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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 8
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General Xenobiochemistry

The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19

Yuan ChenDepartment of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, CA, USA
,
Hua-fen LiuAB SCIEX, Foster City, CA, USA
,
Liling LiuDepartment of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, CA, USA
,
Khanh NguyenDepartment of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, CA, USA
,
Elliott B. JonesAB SCIEX, Foster City, CA, USA
&
Adrian J. FretlandDepartment of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, CA, USACorrespondence[email protected]
Pages 536-546 | Received 16 Mar 2010, Accepted 10 May 2010, Published online: 09 Jun 2010

References

  • Code EL, Crespi CL, Penman BW, Gonzalez FJ, Chang TK, Waxman DJ. (1997). Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos 25:985–993.
  • Ekins S, Vandenbranden M, Ring BJ, Gillespie JS, Yang TJ, Gelboin HV, Wrighton SA. (1998). Further characterization of the expression in liver and catalytic activity of CYP2B6. J Pharmacol Exp Ther 286:1253–1259.
  • Faucette SR, Hawke RL, Lecluyse EL, Shord SS, Yan B, Laethem RM, Lindley CM. (2000). Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metab Dispos 28:1222–1230.
  • Faucette SR, Hawke RL, Shord SS, Lecluyse EL, Lindley CM. (2001). Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation. Drug Metab Dispos 29:1123–1129.
  • Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ. (2000). CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug Metab Dispos 28:1176–1183.
  • Kirchheiner J, Klein C, Meineke I, Sasse J, Zanger UM, Mürdter TE, Roots I, Brockmöller J. (2003). Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics 13:619–626.
  • Lai AA, Schroeder DH. (1983). Clinical pharmacokinetics of bupropion: a review. J Clin Psychiatry 44:82–84.
  • Laizure SC, DeVane CL, Stewart JT, Dommisse CS, Lai AA. (1985). Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose. Clin Pharmacol Ther 38:586–589.
  • Lester CET, Singh R, Sai Y, Jonson RL. (1995) The identification of in vitro metabolites of bupropion using ion trap mass spectrometry. Rapid Commun Mass Spectrom 9:902–910.
  • Loboz KK, Gross AS, Williams KM, Liauw WS, Day RO, Blievernicht JK, Zanger UM, McLachlan AJ. (2006). Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity. Clin Pharmacol Ther 80:75–84.
  • Posner J, Bye A, Dean K, Peck AW, Whiteman PD. (1985). The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses. Eur J Clin Pharmacol 29:97–103.
  • Petsalo A, Turpeinen M, Tolonen A. (2007). Identification of bupropion urinary metabolites by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 21:2547–2554.
  • Schroeder DH. (1983). Metabolism and kinetics of bupropion. J Clin Psychiatry 44:79–81.
  • Schroeder DH, Eiseman JL, Mehta NB, Brent DA, Soroko FE, Welch RM. (1979). The isolation and identification of some basic urinary metabolites of bupropion HCL in man. Pharmacologist 21:191.
  • Turpeinen M, Tolonen A, Uusitalo J, Jalonen J, Pelkonen O, Laine K. (2005). Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Clin Pharmacol Ther 77:553–559.
  • Turpeinen M, Raunio H, Pelkonen O. (2006). The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico. Curr Drug Metab 7:705–714.
  • Welch RM, Lai AA, Schroeder DH. (1987). Pharmacological significance of the species differences in bupropion metabolism. Xenobiotica 17:287–298.

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