CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes

References

• Anzenbacher P, Soucek P, Anzenbacherova E, Gut I, Hruby K, Svoboda Z, Kvetina J. (1998). Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. Drug Metab Dispos 26:56–9.
   PubMed Web of Science ®Google Scholar
• Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J, Wrighton SA. (2003). The conduct of in vitro and in vivo drug–drug interaction studies: a PhRMA perspective. J Clin Pharmacol 43:443–69.
   PubMed Web of Science ®Google Scholar
• Cheng HY, Hsieh MT, Wu CR, Tsai FH, Lu TC, Hsieh CC, Li WC, Lin YT, Peng WH. (2008). Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity. J Pharmacol Sci 107:21–31.
   PubMed Web of Science ®Google Scholar
• Cui YY, Wang MZ. (1992). Metabolic transformation of schizandrin. Acta Pharmaceutica Sinica 27:57–63.
   PubMedGoogle Scholar
• Cui YY, Wang MZ. (1993). Aspects of schizandrin metabolism in vitro and in vivo. Eur J Drug Metab Pharmacokinet 18:155–60.
   Google Scholar
• Egashira N, Kurauchi K, Iwasaki K, Mishima K, Orito K, Oishi R, Fujiwara M. (2008). Schizandrin reverses memory impairment in rats. Phytother Res 22:49–52.
   PubMedGoogle Scholar
• Emoto C, Murase S, Sawada Y, Jones BC, Iwasaki K. (2003). In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalysed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. Drug Metab Pharmacokinet 18:287–95.
   PubMedGoogle Scholar
• Ikeya Y, Sugama K, Tanaka M, Wakamatsu T, Ono H, Takeda S, Oyama T, Maruno M. (1995). Structure determination of biliary metabolites of schizandrin in rat and dog. Chem Pharm Bull 43:121–9.
   PubMed Web of Science ®Google Scholar
• Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T. (2004). Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 32:1351–8.
   PubMed Web of Science ®Google Scholar
• Kararli TT. (1995). Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 16:351–80.
   PubMed Web of Science ®Google Scholar
• Kim SJ, Min HY, Lee EJ, Kim YS, Bae K, Kang SS, Lee SK. (2009). Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytother Res Epub ahead of print.
   Google Scholar
• Kobayashi K, Mimura N, Fujii H, Minami H, Sasaki Y, Shimada N, Chiba K. (2000). Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate. Clin Cancer Res 6:3297–303.
   PubMed Web of Science ®Google Scholar
• Li J, Liu Y, Zhang JW, Wei H, Yang L. (2006). Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs. Comp Med 56:286–90.
   PubMed Web of Science ®Google Scholar
• Liao QF, Yang W, Jia Y, Chen XH, Gao QT, Bi KS. (2005). LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional Chinese medicine preparation Lu-Ying extract. Yakugaku Zasshi 125:509–15.
   PubMed Web of Science ®Google Scholar
• Lin JH. (1995). Species similarities and differences in pharma-cokinetics. Drug Metab Dispos 23:1008–21.
   PubMed Web of Science ®Google Scholar
• Liu HX, Hu Y, Liu Y, He YQ, Li W, Yang L. (2009). Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6. Xenobiotica 39:382–90.
   PubMed Web of Science ®Google Scholar
• Liu HX, Liu Y, Zhang JW, Li W, Liu HT, Yang L. (2008). UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes. Drug Metab Dispos 36:1562–9.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. (2006). Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci 91:356–64.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75.
   PubMed Web of Science ®Google Scholar
• Maeda S, Sudo K, Aburada M, Ikeya Y, Taguchi H, Yoshioka I, Harada M. (1981). Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin [authors’ translation]. Yakugaku Zasshi 101:1030–41.
   PubMedGoogle Scholar
• Maeda S, Sudo K, Miyamoto Y, Takeda S, Shinbo M, Aburada M, Ikeya Y, Taguchi H, Harada M. (1982). Pharmacological studies on schizandra fruits. II. Effects of constituents of Shizandra fruits on drugs induced hepatic damage in rats. Yakugaku Zasshi 102:579–88.
   PubMed Web of Science ®Google Scholar
• Niu XY, Bian ZJ, Ren ZH. (1983). The metabolic fate of schizandrol A and its distribution in brain in rats determined by TLC method. Yao Xue Xue Bao 187:491–5.
   Google Scholar
• Omura T, Sato R. (1964). The carbon monoxide-binding pigment of liver microsomes. I. evidence for its hemoprotein nature. J Biol Chem 239:2370–85.
   PubMed Web of Science ®Google Scholar
• Rae JM, Soukhova NV, Flockhart DA, Desta Z. (2002). Triethylene-thiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism. Drug Metab Dispos 30:525–30.
   PubMed Web of Science ®Google Scholar
• Rath K, Taxis K, Walz G., Gleiter CH, Li SM, Heide L. (2004). Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annual Wormwood). Am J Trop Med Hyg 70:128–32.
   PubMed Web of Science ®Google Scholar
• Walsky RL, Obach RS, Gaman EA, Gleeson JP and Proctor WR. (2005). Selective inhibition of human cytochrome P4502C8 by montelukast. Drug Metab Dispos 33:413–18.
   PubMed Web of Science ®Google Scholar
• Wang SC, Huangfu MJ, Zhao HP, Cao ZF. (2004a). Pharmacokinetic study of schizandrin in Wuling capsules in mice. Lishizhen Med Materia Medica Res 15:468–70.
   Google Scholar
• Wang SC, Zhao HP, Huanfu MJ, Li XW. (2004b). Pharmacokinetic effect of the combination of Fructus schisandrae and Radix salvia miltiorrhizae on schizandrol A and schizandrin B. Chin Trad Pat Med 26:987–91.
   Google Scholar
• Xu M, Wang G, Xie H, Huang Q, Wang W, Jia Y. (2008). Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus schisandrae aqueous extract and Sheng-Mai-San to rats. J Ethnopharmacol 115:483–8.
   PubMed Web of Science ®Google Scholar
• Xu M, Wang G, Xie H, Wang R, Wang W, Li X, Li H, Zhu D, Yue L. (2005). Determination of schizandrin in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci 828:55–61.
   PubMed Web of Science ®Google Scholar
• Xu MJ, Wang GJ, Xie HT, Huang Q, Jia YW. (2007). Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes Acta Pharmaceutica Sinica 42:730–4.
   Google Scholar
• Xu MJ, Wang GJ, Xie HT, Huang Q, Li P, Jia YW, Wu XL. (2006). The study of low bioavailability of schizandrin in rats. Drug Metab Rev 38:95–6.
   Google Scholar
• Zhang JW, Liu Y, Cheng J, Li W, Ma H, Liu HT, Sun J, Wang LM, He YQ, Wang Y, Wang ZT, Yang L. (2007). Inhibition of human liver cytochrome P450 by star fruit juice. J Pharm Pharm Sci 10:496–503.
   PubMed Web of Science ®Google Scholar
• Zhang JW, Liu Y, Zhao JY, Wang LM, Ge GB, Gao Y, Li W, Liu HT, Liu HX, Zhang YY, Sun J, Yang L. (2008). Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Drug Metab Dispos 36:2292–8.
   PubMed Web of Science ®Google Scholar
• Zhang YY, Liu Y, Zhang JW, Ge GB, Wang LM, Sun J, Yang L. (2009). Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel Xenobiotica 39:283–92.
   PubMed Web of Science ®Google Scholar
• Zhang YY, Yang L. (2009). Interactions between human cyto-chrome P450 enzymes and steroids: physiological and pharmacological implications. Expert Opin Drug Metab Toxicol 5:621–9.
   PubMed Web of Science ®Google Scholar
• Zhou SF. (2008). Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 9:310–22.
   PubMed Web of Science ®Google Scholar