Diagnostic potential of inflammatory markers in septic arthritis and periprosthetic joint infections: a clinical study with 719 patients

References

• Tarkowski A. Infection and musculoskeletal conditions: infectious arthritis. Best Pract Res Clin Rheumatol 2006;20:1029–44.
   PubMed Web of Science ®Google Scholar
• Carpenter CR, Schuur JD, Everett WW, Pines JM. Evidence-based diagnostics: adult septic arthritis. Acad Emerg Med 2011;18:781–96.
   PubMed Web of Science ®Google Scholar
• Shmerling RH, Delbanco TL, Tosteson AN, Trentham DE. Synovial fluid tests. What should be ordered? JAMA 1990;264:1009–14.
   Google Scholar
• Mathews CJ, Kingsley G, Field M, Jones A, Weston VC, Phillips M, et al. Management of septic arthritis: a systematic review. Ann Rheum Dis 2007;66:440–5.
   PubMed Web of Science ®Google Scholar
• Soderquist B, Jones I, Fredlund H, Vikerfors T. Bacterial or crystal-associated arthritis? Discriminating ability of serum inflammatory markers. Scand J Infect Dis 1998;30:591–6.
   Google Scholar
• Martinot M, Sordet C, Soubrier M, Puechal X, Saraux A, Liote F, et al. Diagnostic value of serum and synovial procalcitonin in acute arthritis: a prospective study of 42 patients. Clin Exp Rheumatol 2005;23:303–10.
   PubMed Web of Science ®Google Scholar
• Li SF, Cassidy C, Chang C, Gharib S, Torres J. Diagnostic utility of laboratory tests in septic arthritis. Emerg Med J 2007;24:75–7.
   PubMed Web of Science ®Google Scholar
• Jeng GW, Wang CR, Liu ST, Su CC, Tsai RT, Yeh TS, et al. Measurement of synovial tumor necrosis factor-alpha in diagnosing emergency patients with bacterial arthritis. Am J Emerg Med 1997;15:626–9.
   PubMed Web of Science ®Google Scholar
• Trampuz A, Hanssen AD, Osmon DR, Mandrekar J, Steckelberg JM, Patel R. Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med 2004;117:556–62.
   PubMed Web of Science ®Google Scholar
• Lenski M, Scherer MA. Analysis of synovial inflammatory markers to differ infectious from gouty arthritis. Clin Biochem 2014;47:49–55.
   PubMedGoogle Scholar
• Lenski M, Scherer MA. Synovial IL-6 as inflammatory marker in periprosthetic joint infections. J Arthroplasty 2014;29:1105–9.
   PubMedGoogle Scholar
• Lenski M, Scherer MA. The significance of interleukin-6 and lactate in the synovial fluid for diagnosing native septic arthritis. Acta Orthop Belg 2014;80:18–25.
   PubMedGoogle Scholar
• Gratacos J, Vila J, Moya F, Marcos MA, Collado A, Sanmarti R, et al. D-Lactic acid in synovial fluid. A rapid diagnostic test for bacterial synovitis. J Rheumatol 1995;22:1504–8.
   Google Scholar
• Riordan T, Doyle D, Tabaqchali S. Synovial fluid lactic acid measurement in the diagnosis and management of septic arthritis. J Clin Pathol 1982;35:390–4.
   PubMedGoogle Scholar
• Mossman SS, Coleman JM, Gow PJ. Synovial fluid lactic acid in septic arthritis. N Z Med J 1981;93:115–7.
   PubMedGoogle Scholar
• Brook I, Reza MJ, Bricknell KS, Bluestone R, Finegold SM. Synovial fluid lactic acid. A diagnostic aid in septic arthritis. Arthritis Rheum 1978;21:774–9.
   PubMedGoogle Scholar
• Brown MD, Reeves MJ. Evidence-based emergency medicine/skills for evidence-based emergency care. Interval likelihood ratios: another advantage for the evidence-based diagnostician. Ann Emerg Med 2003;42:292–7.
   Google Scholar
• Ghanem E, Parvizi J, Burnett RS, Sharkey PF, Keshavarzi N, Aggarwal A, et al. Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty. J Bone Joint Surg Am 2008;90:1637–43.
   PubMed Web of Science ®Google Scholar
• Fottner A, Birkenmaier C, von Schulze Pellengahr C, Wegener B, Jansson V. Can serum procalcitonin help to differentiate between septic and nonseptic arthritis? Arthroscopy 2008;24:229–33.
   PubMed Web of Science ®Google Scholar
• Ernst AA, Weiss SJ, Tracy LA, Weiss NR. Usefulness of CRP and ESR in predicting septic joints. South Med J 2010;103:522–6.
   PubMed Web of Science ®Google Scholar
• Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, et al. New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 2011;469:2992–4.
   PubMed Web of Science ®Google Scholar
• Gallagher EJ. Evidence-based emergency medicine/editorial. The problem with sensitivity and specificity. Ann Emerg Med 2003;42:298–303.
   PubMedGoogle Scholar
• Andersson RE, Hugander AP, Ghazi SH, Ravn H, Offenbartl SK, Nystrom PO, et al. Diagnostic value of disease history, clinical presentation, and inflammatory parameters of appendicitis. World J Surg 1999;23:133–40.
   PubMedGoogle Scholar
• Krey PR, Bailen DA. Synovial fluid leukocytosis. A study of extremes. Am J Med 1979;67:436–42.
   PubMed Web of Science ®Google Scholar
• Schlapbach P, Ambord C, Blochlinger AM, Gerber NJ. Bacterial arthritis: are fever, rigors, leucocytosis and blood cultures of diagnostic value? Clin Rheumatol 1990;9:69–72.
   PubMedGoogle Scholar
• Kortekangas P, Aro HT, Tuominen J, Toivanen A. Synovial fluid leukocytosis in bacterial arthritis vs. reactive arthritis and rheumatoid arthritis in the adult knee. Scand J Rheumatol 1992;21:283–8.
   PubMed Web of Science ®Google Scholar
• Li SF, Henderson J, Dickman E, Darzynkiewicz R. Laboratory tests in adults with monoarticular arthritis: can they rule out a septic joint? Acad Emerg Med 2004;11:276–80.
   PubMed Web of Science ®Google Scholar
• McGillicuddy DC, Shah KH, Friedberg RP, Nathanson LA, Edlow JA. How sensitive is the synovial fluid white blood cell count in diagnosing septic arthritis? Am J Emerg Med 2007;25:749–52.
   PubMedGoogle Scholar
• Giles JT, Bartlett SJ, Andersen R, Thompson R, Fontaine KR, Bathon JM. Association of body fat with C-reactive protein in rheumatoid arthritis. Arthritis Rheum 2008;58:2632–41.
   PubMed Web of Science ®Google Scholar
• Emery P, Gabay C, Kraan M, Gomez-Reino J. Evidence-based review of biologic markers as indicators of disease progression and remission in rheumatoid arthritis. Rheumatol Int 2007;27:793–806.
   PubMed Web of Science ®Google Scholar
• Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 2005;69:29–35.
   PubMed Web of Science ®Google Scholar
• Neumaier M, Scherer MA. C-reactive protein levels for early detection of postoperative infection after fracture surgery in 787 patients. Acta Orthop 2008;79:428–32.
   PubMed Web of Science ®Google Scholar
• Paakkonen M, Kallio MJ, Kallio PE, Peltola H. Shortened hospital stay for childhood bone and joint infections: analysis of 265 prospectively collected culture-positive cases in 1983–2005. Scand J Infect Dis 2012;44:683–8.
   PubMed Web of Science ®Google Scholar
• Cooper C, Cawley MI. Bacterial arthritis in an English health district: a 10 year review. Ann Rheum Dis 1986;45:458–63.
   PubMed Web of Science ®Google Scholar
• Argen RJ, Wilson CH Jr, Wood P. Suppurative arthritis. Clinical features of 42 cases. Arch Intern Med 1966;117:661–6.
   Google Scholar
• Goldenberg DL, Cohen AS. Acute infectious arthritis. A review of patients with nongonococcal joint infections (with emphasis on therapy and prognosis). Am J Med 1976;60:369–77.
   Google Scholar
• Aronson D, Bartha P, Zinder O, Kerner A, Markiewicz W, Avizohar O, et al. Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome. Int J Obes Relat Metab Disord 2004;28:674–9.
   PubMed Web of Science ®Google Scholar
• Sjoqvist C, Snarski E. Inflammatory markers in patients after hematopoietic stem cell transplantation. Arch Immunol Ther Exp (Warsz) 2013;61:301–7.
   PubMedGoogle Scholar
• Svaldi M, Hirber J, Lanthaler AI, Mayr O, Faes S, Peer E, et al. Procalcitonin-reduced sensitivity and specificity in heavily leucopenic and immunosuppressed patients. Br J Haematol 2001;115:53–7.
   PubMed Web of Science ®Google Scholar
• Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty 2007;22 (6 Suppl 2):90–3.
   PubMedGoogle Scholar
• Bedair H, Ting N, Jacovides C, Saxena A, Moric M, Parvizi J, et al. The Mark Coventry Award: diagnosis of early postoperative TKA infection using synovial fluid analysis. Clin Orthop Relat Res 2011;469:34–40.
   PubMed Web of Science ®Google Scholar
• Cipriano CA, Brown NM, Michael AM, Moric M, Sporer SM, Della Valle CJ. Serum and synovial fluid analysis for diagnosing chronic periprosthetic infection in patients with inflammatory arthritis. J Bone Joint Surg Am 2012;94:594–600.
   PubMedGoogle Scholar
• Spangehl MJ, Masri BA, O’Connell JX, Duncan CP. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg Am 1999;81:672–83.
   PubMed Web of Science ®Google Scholar
• Trampuz A, Piper KE, Jacobson MJ, Hanssen AD, Unni KK, Osmon DR, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 2007;357:654–63.
   PubMed Web of Science ®Google Scholar
• Nilsdotter-Augustinsson A, Briheim G, Herder A, Ljunghusen O, Wahlstrom O, Ohman L. Inflammatory response in 85 patients with loosened hip prostheses: a prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening. Acta Orthop 2007;78:629–39.
   PubMed Web of Science ®Google Scholar
• Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RS, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res 2008;466:2628–33.
   PubMedGoogle Scholar
• Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am 2008;90:1869–75.
   PubMed Web of Science ®Google Scholar
• Hugle T, Schuetz P, Mueller B, Laifer G, Tyndall A, Regenass S, et al. Serum procalcitonin for discrimination between septic and non-septic arthritis. Clin Exp Rheumatol 2008;26:453–6.
   PubMed Web of Science ®Google Scholar
• Faesch S, Cojocaru B, Hennequin C, Pannier S, Glorion C, Lacour B, et al. Can procalcitonin measurement help the diagnosis of osteomyelitis and septic arthritis? A prospective trial. Ital J Pediatr 2009;35:33.
   PubMed Web of Science ®Google Scholar
• Butbul-Aviel Y, Koren A, Halevy R, Sakran W. Procalcitonin as a diagnostic aid in osteomyelitis and septic arthritis. Pediatr Emerg Care 2005;21:828–32.
   PubMed Web of Science ®Google Scholar
• Maharajan K, Patro DK, Menon J, Hariharan AP, Parija SC, Poduval M, et al. Serum Procalcitonin is a sensitive and specific marker in the diagnosis of septic arthritis and acute osteomyelitis. J Orthop Surg Res 2013;8:19.
   PubMed Web of Science ®Google Scholar
• Di Cesare PE, Chang E, Preston CF, Liu CJ. Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am 2005;87:1921–7.
   PubMedGoogle Scholar