References
- Beal SL, Boeckmann A, Sheiner LB. (1992). Nonmem users guide. San Francisco, CA: Universidad de California
- Bermejo M, Avdeef A, Ruiz A, et al. (2004). PAMPA – a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur J Pharm Sci 21:429–41
- Bermejo M, Merino V, Garrigues TM, et al. (1999). Validation of a biophysical drug absorption model by the PATQSAR system. J Pharm Sci 88:398–405
- Blondeau JM. (1999). Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 21:3–40; discussion 41–2
- Doluisio JT, Billups NF, Dittert LW, et al. (1969). Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates. J Pharm Sci 58:1196–200
- Domagala JM. (1994). Structure-activity and structure-side-effect relationships for the quinolone antibacterials. J Antimicrob Chemother 33:685–706
- Escribano E, Calpena AC, Garrigues TM, et al. (1997). Structure-absorption relationships of a series of 6-fluoroquinolones. Antimicrob Agents Chemother 41:1996–2000
- Gamsiz ED, Thombre AG, Ahmed I, Carrier RL. (2011). Drug salts and solubilization: modeling the influence of cyclodextrins on oral absorption. Ann Biomed Eng 39:455–68
- Gonzalez-Alvarez I, Fernandez-Teruel C, Casabo-Alos VG, et al. (2007). In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results. Biopharm Drug Dispos 28:229–39
- Gonzalez-Alvarez I, Fernandez-Teruel C, Garrigues TM, et al. (2005). Kinetic modelling of passive transport and active efflux of a fluoroquinolone across Caco-2 cells using a compartmental approach in NONMEM. Xenobiotica 35:1067–88
- Griffiths NM, Hirst BH, Simmons NL. (1993). Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. Br J Pharmacol 108:575–6
- Griffiths NM, Hirst BH, Simmons NL. (1994). Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway? J Pharmacol Exp Ther 269:496–502
- Houston J, Wood S. (1983). Gastrointestinal absorption of drugs an other xenobiotics. In: Bridges JW, Chasseaud LF, eds. Progress in Drug Metabolism, Vol. 4. New York: Wiley, 57–130
- Ito A, Hirai K, Inoue M, et al. (1980). In vitro antibacterial activity of AM-715, a new nalidixic acid analog. Antimicrob Agents Chemother 17:103–8
- Lennernäs, H. (2007). Animal data: the contributions of the Using Chamber and perfusion systems to predicting human oral drug delivery in vivo. Adv Drug Deliv Rev 59:1103–20
- Naruhashi K, Tamai I, Inoue N, et al. (2001). Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. J Pharm Pharmacol 53:699–709
- Naruhashi K, Tamai I, Inoue N, et al. (2002). Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. Antimicrob Agents Chemother 46:344–9
- Ramon J, Dautrey S, Farinoti R, et al. (1994). Intestinal elimination of ciprofloxacin in rabbits. Antimicrob Agents Chemother 38:757–60
- Reix N, Guhmann P, Bietiger W, et al. (2012). Duodenum-specific drug delivery: in vivo assessment of a pharmaceutically developed enteric-coated capsule for a broad applicability in rat studies. Int J Pharm 422:338–40
- Rodriguez-Ibanez M, Nalda-Molina R, Montalar-Montero M, et al. (2003). Transintestinal secretion of ciprofloxacin, grepafloxacin and sparfloxacin: in vitro and in situ inhibition studies. Eur J Pharm Biopharm 55:241–6
- Rodriguez-Ibanez M, Sanchez-Castano G, Montalar-Montero M, et al. (2006). Mathematical modelling of in situ and in vitro efflux of ciprofloxacin and grepafloxacin. Int J Pharm 307:33–41
- Rubinstein E, St Julien L, Ramon J, et al. (1994). The intestinal elimination of ciprofloxacin in the rat. J Infect Dis 169:218–21
- Ruiz-Garcia A, Bermejo M, Merino V, et al. (1999). Pharmacokinetics, bioavailability and absorption of flumequine in the rat. Eur J Pharm Biopharm 48:253–8
- Ruiz-Garcia A, Lin H, Pla-Delfina JM, Hu M. (2002). Kinetic characterization of secretory transport of a new ciprofloxacin derivative (CNV97100) across Caco-2 cell monolayers. J Pharm Sci 91:2511–9
- Sanchez-Castano G, Ruiz-Garcia A, Banon N, et al. (2000). Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones. J Pharm Sci 89:1395–403
- Staib AH, Beermann D, Harder S, et al. (1989). Absorption differences of ciprofloxacin along the human gastrointestinal tract determined using a remote-control drug delivery device (HF-capsule). Am J Med 87:66–9S
- Talens-Visconti R, Garrigues TM, Canton E, et al. (2002). Activity-bioavailability balance in oral drug development for a selected group of 6-fluoroquinolones. J Pharm Sci 91:2452–64
- Torres-Molina F, Aristorena JC, Garcia-Carbonell C, et al. (1992). Influence of permanent cannulation of the jugular vein on pharmacokinetics of amoxycillin and antipyrine in the rat. Pharm Res 9:1587–91
- Wagner JG. (1993). Pharmacokinetics for the pharmaceutical scientist. Lancaster, PA: Technomic