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Research Article

Severe sepsis and systemic inflammatory response syndrome in emergency department patients with suspected severe infection

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Pages 186-193 | Received 26 Sep 2011, Accepted 06 Aug 2012, Published online: 31 Oct 2012

References

  • Flaatten H. Epidemiology of sepsis in Norway in 1999. Crit Care 2004;8:R180–4.
  • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303–10.
  • Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, . Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34: 1589–96.
  • Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, . Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368–77.
  • Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, . Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296–327.
  • Wang HE, Shapiro NI, Angus DC, Yealy DM. National estimates of severe sepsis in United States emergency departments. Crit Care Med 2007;35:1928–36.
  • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, . Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644–55.
  • Trzeciak S, Zanotti-Cavazzoni S, Parrillo JE, Dellinger RP. Inclusion criteria for clinical trials in sepsis: did the American College of Chest Physicians/Society of Critical Care Medicine consensus conference definitions of sepsis have an impact?Chest 2005;127:242–5.
  • Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31:1250–6.
  • Vincent JL. Dear SIRS, I'm sorry to say that I don't like you. Crit Care Med 1997;25:372–4.
  • Cohen J, Guyatt G, Bernard GR, Calandra T, Cook D, Elbourne D, . New strategies for clinical trials in patients with sepsis and septic shock. Crit Care Med 2001;29: 880–6.
  • Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 1995;273:117–23.
  • Sprung CL, Sakr Y, Vincent JL, Le Gall JR, Reinhart K, Ranieri VM, . An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study. Intensive Care Med 2006;32: 421–7.
  • Salvo I, de Cian W, Musicco M, Langer M, Piadena R, Wolfler A, . The Italian SEPSIS study: preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med 1995;21(Suppl 2): S244–9.
  • Alberti C, Brun-Buisson C, Goodman SV, Guidici D, Granton J, Moreno R, . Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients. Am J Respir Crit Care Med 2003;168: 77–84.
  • Shapiro NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med 2003;31:670–5.
  • Gille-Johnson P, Hansson KE, Gårdlund B. Clinical and laboratory variables identifying bacterial infection and bacteraemia in the emergency department. Scand J Infect Dis 2012 Jul 17. [Epub ahead of print]
  • Robenshtok E, Shefet D, Gafter-Gvili A, Paul M, Vidal L, Leibovici L. Empiric antibiotic coverage of atypical pathogens for community acquired pneumonia in hospitalized adults. Cochrane Database Syst Rev 2008:(1); CD004418.
  • Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, . Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111–24.
  • Beale R, Reinhart K, Brunkhorst FM, Dobb G, Levy M, Martin G, . Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection 2009;37:222–32.
  • Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, . Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005;353:1332–41.
  • Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, . Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699–709.
  • Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, . Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med 2002;28:108–21.
  • Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, . Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA 1995;274:968–74.
  • Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, . Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009;37:1670–7.
  • Heffner AC, Horton JM, Marchick MR, Jones AE. Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Clin Infect Dis 2010;50:814–20.
  • Jones AE, Trzeciak S, Kline JA. The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med 2009;37: 1649–54.
  • Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, . Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011;39:2066–71.
  • Gaieski DF, Mikkelsen ME, Band RA, Pines JM, Massone R, Furia FF, . Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010;38:1045–53.
  • Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, . Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006;34: 344–53.
  • Darenberg J, Ihendyane N, Sjolin J, Aufwerber E, Haidl S, Follin P, . Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2003; 37:333–40.
  • Ortqvist A, Kalin M, Julander I, Mufson MA. Deaths in bacteremic pneumococcal pneumonia. A comparison of two populations—Huntington, WVa, and Stockholm, Sweden.Chest 1993;103:710–6.
  • Shapiro N, Howell MD, Bates DW, Angus DC, Ngo L, Talmor D. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med 2006;48:583–90, 590.e1.
  • Bossink AW, Groeneveld J, Hack CE, Thijs LG. Prediction of mortality in febrile medical patients: how useful are systemic inflammatory response syndrome and sepsis criteria?Chest 1998;113:1533–41.
  • Dremsizov T, Clermont G, Kellum JA, Kalassian KG, Fine MJ, Angus DC. Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?Chest 2006;129:968–78.
  • Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, . Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012;366: 2055–64.
  • Gibot S, Bene MC, Noel R, Massin F, Guy J, Cravoisy A, . Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med 2012;186: 65–71.
  • Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, . A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med 2009;37:96–104.

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