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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 8
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Research Article

Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences

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Pages 716-721 | Received 22 Jan 2014, Accepted 14 Feb 2014, Published online: 11 Mar 2014

References

  • Dahms M, Lotz R, Lang W, et al. (1997). Elucidation of phase I and phase II metabolic pathways of rhein: species differences and their potential relevance. Drug Metab Dispos 25:442–52
  • Dong R-H, Fang Z-Z, Zhu L-L, et al. (2012). Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol. Xenobiotica 42:1009–16
  • Fisher MB, Paine MF, Strelevitz TJ, Wrighton SA. (2001). The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metab Rev 33:273–97
  • Liu W, Feng Q, Li Y, et al. (2012). Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. Toxicol Appl Pharmacol 265:316–24
  • Miners JO, Knights KM, Houston JB, Mackenzie PI. (2006). In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises. Biochem Pharmacol 71:1531–9
  • Ritter JK. (2000). Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions. Chem Biol Interact 129:171–93
  • Soars MG, Burchell B, Riley RJ. (2002). In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance. J Pharmacol Exp Ther 301:382–90
  • Tukey RH, Strassburg CP. (2000). Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581–616
  • Turgeon D, Carrier JS, Chouinard S, Belanger A. (2003). Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics. Drug Metab Dispos 31:670–6
  • Wu B, Kulkarni K, Basu S, et al. (2011). First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci 100:3655–81
  • Zhang C, Wang R, Liu B, Tu G. (2011). Structure elucidation of a sodium salified anthraquinone from the seeds of Cassia obtusifolia by NMR technique assisted with acid-alkali titration. Magn Reson Chem 49:529–32
  • Zhang N, Dong N, Pang L, et al. (2013). Quantitative determination and pharmacokinetic study of aurantio-obtusin in rat plasma by liquid chromatography-mass spectrometry. J Chromatogr Sci [Epub ahead of print]. doi: 10.1093/chromsci/bmt159

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