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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 3
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Animal Pharmacokinetics and Metabolism

ϵ-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation

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Pages 310-315 | Received 03 Jul 2011, Accepted 28 Aug 2011, Published online: 12 Oct 2011

References

  • Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254.
  • Chiou WL. (1978). Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level–time curve. J Pharmacokinet Biopharm 6:539–546.
  • Choi SM, Shin JH, Kang KK, Ahn BO, Yoo M. (2007). Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models. Dig Dis Sci 52:3075–3080.
  • Choi YH, Chung SJ, Lee MG. (2008). Pharmacokinetic interaction between DA-8159, a new erectogenic, and metformin in rats: Competitive inhibition of metabolism via hepatic CYP3A1/2. Br J Pharmacol 153:1568–1578.
  • Choi YH, Lee U, Suh JH, Kim YG, Choi EY, Oh E, Lee MG. (2010). Pharmacokinetics and first-pass effects of epsilon-acetamidocaproic acid after administration of zinc acexamate in rats. Xenobiotica 40:485–498.
  • Choi YH, Lee U, Suh JH, Kim YG, Lee M, Oh E, Lee MG. (2011). Pharmacokinetic interaction between ?-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: Inhibition of active renal secretion of AACA by cimetidine. Xenobiotica 41:409–415.
  • Colpaert S, Liu Z, De Greef B, Rutgeerts P, Ceuppens JL, Geboes K. (2001). Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model. Aliment Pharmacol Ther 15:1827–1836.
  • Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res 10:1093–1095.
  • Escolar G, Navarro C, Sendros S, Bulbena O. (1987). Effect of cold-restraint stress and zinc acexamate on gastric mucus production in intact glands. Arch Int Pharmacodyn Ther 290:128–137.
  • Gibaldi M, Perrier D. (1982). Pharmacokinetics. 2nd ed. New York: Marcel Dekker.
  • Guilarte Lopez-Manas J, Valenzuela BM, Caballero Plasencia AM, Martin Ruiz JL. (1998). Endoscopic, histologic and morphometric evaluation of the gastric mucosa in patients with osteoarthritis treated with piroxicam and zinc acexamate. Gastroenterol Hepatol 21:212–217.
  • Higuchi K, Umegaki E, Watanabe T, Yoda Y, Morita E, Murano M, Tokioka S, Arakawa T. (2009). Present status and strategy of NSAIDs-induced small bowel injury. J Gastroenterol 44:879–888.
  • Lee MG, Chiou WL. (1983). Evaluation of potential causes for the incomplete bioavailability of furosemide: Gastric first-pass metabolism. J Pharmacokinet Biopharm 11:623–640.
  • Lote CJ, Haylor J, Towers J. (1984). The effect of urine pH on the reduction of urinary PGE2 excretion by indomethacin. Biochem Pharmacol 33:1564–1566.
  • Mitruka BM, Rawnsley HM. (1982). Clinical biomedical and hematological reference values in normal experimental animals and normal humans. 2nd ed. New York: Masson Publishing USA Inc.
  • Thomson JM, Turner L, Poller L. (1973). Inhibition of gastric plasmin activity by epsilon-aminocaproic acid. Ann R Coll Surg Engl 53:340–347.
  • Wilkinson GR, Shand DG. (1975). Commentary: A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377–390.

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