Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 3
284
Views
24
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats

, , , , , , , & show all
Pages 207-216 | Received 29 Sep 2009, Accepted 28 Oct 2009, Published online: 10 Feb 2010

References

  • Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res 10:1093–5.
  • Honda T, Kubo S, Masuda T, Arai M, Kobayashi Y, Yamashita M. (2009). Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en. Bioorg Med Chem Lett 19:2938–40.
  • Honda T, Masuda T, Yoshida S, Arai M, Kaneko S, Yamashita M. (2002b). Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir. Bioorg Med Chem Lett 12:1925–28.
  • Honda T, Masuda T, Yoshida S, Arai M, Kobayashi Y, Yamashita M. (2002a). Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives. Bioorg Med Chem Lett 12:1921–24.
  • Ishizuka H, Yoshiba S, Okabe H, Yoshihara K. (Forthcoming 2009). Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers. J Clin Pharmacol (In Press).
  • Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. (2009). In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460:1021–5.
  • Koyama K, Takahashi M, Oitate M, Nakai N, Takakusa H, Miura SI, Okazaki O. (2009). CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long retention profile in the mouse respiratory tract. Antimicrob Agents Chemother 53:4845–51.
  • Neumann G, Noda T, Kawaoka Y. (2009). Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459:931–9.
  • Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S. (2009). CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother 53:186–92.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.