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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 8
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Research Article

Comparative single-dose pharmacokinetics of rasagiline in minipigs after oral dosing or transdermal administration via a newly developed patch

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Pages 705-710 | Received 18 Oct 2012, Accepted 10 Dec 2012, Published online: 23 Jan 2013

References

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  • Lecht S, Haroutiunian S, Hoffman A, Lazarovici P. (2007). Rasagiline – a novel MAO-B inhibitor in Parkinson’s disease therapy. Ther Clin Risk Manag 3:467–74
  • Sterling J, Veinberg A, Lerner D. (1998). A controlled trial of rasagiline in early Parkinson disease. J Neural Transm Suppl 52:301–5
  • Thébault JJ, Guillaume M, Levy R. (2004). Tolerability, safety, pharmacodynamics, and pharmacokinetics of rasagiline: a potent, selective, and irreversible monoamine oxidase type B inhibitor. Pharmacotherapy 24:1295–305
  • van der Laan JW, Brightwell J, McAnulty P. (2010). Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products. J Pharmacol Toxicol Methods 62:184–95
  • Youdim MBH, Gross A, Finberg JPM. (2001). Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol 132:500–6

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