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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 10
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Animal Pharmacokinetics and Metabolism

Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats

Jin Sook Song
,
Jung-Woo ChaeCollege of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
,
Kyeong-Ryoon LeeDepartment of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
,
Byung Hoi LeeDrug Discovery Platform Technology Team, Division of Bio-organic Science, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea
,
Eun Jeong ChoiDrug Discovery Platform Technology Team, Division of Bio-organic Science, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea
,
Sung Hoon AhnDrug Discovery Platform Technology Team, Division of Bio-organic Science, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea
,
Kwang-il KwonCollege of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
&
Myung Ae BaeDrug Discovery Platform Technology Team, Division of Bio-organic Science, Korea Research Institute of Chemical Technology, Daejeon, Republic of KoreaCorrespondence[email protected] [email protected]
 show all
Pages 895-902 | Received 30 Mar 2011, Accepted 09 May 2011, Published online: 09 Jun 2011

References

  • Abdullayeva R, Ganiyev M, Asmetov V. (2009). Effects of diumancal and decursinol on 5-hydroxytryptamine level in rat brain. Georgian Med News:84–88.
  • Ahn KS, Sim WS, Kim IH. (1996). Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med 62:7–9.
  • Beubler E, Lembeck F. (1979). Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists. Naunyn Schmiedebergs Arch Pharmacol 306:113–118.
  • Choi SS, Han KJ, Lee JK, Lee HK, Han EJ, Kim DH, Suh HW. (2003). Antinociceptive mechanisms of orally administered decursinol in the mouse. Life Sci 73:471–485.
  • Grès MC, Julian B, Bourrié M, Meunier V, Roques C, Berger M, Boulenc X, Berger Y, Fabre G. (1998). Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Pharm Res 15:726–733.
  • Hirohashi T, Suzuki H, Chu XY, Tamai I, Tsuji A, Sugiyama Y. (2000). Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). J Pharmacol Exp Ther 292:265–270.
  • Jung JS, Yan JJ, Song DK. (2008). Protective effect of decursinol on mouse models of sepsis: enhancement of interleukin-10. Korean J Physiol Pharmacol 12:79–81.
  • Kang SY, Lee KY, Sung SH, Park MJ, Kim YC. (2001). Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. J Nat Prod 64:683–685.
  • Kang SY, Lee KY, Sung SH, Kim YC. (2005). Four new neuroprotective dihydropyranocoumarins from Angelica gigas. J Nat Prod 68:56–59.
  • Kang SY, Kim YC. (2007). Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. J Pharm Pharmacol 59:863–870.
  • Kim KM, Kim MJ, Kang JS. (2009). Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas Nakai. J Microbiol Biotechnol 19:1569–1572.
  • Lee JK, Choi SS, Lee HK, Han KJ, Han EJ, Suh HW. (2003a). Effects of ginsenoside Rd and decursinol on the neurotoxic responses induced by kainic acid in mice. Planta Med 69:230–234.
  • Lee S, Shin DS, Kim JS, Oh KB, Kang SS. (2003b). Antibacterial coumarins from Angelica gigas roots. Arch Pharm Res 26:449–452.
  • Lin JH. (1994). Dose-dependent pharmacokinetics: experimental observations and theoretical considerations. Biopharm Drug Dispos 15:1–31.
  • Seo YJ, Kwon MS, Park SH, Sim YB, Choi SM, Huh GH, Lee JK, Suh HW. (2009). The analgesic effect of decursinol. Arch Pharm Res 32:937–943.
  • Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, Kang SS, Lee SK, Park KK. (2009). Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Cancer Lett 280:86–92.
  • Son SH, Park KK, Park SK, Kim YC, Kim YS, Lee SK, Chung WY. (2010). Decursin and Decursinol from Angelica gigas Inhibit the Lung Metastasis of Murine Colon Carcinoma. Phytother Res.
  • Yan JJ, Kim DH, Moon YS, Jung JS, Ahn EM, Baek NI, Song DK. (2004). Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice. Prog Neuropsychopharmacol Biol Psychiatry 28:25–30.

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