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Xenobiotica
the fate of foreign compounds in biological systems
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Review Article

Cryopreservation of precision-cut tissue slices

, , , , &
Pages 113-132 | Received 21 Aug 2012, Accepted 05 Sep 2012, Published online: 30 Oct 2012

References

  • Al-Fageeh MB, Marchant RJ, Carden MJ, Smales CM. (2006). The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production. Biotechnol Bioeng 93:829–835.
  • Axelsson H, Granhall C, Floby E, Jaksch Y, Svedling M, Sohlenius-Sternbeck AK. (2003). Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. Toxicol In Vitro 17:481–488.
  • Boess F, Kamber M, Romer S, Gasser R, Muller D, Albertini S, Suter L. (2003). Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: Possible implications for toxicogenomics use of in vitro systems. Toxicol Sci 73:386–402.
  • Booth ED, Dofferhoff O, Boogaard PJ, Watson WP. (2004). Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver. Xenobiotica 34:31–48.
  • Boutron P, Arnaud F. (1984). Comparison of the cryoprotection of red blood cells by 1,2-propanediol and glycerol. Cryobiology 21:348–358.
  • Brandon EF, Raap CD, Meijerman I, Beijnen JH, Schellens JH. (2003). An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons. Toxicol Appl Pharmacol 189:233–246.
  • Brockbank KG, Song YC. (2004). Morphological analyses of ice-free and frozen cryopreserved heart valve explants. J Heart Valve Dis 13:297–301.
  • Burch HB, Lowry OH, Meinhardt L, Max P Jr, Chyu K. (1970). Effect of fructose, dihydroxyacetone, glycerol, and glucose on metabolites and related compounds in liver and kidney. J Biol Chem 245:2092–2102.
  • Burton V, Mitchell HK, Young P, Petersen NS. (1988). Heat shock protection against cold stress of Drosophila melanogaster. Mol Cell Biol 8:3550–3552.
  • Carranza-Rosales P, Santiago-Mauricio MG, Guzmán-Delgado NE, Vargas-Villarreal J, Lozano-Garza G, Ventura-Juárez J, Balderas-Rentería I, Morán-Martínez J, Gandolfi AJ. (2010). Precision-cut hamster liver slices as an ex vivo model to study amoebic liver abscess. Exp Parasitol 126:117–125.
  • Chesné C, Guillouzo A. (1988). Cryopreservation of isolated rat hepatocytes: A critical evaluation of freezing and thawing conditions. Cryobiology 25:323–330.
  • Clark P, Fahy GM, Karow AM Jr. (1984). Factors influencing renal cryopreservation. I. Effects of three vehicle solutions and the permeation kinetics of three cryoprotectants assessed with rabbit cortical slices. Cryobiology 21:260–273.
  • Corwin WL, Baust JM, Baust JG, Van Buskirk RG. (2011). The unfolded protein response in human corneal endothelial cells following hypothermic storage: Implications of a novel stress pathway. Cryobiology 63:46–55.
  • Crowe JH, Hoekstra FA, Crowe LM, Anchordoguy TJ, Drobnis E. (1989). Lipid phase transitions measured in intact cells with Fourier transform infrared spectroscopy. Cryobiology 26:76–84.
  • Day SH, Nicoll-Griffith DA, Silva JM. (1999). Cryopreservation of rat and human liver slices by rapid freezing. Cryobiology 38:154–159.
  • de Graaf IA, van der Voort D, Brits JH, Koster HJ. (2000). Increased post-thaw viability and phase I and II biotransformation activity in cryopreserved rat liver slices after improvement of a fast-freezing method. Drug Metab Dispos 28:1100–1106.
  • de Graaf IA, Koster HJ. (2001). Water crystallization within rat precision-cut liver slices in relation to their viability. Cryobiology 43:224–237.
  • de Graaf IA, Geerlinks A, Koster HJ. (2002). Incubation at 37 degrees C prior to cryopreservation decreases viability of liver slices after cryopreservation by rapid freezing. Cryobiology 45:1–9.
  • de Graaf IAM. (2003). Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicol In Vitro 17:1–17.
  • de Graaf IA, Draaisma AL, Schoeman O, Fahy GM, Groothuis GM, Koster HJ. (2007). Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification. Cryobiology 54:1–12.
  • de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM. (2010). Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nat Protoc 5:1540–1551.
  • de Kanter R, Koster HJ. (1995). Cryopreservation of rat and monkey liver slices. ATLA 23:653–665.
  • de Kanter R, Olinga P, Hof I, de Jager M, Verwillegen WA, Slooff MJ, Koster HJ, Meijer DK, Groothuis GM. (1998). A rapid and simple method for cryopreservation of human liver slices. Xenobiotica 28:225–234.
  • de Kanter R, Monshouwer M, Meijer DK, Groothuis GM. (2002). Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues. Curr Drug Metab 3:39–59.
  • de Kanter R, Tuin A, van de Kerkhof E, Martignoni M, Draaisma AL, de Jager MH, de Graaf IA, Meijer DK, Groothuis GM. (2005). A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies. J Pharmacol Toxicol Methods 51:65–72.
  • Dias CL, Ala-Nissila T, Wong-ekkabut J, Vattulainen I, Grant M, Karttunen M. (2010). The hydrophobic effect and its role in cold denaturation. Cryobiology 60:91–99.
  • Eisenberg DP, Taylor MJ, Rabin Y. (2012). Thermal expansion of the cryoprotectant cocktail DP6 combined with synthetic ice modulators in presence and absence of biological tissues. Cryobiology 65:117–125.
  • Ekins S. (1996). Vitrification of precision-cut rat liver slices. Cryo-Letters 17:7–14.
  • Ekins S, Murray GI, Hawksworth GM (1996a). Ultrastructural and metabolic effects after vitrification of precision-cut rat liver slices with antifreeze proteins. Cryo-Letters 17:157–164.
  • Ekins S, Williams JA, Murray GI, Burke MD, Marchant NC, Engeset J, Hawksworth GM. (1996b). Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices. Drug Metab Dispos 24:990–995.
  • Elferink MG, Olinga P, Draaisma AL, Merema MT, Bauerschmidt S, Polman J, Schoonen WG, Groothuis GM. (2008). Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. Toxicol Appl Pharmacol 229:300–309.
  • Fahy GM. (1980a). Analysis of “solution effects” injury. Equations for calculating phase diagram information for the ternary systems NaCl-dimethylsulfoxide-water and NaCl-glycerol-water. Biophys J 32:837–850.
  • Fahy GM. (1980b). Analysis of “solution effects” injury: Rabbit renal cortex frozen in the presence of dimethyl sulfoxide. Cryobiology 17:371–388.
  • Fahy GM. (1981). Analysis of “solution effects” injury: Cooling rate dependence of the functional and morphological sequellae of freezing in rabbit renal cortex protected with dimethyl sulfoxide. Cryobiology 18:550–570.
  • Fahy GM, Hirsh A. (1982). Prospects for organ preservation by vitrification. In: Pegg DE, Jacobsen IA, Halasz NA, editors. Organ Preservation, Basic and Applied Aspects. Lancaster: MTP Press, 399–404.
  • Fahy GM. (1984). Cryoprotectant toxicity: Biochemical or osmotic? Cryo-Letters 5:79–90.
  • Fahy GM, MacFarlane DR, Angell CA, Meryman HT. (1984). Vitrification as an approach to cryopreservation. Cryobiology 21:407–426.
  • Fahy GM. (1986). The relevance of cryoprotectant “toxicity” to cryobiology. Cryobiology 23:1–13.
  • Fahy GM. (1987). Biological effects of vitrification and devitrification. In: Pegg DE, Karow AM, Jr, editors. The Biophysics of Organ Cryopreservation. New York: Plenum Press, 265–293.
  • Fahy GM, Levy DI, Ali SE. (1987). Some emerging principles underlying the physical properties, biological actions, and utility of vitrification solutions. Cryobiology 24:196–213.
  • Fahy GM, Lilley TH, Linsdell H, Douglas MS, Meryman HT. (1990a). Cryoprotectant toxicity and cryoprotectant toxicity reduction: In search of molecular mechanisms. Cryobiology 27:247–268.
  • Fahy GM, Saur J, Williams RJ. (1990b). Physical problems with the vitrification of large biological systems. Cryobiology 27:492–510.
  • Fahy GM, da Mouta C, Tsonev L, Khirabadi BS, Mehl P, Meryman HT. (1995). Cellular injury associated with organ cryopreservation: Chemical toxicity and cooling injury. In: Lemasters JJ, Oliver C, editors. Cell Biology of Trauma. Boca Raton: CRC Press.
  • Fahy GM, Wowk B, Wu J, Paynter S. (2004a). Improved vitrification solutions based on the predictability of vitrification solution toxicity. Cryobiology 48:22–35.
  • Fahy GM, Wowk B, Wu J, Phan J, Rasch C, Chang A, Zendejas E. (2004b). Cryopreservation of organs by vitrification: Perspectives and recent advances. Cryobiology 48:157–178.
  • Fahy GM. (2005). Vitrification as an approach to cryopreservation: General perspectives. Cryobiology 51:348–349.
  • Fahy GM. (2007). Theoretical considerations for oocyte cryopreservation by freezing. Reprod Biomed Online 14:709–714.
  • Fahy GM, Rall WF. (2007). Vitrification: An overview. In: Liebermann J, Tucker MJ, editors. Vitrification in Assisted Reproduction: A User’s Manual and Troubleshooting Guide. London: Informa Healthcare, 1–20.
  • Fahy GM, Wowk B, Pagotan R, Chang A, Phan J, Thomson B, Phan L. (2009). Physical and biological aspects of renal vitrification. Organogenesis 5:167–175.
  • Fahy GM. (2010). Cryoprotectant toxicity neutralization. Cryobiology 60:S45–S53.
  • Fisher R, Putnam CW, Koep LJ, Sipes IG, Gandolfi AJ, Brendel K. (1991). Cryopreservation of pig and human liver slices. Cryobiology 28:131–142.
  • Fisher RL, Hasal SJ, Sanuik JT, Scott KS, Gandolfi AJ, Brendel K. (1993). Cold- and cryopreservation of human liver and kidney slices. Cryobiology 30:250–261.
  • Fisher RL, Smith MS, Hasal SJ, Hasal KS, Gandolfi AJ, Brendel K. (1994). The use of human lung slices in toxicology. Hum Exp Toxicol 13:466–471.
  • Fisher RL, Hasal SJ, Sanuik JT, Hasal KS, Gandolfi AJ, Brendel K. (1996). Cold- and cryopreservation of dog liver and kidney slices. Cryobiology 33:163–171.
  • Fisher RL, Hasal SJ, Lipscomb JC, Gandolfi AJ, Brendel K. (2002). Cold and cryopreservation of monkey liver slices. Toxicol Mech Methods 12:119–133.
  • Franks F, Mathias SF, Galfre P, Webster SD, Brown D. (1983). Ice nucleation and freezing in undercooled cells. Cryobiology 20:298–309.
  • Freeman BA, O’Neil JJ. (1984). Tissue slices in the study of lung metabolism and toxicology. Environ Health Perspect 56:51–60.
  • Glöckner R, Meier J, Muller D. (1996). Biotransformation in cryopreserved rat liver slices. Exp Toxicol Pathol 48:151–155.
  • Glöckner R, Steinmetzer P, Drobner C, Müller D. (1998). Application of cryopreserved precision-cut liver slices in pharmacotoxicology–principles, literature data and own investigations with special reference to CYP1A1-mRNA induction. Exp Toxicol Pathol 50:440–449.
  • Glöckner R, Steinmetzer P, Drobner C, Müller D. (1999). Use of Fresh and Cryopreserved Human Liver Slices in Toxicology with Special Reference to In vitro Induction of Cytochrome P450. Toxicol In Vitro 13:531–535.
  • Glöckner R, Rost M, Pissowotzki K, Müller D. (2001). Monooxygenation, conjugation and other functions in cryopreserved rat liver slices until 24 h after thawing. Toxicology 161:103–109.
  • Glöckner R, Steinmetzer P, Lupp A, Danz M, Müller D. (2002). In vitro induction of cytochrome P450 2B1- and 3A1-mRNA and enzyme immunostaining in cryopreserved precision-cut rat liver slices. Toxicology 176:187–193.
  • Granhall C, Floby E, Nordmark A, Orzechowski A, Thörne A, Tybring G, Sohlenius-Sternbeck AK. (2002). Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months. Xenobiotica 32:985–996.
  • Groneberg DA, Grosse-Siestrup C, Fischer A. (2002). In vitro models to study hepatotoxicity. Toxicol Pathol 30:394–399.
  • Groothuis GM, de Graaf IA. (2012). Precision-cut intestinal slices as in vitro tool for studies on drug metabolism. Curr Drug Metab (Epub ahead of print on April 9th).
  • Guan N, de Jager MH, Ramana P, Blomsma SA, Fahy GM, Groothuis GMM de Graaf IAM (2012a). The influence of polyvinylpyrrolidone (PVP) in the toxicity of cryoprotective agents in different liver cell types and on vitrification outcome in precision-cut liver and kidney slices. Drug Metab Rev. (Submitted)
  • Guan N, Blomsma SA, Fahy GM, Groothius GM, de Graaf IA (2012b). Microarray analysis of gene expression changes due to chilling injury in precision cut liver slices (PCLS). Toxicologist. (Submitted)
  • Guan N, Blomsma SA, van Midwoud PM, Fahy GM, Groothuis GM, de Graaf IA. (2012c). Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices. Cryobiology. (Epub ahead of print on June 18th)
  • Guan N, de Jager MH, Sterbova P, Blomsma SA, Fahy GM, Groothuis GMM, de Graaf IAM (2012d)). The effect of hypothermic in situ liver perfusion on the toxicity of cryoprotective agents in precision-cut liver slices (In preparation).
  • Hamilton R, Holst HI, Lehr HB. (1973). Successful preservation of canine small intestine by freezing. J Surg Res 14:313–318.
  • Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. (2003). An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11:619–633.
  • Hays LM, Feeney RE, Crowe LM, Crowe JH, Oliver AE. (1996). Antifreeze glycoproteins inhibit leakage from liposomes during thermotropic phase transitions. Proc Natl Acad Sci USA 93:6835–6840.
  • Hays LM, Crowe JH, Wolkers W, Rudenko S. (2001). Factors affecting leakage of trapped solutes from phospholipid vesicles during thermotropic phase transitions. Cryobiology 42:88–102.
  • He L, Bailey JL, Buhr MM. (2001). Incorporating lipids into boar sperm decreases chilling sensitivity but not capacitation potential. Biol Reprod 64:69–79.
  • Horvath G, Seidel GE Jr. (2006). Vitrification of bovine oocytes after treatment with cholesterol-loaded methyl-beta-cyclodextrin. Theriogenology 66:1026–1033.
  • Huang L, Mo Y, Wang W, Li Y, Zhang Q, Yang D. (2008). Cryopreservation of human ovarian tissue by solid-surface vitrification. Eur J Obstet Gynecol Reprod Biol 139:193–198.
  • Hui SW, Parsons DF. (1976). Phase transition of plasma membranes of rat hepatocyte and hepatoma cells by electron diffraction. Cancer Res 36:1918–1923.
  • Jacob SW, Herschler R. (1986). Pharmacology of DMSO. Cryobiology 23:14–27.
  • Jans AW, Willem R. (1988). 13C-NMR study of glycerol metabolism in rabbit renal cells of proximal convoluted tubules. Eur J Biochem 174:67–73.
  • Karlsson JO, Cravalho EG, Borel Rinkes IH, Tompkins RG, Yarmush ML, Toner M. (1993). Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide. Biophys J 65:2524–2536.
  • Karow AM, Jr. (1974). Cryopreservation: Pharmacological considerations. In: Karow AM, Jr, Abouna GJM, Humphries AH, Jr, editors. Organ Preservation for Transplantation. Boston: Little, Brown, and Company, 86–107.
  • Kasper HU, Konze E, Kutinová Canová N, Dienes HP, Dries V. (2011). Cryopreservation of precision cut tissue slices (PCTS): Investigation of morphology and reactivity. Exp Toxicol Pathol 63:575–580.
  • Kirpatovskii VI, Nadtochii ON, Stepina NI, Kuznetsov VM, Obukhova TV. (1991). [The reasons for the inefficiency of local kidney hypothermia during the temporary discontinuation of their blood supply]. Urol Nefrol (Mosk) (6):29–35.
  • Kuwayama M, Vajta G, Kato O, Leibo SP. (2005). Highly efficient vitrification method for cryopreservation of human oocytes. Reprod Biomed Online 11:300–308.
  • LaRossa D, Hamilton R, Ketterer F, Lehr HB. (1973). Preservation of structure and function in canine small intestinal autografts after freezing. Plast Reconstr Surg 52:174–177.
  • Lerche-Langrand C, Toutain HJ. (2000). Precision-cut liver slices: Characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:221–253.
  • Leth PM, Gregersen M. (2005). Ethylene glycol poisoning. Forensic Sci Int 155:179–184.
  • Lopez CF, Darst RK, Rossky PJ. (2008). Mechanistic elements of protein cold denaturation. J Phys Chem B 112:5961–5967.
  • Lovelock JE. (1953). The mechanism of the protective action of glycerol against haemolysis by freezing and thawing. Biochim Biophys Acta 11:28–36.
  • Lupp A, Glöckner R, Danz M, Müller D. (2002). Cryopreserved precision-cut rat liver slices: Morphology and cytochrome P450 isoforms expression after prolonged incubation. Toxicol In Vitro 16:749–758.
  • Lyons JM. (1972). Phase transitions and control of cellular metabolism at low temperatures. Cryobiology 9:341–350.
  • Lyons JM, Raison JK. (1970). Oxidative activity of mitochondria isolated from plant tissues sensitive and resistant to chilling injury. Plant Physiol 45:386–389.
  • Maas WJ, de Graaf IA, Schoen ED, Koster HJ, van de Sandt JJ, Groten JP. (2000a). Assessment of some critical factors in the freezing technique for the cryopreservation of precision-cut rat liver slices. Cryobiology 40:250–263.
  • Maas WJ, Leeman WR, Groten JP, van de Sandt JJ. (2000b). Cryopreservation of precision-cut rat liver slices using a computer-controlled freezer. Toxicol In Vitro 14:523–530.
  • Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D. (2004). CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18:3066–3077.
  • Martignoni M, Monshouwer M, de Kanter R, Pezzetta D, Moscone A, Grossi P. (2004). Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation. Toxicol In Vitro 18:121–128.
  • Martino A, Songsasen N, Leibo SP. (1996). Development into blastocysts of bovine oocytes cryopreserved by ultra-rapid cooling. Biol Reprod 54:1059–1069.
  • Mazur P. (1963). Kinetics of water loss from cells at subzero temperatures and the likelihood of intracellular freezing. J Gen Physiol 47:347–369.
  • Mazur P. (1970). Cryobiology: The freezing of biological systems. Science 168:939–949.
  • Mazur P. (1984). Freezing of living cells: Mechanisms and implications. Am J Physiol 247:C125–C142.
  • Mazur P. (1988). Stopping biological time. The freezing of living cells. Ann N Y Acad Sci 541:514–531.
  • Mazur P, Schneider U, Mahowald AP. (1992). Characteristics and kinetics of subzero chilling injury in Drosophila embryos. Cryobiology 29:39–68.
  • McGrath JJ. (1987). Cold shock: Thermoelastic stress in chilled biological membranes. In: Diller KR, editors. Network Thermodynamics, Heat and Mass Transfer in Biotechnology. New York: United Engineering Center, 57–66.
  • McGrath JJ. (1989). Protecting biological material against chilling injury. European Patent Office.
  • Meryman HT. (1958). Ice crystal formation in tissues. Research Reviews (Naval Medical Research Institute). February, 1–6.
  • Meryman HT. (1970). The exceeding of a minimum tolerable cell volume in hypertonic suspension as a cause of freezing injury. In: Wolstenholme GEW, O’Connor M, editors. The Frozen Cell. London: J & A Churchill, 51–64.
  • Meryman HT. (1974). Freezing injury and its prevention in living cells. Annu Rev Biophys Bioeng 3:341–363.
  • Meryman HT, Williams RJ, Douglas MS. (1977). Freezing injury from “solution effects” and its prevention by natural or artificial cryoprotection. Cryobiology 14:287–302.
  • Meryman HT. (2007). Cryopreservation of living cells: Principles and practice. Transfusion 47:935–945.
  • Moreno L, Perez-Vizcaino F, Harrington L, Faro R, Sturton G, Barnes PJ, Mitchell JA. (2006). Pharmacology of airways and vessels in lung slices in situ: Role of endogenous dilator hormones. Respir Res 7:111.
  • Movassaghi S, Saki G, Javadnia F, Panahi M, Mahmoudi M, Rhim F. (2009). Effects of methyl-beta-cyclodextrin and cholesterol on cryosurvival of spermatozoa from C57BL/6 mouse. Pak J Biol Sci 12:19–25.
  • Murata N, Ishizaki-Nishizawa O, Higashi S, Hayashi H, Tasaka Y, Nishida I. (1992). Genetically engineered alteration in the chilling sensitivity of plants. Nature 356:710–713.
  • Okada T, Yoshida H, Akazawa R, Negishi M, Mori K. (2002). Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366:585–594.
  • Okaniwa G, Nakada T, Kawakami M, Fujimura S, Arakaki Y. (1973). Studies on the preservation of canine lung at subzero temperatures. J Thorac Cardiovasc Surg 65:180–186.
  • Olinga P, Merema MT, Hof IH, De Jager MH, De Jong KP, Slooff MJ, Meijer DK, Groothuis GM. (1998). Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver. Xenobiotica 28:349–360.
  • Pamornsakda T, Pojprasath T, Suwimonteerabutr J, Tharasanit T. (2011). Effects of cholesterol-loaded cyclodextrins on the quality of frozen-thawed equine epididymal sperm. Cryobiology 63:90–95.
  • Panoutsopoulos GI. (2005). Phenylacetaldehyde oxidation by freshly prepared and cryopreserved guinea pig liver slices: The role of aldehyde oxidase. Int J Toxicol 24:103–109.
  • Panoutsopoulos GI, Beedham C. (2005). Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices. Pharmacology 73:199–208.
  • Parrish AR, Gandolfi AJ, Brendel K. (1995). Precision-cut tissue slices: Applications in pharmacology and toxicology. Life Sci 57:1887–1901.
  • Pegg DE, Jacobsen IA, Diaper MP, Foreman J. (1986). Optimization of a vehicle solution for the introduction and removal of glycerol with rabbit kidneys. Cryobiology 23:53–63.
  • Pegg DE. (2010). The relevance of ice crystal formation for the cryopreservation of tissues and organs. Cryobiology 60:S36–S44.
  • Pichugin Y, Fahy GM, Morin R. (2006). Cryopreservation of rat hippocampal slices by vitrification. Cryobiology 52:228–240.
  • Plazar J, Hreljac I, Pirih P, Filipic M, Groothuis GM. (2007). Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices. Toxicol In Vitro 21:1134–1142.
  • Rall WF, Fahy GM. (1985). Ice-free cryopreservation of mouse embryos at -196 degrees C by vitrification. Nature 313:573–575.
  • Rasmussen DH, Macaulay MN, MacKenzie AP. (1975). Supercooling and nucleation of ice in single cells. Cryobiology 12:328–339.
  • Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. (2007). Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 96:2–15.
  • Rubinsky B, Perez PA, Carlson ME. (2005). The thermodynamic principles of isochoric cryopreservation. Cryobiology 50:121–138.
  • Schindelin H, Marahiel MA, Heinemann U. (1993). Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein. Nature 364:164–168.
  • Snow JT, Finley JW, Friedman M. (1975). Oxidation of sulfhydryl groups to disulfides by sulfoxides. Biochem Biophys Res Commun 64:441–447.
  • Song YC, Hagen PO, Lightfoot FG, Taylor MJ, Smith AC, Brockbank KG. (2000a). In vivo evaluation of the effects of a new ice-free cryopreservation process on autologous vascular grafts. J Invest Surg 13:279–288.
  • Song YC, Khirabadi BS, Lightfoot F, Brockbank KG, Taylor MJ. (2000b). Vitreous cryopreservation maintains the function of vascular grafts. Nat Biotechnol 18:296–299.
  • Song YC, An YH, Kang QK, Li C, Boggs JM, Chen Z, Taylor MJ, Brockbank KG. (2004a). Vitreous preservation of articular cartilage grafts. J Invest Surg 17:65–70.
  • Song YC, Li H, Ye YH, Shan CY, Yang YM, Tan RX. (2004b). Endophytic naphthopyrone metabolites are co-inhibitors of xanthine oxidase, SW1116 cell and some microbial growths. FEMS Microbiol Lett 241:67–72.
  • Sonna LA, Fujita J, Gaffin SL, Lilly CM. (2002). Invited review: Effects of heat and cold stress on mammalian gene expression. J Appl Physiol 92:1725–1742.
  • Takahashi T, Williams RJ. (1983). Thermal shock hemolysis in human red cells. I. The effects of temperature, time, and osmotic stress. Cryobiology 20:507–520.
  • Takahashi T, Hirsh A, Erbe EF, Bross JB, Steere RL, Williams RJ. (1986). Vitrification of human monocytes. Cryobiology 23:103–115.
  • Takahashi T, Fahy GM. (2012). Cryoprotectants. In: Fujikawa S, editor. Handbook of Freezing and Air Conditioning. 6th edition. Tokyo: Japan Society of Refrigerating and Air Conditioning Engineers. In press.
  • Tanaka-Matsuura LM, Werner RS, Farah CS, Romaldini JH. (1984). Cryopreserved human thyroid tissue for TSAb determination: Comparison with fresh tissue. Horm Res 20:124–128.
  • Taylor MJ, Song YC, Brockbank KG. (2004). Vitrification in tissue preservation: New developments. In: Fuller BJ, Lane N, Benson EE, editors. Life in the Frozen State. Boca Raton: CRC Press; 603–641.
  • Tomczak MM, Hincha DK, Estrada SD, Wolkers WF, Crowe LM, Feeney RE, Tablin F, Crowe JH. (2002). A mechanism for stabilization of membranes at low temperatures by an antifreeze protein. Biophys J 82:874–881.
  • Tsonev LI, Stoiancheva KN, Fahy GM. (1994). Permeation of 2,3-butanediol and dimethyl sulfoxide in renal cortex. Cryo-Letters 15:251–266.
  • van de Bovenkamp M, Groothuis GM, Draaisma AL, Merema MT, Bezuijen JI, van Gils MJ, Meijer DK, Friedman SL, Olinga P. (2005). Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. Toxicol Sci 85:632–638.
  • van de Bovenkamp M, Groothuis GM, Meijer DK, Olinga P. (2006). Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro. J Hepatol 45:696–703.
  • van Midwoud PM, Merema MT, Verpoorte E, Groothuis GM. (2010). A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip 10:2778–2786.
  • VanBogelen RA, Neidhardt FC. (1990). Ribosomes as sensors of heat and cold shock in Escherichia coli. Proc Natl Acad Sci USA 87:5589–5593.
  • Vanhulle VP, Martiat GA, Verbeeck RK, Horsmans Y, Calderon PB, Eeckhoudt SL, Taper HS, Delzenne N. (2001). Cryopreservation of rat precision-cut liver slices by ultrarapid freezing: Influence on phase I and II metabolism and on cell viability upon incubation for 24 hours. Life Sci 68:2391–2403.
  • Vanhulle VP, Martiat GA, Bontemps F, Vincent MF, Pycke JM, Verbeeck RK, Horsmans Y, Delzenne N. (2003). Cryopreservation of rat precision-cut liver slices is associated with major metabolic stress and ionic perturbations. Cell Physiol Biochem 13:103–112.
  • Vanhulle VP, Neyrinck AM, Pycke JM, Horsmans Y, Delzenne NM. (2006). Role of apoptotic signaling pathway in metabolic disturbances occurring in liver tissue after cryopreservation: Study on rat precision-cut liver slices. Life Sci 78:1570–1577.
  • Vickers AE, Fisher RL. (2005). Precision-cut organ slices to investigate target organ injury. Expert Opin Drug Metab Toxicol 1:687–699.
  • Vittorelli A, Gauthier C, Michoudet C, Baverel G. (2004). Metabolic viability and pharmaco-toxicological reactivity of cryopreserved human precision-cut renal cortical slices. Toxicol In Vitro 18:285–292.
  • Wada H, Gombos Z, Murata N. (1990). Enhancement of chilling tolerance of a cyanobacterium by genetic manipulation of fatty acid desaturation. Nature 347:200–203.
  • Weisburger JH, Yamamoto RS, Glass RM, Frankel HH. (1969). Prevention by arginine glutamate of the carcinogenicity of acetamide in rats. Toxicol Appl Pharmacol 14:163–175.
  • Williams RJ, Carnahan DL. (1990). Fracture faces and other interfaces as ice nucleation sites. Cryobiology 27:479–482.
  • Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, Putnam CW, Krumdieck CL, Brendel K. (1991). Biotransformation activity in vitrified human liver slices. Cryobiology 28:216–226.
  • Wowk B, Darwin M, Harris SB, Russell SR, Rasch CM. (1999). Effects of solute methoxylation on glass-forming ability and stability of vitrification solutions. Cryobiology 39:215–227.
  • Wowk B, Leitl E, Rasch CM, Mesbah-Karimi N, Harris SB, Fahy GM. (2000). Vitrification enhancement by synthetic ice blocking agents. Cryobiology 40:228–236.
  • Wowk B, Fahy GM. (2002). Inhibition of bacterial ice nucleation by polyglycerol polymers. Cryobiology 44:14–23.
  • Wowk B, Fahy GM. (2005). Toward large organ vitrification: Extremely low critical cooling and warming rates of M22 vitrification solution. Cryobiology 51:362.
  • Zeron Y, Tomczak M, Crowe J, Arav A. (2002). The effect of liposomes on thermotropic membrane phase transitions of bovine spermatozoa and oocytes: Implications for reducing chilling sensitivity. Cryobiology 45:143–152.
  • Zimmermann G, Tennyson C, Drapanas T. (1971). Studies of preservation of liver and pancreas by freezing techniques. Transplant Proc 3:657–659.

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