhang Z, Stanley Jr SL, Sansonetti PJ, . Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med 2008; 205:1121–32.

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