Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 6
686
Views
80
CrossRef citations to date
0
Altmetric
Pharmacogenetics

Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations

, , , , , , , & show all
Pages 501-510 | Received 08 Dec 2010, Accepted 13 Jan 2011, Published online: 22 Feb 2011

References

  • Arrese M, Trauner M, Ananthanarayanan M, Pizarro M, Solís N, Accatino L, Soroka C, Boyer JL, Karpen SJ, Miquel JF, Suchy FJ. (2003). Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat. J Hepatol 38:148–155.
  • Bhat BG, Rapp SR, Beaudry JA, Napawan N, Butteiger DN, Hall KA, Null CL, Luo Y, Keller BT. (2003). Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE−/− mice by SC-435. J Lipid Res 44:1614–1621.
  • Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA. (1998). Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol 274:G157–G169.
  • Criado JJ, Domínguez MF, Medarde M, Fernández ER, Macías RI, Marín JJ. (2000). Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate(O,O′) Pt(II) and cis-diamminebis-ursodeoxycholate(O,O′) Pt(II) complexes. Bioconjug Chem 11:167–174.
  • Dawson PA, Oelkers P. (1995). Bile acid transporters. Curr Opin Lipidol 6:109–114.
  • Deng JW, Shon JH, Shin HJ, Park SJ, Yeo CW, Zhou HH, Song IS, Shin JG. (2008). Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Pharm Res 25:1807–1814.
  • Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. (2002). The structure of haplotype blocks in the human genome. Science 296:2225–2229.
  • Hagenbuch B, Stieger B, Foguet M, Lübbert H, Meier PJ. (1991). Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci USA 88:10629–10633.
  • Ho RH, Leake BF, Roberts RL, Lee W, Kim RB. (2004). Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem 279:7213–7222.
  • Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, Kim RB. (2006). Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 130:1793–1806.
  • Holzer A, Harsch S, Renner O, Strohmeyer A, Schimmel S, Wehkamp J, Fritz P, Stange EF. (2008). Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion 78:52–59.
  • Huff MW, Telford DE, Edwards JY, Burnett JR, Barrett PH, Rapp SR, Napawan N, Keller BT. (2002). Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB. Arterioscler Thromb Vasc Biol 22:1884–1891.
  • Jung D, Fantin AC, Scheurer U, Fried M, Kullak-Ublick GA. (2004). Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut 53:78–84.
  • Jung D, Fried M, Kullak-Ublick GA. (2002). Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. J Biol Chem 277:30559–30566.
  • Kang HJ, Song IS, Shin HJ, Kim WY, Lee CH, Shim JC, Zhou HH, Lee SS, Shin JG. (2007). Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population. Drug Metab Dispos 35:667–675.
  • Kitamura S, Maeda K, Wang Y, Sugiyama Y. (2008). Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos 36:2014–2023.
  • Love MW, Craddock AL, Angelin B, Brunzell JD, Duane WC, Dawson PA. (2001). Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. Arterioscler Thromb Vasc Biol 21:2039–2045.
  • Mareninova O, Shin JM, Vagin O, Turdikulova S, Hallen S, Sachs G. (2005). Topography of the membrane domain of the liver Na+-dependent bile acid transporter. Biochemistry 44:13702–13712.
  • Oelkers P, Kirby LC, Heubi JE, Dawson PA. (1997). Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest 99:1880–1887.
  • Pourmand N, Elahi E, Davis RW, Ronaghi M. (2002). Multiplex pyrosequencing. Nucleic Acids Res 30:e31.
  • Rausa FM, Tan Y, Zhou H, Yoo KW, Stolz DB, Watkins SC, Franks RR, Unterman TG, Costa RH. (2000). Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol 20:8264–8282.
  • Renner O, Harsch S, Schaeffeler E, Schwab M, Klass DM, Kratzer W, Stange EF. (2009). Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression. Hum Genet 125:381–391.
  • Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL, Stoffel M. (2001). Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet 27:375–382.
  • Sundaram U, Wisel S, Stengelin S, Kramer W, Rajendran V. (1998). Mechanism of inhibition of Na+-bile acid cotransport during chronic ileal inflammation in rabbits. Am J Physiol 275:G1259–G1265.
  • Zollner G, Fickert P, Silbert D, Fuchsbichler A, Marschall HU, Zatloukal K, Denk H, Trauner M. (2003). Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J Hepatol 38:717–727.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.