Biomarkers of toluene exposure in rats: mercapturic acids versus traditional indicators (urinary hippuric acid and o-cresol and blood toluene)

References

• Agency for Toxic Substances and Disease Registry. (2000). Toxicological profile for toluene. Atlanta (GA): Agency for Toxic Substances and Disease Registry
   Google Scholar
• Angerer J, Kramer A. (1997). Occupational chronic exposure to organic solvents. XVI. Ambient and biological monitoring of workers exposed to toluene. Int Arch Occup Environ Health 69:91–6
   PubMed Web of Science ®Google Scholar
• Angerer J, Schildbach M, Krämer A. (1997). S-p-toluylmercapturic acid in the urine of workers exposed to toluene: a new biomarker for toluene exposure. Arch Toxicol 72:119–23
   Google Scholar
• Apostoli P, Brugnone F, Perbellini L, et al. (1982). Biomonitoring of occupational toluene exposure. Int Arch Occup Environ Health 50:153–68
   PubMed Web of Science ®Google Scholar
• Aylward LL, Barton HA, Hays SM. (2008). Biomonitoring Equivalents (BE) dossier for toluene (CAS No. 108-88-3). Regul Toxicol Pharmacol 51:S27–36
   Google Scholar
• Benignus VA, Muller KE, Graham JA, Barton CN. (1984). Toluene levels in blood and brain of rats as a function of toluene level in inspired air. Environ Res 33:39–46
   PubMed Web of Science ®Google Scholar
• Campo P, Blachère V, Payan JP, et al. (2006). Toluene toxicokinetics and metabolism parameters in the rat and guinea pig. Environ Toxicol Pharmacol 21:276–82
   PubMedGoogle Scholar
• Cosnier F, Brochard C, Burgart M, Cossec B. (2012). Mercapturic acids derived from toluene in rat urine samples: identification and measurement by gas chromatography – tandem mass spectrometry. Anal Bioanal Chem 404:1907–17
   PubMed Web of Science ®Google Scholar
• Cossec B, Cosnier F, Burgart M, et al. (2010). Glutathione pathway in ethylbenzene metabolism: novel biomarkers of exposure in the rat. Chemosphere 81:1334–41
   PubMed Web of Science ®Google Scholar
• de Rosa E, Bartolucci GB, Sigon M, et al. (1987). Hippuric acid and ortho-cresol as biological indicators of occupational exposure to toluene. Am J Ind Med 11:529–37
   PubMed Web of Science ®Google Scholar
• Dossing M, Aelum JB, Hansen SH, et al. (1983). Urinary hippuric acid and orthocresol excretion in man during experimental exposure to toluene. Br J Ind Med 40:470–3
   PubMedGoogle Scholar
• Ducos P, Berode M, Francin JM, et al. (2008). Biological monitoring of exposure to solvents using the chemical itself in urine: application to toluene. Int Arch Occup Environ Health 81:273–84
   PubMed Web of Science ®Google Scholar
• Ferrari M, Negri S, Zadra P, et al. (2008). Saliva as an analytical tool to measure occupational exposure to toluene. Int Arch Occup Environ Health 81:1021–8
   PubMed Web of Science ®Google Scholar
• Fustinoni S, Buratti M, Giampiccolo R, et al. (2000). Comparison between blood and urinary toluene as biomarkers of exposure to toluene. Int Arch Occup Environ Health 73:389–96
   PubMed Web of Science ®Google Scholar
• Fustinoni S, Mercadante R, Campo L, et al. (2007). Comparison between urinary o-cresol and toluene as biomarkers of toluene exposure. J Occup Environ Hyg 4:1–9
   PubMed Web of Science ®Google Scholar
• Ghittori S, Alessio A, Negri S, et al. (2004). A field method for sampling toluene in end-exhaled air, as a biomarker of occupational exposure: correlation with other exposure indices. Ind Health 42:226–34
   PubMed Web of Science ®Google Scholar
• Hannigan JH, Bowen SE. (2010). Reproductive toxicology and teratology of abused toluene. Syst Biol Reprod Med 56:184–200
   PubMed Web of Science ®Google Scholar
• Hasegawa K, Shiojima S, Koizumi A, Ikeda M. (1983). Hippuric acid and o-cresol in the urine of workers exposed to toluene. Int Arch Occup Environ Health 52:197–208
   PubMed Web of Science ®Google Scholar
• Haufroid V, Lison D. (2005). Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a minireview. Int Arch Occup Environ Health 78:343–54
   PubMed Web of Science ®Google Scholar
• Hoet P, Lison D. (2008). Ototoxicity of toluene and styrene: state of current knowledge. Crit Rev Toxicol 38:127–70
   PubMed Web of Science ®Google Scholar
• Ikeda M. (1999). Solvents in urine as exposure markers. Toxicol Lett 108:99–106
   PubMed Web of Science ®Google Scholar
• Ikeda M, Ukai H, Kawai T, et al. (2008). Changes in correlation coefficients of exposure markers as a function of intensity of occupational exposure to toluene. Toxicol Lett 179:148–54
   PubMed Web of Science ®Google Scholar
• Inoue O, Kanno E, Kasai K, et al. (2004). Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene. Toxicol Lett 147:177–86
   PubMed Web of Science ®Google Scholar
• Inoue O, Kanno E, Yusa T, et al. (2002). Urinary benzylmercapturic acid as a marker of occupational exposure to toluene. Int Arch Occup Environ Health 75:341–7
   PubMed Web of Science ®Google Scholar
• Inoue O, Kawai T, Ukai H, et al. (2008). Limited validity of o-cresol and benzylmercapturic acid in urine as biomarkers of occupational exposure to toluene at low levels. Ind Health 46:318–25
   PubMedGoogle Scholar
• Inoue O, Seiji K, Ishihara N, et al. (1984). Increased o- and p-cresol/hippuric acid ratios in the urine of four strains of rat exposed to toluene at thousands-ppm levels. Toxicol Lett 23:249–57
   PubMedGoogle Scholar
• Kawai T, Eitaki Y, Ukai H, et al. (2010). Validation of urine density correction in cases of hippuric acid and un-metabolized toluene in urine of workers exposed to toluene. Ind Health 48:154–63
   PubMedGoogle Scholar
• Kawai T, Mizunuma K, Okada Y, et al. (1996). Toluene itself as the best urinary marker of toluene exposure. Int Arch Occup Environ Health 68:289–97
   PubMed Web of Science ®Google Scholar
• Kawai T, Ukai H, Inoue O, et al. (2008). Evaluation of biomarkers of occupational exposure to toluene at low levels. Int Arch Occup Environ Health 81:253–62
   PubMed Web of Science ®Google Scholar
• Kawai T, Yamauchi T, Miyama Y, et al. (2007). Benzyl alcohol as a marker of occupational exposure to toluene. Ind Health 45:143–50
   PubMed Web of Science ®Google Scholar
• Linhart I, Mraz J, Dabrowska L, et al. (2012). Vinylphenylmercapturic acids in human urine as biomarkers of styrene ring oxidation. Toxicol Lett 213:260–5
   PubMed Web of Science ®Google Scholar
• Linhart I, Mraz J, Scharff J, et al. (2010). New urinary metabolites formed from ring-oxidized metabolic intermediates of styrene. Chem Res Toxicol 23:251–7
   PubMed Web of Science ®Google Scholar
• Lof A, Hjelm EW, Colmsjo A, et al. (1993). Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene. Br J Ind Med 50:55–9
   PubMedGoogle Scholar
• Lovreglio P, Barbieri A, Carrieri M, et al. (2010). Validity of new biomarkers of internal dose for use in the biological monitoring of occupational and environmental exposure to low concentrations of benzene and toluene. Int Arch Occup Environ Health 83:341–56
   PubMed Web of Science ®Google Scholar
• Maestri L, Ghittori S, Imbriani M. (1997). Determination of specific mercapturic acids as an index of exposure to environmental benzene, toluene, and styrene. Ind Health 35:489–501
   PubMed Web of Science ®Google Scholar
• Mizunuma K, Horiguchi S, Kawai T, et al. (1994). Toluene in blood as a marker of choice for low-level exposure to toluene. Int Arch Occup Environ Health 66:309–15
   PubMedGoogle Scholar
• Pierce CH, Chen YL, Dills RL, et al. (2002). Toluene metabolites as biological indicators of exposure. Toxicol Lett 129:65–76
   PubMed Web of Science ®Google Scholar
• Pierce CH, Dills RL, Morgan MS, et al. (1998). Biological monitoring of controlled toluene exposure. Int Arch Occup Environ Health 71:433–44
   PubMed Web of Science ®Google Scholar
• Takahashi S, Kagawa M, Shiwaku K, Matsubara K. (1994). Determination of S-benzyl-N-acetyl-L-cysteine by gas-chromatography mass-spectrometry as a new marker of toluene exposure. J Anal Toxicol 18:78–80
   PubMed Web of Science ®Google Scholar
• Truchon G, Tardif R, Brodeur J. (1996). Gas chromatographic determination of urinary o-cresol for the monitoring of toluene exposure. J Anal Toxicol 20:309–12
   PubMedGoogle Scholar
• Truchon G, Tardif R, Brodeur J. (1999). o-Cresol: a good indicator of exposure to low levels of toluene. Appl Occup Environ Hyg 14:677–81
   PubMedGoogle Scholar
• Ukai H, Kawai T, Inoue O, et al. (2007). Comparative evaluation of biomarkers of occupational exposure to toluene. Int Arch Occup Environ Health 81:81–93
   PubMed Web of Science ®Google Scholar
• US Environmental Protection Agency. (2005). Toxicological review of toluene. Washington (DC): US Environmental Protection Agency
   Google Scholar