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Original Article

Is Penicillin the Appropriate Treatment for Recurrent Tonsillopharyngitis? Results from a Comparative Randomized Blind Study of Cefuroxime Axetil and Phenoxymethylpenicillin in Children

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Pages 221-228 | Received 12 Nov 1994, Accepted 14 Mar 1995, Published online: 08 Jul 2009

References

  • Denny F. W., Wannamaker L. W., Brink W. R., et al. Prevention of rheumatic fever: treatment of the preceding streptococcal infections. JAMA 1950; 143: 151–153
  • Gastanaduy A. S., Kaplan E. L., Huwe B. B., , Failure of penicillin to eradicate Group, et al. A streptococci during an outbreak of pharyngitis. Lancet 1980; 2: 498–501
  • Stillerman M., Comparison of oral cephalosporins with penicillin therapy for Group. A streptococcal pharyngitis. Pediatr Infect Dis J 1986; 5: 649–654
  • Pichichero M. E., The rising incidence of penicillin treatment failures in Group. A streptococcal tonsillopharyngitis: an emerging role for the cephalosporins?. Pediatr Infect Dis J 1991; 10: 50–55
  • Brook I., Treatment of patients with acute recurrent tonsillitis due to Group. A b˜-haemolytic streptococci: a prospective randomized study comparing penicillin and amoxycillin clavulanate potassium. J Antimicrob Chemother 1989; 24: 227–253
  • Kaplan E. L., Johnsson D. R., Clinical and laboratory observations: Eradication of Group. A streptococci from the upper respiratory tract by amoxicillin with clavulanate after oral penicillin V treatment failure. J Pediatr 1988; 113: 400–403
  • Pichichero M. E., Margolis P. A., A comparison of cephalosporins and penicillin in the treatment of Group. A beta-hemolytic streptococcal pharyngitis: a meta-analysis supporting the concept of microbial copathogenicity. Pediatr Infect Dis J 1991; 10: 275–281
  • Holm S. E. Reasons for failures in penicillin treatment of streptococcal tonsillitis and possible alternatives. Pediatr Infect Dis J 1994; 13: 66–69
  • Maxted W. R., Widdowson J. P., The protein antigens of Group. A streptococci. Streptococci and Streptococcal Diseases, L. W. Wannamaker, J. M. Matsen. Academic Press, New York 1972; 251–264
  • Ericsson H. M., Sherris J. S. Antïoiotic sensitivity testing: Report of an international collaborative study. Acta Pathol Microbiol Scand [B] 1971, Suppl 217
  • O'Callaghan C. H., Morris A., Kirkby S. M., Shingler A. Novel method for detection of beta-lactamase by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother 1972; 1: 283–288
  • Roos K., Grahn E., Holm S. E. Evaluation of beta-lactamase activity and microbial interference in treatment failures of acute streptococcal tonsillitis. Scand J Infect Dis 1986; 18: 313–319
  • Holm S. E., Roos K., Strömberg A. A randomised study of treatment of streptococcal tonsillopharyngitis with cefadroxil or phenoxy-methylpenicillin (penicillin V). Pediatr Infect Dis J 1991; 10: 68–71
  • Strömberg A., Schwan A., Cars O., Five versus 10 days treatment of group. A streptococcal tonsillopharyngitis: a randomized controlled clinical trial with phenoxymethylpenicillin and cefadroxil. Scand J Infect Dis 1988; 20: 37–46
  • Milatovic D. Evaluation of cefadroxil, penicillin and erythromycin in the treatment of streptococcal tonsillo-pharyngitis. Pediatr Infect Dis J 1991; 10: 61–63
  • Milatovic D., Knauer J. Cefadroxil versus penicillin in the treatment of pharyngitis. Eur J Clin Microbiol Infect Dis 1989; 8: 282–288
  • Pichichero M. E., Disney E. A., Aronowitz G. H., et al. Randomised, single-blind evaluation of cefadroxil and phenoxymethyl penicillin in the treatment of streptococcal pharyngitis. Antimicrob Agents Chemother 1987; 31: 903–906
  • Pichichero M. E., McLinn S. E., Gooch M. W., , Ceftibuten vs penicillin V in Group, et al. A beta-hemolytic streptococcal pharyngitis. Pediatr Infect Dis J 1993; 12: 64–69
  • Stjernquist-Desatnik A., Orrling A., Kamme C., Schalén C., Eradication of group. A streptococci from the throat after oral penicillin V treatment failure: A comparison between clindamycin and penicillin V. Proceedings of XII Lancefield symposium on streptococci and streptococcal diseases. 1993. St Petersburg Sept., 1993, [in press]
  • Pichichero M. Cephalosporins are superior to penicillin for treatment of streptococcal tonsillopharyngitis: is the difference worth it?. Pediatr Infect Dis J 1993; 12: 268–274
  • Shulman S. T., Gerber M. A., Tanz R. R., Markowitz M. Streptococcal pharyngitis: the case for penicillin therapy. Pediatr Infect Dis J 1993; 13: 1–7
  • Markowitz M., Gerber M. A., Kaplan E. L. Treatment of streptococcal tonsillopharyngitis: Reports of penicillin's demise are premature. J Pediatr 1993; 123: 679–685
  • Tunér K., Nord C. E. Emergence of beta-lactamase producing bacteria in the tonsils during penicillin treatment. Eur J Clin Microbiol 1986; 5: 399–404
  • Grahn E., Holm S. E., Roos K. Penicillin tolerance in beta-streptococci isolated from patients with tonsillitis. Scand J Infect Dis 1987; 19: 421–426
  • Kim K. S., Kaplan E. L., Association of penicillin tolerance with failure to eradicate Group. A streptococci from patients with pharyngitis. J Pediatr 1985; 107: 681–684
  • Wise R., Bercnet S. A., Dent J. The pharmacokinetics of orally absorbed cefuroxime compared with amoxycillin-clavulanic acid. J Antimicrob Chemother 1984; 13: 603–610
  • Grahn E., Holm S. E. Bacterial interference in the throat flora during a streptococcal tonsillitis outbreak in an apartment house area. Zbl Bakt Hyg A 1983; 256: 72–79
  • Brook I. The role of b˜-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection. Rev Infect Dis 1984; 6: 601–607
  • Roos K., Holm S. E., Grahn E., Lind L. Alpha-streptococci as supplementary treatment of recurrent streptococcal tonsillitis: a randomized placebo controlled study. Scand J Infect Dis 1993; 25: 31–35
  • Kaplan E. L., Gastanaduy A. S., Huwe B. B., The role of the carrier in treatment failures after antibiotic treatment for group. A streptococci in the upper respiratory tract. J Lab Clin Med 1981; 98: 326–335
  • Strömberg A., Schwan A., Cars O. Throat carrier rates of beta-haemolytic Streptococci among healthy adults and children. Scand J Infect Dis 1988; 20: 411–417

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