198
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Spleen enlargement is a common finding in acute Puumala hantavirus infection and it does not associate with thrombocytopenia

, , , &
Pages 723-726 | Received 12 Feb 2014, Accepted 28 May 2014, Published online: 14 Aug 2014

References

  • Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T, Vapalahti O. Hantavirus infections in Europe and their impact on public health. Rev Med Virol 2013;23: 35–49.
  • Vaheri A, Strandin T, Hepojoki J, Sironen T, Henttonen H, Mäkelä S, et al. Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol 2013;11:539–50.
  • Mustonen J, Mäkelä S, Outinen T, Laine O, Jylhävä J, Arstila PT, et al. The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions. Antiviral Res 2013;100:589–604.
  • Linderholm M, Ahlm C, Settergren B, Waage A, Tärnvik A. Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome. J Infect Dis 1996;173:38–43.
  • Mäkelä S, Mustonen J, Ala-Houhala I, Hurme M, Koivisto AM, Vaheri A, et al. Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala hantavirus-induced nephritis. Am J Kidney Dis 2004;43:809–16.
  • Terajima M, Hayasaka D, Maeda K, Ennis FA. Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: do CD8 + T cells trigger capillary leakage in viral hemorrhagic fevers?. Immunol Lett 2007;113:117–20.
  • Paakkala A, Mustonen J, Viander M, Huhtala H, Pasternack A. Complement activation in nephropathia epidemica caused by Puumala hantavirus. Clin Nephrol 2000;53:424–31.
  • Sane J, Laine O, Mäkelä S, Paakkala A, Jarva H, Mustonen J, et al. Complement activation in Puumala hantavirus infection correlates with disease severity. Ann Med 2012;44:468–75.
  • Lee M. Coagulopathy in patients with hemorrhagic fever with renal syndrome. J Korean Med Sci 1987;2:201–11.
  • Mosshammer D, Reichert E, Reichert W. Nephropathia epidemica caused by Puumala hantavirus infection: a case report from the outpatient sector. Dtsch Med Wochenschr 2010;135:2518–22.
  • Denecke B, Bigalke B, Haap M, Overkamp D, Lehnert H, Haas CS. Hantavirus infection: a neglected diagnosis in thrombocytopenia and fever?. Mayo Clin Proc 2010;85: 1016–20.
  • Baty V, Schuhmacher H, Bourgoin C, Latger V, Buisine J, May T, et al. [Hemophagocytic syndrome and hemorrhagic fever with renal syndrome.] Presse Med 1998;27:1577 (in French).
  • Lee JJ, Chung IJ, Shin DH, Cho SH, Cho D, Ryang DW, et al. Hemorrhagic fever with renal syndrome presenting with hemophagocytic lymphohistiocytosis. Emerg Infect Dis 2002;8:209–10.
  • Park KH, Kang YU, Kang SJ, Jung YS, Jang HC, Jung SI. Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea. Am J Trop Med Hyg 2011;84:229–33.
  • Alexeyev OA, Morozov VG, Efremov AG, Settergren B. A case of haemorrhagic fever with renal syndrome complicated by spleen haemorrhage. Scand J Infect Dis 1994;26:491–2.
  • Paakkala A, Dastidar P, Ryymin P, Huhtala H, Mustonen J. Renal MRI findings and their clinical associations in nephropathia epidemica: analysis of quantitative findings. Eur Radiol 2005;15:968–74.
  • Card J, Outschoorn UM. Hypersplenism and hyposplenism. In: Kaushansky K, Lichtman M, Beutler E, Kipps T, Prchal J, Seligsohn U, editors. Williams hematology, 8th edn. McGraw-Hill; 2010 pp 815–17.
  • Benter T, Klühs L, Teichgräber U. Sonography of the spleen. J Ultrasound Med 2011;30:1281–93.
  • Spielmann A, DeLong D, Kliewer M. Sonographic evaluation of spleen size in tall healthy athletes. Am J Roentgenol 2005;184:45–9.
  • Dommerby H, Stangerup SE, Stangerup M, Hancke S. Hepatosplenomegaly in infectious mononucleosis, assessed by ultrasonic scanning. J Laryngol Otol 1986;100:573–9.
  • Aster RH. Pooling of platelets in the spleen: role in the pathogenesis of “hypersplenic” thrombocytopenia. J Clin Invest 1966;45:645–57.
  • George JN. Platelets. Lancet 2000;355:1531–9.
  • Sironen T, Klingström J, Vaheri A, Andersson LC, Lundkvist Å, Plyusnin A. Pathology of Puumala hantavirus infection in macaques. PLoS One 2008;3:e3035.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.