Isolation and identification of the metabolites of paeonol in human urine

References

• Chou TC. (2003). Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol 139:1146–1152.
   PubMed Web of Science ®Google Scholar
• Du Q, Feng GZ, Shen L, Cui J, Cai JK. (2010). Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma. Can J Physiol Pharmacol 88:1010–1016.
   PubMed Web of Science ®Google Scholar
• Gjertsen FB, Solheim E, Scheline RR. (1988). Metabolism of aromatic plant ketones in rats: acetovanillone and paeonol. Xenobiotica 18:225–234.
   PubMed Web of Science ®Google Scholar
• Hirai A, Tamura Y, Yoshida H. (1985). Mechanism of antithrombotic and anti-inflammatory actions of moutan cortex. Wakan Iyaku Gakkaishi 2:63–65.
   Google Scholar
• Hsieh CL, Cheng CY, Tsai TH, Lin IH, Liu CH, Chiang SY, Lin JG, Lao CJ, Tang NY. (2006). Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol 106:208–215.
   PubMed Web of Science ®Google Scholar
• Huang H, Chang EJ, Lee Y, Kim JS, Kang SS, Kim HH. (2008). A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages. Inflamm Res 57:189–198.
   PubMed Web of Science ®Google Scholar
• Juan YC, Tsai WJ, Lin YL, Wang GJ, Cheng JJ, Yang HY, Hsu CY, Liu HK. (2010). The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK). Phytomedicine 17:626–634.
   PubMed Web of Science ®Google Scholar
• Kim SH, Kim SA, Park MK, Kim SH, Park YD, Na HJ, Kim HM, Shin MK, Ahn KS. (2004). Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. Int Immunopharmacol 4:279–287.
   PubMed Web of Science ®Google Scholar
• Lau CH, Chan CM, Chan YW, Lau KM, Lau TW, Lam FC, Law WT, Che CT, Leung PC, Fung KP, Ho YY, Lau CB. (2007). Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol. Phytomedicine 14:778–784.
   PubMed Web of Science ®Google Scholar
• Li H, Dai M, Jia W. (2009). Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity. Planta Med 75:7–11.
   PubMedGoogle Scholar
• Li N, Fan LL, Sun GP, Wan XA, Wang ZG, Wu Q, Wang H. (2010). Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo. World J Gastroenterol 16:4483–4490.
   PubMed Web of Science ®Google Scholar
• Li XJ, Shi XW, Shuai Q, Gao JM, Zhang AL. (2011). Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor. Nat Prod Commun 6:1129–1130.
   PubMed Web of Science ®Google Scholar
• Liu HX, Hu Y, He YQ, Liu Y, Li W, Yang L. (2009). Ultra-performance liquid chromatographic-electrospray mass spectrometric determination (UPLC-ESI-MS) of O-demethylated metabolite of paeonol in vitro: assay development, human liver microsome activities and species differences. Talanta 79:1433–1440.
   PubMedGoogle Scholar
• Ma LY, Miao JH, Xu XD, Tang BL, Zhang Q. (2009). Pharmacokinetic features and absolute bioavailability of paeonol in conscious rat. Shizhen Guoyi Guoyao 20:413–414.
   Google Scholar
• Mimura K, Baba S. (1980). Studies on the biotransformation of paeonol by isotope tracer techniques. II. Species differences in metabolism. Chem Pharm Bull 28:1704–1710.
   PubMed Web of Science ®Google Scholar
• Miyazawa M, Maruyama H, Kameoka H. (1983). Volatile flavor components of crude drugs. Part I. Essential oil constituents of “ Moutan Radicis Cortex” Paeonia moutan Sims. (=P. suffruticosa Andrews). Agric Biol Chem 47:2925–2927.
   Web of Science ®Google Scholar
• Nizamutdinova IT, Oh HM, Min YN, Park SH, Lee MJ, Kim JS, Yean MH, Kang SS, Kim YS, Chang KC, Kim HJ. (2007). Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. Int Immunopharmacol 7:343–350.
   PubMed Web of Science ®Google Scholar
• Pan JY, Cheng YY. (2006). Identification and analysis of absorbed and metabolic components in rat plasma after oral administration of ‘Shuangdan’ granule by HPLC-DAD-ESI-MS/MS. J Pharm Biomed Anal 42:565–572.
   PubMedGoogle Scholar
• Papandreou V, Magiatis P, Chinou I, Kalpoutzakis E, Skaltsounis AL, Tsarbopoulos A. (2002). Volatiles with antimicrobial activity from the roots of Greek Paeonia taxa. J Ethnopharmacol 81:101–104.
   PubMed Web of Science ®Google Scholar
• Shanta T, Mathew AG. (1970). Modified procedure for quantitative chromatographic estimation of polyphenols by Folin-Denis method. Laboratory Practice 19:917–919.
   Google Scholar
• Sun GP, Shen YX, Zhang LL, Zhou AW, Wei W, Xu SY. (2003). Study on immunomodulation and antitumor activity of paeonol in HepA tumor mice. Chin Pharmacol Bull 19:160–162.
   Google Scholar
• Sun GP, Wang H, Xu SP, Shen YX, Wu Q, Chen ZD, Wei W. (2008). Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production. Eur J Pharmacol 584:246–252.
   PubMed Web of Science ®Google Scholar
• Wang JJ, Li QW, Ou YT, Li CJ, Tian YZ, Sun XX. (2010). Antitumor effects of paeonol on mice bearing EMT6 breast infiltrating ductal carcinoma. Lat Am J Pharm 29:369–375.
   Google Scholar
• Wang XJ, Sun WJ, Zhang N, Sun H, Geng F, Piao CY. (2007). Isolation and identification of constituents absorbed into blood after oral administration of liuwei dihuang pill. Chin J Nat Med 5:277–280.
   Google Scholar
• Wu GZ, Hang BQ, Hang JX, Lin GX. (1990). Anti-hypersensitive effect of paeonol. J China Pharm Univ 21:103–106.
   Google Scholar
• Xie Y, Zhou H, Wong YF, Xu HX, Jiang ZH, Liu L. (2008). Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC-DAD-MS method. J Pharm Biomed Anal 46:748–756.
   PubMed Web of Science ®Google Scholar
• Xing G, Zhang Z, Liu J, Hu H, Sugiura N. (2010). Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro. Mol Med Report 3:57–61.
   PubMedGoogle Scholar
• Yasuda T, Kon R, Nakazawa T, Ohsawa K. (1999). Metabolism of paeonol in rats. J Nat Prod 62:1142–1144.
   PubMed Web of Science ®Google Scholar
• Yun-Choi HS, Kang SS, Kim MH, Jung KH. (1993). Anti-thrombotic effects of analogs of protocatechuic acid and gallic acid. Yakhak Hoechi 37:453–457.
   Google Scholar
• Zhang HY, Ge N, Zhang ZY. (1999). Theoretical elucidation of activity difference of five phenolic antioxidant. Acta Pharmacol Sin 20:363–366.
   Web of Science ®Google Scholar