Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 7
240
Views
9
CrossRef citations to date
0
Altmetric
Pharmacogenetics

Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine

, , , , , & show all
Pages 636-640 | Received 04 Oct 2012, Accepted 05 Nov 2012, Published online: 19 Dec 2012

References

  • Allen JD, Schinkel AH. (2002). Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2). Mol Cancer Ther 1:427–34
  • Allikmets R, Schriml LM, Hutchinson A, et al. (1998). A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 58:5337–9
  • Anderson PL, Lamba J, Aquilante CL, et al. (2006). Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr 42:441–9
  • Chen Y, Li S, Brown C, et al. (2009). Effect of genetic variation in the OCT2 on the renal elimination of metformin. Pharmacogenet Genomics 19:497–504
  • Choi MK, Song IS. (2012). Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Biopharm Drug Dispos 33:170–8
  • Doong SL, Tsai CH, Schinazi RF, et al. (1991). Inhibition of the replication of hepatitis B virus in vitro by 2′,3′-dideoxy-3′-thiacytidine and related analogues. Proc Natl Acad Sci USA 88:8495–9
  • Epivir® (lamivudine) prescribing information. GlaxoSmithKline. Research Triangle Park, NC, USA, 2011
  • Fukushima-Uesaka H, Maekawa K, Ozawa S, et al. (2004). Fourteen novel single nucleotide polymorphisms in the SLC22A2 gene encoding human organic cation transporter (OCT2). Drug Metab Pharmacokinet 19:239–44
  • Gorboulev V, Ulzheimer JC, Akhoundova A, et al. (1997). Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16:871–81
  • Heald AE, Hsyu PH, Yuen GJ, et al. (1996). Pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with renal dysfunction. Antimicrob Agents Chemother 40:1514–19
  • Johnson MA, Moore KH, Yuen GJ, et al. (1999). Clinical pharmacokinetics of lamivudine. Clin Pharmacokinet 36:41–66
  • Jung N, Lehmann C, Rubbert A, et al. (2008). Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection. Drug Metab Dispos 36:1616–23
  • Jung N, Lehmann C, Rubbert A, et al. (2012). Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients. Infection. Available from: http://link.springer.com/article/10.1007%2Fs15010-012-0308-8 [last accessed 29 Oct 2012]
  • Kang HJ, Song IS, Shin HJ, et al. (2007). Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population. Drug Metab Dispos 35:667–75
  • Koepsell H, Lips K, Volk C. (2007). Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24:1227–51
  • Kurata T, Muraki Y, Mizutani H, et al. (2010). Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Drug Metab Pharmacokinet 25:328–34
  • Minuesa G, Volk C, Molina-Arcas M, et al. (2009). Transport of lamivudine [(−)-beta-l-2′,3′-dideoxy-3′-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther 329:252–61
  • Moore KH, Yuen GJ, Raasch RH, et al. (1996). Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazole. Clin Pharmacol Ther 59:550–8
  • Motohashi H, Sakurai Y, Saito H, et al. (2002). Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13:866–74
  • Nies AT, Koepsell H, Winter S, et al. (2009). Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50:1227–40
  • Ogasawara K, Terada T, Motohashi H, et al. (2008). Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney. J Hum Genet 53:607–14
  • Okuda M, Saito H, Urakami Y, et al. (1996). cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 224:500–7
  • Schuetz JD, Connelly MC, Sun D, et al. (1999). MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5:1048–51
  • Song IS, Shin HJ, Shim EJ, et al. (2008). Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther 84:559–62
  • Soudeyns H, Yao XI, Gao Q, et al. (1991). Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2′-deoxy-3′-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog. Antimicrob Agents Chemother 35:1386–90
  • Takubo T, Kato T, Kinami J, et al. (2000). Effect of lamivudine on uptake of organic cations by rat renal brush-border and basolateral membrane vesicles. J Pharm Pharmacol 52:569–75
  • Takubo T, Kato T, Kinami J, et al. (2002). Uptake of lamivudine by rat renal brush border membrane vesicles. J Pharm Pharmacol 54:111–17
  • Turriziani O, Schuetz JD, Focher F, et al. (2002). Impaired 2′,3′-dideoxy-3′-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. Biochem J 368:325–32
  • Wada S, Tsuda M, Sekine T, et al. (2000). Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther 294:844–9
  • Wang ZJ, Yin OQ, Tomlinson B, et al. (2008). OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet Genomics 18:637–45
  • Wijnholds J, Mol CA, van Deemter L, et al. (2000). Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97:7476–81
  • Yonezawa A, Masuda S, Nishihara K, et al. (2005). Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat. Biochem Pharmacol 70:1823–31
  • Zolk O, Solbach TF, König J, et al. (2009). Functional characterization of the human organic cation transporter 2 variant p.270Ala > Ser. Drug Metab Dispos 37:1312–18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.