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Original Article

Effects of Intravesical Instillation of 5-Fluorouracil and Interferon in Patients with Recurrent Superficial Urinary Bladder Carcinoma: A Clinical and Pharmacodynamic Study

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Pages 343-347 | Received 10 May 1996, Accepted 04 Oct 1996, Published online: 09 Jul 2009

References

  • Chodak G W. Intravesical interferon treatment of superficial bladder cancer. Urology 1989; 34(4 Suppl)84–86
  • Conrad A H, Ruddle F H. Regulation of thymidylate synthase activity in cultured mammalian cells. J Cell Sci 1972; 10: 471–486
  • Engelmann U, Knopf H J, Graff J. Interferon‐alpha 2b instillation prophylaxis in superficial bladder cancer: a prospective, controlled three‐armed trial, project group bochum: interferon and superficial bladder cancer. Anticancer Drugs 1992; 1: 33–37
  • Ferrari P, Castagnetti G, Pollastri C A, Ferrari G, Tavoni F, Grassi D. Chemoimmunotherapy for prophylaxis of recurrence in superficial bladder cancer: interferon‐alpha 2b versus interferon‐alpha 2b with epirubicin. Anticancer Drugs 1992; 1: 25–27
  • Hoelt W, Hasun R, Albrecht W. Prospective, randomized trial to evaluate high‐versus low‐dose interferon‐alpha 2b versus conventional chemotherapy in prevention of the recurrence of superficial transitional cell carcinoma of the urinary bladder. Anticancer Drugs 1992; 1: 29–32
  • Horikoshi T, Danenberg K D, Stadlbauer T HW, et al. Quantitation of thymidylate synthase, Dihydrofolate reductase, and DT‐ Diaphorase Gene expression in Human Tumours using the Polymerase Chain Reaction. Cancer Res 1992; 52: 108–116
  • Huland H, Klöppel G, Feddersen I, et al. Comparison of different schedules of cytostatic intravesical instillations in patients with superficial bladder carcinoma: Evaluation of a prospective multicenter study with 419 patients. J Urol 1990; 144: 68–72
  • Kim S, Mo S H, Yun H J, et al. Synergistic antitumour effects of 5‐fluorouracil (5‐FU) and alpha‐interferon 2a in gastic cancer cells. Proc Annu Meet Am Assoc Cancer Res 1993; 34: A1677
  • Lamm D L. Diagnosis and treatment of bladder cancer. Anticancer Drugs 1992; 3(Suppl)39–47
  • Leissner K ‐H, Johansson S. Topical application of 5‐fluorouracil cream: a therapeutic alternative in the treatment of urothelial tumours of the distal urethra. A case report. Scand J Urol Nephrol 1980; 14: 115
  • Leissner K ‐H, Gustavsson B. Intravesical high dose 5‐fluorouracil instillations combined with allopurinol‐ A therapeutic alternative in the treatment of multiple bladder tumours. J Urol 1984; 132: 34–36
  • Malmström P ‐U, Busch C, Norlén B J. Recurrence, progression and survival in bladder cancer. Scand J Urol Nephrol 1987; 21: 185–195
  • Martinez‐Pineiro J A, León J J, Martinez‐Pineiro L J. Bacillus Calmette‐Guerin versus doxyrubicin versus thiotepa: A randomizedprospective study in 202 patients with superficial bladder cancer. J Urol 1990; 143: 502–506
  • Migliari R, El‐Demiry M, Muscas G, Usai E. Intravesical instillation of beta‐interferon in the treatment of sladder cancer. Br J Urol 1992; 70: 169–173
  • Spears C P, Gustavsson B G, Berne M, Frosing R. Mechanisms of innate resistance to Thymidylate inhibition after 5‐fluorouracil. Cancer Res 1984; 48: 5894–5900
  • Spears C P, Gustavsson B G. Serial biopsy, free and total TS, FdUMP and dUMP. Adv Exp Med Biol 1988; 244: 97–106
  • Rawls W H, Lamm D L, Low B A. Fatal sepsis following bacillus Calmette‐Guerin administration for bladder cancer. J Urol 1990; 144: 1328–1331
  • Sarosdy M. High‐dose versus low‐dose intravesical interferon‐alpha 2b in the treatment of carcinoma in situ; a randomized, controlled study. Anticancer Drugs 1992; 1: 13–7
  • Sparano J A, Wadler S, Schwartz B L, Diasio R. Clinical and pharmacological studies of interferon and chemotherapy in gastrointestinal and breast cancer. Int J Clin Pharmacol Res 1993; 13: 1–9
  • Spears C P, Gustafsson B, Frosing R. Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration. Investigational New Drugs 1989; 7: 27–36
  • Soloway M S, Perito P E. Superficial bladder cancer: diagnosis surveillance and treatment. J Cell Biochem 1992; 161: 120–127, (Suppl)
  • Torti F M, Lum B L. The biology and treatment of superficial bladder cancer. J Clin Oncol 1984; 2: 505–531
  • Torti F M, Shortliffe L D, Williams R D. Alpha‐interferon in superficial bladder cancer: A Northern California Oncology Group study. J Clin Oncol 1988; 6: 476–483
  • Van der Wilt C L, Pinedo H M, Smid K, Peters G J. Elevation of thymidylate synthase following 5‐flourour‐acil treatment is prevented by the addition of leucovorin in murine colon tumours. Cancer Res 1992; 52: 4922–4928

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