Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 7
179
Views
3
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats

, &
Pages 585-592 | Received 16 Dec 2010, Accepted 11 Mar 2011, Published online: 09 Apr 2011

References

  • Aramaki S, Suzuki E, Ishidaka O, Momose A. (1995). Effects of exercise on plasma concentrations of caffeine and its metabolites in horses. Biol Pharm Bull 18:1607–1609.
  • Barstow L, Small RE. (1990). Liver function assessment by drug metabolism. Pharmacotherapy 10:280–288.
  • Berthou F, Guillois B, Riche C, Dreano Y, Jacqz-Aigrain E, Beaune PH. (1992). Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes. Xenobiotica 22:671–680.
  • Bonati M, Latini R, Tognoni G, Young JF, Garattini S. (1984). Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouse. Drug Metab Rev 15:1355–1383.
  • Boothe DM, Cullen JM, Calvin JA, Jenkins WL, Brown SA, Green RA, Corrier DE. (1994). Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease. Am J Vet Res 55:254–261.
  • Burke MD, Thompson S, Weaver RJ, Wolf CR, Mayer RT. (1994). Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 48:923–936.
  • Christensen M, Andersson K, Dalén P, Mirghani RA, Muirhead GJ, Nordmark A, Tybring G, Wahlberg A, Yasar U, Bertilsson L. (2003). The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes. Clin Pharmacol Ther 73:517–528.
  • Chung WG, Cha YN. (1997). Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes. Biochem Biophys Res Commun 235:685–688.
  • Cornelius CE. (1987). A review of new approaches to assessing hepatic function in animals. Vet Res Commun 11:423–441.
  • Danielson TJ, Golsteyn LR. (1996). Systemic clearance and demethylation of caffeine in sheep and cattle. Drug Metab Dispos 24:1058–1061.
  • Dorrbecker SH, Ferraina RA, Dorrbecker BR, Kramer PA. (1987). Caffeine and paraxanthine pharmacokinetics in the rabbit: concentration and product inhibition effects. J Pharmacokinet Biopharm 15:117–132.
  • Elsheikh HA, Ali BH, Homeida AM, Hassan T, Hapke HJ. (1991). Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats. J Vet Pharmacol Ther 14:269–275.
  • Faber MS, Jetter A, Fuhr U. (2005). Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol 97:125–134.
  • Fuhr U, Rost KL. (1994). Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva. Pharmacogenetics 4:109–116.
  • Fuhr U, Rost KL, Engelhardt R, Sachs M, Liermann D, Belloc C, Beaune P, Janezic S, Grant D, Meyer UA, Staib AH. (1996). Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations. Pharmacogenetics 6:159–176.
  • Golden DL, Spano JS, Wilson RC, DeGraves FJ, Whatley EM. (1994). Application of an enzyme-multiplied immunoassay technique for determination of caffeine elimination kinetics as a test of liver function in clinically normal dogs. Am J Vet Res 55:790–794.
  • Holstege A, Staiger M, Haag K, Gerok W. (1989). Correlation of caffeine elimination and Child’s classification in liver cirrhosis. Klin Wochenschr 67:6–15.
  • Institute of Medicine Staff. (2001). Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC, USA: National Academic Press.
  • Janus K, Antoszek J. (2000). The effect of sex and age on caffeine pharmacokinetics in cattle. Res Vet Sci 69:33–37.
  • Janus K, Antoszek J, Suszycki S. (2001). The effect of short-term starvation or water deprivation on caffeine pharmacokinetics in calves. Res Vet Sci 70:109–113.
  • Jodynis-Liebert J, Flieger J, Matuszewska A, Juszczyk J. (2004). Serum metabolite/caffeine ratios as a test for liver function. J Clin Pharmacol 44:338–347.
  • Juskevich JC. (1987). Comparative metabolism in food-producing animals: programs sponsored by the Center for Veterinary Medicine. Drug Metab Rev 18:345–362.
  • Kalow W, Tang BK. (1993). The use of caffeine for enzyme assays: a critical appraisal. Clin Pharmacol Ther 53:503–514.
  • Machala M, Soucek P, Neca J, Ulrich R, Lamka J, Szotáková B, Skálová L. (2003). Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants. Arch Toxicol 77:555–560.
  • Matsunaga NK, Isawa M, Kizu J, Miyazaki N, Takanaka A, Nakashima E. (2003). Application of the PKCYP test to predict caffeine clearance mediated by CYP1A2 in a rat acute liver injury model. Drug Metab Pharmacokinet 18:296–302.
  • Monshouwer M, Witkamp RF, Nijmeijer SM, Pijpers A, Verheijden JH, Van Miert AS. (1995). Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig. Xenobiotica 25:491–499.
  • Peck K, Mealey KL, Matthews NS, Taylor TS. (1997). Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys. Am J Vet Res 58:881–884.
  • Rostami-Hodjegan A, Nurminen S, Jackson PR, Tucker GT. (1996). Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment. Pharmacogenetics 6:121–149.
  • Schumacher J, Spano JS, Wilson RC, DeGraves FJ, Duran SH, Ruffin DC. (1994). Caffeine clearance in the horse. Vet Res Commun 18:367–372.
  • Spigset O, Hägg S, Söderström E, Dahlqvist R. (1999). The paraxanthine:caffeine ratio in serum or in saliva as a measure of CYP1A2 activity: when should the sample be obtained? Pharmacogenetics 9:409–412.
  • Szotáková B, Baliharová V, Lamka J, Nozinová E, Wsól V, Velík J, Machala M, Neca J, Soucek P, Susová S, Skálová L. (2004). Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep. Res Vet Sci 76:43–51.
  • Taha AA, Elsheikh HA, Khalafalla AE, Osman IA, Abdullah AS. (1999). Disposition kinetics of tylosin administered intravenously and intramuscularly in desert sheep and Nubian goats. Vet J 158:210–215.
  • Tanaka E, Ishikawa A, Misawa S. (1992a). Simplified test for determination of drug-oxidizing capacity in rats with chemical-induced liver injury using caffeine and trimethadione as model drugs. Pharmacol Toxicol 70:177–180.
  • Tanaka E, Ishikawa A, Yamamoto Y, Osada A, Tsuji K, Fukao K, Misawa S, Iwasaki Y. (1992b). A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethyl metabolites. Int J Clin Pharmacol Ther Toxicol 30:336–341.
  • Tanaka E, Ishikawa A, Yamamoto Y, Uchida E, Kobayashi S, Yasuhara H, Misawa S. (1992c). A simplified approach for evaluation of hepatic drug-oxidizing activity with a simultaneous determination of caffeine and trimethadione and their demethylated metabolites in rats with a selective cytochrome P-450 inducer. Biopharm Drug Dispos 13:263–272.
  • Tanaka E, Ishikawa A, Yamamoto Y, Uchida E, Kobayashi S, Yasuhara H, Misawa S. (1992d). Simplified approach for evaluation of hepatic drug-oxidizing capacity with a simultaneous measurement of caffeine and its primary demethylated metabolites in carbon tetrachloride-intoxicated rats. Xenobiotica 22:535–541.
  • Tang-Liu DD, Williams RL, Riegelman S. (1983). Disposition of caffeine and its metabolites in man. J Pharmacol Exp Ther 224:180–185.
  • Tarantino G. (2009). Could quantitative liver function tests gain wide acceptance among hepatologists? World J Gastroenterol 15:3457–3461.
  • Tassaneeyakul W, Birkett DJ, McManus ME, Tassaneeyakul W, Veronese ME, Andersson T, Tukey RH, Miners JO. (1994). Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol 47:1767–1776.
  • Tassaneeyakul W, Birkett DJ, Veronese ME, McManus ME, Tukey RH, Quattrochi LC, Gelboin HV, Miners JO. (1993). Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther 265:401–407.
  • Tassaneeyakul W, Mohamed Z, Birkett DJ, McManus ME, Veronese ME, Tukey RH, Quattrochi LC, Gonzalez FJ, Miners JO. (1992). Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques. Pharmacogenetics 2:173–183.
  • Terziivanov D, Bozhinova K, Dimitrova V, Atanasova I. (2003). Nonparametric expectation maximisation (NPEM) population pharmacokinetic analysis of caffeine disposition from sparse data in adult Caucasians: systemic caffeine clearance as a biomarker for cytochrome P450 1A2 activity. Clin Pharmacokinet 42:1393–1409.
  • Uney K, Traş B. (2011). Comparative pharmacokinetics and metabolisms of caffeine in sheep breeds. J Vet Med Sci 73:25–31.
  • van’t Klooster GA, Blaauboer BJ, Noordhoek J, van Miert AS. (1993). Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle. Biochem Pharmacol 46:1781–1790.
  • Verbeeck RK. (2008). Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol 64:1147–1161.
  • Warszawski D, Gorodischer R. (1981). Tissue distribution of caffeine in premature infants and in newborn and adult dogs. Pediatr Pharmacol (New York) 1:341–346.
  • Wasfi IA, Boni NS, Elghazali M, Abdel Hadi AA, Almuhrami AM, Barezaig IM, Alkatheeri NA. (2000). The pharmacokinetics, metabolism and urinary detection time of caffeine in camels. Res Vet Sci 69:69–74.
  • Yamaoka K, Nakagawa T, Uno T. (1978). Application of Akaike’s information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 6:165–175.
  • Zaigler M, Tantcheva-Poór I, Fuhr U. (2000). Problems and perspectives of phenotyping for drug-metabolizing enzymes in man. Int J Clin Pharmacol Ther 38:1–9.
  • Zweers-Zeilmaker WM, Batzias J, Maas RF, Horbach GJ, van Miert AS, Witkamp RF. (1996). In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers. Xenobiotica 26:1131–1141.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.