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Case Reports

Decreased serum linezolid concentrations in two patients receiving linezolid and rifampicin due to bone infections

, , , , , , & show all
Pages 548-550 | Received 17 Jan 2012, Accepted 21 Jan 2012, Published online: 04 Mar 2012

References

  • Egle H, Trittler R, Kümmerer K, Lemmen SW. Linezolid and rifampin: drug interaction contrary to expectations? Clin Pharmacol Ther 2005;77:451–3.
  • Gandelman K, Zhu T, Fahmi OA, Glue P, Lian K, Obach RS, . Unexpected effect of rifampin on the pharmacokinetics of linezolid: in silico and in vitro approaches to explain its mechanism. J Clin Pharmacol 2011;51: 229–36.
  • Soriano A, Ortega M, García S, Peñarroja G, Bové A, Marcos M, . Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. Antimicrob Agents Chemother 2007;51:2559–63.
  • Gebhart BC, Barker BC, Markewitz BA. Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin. Pharmacotherapy 2007;27:476–9.
  • Sperber SJ, Levine JF, Gross PA. Persistent MRSA bacteremia in a patient with low linezolid levels. Clin Infect Dis 2002;36:675–6.

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