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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 6
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General Xenobiochemistry

A novel matrix for the short-term storage of cells: utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes

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Pages 487-497 | Received 09 Aug 2012, Accepted 05 Oct 2012, Published online: 09 Nov 2012

References

  • Aidasani D, Zaya MJ, Malpas PB, Locuson CW. (2008). In vitro drug-drug interaction screens for canine veterinary medicines: evaluation of cytochrome P450 reversible inhibition. Drug Metab Dispos 36:1512–1518.
  • Alexandre E, Viollon-Abadie C, David P, Gandillet A, Coassolo P, Heyd B, Mantion G, Wolf P, Bachellier P, Jaeck D, Richert L. (2002). Cryopreservation of adult human hepatocytes obtained from resected liver biopsies. Cryobiology 44:103–113.
  • Alvarez M, Rhodes SJ, Bidwell JP. (2003). Context-dependent transcription: all politics is local. Gene 313:43–57.
  • Badolo L, Trancart MM, Gustavsson L, Chesné C. (2011). Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytes. Chem Biol Interact 190:165–170.
  • Chiba Y, Yamashita Y, Ueno M, Fujisawa H, Hirayoshi K, Hohmura K, Tomimoto H, Akiguchi I, Satoh M, Shimada A, Hosokawa M. (2005). Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations. J Gerontol A Biol Sci Med Sci 60:1087–1098.
  • Clayton DF, Darnell Jr JE. (1983). Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol Cell Biol 3:1552–1561.
  • Di Marco A, D’Antoni M, Attaccalite S, Carotenuto P, Laufer R. (2005). Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. Drug Metab Dispos 33:812–819.
  • DiPersio CM, Jackson DA, Zaret KS. (1991). The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol Cell Biol 11:4405–4414.
  • Ghibellini G, Vasist LS, Leslie EM, Heizer WD, Kowalsky RJ, Calvo BF, Brouwer KL. (2007). In vitro-in vivo correlation of hepatobiliary drug clearance in humans. Clin Pharmacol Ther 81:406–413.
  • Griffin SJ, Houston RJ. (2004). Prediction of in vitro intrinsic clearance from hepatocytes: Comparison of suspension and monolayer cultures. Drug Metab Dispos 33:115–120.
  • Grime K, Riley RJ. (2006). The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions. Curr Drug Metab 7:251–264.
  • Grime K, Webborn PJ, Riley RJ. (2008). Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes. Drug Metab Dispos 36:1670–1678.
  • Grunstein M. (1997). Histone acetylation in chromatin structure and transcription. Nature 389:349–352.
  • Honkakoski P, Negishi M. (2000). Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 347:321–337.
  • Illouz S, Alexandre E, Pattenden C, Mark L, Bachellier P, Webb M, Berry D, Dennison A, Richert L. (2008). Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. Phytother Res 22:1688–1691.
  • Jefferson DM, Clayton DF, Darnell JE Jr, Reid LM. (1984). Posttranscriptional modulation of gene expression in cultured rat hepatocytes. Mol Cell Biol 4:1929–1934.
  • Kato M, Chiba K, Horikawa M, Sugiyama Y. (2005). The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes. Drug Metab Pharmacokinet 20:236–243.
  • Kenny JR, Grime K. (2006). Pharmacokinetic consequences of time-dependent inhibition using the isolated perfused rat liver model. Xenobiotica 36:351–365.
  • Kobayashi O, Sakaguchi M, Okitsu T, Totsugawa T, Maruyama M, Matsumura T, Watanabe T, Noguchi H, Kosaka Y, Fujiwara T, Tanaka N. (2002). Improvement in the differentiated hepatic phenotype of immortalized human hepatocytes by adenovirus mediated p21 gene transfer. ASAIO J 48:355–359.
  • Kusuhara H, Sugiyama Y. (2010). Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters. Drug Metab Rev 42:539–550.
  • LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. (2000). Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Mol Toxicol 14:177–188.
  • Letschert K, Keppler D, König J. (2004). Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 14:441–452.
  • Li AP, Lu C, Brent JA, Pham C, Fackett A, Ruegg CE, Silber PM. (1999). Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem Biol Interact 121:17–35.
  • Li AP. (2008). Human hepatocytes as an effective alternative experimental system for the evaluation of human drug properties: general concepts and assay procedures. ALTEX 25:33–42.
  • McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ. (2004). Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab Dispos 32:1247–1253.
  • McGinnity DF, Tucker J, Trigg S, Riley RJ. (2005). Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes. Drug Metab Dispos 33:1700–1707.
  • Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J. (2002). A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J Biol Chem 277:43058–43063.
  • Nakakariya M, Ono M, Amano N, Moriwaki T, Maeda K, Sugiyama Y. (2012). In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes. Drug Metab Dispos 40:602–609.
  • Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T. (2002). Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther 302:804–813.
  • O’Donnell CJ, Grime K, Courtney P, Slee D, Riley RJ. (2007). The development of a cocktail CYP2B6, CYP2C8, and CYP3A5 inhibition assay and a preliminary assessment of utility in a drug discovery setting. Drug Metab Dispos 35:381–385.
  • Parker AJ, Houston BJ. (2008). Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir. Drug Metab Dispos 36:1375–1384.
  • Rana B, Xie Y, Mischoulon D, Bucher NL, Farmer SR. (1995). The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle. J Biol Chem 270:18123–18132.
  • Sahi J, Grepper S, Smith C. (2010). Hepatocytes as a tool in drug metabolism, transport and safety evaluations in drug discovery. Curr Drug Discov Technol 7:188–198.
  • Saliem M, Holm F, Tengzelius RB, Jorns C, Nilsson LM, Ericzon BG, Ellis E, Hovatta O. (2012). Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution. World J Hepatol 4:176–183.
  • Sasakawa Y, Naoe Y, Sogo N, Inoue T, Sasakawa T, Matsuo M, Manda T, Mutoh S. (2005). Marker genes to predict sensitivity to FK228, a histone deacetylase inhibitor. Biochem Pharmacol 69:603–616.
  • Schrem H, Klempnauer J, Borlak J. (2002). Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev 54:129–158.
  • Seglen GB. (1976). Preparation of isolated rat liver cells. Methods Cell Biol 13:29–83.
  • Shitara Y, Li AP, Kato Y, Lu C, Ito K, Itoh T, Sugiyama Y. (2003). Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes. Drug Metab Pharmacokinet 18:33–41.
  • Shitara Y, Hirano M, Sato H, Sugiyama Y. (2004). Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther 311:228–236.
  • Shou M, Norcross R, Sandig G, Lu P, Li Y, Lin Y, Mei Q, Rodrigues AD, Rushmore TH. (2003). Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450. Drug Metab Dispos 31:1161–1169.
  • Soars MG, Grime K, Sproston JL, Webborn PJ, Riley RJ. (2007). Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo. Drug Metab Dispos 35:859–865.
  • Soars MG, Fettes M, O’Sullivan AC, Riley RJ, Ethell BT, Burchell B. (2003). Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily. Biochem Pharmacol 65:1251–1259.
  • Sohlenius-Sternbeck AK, Schmidt S. (2005). Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes. Xenobiotica 35:727–736.
  • Terry C, Hughes RD, Mitry RR, Lehec SC, Dhawan A. (2007). Cryopreservation-induced nonattachment of human hepatocytes: role of adhesion molecules. Cell Transplant 16:639–647.
  • Terry C, Dhawan A, Mitry RR, Lehec SC, Hughes RD. (2010). Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation. Liver Transpl 16:229–237.
  • Tirona RG, Leake BF, Merino G, Kim RB. (2001). Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J Biol Chem 276:35669–35675.
  • Tirona RG, Kim RB. (2005). Nuclear receptors and drug disposition gene regulation. J Pharm Sci 94:1169–1186.
  • Tucker GT, Houston JB, Huang SM. (2001). Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus. Clin Pharmacol Ther 70:103–114.
  • Weaver R, Graham KS, Beattie IG, Riley RJ. (2003). Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation. Drug Metab Dispos 31:955–966.
  • Zhao P, Kunze KL, Lee CA. (2005). Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes. Drug Metab Dispos 33:853–861.

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