Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 1
397
Views
16
CrossRef citations to date
0
Altmetric
Review Article

Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices

, &
Pages 73-83 | Received 19 Aug 2012, Accepted 11 Sep 2012, Published online: 30 Oct 2012

References

  • Artursson P, Ungell AL, Löfroth JE. (1993). Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm Res 10:1123–1129.
  • Bader A, Hansen T, Kirchner G, Allmeling C, Haverich A, Borlak JT. (2000). Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions. Br J Pharmacol 129:331–342.
  • Bailey MJ, Dickinson RG. (2003). Acyl glucuronide reactivity in perspective: biological consequences. Chem Biol Interact 145:117–137.
  • Bjarnason I, MacPherson A, Hollander D. (1995). Intestinal permeability: an overview. Gastroenterology 108:1566–1581.
  • Boelsterli UA. (2011). Acyl glucuronides: mechanistic role in drug toxicity? Curr Drug Metab 12:213–214.
  • Boelsterli UA, Ramirez-Alcantara V. (2011). NSAID acyl glucuronides and enteropathy. Curr Drug Metab 12:245–252.
  • Brandsch C, Friedl P, Lange K, Richter T, Mothes T. (1998). Primary culture and transfection of epithelial cells of human small intestine. Scand J Gastroenterol 33:833–838.
  • Camera A, Andretta C, Villa MR, Volpicelli M, Picardi M, Rossi M, Rinaldi CR, Della Cioppa P, Ciancia R, Selleri C, Rotoli B. (2003). Intestinal toxicity during induction chemotherapy with cytarabine-based regimens in adult acute myeloid leukemia. Hematol J 4:346–350.
  • Chassany O, Michaux A, Bergmann JF. (2000). Drug-induced diarrhoea. Drug Saf 22:53–72.
  • Chou TC, Hutchinson DJ, Schmid FA, Philips FS. (1975). Metabolism and selective effects of 1-beta-D-arabinofuranosylcytosine in L1210 and Host tissues in vivo. Cancer Res 35:225–236.
  • Dadhania VP, Tripathi DN, Vikram A, Ramarao P, Jena GB. (2010). Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine. Chem Biol Interact 183:85–97.
  • Davies NM, Saleh JY, Skjodt NM. (2000). Detection and prevention of NSAID-induced enteropathy. J Pharm Pharmaceut Sci 3(1):137–155.
  • Dawson PA. (2011). Role of the intestinal bile acid transporters in bile acid and drug disposition. Handb Exp Pharmacol:169–203.
  • de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM. (2006). Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. Drug Metab Dispos 34:591–599.
  • de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM. (2010). Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nat Protoc 5:1540–1551.
  • de Kanter R, Monshouwer M, Meijer DK, Groothuis GM. (2002a). Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues. Curr Drug Metab 3:39–59.
  • de Kanter R, De Jager MH, Draaisma AL, Jurva JU, Olinga P, Meijer DK, Groothuis GM. (2002b). Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica 32:349–362.
  • de Kanter R, Monshouwer M, Draaisma AL, De Jager MH, de Graaf IA, Proost JH, Meijer DK, Groothuis GM. (2004). Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. Xenobiotica 34:229–241.
  • de Kanter R, Tuin A, van de Kerkhof E, Martignoni M, Draaisma AL, de Jager MH, de Graaf IA, Meijer DK, Groothuis GM. (2005). A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies. J Pharmacol Toxicol Methods 51:65–72.
  • Dewit L, Oussoren Y, Bartelink H. (1986). The effects of cis-diamminedichloroplatinum (II) and radiation on the proliferation kinetics of mouse duodenal crypt cells and on a partially synchronized crypt cell population. Int J Radiat Oncol Biol Phys 12:1977–1985.
  • Dionne S, D’Agata ID, Hiscott J, Vanounou T, Seidman EG. (1998). Colonic explant production of IL-1and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD). Clin Exp Immunol 112:435–442.
  • Dionne S, Laberge S, Deslandres C, Seidman EG. (2003). Modulation of cytokine release from colonic explants by bacterial antigens in inflammatory bowel disease. Clin Exp Immunol 133:108–114.
  • Dormann H, Krebs S, Muth-Selbach U, Criegee-Rieck M, Radespiel-Tröger M, Levy M, Hahn EG, Brune K, Schneider HT. (2001). Adverse drug reactions in patients with gastroenterological diseases: does age increase the risk? Aliment Pharmacol Ther 15:171–180.
  • Droleskey RE, Oyofo BA, Hargis BM, Corrier DE, DeLoach JR. (1994). Effect of mannose on Salmonella typhimurium-mediated loss of mucosal epithelial integrity in cultured chick intestinal segments. Avian Dis 38:275–281.
  • Elamin E, Jonkers D, Juuti-Uusitalo K, van Ijzendoorn S, Troost F, Duimel H, Broers J, Verheyen F, Dekker J, Masclee A. (2012). Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model. PLoS ONE 7:e35008.
  • Fortun PJ, Hawkey CJ. (2007). Nonsteroidal antiinflammatory drugs and the small intestine. Curr Opin Gastroenterol 23:134–141.
  • Fortuna A, Alves G, Falcão A, Soares-da-Silva P. (2012). Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique. Epilepsia 53:529–538.
  • Gebhardt R, Hengstler JG, Müller D, Glöckner R, Buenning P, Laube B, Schmelzer E, Ullrich M, Utesch D, Hewitt N, Ringel M, Hilz BR, Bader A, Langsch A, Koose T, Burger HJ, Maas J, Oesch F. (2003). New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev 35:145–213.
  • Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG; Investigators. (2005). Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 3:133–141.
  • Graham DY, Opekun AR, Willingham FF, Qureshi WA. (2005). Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 3:55–59.
  • Groothuis GM, de Graaf IA. (2012). Precision-cut intestinal slices as in vitro tool for studies on drug metabolism. Curr Drug Metab (in press).
  • Hayeshi R, Hilgendorf C, Artursson P, Augustijns P, Brodin B, Dehertogh P, Fisher K, Fossati L, Hovenkamp E, Korjamo T, Masungi C, Maubon N, Mols R, Müllertz A, Mönkkönen J, O’Driscoll C, Oppers-Tiemissen HM, Ragnarsson EG, Rooseboom M, Ungell AL. (2008). Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories. Eur J Pharm Sci 35:383–396.
  • Johanson KJ, Rydberg B. (1977). The effect of 60Co gamma-radiation and hydroxyurea on the in vivo chain growth of DNA in crypt cells of the small intestine of the mouse. Int J Radiat Biol Relat Stud Phys Chem Med 31:441–449.
  • Kent TH, Cardelli RM, Stamler FW. (1969). Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol 54:237–249.
  • Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM. (2011). The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicol In Vitro 25:80–90.
  • Khan AA, Chow EC, van Loenen-Weemaes AM, Porte RJ, Pang KS, Groothuis GM. (2009a). Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. Eur J Pharm Sci 37:115–125.
  • Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM. (2009b). Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos 30:241–258.
  • Krag E, Phillips SF. (1974). Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunum. J Clin Invest 53:1686–1694.
  • Lash LH, Hagen TM, Jones DP. (1986). Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proc Natl Acad Sci USA 83:4641–4645.
  • Lennernäs H, Knutson L, Knutson T, Hussain A, Lesko L, Salmonson T, Amidon GL. (2002). The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique. Eur J Pharm Sci 15:271–277.
  • Leonard F, Collnot EM, Lehr CM. (2010). A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro. Mol Pharm 7:2103–2119.
  • Li M, Si L, Pan H, Rabba AK, Yan F, Qiu J, Li G. (2011). Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion. Int J Pharm 403:37–45.
  • Lim YJ, Yang CH. (2012). Non-steroidal anti-inflammatory drug-induced enteropathy. Clin Endosc 45:138–144.
  • Lin JH, Chiba M, Baillie TA. (1999). Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacol Rev 51:135–158.
  • Mahmud T, Rafi SS, Scott DL, Wrigglesworth JM, Bjarnason I. (1996). Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum 39:1998–2003.
  • Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I. (2005). A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology 128:1172–1178.
  • Margolis S, Philips FS, Sternberg SS. (1971). The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis. Cancer Res 31:2037–2046.
  • Martignoni M, de Kanter R, Grossi P, Mahnke A, Saturno G, Monshouwer M. (2004). An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR. Chem Biol Interact 151:1–11.
  • Martignoni M, Groothuis GM, de Kanter R. (2006). Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2:875–894.
  • Mazzarella G, Stefanile R, Camarca A, Giliberti P, Cosentini E, Marano C, Iaquinto G, Giardullo N, Auricchio S, Sette A, Troncone R, Gianfrani C. (2008). Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis. Gastroenterology 134:1017–1027.
  • Meddings JB, Gibbons I. (1998). Discrimination of site-specific alterations in gastrointestinal permeability in the rat. Gastroenterology 114:83–92.
  • Metzger M, Bareiss PM, Nikolov I, Skutella T, Just L. (2007). Three-dimensional slice cultures from murine fetal gut for investigations of the enteric nervous system. Dev Dyn 236:128–133.
  • Mitchell EP. (2006). Gastrointestinal toxicity of chemotherapeutic agents. Semin Oncol 33:106–120.
  • Niu X, Langelaar M, de Graaf I, Groothuis G. (2012). The role of metabolism in diclofenac-induced intestinal toxicity in human in vitro. Toxicol Lett 211(Suppl):S115. Available at: http://dx.doi.org/10.1016/j.toxlet.2012.03.425.
  • Olinga P, Merema MT, de Jager MH, Derks F, Melgert BN, Moshage H, Slooff MJ, Meijer DK, Poelstra K, Groothuis GM. (2001). Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. J Hepatol 35:187–194.
  • Pang KS, Weiss M, Macheras P. (2007). Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts. AAPS J 9:E268–E283.
  • Possidente M, Dragoni S, Franco G, Gori M, Bertelli E, Teodori E, Frosini M, Valoti, M. (2011). Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters. Eur J Pharm Biopharm 79(2):343–348.
  • Randall KJ, Turton J, Foster JR. (2011). Explant culture of gastrointestinal tissue: a review of methods and applications. Cell Biol Toxicol 27:267–284.
  • Reuter BK, Davies NM, Wallace JL. (1997). Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology 112:109–117.
  • Robert A, Asano T. (1977). Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins 14:333–341.
  • Roskott AM, Nieuwenhuijs VB, Leuvenink HG, Dijkstra G, Ottens P, de Jager MH, Gonalves Dias Pereira P, Fidler V, Groothuis GM, Ploeg RJ, de Graaf IA. (2010). Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution. Transplantation 90:622–629.
  • Rozehnal V, Nakai D, Hoepner U, Fischer T, Kamiyama E, Takahashi M, Yasuda S, Mueller J. (2012). Human small intestinal and colonic tissue mounted in the Ussing chamber as a tool for characterizing the intestinal absorption of drugs. Eur J Pharm Sci 46:367–373.
  • Sambruy Y, Ferruzza S, Ranaldi G, De Angelis I. (2001). Intestinal cell culture models: applications in toxicology and pharmacology. Cell Biol Toxicol 17:301–317.
  • Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H. (2009). Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459:262–265.
  • Siissalo S, Heikkinen AT. (2012). In vitro methods to study the interplay of drug metabolism and efflux in the intestine. Curr Drug Metab (in press).
  • Skonberg C, Olsen J, Madsen KG, Hansen SH, Grillo MP. (2008). Metabolic activation of carboxylic acids. Expert Opin Drug Metab Toxicol 4:425–438.
  • Somasundaram S, Rafi S, Hayllar J, Sigthorsson G, Jacob M, Price AB, Macpherson A, Mahmod T, Scott D, Wrigglesworth JM, Bjarnason I. (1997). Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine. Gut 41:344–353.
  • Treinen-Moslen M, Kanz MF. (2006). Intestinal tract injury by drugs: Importance of metabolite delivery by yellow bile road. Pharmacol Ther 112:649–667.
  • van de Kerkhof EG, de Graaf IA, de Jager MH, Groothuis GM. (2007). Induction of phase I and II drug metabolism in rat small intestine and colon in vitro. Drug Metab Dispos 35(6):898–907.
  • van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM. (2005). Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug Metab Dispos 33(11):1613–1620.
  • van de Kerkhof EG, de Graaf IA, Groothuis GM. (2007). In vitro methods to study intestinal drug metabolism. Curr Drug Metab 8(7):658–675.
  • van de Kerkhof EG, de Graaf IA, Ungell AL, Groothuis GM. (2008). Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metab Dispos 36(3):604–613.
  • van de Kerkhof EG, Ungell AL, Sjoberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM. (2006). Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations. Drug Metab Dispos 34(11):1893–1902.
  • van de Kerkhof EG. (2007). Drug metabolism in human and rat intestine: an in vitro approach. PhD Thesis, University of Groningen, Groningen, 2007. Available at: http://dissertations.ub.rug.nl/faculties/science/2007/e.g.van.de.kerkhof/.
  • van Midwoud PM, Merema MT, Verpoorte E, Groothuis GM. (2010). A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip 10:2778–2786.
  • Vickers AE, Fischer V, Connors S, Fisher RL, Baldeck JP, Maurer G, Brendel K. (1992). Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines. Drug Metab Dispos 20:802–809.
  • Vickers AE, Fisher RL. (2005). Precision-cut organ slices to investigate target organ injury. Expert Opin Drug Metab Toxicol 1:687–699.
  • Vickers AE, Fisher RL, Brendel K, Guertler J, Dannecker R, Keller B, Fischer V. (1995). Sites of biotransformation for the cyclosporin derivative SDZ IMM 125 using human liver and kidney slices and intestine. Comparison with rat liver slices and cyclosporin A metabolism. Drug Metab Dispos 23:327–333.
  • Vickers AE, Zollinger M, Dannecker R, Tynes R, Heitz F, Fischer V. (2001). In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metab Dispos 29:1269–1276.
  • Yadav S, Pillai KK, Kapur P. (2011). Severity assessment and pattern of adverse drug reactions with anti-tubercular therapy. Pharmacology online 3:706–712. Available at: http://www.unisa.it/uploads/5917/67.yadav.pdf.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.